Detailed entry information

Protein Information (annotations from UniProt)

Database IDHIV0000972
UniProt IDP21860
Primary gene name(s)ERBB3
Synonym gene name(s)HER3
Protein nameReceptor tyrosine-protein kinase erbB-3
Protein functionTyrosine-protein kinase that plays an essential role as cell surface receptor for neuregulins. Binds to neuregulin-1, NRG1 and is activated by it; ligand-binding increases phosphorylation on tyrosine residues and promotes its association with the p85 subunit of phosphatidylinositol 3-kinase, PubMed:20682778. May also be activated by CSPG5, PubMed:15358134. {ECO:0000269|PubMed:15358134, ECO:0000269|PubMed:20682778}.
Subcellular locationIsoform 1: Cell membrane;
Single-pass type I membrane protein.;
SUBCELLULAR LOCATION: Isoform 2: Secreted.
ECO codeClick here for more information.
Amino acid sequence
FASTA format: P21860
Gene Ontology
(Biological Process)
Complete annatation
cranial nerve development [GO:0021545];
endocardial cushion development [GO:0003197];
ERBB2 signaling pathway [GO:0038128];
extrinsic apoptotic signaling pathway in absence of ligand [GO:0097192];
heart development [GO:0007507];
MAPK cascade [GO:0000165];
negative regulation of cell adhesion [GO:0007162];
negative regulation of neuron apoptotic process [GO:0043524];
negative regulation of secretion [GO:0051048];
negative regulation of signal transduction [GO:0009968];
neuron apoptotic process [GO:0051402];
peripheral nervous system development [GO:0007422];
phosphatidylinositol 3-kinase signaling [GO:0014065];
phosphatidylinositol-mediated signaling [GO:0048015];
positive regulation of calcineurin-NFAT signaling cascade [GO:0070886];
positive regulation of cardiac muscle tissue development [GO:0055025];
positive regulation of gene expression [GO:0010628];
positive regulation of phosphatidylinositol 3-kinase signaling [GO:0014068];
positive regulation of protein tyrosine kinase activity [GO:0061098];
regulation of cell motility [GO:2000145];
regulation of cell proliferation [GO:0042127];
regulation of phosphatidylinositol 3-kinase signaling [GO:0014066];
Schwann cell differentiation [GO:0014037];
signal transduction [GO:0007165];
transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169];
wound healing [GO:0042060]
Gene Ontology
(Molecular Function)
Complete annatation
ATP binding [GO:0005524];
growth factor binding [GO:0019838];
identical protein binding [GO:0042802];
phosphatidylinositol-4,5-bisphosphate 3-kinase activity [GO:0046934];
protein heterodimerization activity [GO:0046982];
protein homodimerization activity [GO:0042803];
protein tyrosine kinase activator activity [GO:0030296];
protein tyrosine kinase activity [GO:0004713];
Ras guanyl-nucleotide exchange factor activity [GO:0005088];
transmembrane signaling receptor activity [GO:0004888]
Gene Ontology
(Cellular Component)
Complete annatation
apical plasma membrane [GO:0016324];
basolateral plasma membrane [GO:0016323];
extracellular space [GO:0005615];
integral component of plasma membrane [GO:0005887];
intracellular [GO:0005622];
lateral plasma membrane [GO:0016328];
plasma membrane [GO:0005886];
receptor complex [GO:0043235]
Protein-protein interaction108377
Phylogenetic treeP21860
HIV replication factor status Zhou et al., Cell. Host. Microbe., 2008
Brass et al., Science, 2008
Smith et al., J. Immunol, 2010
gene status
Lu et al., J. Virol., 2011
      Folds changes 8h: unknown; Folds changes 16h: unknown; Tested: unknown;
Schoggins JW and Rice CM, Curr. Opin. Virol., 2011
      Targeted viruses: unknown
      Viral life cycle: unknown
      Mechanism related to antiviral activity: unknown
Anti-viral restriction factor Liu et al., Retrovirology, 2011
      unknown (Triplicates)

Gene Expression Profile       top

            Up-regulated;            Down-regulated

For brief introduction to each study, please go to the help page.

Gene expression during HIV latency

(1). Mohammadi et al., PLoS Pathog., 2014

Differentially expressed transcripts (Pairwise) during latency and subsequent viral reactivation using several agents - Primary CD4+ T-cell based model

DMSO: Dimethyl suloxyde (negative control) - 0.0033% final
SAHA: Vorinostat (Histone deacetylase inhibitor) - 0.5 μM
CD3: TCR Stimulation by IL-2+ antiCD3/anti-CD28 antibodies
IL7: Interleukin-7 based stimulation
DISU: Disulfiram (alcohol dehydrogenase inhibitor) - 0.5 μM
AZA: 5-azacytidine (AZA; DNA methylation inhibitor) - 1 μM
Experimental Condition Log2 Fold Change P value Adjusted P value
AZA vs. CD3-4.8482192125608900
AZA vs. DISU-0.8302626363752930.00153446108047650.100567244900447
AZA vs. IL7-0.4212364259311260.04371156015535850.632365053135749
AZA vs. SAHA0.573202230978410.02057576274808440.157201747422516
DISU vs. CD34.0070151199952300
DISU vs. IL70.3985723420980290.1207880500968520.454765650932143
DISU vs. SAHA1.405725915468522.70664566814904e-060.00022133005961992
DMSO vs. AZA0.007632311346001510.9693116930295941
DMSO vs. CD34.8465740955069600
DMSO vs. DISU0.8366806031413020.0009793588968981530.0641903233706729
DMSO vs. IL7-0.4219866128127790.03158208922794890.362328763402839
DMSO vs. SAHA0.5597568867571280.01917263502275360.137989867444087
HIV vs. Mock in Activationunknownunknownunknown
HIV vs. Mock in Latency0.3532931505992030.04233904027566320.8029016628186
IL7 vs. CD34.4313763459258700
SAHA vs. CD35.398295692380500
SAHA vs. IL70.9922174838281926.73969278829345e-050.00141975271041595
(2). Iglesias-Ussel et al., J. Virol., 2013

Up and Downregulated transcripts during Latency (Latently infected CD4+ T cells vs Uninfected)- Primary CD4+Tcell based model
Log2 Fold Change P Value
unknown unknown

Gene expression during HIV infection and replication

(1). Imbeault et al., PloS Pathog., 2012

Transcriptomic profiling of HIV-1 infected CD4+ T cells - Primary CD4+ T cells
Experiment type Log2 Fold Change P Value Adjusted P Value
Infected vs. Mock unknown unknown unknown
Infected vs. Bystander unknown unknown unknown
(2). Lefebvre et al., J. Virol., 2011

Transcriptome analysis of T-cell line (Sup T1)
Log2 Fold Change unknown
(3). Li et al., J. Immunol., 2013

Lymphatic tissue
Acute Fold Change Acute P Value Asymt Fold Change Asypt P Value AIDS Fold Change AIDS P Value
unknown unknown unknown unknown unknown unknown
(4). Chang et al., MBio., 2011

Transcriptome analysis of T-cell line (Sup T1)

Derived from Sherrill-Mix et al., BMC Retrovirol., 2015 cross validation
Up-regulated (True) TRUE
(5). Sherrill-Mix et al., BMC Retrovirol., 2015

Deep RNA-seq analysis of primary human T cell infected with low passage HIV isolate HIV89.6 - Primary CD4+ T cell based
Test Status Log2 Fold Change P Value
OK -0.171855 0.730617
(6). Rotger et al., PLoS Pathog., 2010

Genome-wide mRNA expression of CD4+ T cells from HIV-infected patient
(Genes differentially expressed (at adjusted p<0.01) according to the empirical Bayes approach)
Log2 Fold Change P Value
unknown unknown

Proteomic/Transcriptomics studies indicating differentially expressed genes mediated by HIV

(1). Greenwood et al., Elife, 2016

Activated (CD3/CD28) Primary human CD4+ T cells infected with pNL4-3-dE-EGFP. The table shows the complete (unfiltered) TMT (tandem mass tag)-based proteomic time course dataset
6 h 24 h 48 h 72 h RTi
unknown unknown unknown unknown unknown
(2). Navare et al., Virology, 2012

SUP-T1 cell line
FC-4hpi P-value FC-8hpi P-value FC-20hpi P-value Category
unknown unknown unknown unknown unknown unknown unknown
(3). Hyrcza et al., J. Virolo., 2007

Primary human CD4+ and CD8+ T Cells
Affymetrix Prob ID Fold Change In CD8? Category
unknown unknown unknown unknown

Protein Overview       top

Drug-protein Interaction       (annotations from DrugBank)      top

not found

Protein Secondary Structure       (annotations from PDB)      top

PDB Accession Method Resolution Chain Structure Preview
1M6B X-ray 2.6Å A/B=20-640.
2L9U NMR - A/B=639-670.
3KEX X-ray 2.8Å A/B=698-1019.
3LMG X-ray 2.8Å A/B=684-1020.
3P11 X-ray 3.7Å A=20-532.
4LEO X-ray 2.6Å C=20-631.
4OTW X-ray 2.5Å A=698-1020.
4P59 X-ray 3.4Å A=20-640.
4RIW X-ray 3.1Å A/C=698-1020.
4RIX X-ray 3.1Å A/C=698-1020.
4RIY X-ray 2.9Å A/C=698-1020.
5CUS X-ray 3.2Å A/B/C/D=20-641.

HIV-1 Interaction       (annotations from NCBI HIV-1 Interaction Database)      top

not found

Metabolic/Signalling Pathway       (annotations from KEGG database)      top

Pathway Accession Number Description
hsa01521 EGFR tyrosine kinase inhibitor resistance - Homo sapiens (human)
hsa04012 ErbB signaling pathway - Homo sapiens (human)
hsa04020 Calcium signaling pathway - Homo sapiens (human)
hsa04144 Endocytosis - Homo sapiens (human)
hsa05205 Proteoglycans in cancer - Homo sapiens (human)
hsa05206 MicroRNAs in cancer - Homo sapiens (human)