Detailed entry information

Protein Information (annotations from UniProt)

Database IDHIV0000944
UniProt IDQ9H9T3
Primary gene name(s)ELP3
Synonym gene name(s)unknown
Protein nameElongator complex protein 3
Protein functionCatalytic histone acetyltransferase subunit of the RNA polymerase II elongator complex, which is a component of the RNA polymerase II, Pol II holoenzyme and is involved in transcriptional elongation. Elongator may play a role in chromatin remodeling and is involved in acetylation of histones H3 and probably H4. Involved in acetylation of alpha-tubulin, PubMed:19185337. May also have a methyltransferase activity. Involved in cell migration. Involved in neurogenesis. Regulates the migration and branching of projection neurons in the developing cerebral cortex, through a process depending on alpha-tubulin acetylation, By similarity. {ECO:0000250|UniProtKB:Q9CZX0, ECO:0000269|PubMed:11714725, ECO:0000269|PubMed:11818576, ECO:0000269|PubMed:15902492, ECO:0000269|PubMed:16713582, ECO:0000269|PubMed:19185337}.
Subcellular locationCytoplasm {ECO:0000269|PubMed:19185337}.;
SUBCELLULAR LOCATION: Isoform 1: Nucleus.;
SUBCELLULAR LOCATION: Isoform 2: Cytoplasm. Nucleus.
ECO codeClick here for more information.
Amino acid sequence
FASTA format: Q9H9T3
Gene Ontology
(Biological Process)
Complete annatation
central nervous system development [GO:0007417];
histone H3 acetylation [GO:0043966];
histone H4 acetylation [GO:0043967];
neuron migration [GO:0001764];
positive regulation of cell migration [GO:0030335];
regulation of transcription from RNA polymerase II promoter [GO:0006357];
transcription elongation from RNA polymerase II promoter [GO:0006368]
Gene Ontology
(Molecular Function)
Complete annatation
H3 histone acetyltransferase activity [GO:0010484];
H4 histone acetyltransferase activity [GO:0010485];
iron-sulfur cluster binding [GO:0051536];
metal ion binding [GO:0046872];
phosphorylase kinase regulator activity [GO:0008607]
Gene Ontology
(Cellular Component)
Complete annatation
cytoplasm [GO:0005737];
Elongator holoenzyme complex [GO:0033588];
histone acetyltransferase complex [GO:0000123];
nucleolus [GO:0005730];
transcription elongation factor complex [GO:0008023]
Protein-protein interaction120444
Phylogenetic treeQ9H9T3
HIV replication factor status Zhou et al., Cell. Host. Microbe., 2008
Brass et al., Science, 2008
Smith et al., J. Immunol, 2010
gene status
Lu et al., J. Virol., 2011
      Folds changes 8h: unknown; Folds changes 16h: unknown; Tested: unknown;
Schoggins JW and Rice CM, Curr. Opin. Virol., 2011
      Targeted viruses: unknown
      Viral life cycle: unknown
      Mechanism related to antiviral activity: unknown
Anti-viral restriction factor Liu et al., Retrovirology, 2011
      unknown (Triplicates)

Gene Expression Profile       top

            Up-regulated;            Down-regulated

For brief introduction to each study, please go to the help page.

Gene expression during HIV latency

(1). Mohammadi et al., PLoS Pathog., 2014

Differentially expressed transcripts (Pairwise) during latency and subsequent viral reactivation using several agents - Primary CD4+ T-cell based model

DMSO: Dimethyl suloxyde (negative control) - 0.0033% final
SAHA: Vorinostat (Histone deacetylase inhibitor) - 0.5 μM
CD3: TCR Stimulation by IL-2+ antiCD3/anti-CD28 antibodies
IL7: Interleukin-7 based stimulation
DISU: Disulfiram (alcohol dehydrogenase inhibitor) - 0.5 μM
AZA: 5-azacytidine (AZA; DNA methylation inhibitor) - 1 μM
Experimental Condition Log2 Fold Change P value Adjusted P value
AZA vs. CD30.4218843341440690.1990432939158910.303712699449692
AZA vs. DISU0.09811697420234230.6991774097356860.969609310121983
AZA vs. IL70.1378670487857870.4768662940745070.999311006273513
AZA vs. SAHA-0.1515247066475610.5377174535347580.84239793125992
DISU vs. CD3-0.3359642029744820.3546036672177550.488244033580603
DISU vs. IL70.03006364320195840.9053434526016110.982189124739072
DISU vs. SAHA-0.2475948474286990.3986715110037950.759369039694218
DMSO vs. AZA-0.01006758907092150.9526450476156421
DMSO vs. CD3-0.4407590290768070.1698573398155250.262397541460304
DMSO vs. DISU-0.1094027842638030.6552253896754050.950002654032543
DMSO vs. IL70.1548096379674820.3931344693386120.842829931235466
DMSO vs. SAHA-0.148068875387450.5325707090941450.829706280602714
HIV vs. Mock in Activation0.1716829998331120.7827086356926360.999983755607037
HIV vs. Mock in Latency0.09804692715468640.5567581712618550.999834320637052
IL7 vs. CD3-0.2777070699720410.3888450121117030.525849436886653
SAHA vs. CD3-0.5967896394765970.09420830455464310.165874418698268
SAHA vs. IL7-0.2916782854851180.2338858079155170.474252713010292
(2). Iglesias-Ussel et al., J. Virol., 2013

Up and Downregulated transcripts during Latency (Latently infected CD4+ T cells vs Uninfected)- Primary CD4+Tcell based model
Log2 Fold Change P Value
unknown unknown

Gene expression during HIV infection and replication

(1). Imbeault et al., PloS Pathog., 2012

Transcriptomic profiling of HIV-1 infected CD4+ T cells - Primary CD4+ T cells
Experiment type Log2 Fold Change P Value Adjusted P Value
Infected vs. Mock unknown unknown unknown
Infected vs. Bystander unknown unknown unknown
(2). Lefebvre et al., J. Virol., 2011

Transcriptome analysis of T-cell line (Sup T1)
Log2 Fold Change unknown
(3). Li et al., J. Immunol., 2013

Lymphatic tissue
Acute Fold Change Acute P Value Asymt Fold Change Asypt P Value AIDS Fold Change AIDS P Value
unknown unknown unknown unknown unknown unknown
(4). Chang et al., MBio., 2011

Transcriptome analysis of T-cell line (Sup T1)

Derived from Sherrill-Mix et al., BMC Retrovirol., 2015 cross validation
Up-regulated (True) FALSE
(5). Sherrill-Mix et al., BMC Retrovirol., 2015

Deep RNA-seq analysis of primary human T cell infected with low passage HIV isolate HIV89.6 - Primary CD4+ T cell based
Test Status Log2 Fold Change P Value
OK -0.224405 0.107919
(6). Rotger et al., PLoS Pathog., 2010

Genome-wide mRNA expression of CD4+ T cells from HIV-infected patient
(Genes differentially expressed (at adjusted p<0.01) according to the empirical Bayes approach)
Log2 Fold Change P Value
unknown unknown

Proteomic/Transcriptomics studies indicating differentially expressed genes mediated by HIV

(1). Greenwood et al., Elife, 2016

Activated (CD3/CD28) Primary human CD4+ T cells infected with pNL4-3-dE-EGFP. The table shows the complete (unfiltered) TMT (tandem mass tag)-based proteomic time course dataset
6 h 24 h 48 h 72 h RTi
0.98 0.923 0.964 0.774 0.921
(2). Navare et al., Virology, 2012

SUP-T1 cell line
FC-4hpi P-value FC-8hpi P-value FC-20hpi P-value Category
unknown unknown unknown unknown unknown unknown unknown
(3). Hyrcza et al., J. Virolo., 2007

Primary human CD4+ and CD8+ T Cells
Affymetrix Prob ID Fold Change In CD8? Category
unknown unknown unknown unknown

Protein Overview       top

Drug-protein Interaction       (annotations from DrugBank)      top

not found

Protein Secondary Structure       (annotations from PDB)      top

not found

HIV-1 Interaction       (annotations from NCBI HIV-1 Interaction Database)      top

not found

Metabolic/Signalling Pathway       (annotations from KEGG database)      top

Pathway Accession Number Description
not found