Detailed entry information

Protein Information (annotations from UniProt)

Database IDHIV0000943
UniProt IDQ9BW60
Primary gene name(s)ELOVL1
Synonym gene name(s)SSC1
Protein nameElongation of very long chain fatty acids protein 1
Protein functionCatalyzes the first and rate-limiting reaction of the four that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. Condensing enzyme that exhibits activity toward saturated C18 to C26 acyl-CoA substrates, with the highest activity towards C22:0 acyl-CoA. May participate in the production of both saturated and monounsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. Important for saturated C24:0 and monounsaturated C24:1 sphingolipid synthesis. Indirectly inhibits RPE65 via production of VLCFAs. {ECO:0000255|HAMAP-Rule:MF_03201, ECO:0000269|PubMed:20166112, ECO:0000269|PubMed:20937905}.
Subcellular locationEndoplasmic reticulum membrane {ECO:0000255|HAMAP-Rule:MF_03201, ECO:0000269|PubMed:20937905};
Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_03201}.
ECO codeClick here for more information.
Amino acid sequence
FASTA format: Q9BW60
Gene Ontology
(Biological Process)
Complete annatation
alpha-linolenic acid metabolic process [GO:0036109];
fatty acid elongation, monounsaturated fatty acid [GO:0034625];
fatty acid elongation, polyunsaturated fatty acid [GO:0034626];
fatty acid elongation, saturated fatty acid [GO:0019367];
linoleic acid metabolic process [GO:0043651];
long-chain fatty-acyl-CoA biosynthetic process [GO:0035338];
sphingolipid biosynthetic process [GO:0030148];
unsaturated fatty acid biosynthetic process [GO:0006636];
very long-chain fatty acid biosynthetic process [GO:0042761]
Gene Ontology
(Molecular Function)
Complete annatation
fatty acid elongase activity [GO:0009922]
Gene Ontology
(Cellular Component)
Complete annatation
endoplasmic reticulum [GO:0005783];
endoplasmic reticulum membrane [GO:0005789];
integral component of endoplasmic reticulum membrane [GO:0030176];
membrane [GO:0016020]
Protein-protein interaction122312
Phylogenetic treeQ9BW60
HIV replication factor status Zhou et al., Cell. Host. Microbe., 2008
Brass et al., Science, 2008
Smith et al., J. Immunol, 2010
gene status
Lu et al., J. Virol., 2011
      Folds changes 8h: unknown; Folds changes 16h: unknown; Tested: unknown;
Schoggins JW and Rice CM, Curr. Opin. Virol., 2011
      Targeted viruses: unknown
      Viral life cycle: unknown
      Mechanism related to antiviral activity: unknown
Anti-viral restriction factor Liu et al., Retrovirology, 2011
      unknown (Triplicates)

Gene Expression Profile       top

            Up-regulated;            Down-regulated

For brief introduction to each study, please go to the help page.

Gene expression during HIV latency

(1). Mohammadi et al., PLoS Pathog., 2014

Differentially expressed transcripts (Pairwise) during latency and subsequent viral reactivation using several agents - Primary CD4+ T-cell based model

DMSO: Dimethyl suloxyde (negative control) - 0.0033% final
SAHA: Vorinostat (Histone deacetylase inhibitor) - 0.5 μM
CD3: TCR Stimulation by IL-2+ antiCD3/anti-CD28 antibodies
IL7: Interleukin-7 based stimulation
DISU: Disulfiram (alcohol dehydrogenase inhibitor) - 0.5 μM
AZA: 5-azacytidine (AZA; DNA methylation inhibitor) - 1 μM
Experimental Condition Log2 Fold Change P value Adjusted P value
AZA vs. CD30.481291947775950.1423443833957080.232893996132735
AZA vs. DISU0.01721300339496880.945800231679040.996198528027442
AZA vs. IL70.09047806611680550.6389252712025560.999311006273513
AZA vs. SAHA-0.4777336864473320.05160367114089380.275777429626806
DISU vs. CD3-0.4760164004172160.1896814774441120.306163249918893
DISU vs. IL70.0631442309099280.8022271655313330.956438858137228
DISU vs. SAHA-0.4921088091794340.09283542967282010.389206675076915
DMSO vs. AZA0.03884348493030180.8174653616237771
DMSO vs. CD3-0.453849407423030.1563955744773850.245004374051196
DMSO vs. DISU0.01978329471547990.9354342144615180.99119945388848
DMSO vs. IL70.05894011093117260.7437826200652720.948927132488488
DMSO vs. SAHA-0.5213232898276420.02791064592729310.176655851682747
HIV vs. Mock in Activation0.2908793074725960.6420816028719470.999983755607037
HIV vs. Mock in Latency0.05928191991017960.7210374058047050.999834320637052
IL7 vs. CD3-0.3861623843841240.2297160912678160.358512180956698
SAHA vs. CD3-0.9817539456723580.005923606058215290.0164732871927117
SAHA vs. IL7-0.5694899286120520.02007530382463820.100707199789138
(2). Iglesias-Ussel et al., J. Virol., 2013

Up and Downregulated transcripts during Latency (Latently infected CD4+ T cells vs Uninfected)- Primary CD4+Tcell based model
Log2 Fold Change P Value
unknown unknown

Gene expression during HIV infection and replication

(1). Imbeault et al., PloS Pathog., 2012

Transcriptomic profiling of HIV-1 infected CD4+ T cells - Primary CD4+ T cells
Experiment type Log2 Fold Change P Value Adjusted P Value
Infected vs. Mock unknown unknown unknown
Infected vs. Bystander unknown unknown unknown
(2). Lefebvre et al., J. Virol., 2011

Transcriptome analysis of T-cell line (Sup T1)
Log2 Fold Change unknown
(3). Li et al., J. Immunol., 2013

Lymphatic tissue
Acute Fold Change Acute P Value Asymt Fold Change Asypt P Value AIDS Fold Change AIDS P Value
unknown unknown unknown unknown unknown unknown
(4). Chang et al., MBio., 2011

Transcriptome analysis of T-cell line (Sup T1)

Derived from Sherrill-Mix et al., BMC Retrovirol., 2015 cross validation
Up-regulated (True) TRUE
(5). Sherrill-Mix et al., BMC Retrovirol., 2015

Deep RNA-seq analysis of primary human T cell infected with low passage HIV isolate HIV89.6 - Primary CD4+ T cell based
Test Status Log2 Fold Change P Value
OK -0.0127895 0.953545
(6). Rotger et al., PLoS Pathog., 2010

Genome-wide mRNA expression of CD4+ T cells from HIV-infected patient
(Genes differentially expressed (at adjusted p<0.01) according to the empirical Bayes approach)
Log2 Fold Change P Value
unknown unknown

Proteomic/Transcriptomics studies indicating differentially expressed genes mediated by HIV

(1). Greenwood et al., Elife, 2016

Activated (CD3/CD28) Primary human CD4+ T cells infected with pNL4-3-dE-EGFP. The table shows the complete (unfiltered) TMT (tandem mass tag)-based proteomic time course dataset
6 h 24 h 48 h 72 h RTi
0.938 0.976 1.085 1.226 0.861
(2). Navare et al., Virology, 2012

SUP-T1 cell line
FC-4hpi P-value FC-8hpi P-value FC-20hpi P-value Category
unknown unknown unknown unknown unknown unknown unknown
(3). Hyrcza et al., J. Virolo., 2007

Primary human CD4+ and CD8+ T Cells
Affymetrix Prob ID Fold Change In CD8? Category
unknown unknown unknown unknown

Protein Overview       top

Drug-protein Interaction       (annotations from DrugBank)      top

not found

Protein Secondary Structure       (annotations from PDB)      top

not found

HIV-1 Interaction       (annotations from NCBI HIV-1 Interaction Database)      top

not found

Metabolic/Signalling Pathway       (annotations from KEGG database)      top

Pathway Accession Number Description
hsa00062 Fatty acid elongation - Homo sapiens (human)