Detailed entry information

Protein Information (annotations from UniProt)

Database IDHIV0000929
UniProt IDQ13542
Primary gene name(s)EIF4EBP2
Synonym gene name(s)unknown
Protein nameEukaryotic translation initiation factor 4E-binding protein 2
Protein functionRepressor of translation initiation involved in synaptic plasticity, learning and memory formation, By similarity. Regulates EIF4E activity by preventing its assembly into the eIF4F complex: hypophosphorylated form of EIF4EBP2 competes with EIF4G1/EIF4G3 and strongly binds to EIF4E, leading to repress translation. In contrast, hyperphosphorylated form dissociates from EIF4E, allowing interaction between EIF4G1/EIF4G3 and EIF4E, leading to initiation of translation, PubMed:25533957. EIF4EBP2 is enriched in brain and acts as a regulator of synapse activity and neuronal stem cell renewal via its ability to repress translation initiation, By similarity. Mediates the regulation of protein translation by hormones, growth factors and other stimuli that signal through the MAP kinase and mTORC1 pathways, By similarity. {ECO:0000250|UniProtKB:P70445, ECO:0000269|PubMed:25533957}.
Subcellular locationunknown
ECO codeClick here for more information.
Amino acid sequence
FASTA format: Q13542
Gene Ontology
(Biological Process)
Complete annatation
cAMP-mediated signaling [GO:0019933];
insulin receptor signaling pathway [GO:0008286];
memory [GO:0007613];
modulation of synaptic transmission [GO:0050804];
negative regulation of translational initiation [GO:0045947];
regulation of synaptic plasticity [GO:0048167];
social behavior [GO:0035176];
TOR signaling [GO:0031929];
translation [GO:0006412]
Gene Ontology
(Molecular Function)
Complete annatation
eukaryotic initiation factor 4E binding [GO:0008190];
translation repressor activity [GO:0030371]
Gene Ontology
(Cellular Component)
Complete annatation
cytoplasm [GO:0005737]
Protein-protein interaction108294
Phylogenetic treeQ13542
HIV replication factor status Zhou et al., Cell. Host. Microbe., 2008
Brass et al., Science, 2008
Smith et al., J. Immunol, 2010
gene status
Lu et al., J. Virol., 2011
      Folds changes 8h: unknown; Folds changes 16h: unknown; Tested: unknown;
Schoggins JW and Rice CM, Curr. Opin. Virol., 2011
      Targeted viruses: unknown
      Viral life cycle: unknown
      Mechanism related to antiviral activity: unknown
Anti-viral restriction factor Liu et al., Retrovirology, 2011
      unknown (Triplicates)

Gene Expression Profile       top

            Up-regulated;            Down-regulated

For brief introduction to each study, please go to the help page.

Gene expression during HIV latency

(1). Mohammadi et al., PLoS Pathog., 2014

Differentially expressed transcripts (Pairwise) during latency and subsequent viral reactivation using several agents - Primary CD4+ T-cell based model

DMSO: Dimethyl suloxyde (negative control) - 0.0033% final
SAHA: Vorinostat (Histone deacetylase inhibitor) - 0.5 μM
CD3: TCR Stimulation by IL-2+ antiCD3/anti-CD28 antibodies
IL7: Interleukin-7 based stimulation
DISU: Disulfiram (alcohol dehydrogenase inhibitor) - 0.5 μM
AZA: 5-azacytidine (AZA; DNA methylation inhibitor) - 1 μM
Experimental Condition Log2 Fold Change P value Adjusted P value
AZA vs. CD3-0.4444444458240570.1774073547511620.277967131490049
AZA vs. DISU-0.1622230201670640.5218673932701790.940577786941322
AZA vs. IL70.07931205966986030.6794022354126180.999311006273513
AZA vs. SAHA0.1640253551957920.5021526500725780.821962107416011
DISU vs. CD30.2709677585931530.454439006007040.584638864602724
DISU vs. IL70.2322561283925350.3562179923485290.734880303277296
DISU vs. SAHA0.3272522164094470.2674123291271420.645190341266624
DMSO vs. AZA-0.05289996524125530.7514691988558171
DMSO vs. CD30.3815197245361060.2351326616192880.33929823249948
DMSO vs. DISU0.1078352310283480.6587315426238230.950156143725546
DMSO vs. IL70.1392805606973720.437673633188130.861465884101488
DMSO vs. SAHA0.2099393641658670.3745292457268190.722559313342664
HIV vs. Mock in Activation0.03755721240398870.9519793601247310.999983755607037
HIV vs. Mock in Latency0.1328084397661720.4197527874765130.999834320637052
IL7 vs. CD30.5313440673138280.09921231327058440.18864982943453
SAHA vs. CD30.5838481579582390.1056001219846340.181894369448901
SAHA vs. IL70.08138240681827940.7398154629117620.881686126274222
(2). Iglesias-Ussel et al., J. Virol., 2013

Up and Downregulated transcripts during Latency (Latently infected CD4+ T cells vs Uninfected)- Primary CD4+Tcell based model
Log2 Fold Change P Value
unknown unknown

Gene expression during HIV infection and replication

(1). Imbeault et al., PloS Pathog., 2012

Transcriptomic profiling of HIV-1 infected CD4+ T cells - Primary CD4+ T cells
Experiment type Log2 Fold Change P Value Adjusted P Value
Infected vs. Mock unknown unknown unknown
Infected vs. Bystander unknown unknown unknown
(2). Lefebvre et al., J. Virol., 2011

Transcriptome analysis of T-cell line (Sup T1)
Log2 Fold Change unknown
(3). Li et al., J. Immunol., 2013

Lymphatic tissue
Acute Fold Change Acute P Value Asymt Fold Change Asypt P Value AIDS Fold Change AIDS P Value
unknown unknown unknown unknown unknown unknown
(4). Chang et al., MBio., 2011

Transcriptome analysis of T-cell line (Sup T1)

Derived from Sherrill-Mix et al., BMC Retrovirol., 2015 cross validation
Up-regulated (True) FALSE
(5). Sherrill-Mix et al., BMC Retrovirol., 2015

Deep RNA-seq analysis of primary human T cell infected with low passage HIV isolate HIV89.6 - Primary CD4+ T cell based
Test Status Log2 Fold Change P Value
OK -0.354965 0.00746735
(6). Rotger et al., PLoS Pathog., 2010

Genome-wide mRNA expression of CD4+ T cells from HIV-infected patient
(Genes differentially expressed (at adjusted p<0.01) according to the empirical Bayes approach)
Log2 Fold Change P Value
unknown unknown

Proteomic/Transcriptomics studies indicating differentially expressed genes mediated by HIV

(1). Greenwood et al., Elife, 2016

Activated (CD3/CD28) Primary human CD4+ T cells infected with pNL4-3-dE-EGFP. The table shows the complete (unfiltered) TMT (tandem mass tag)-based proteomic time course dataset
6 h 24 h 48 h 72 h RTi
0.883 1.238 0.965 1.258 1.6
(2). Navare et al., Virology, 2012

SUP-T1 cell line
FC-4hpi P-value FC-8hpi P-value FC-20hpi P-value Category
unknown unknown unknown unknown unknown unknown unknown
(3). Hyrcza et al., J. Virolo., 2007

Primary human CD4+ and CD8+ T Cells
Affymetrix Prob ID Fold Change In CD8? Category
unknown unknown unknown unknown

Protein Overview       top

Drug-protein Interaction       (annotations from DrugBank)      top

not found

Protein Secondary Structure       (annotations from PDB)      top

PDB Accession Method Resolution Chain Structure Preview
2MX4 NMR - A=18-62.
3AM7 X-ray 2.2Å B=47-65.

HIV-1 Interaction       (annotations from NCBI HIV-1 Interaction Database)      top

not found

Metabolic/Signalling Pathway       (annotations from KEGG database)      top

Pathway Accession Number Description
hsa03013 RNA transport - Homo sapiens (human)
hsa04213 Longevity regulating pathway - multiple species - Homo sapiens (human)