Detailed entry information

Protein Information (annotations from UniProt)

Database IDHIV0000898
UniProt IDQ92838
Primary gene name(s)EDA
Synonym gene name(s)ED1, EDA2
Protein nameEctodysplasin-A
Protein functionCytokine which is involved in epithelial-mesenchymal signaling during morphogenesis of ectodermal organs. Functions as a ligand activating the DEATH-domain containing receptors EDAR and EDA2R, PubMed:8696334, PubMed:11039935, PubMed:27144394. May also play a role in cell adhesion, By similarity. {ECO:0000250|UniProtKB:O54693, ECO:0000269|PubMed:11039935, ECO:0000269|PubMed:27144394, ECO:0000269|PubMed:8696334}.; FUNCTION: Isoform 1: Binds only to the receptor EDAR, while isoform 3 binds exclusively to the receptor EDA2R. {ECO:0000269|PubMed:11039935, ECO:0000269|PubMed:27144394}.; FUNCTION: Isoform 3: Binds only to the receptor EDA2R. {ECO:0000269|PubMed:11039935, ECO:0000269|PubMed:27144394}.
Subcellular locationCell membrane {ECO:0000250|UniProtKB:O54693};
Single-pass type II membrane protein {ECO:0000250|UniProtKB:O54693}.;
SUBCELLULAR LOCATION: Ectodysplasin-A, secreted form: Secreted {ECO:0000269|PubMed:11309369}.
ECO codeClick here for more information.
Amino acid sequence
FASTA format: Q92838
Gene Ontology
(Biological Process)
Complete annatation
cell differentiation [GO:0030154];
cell-matrix adhesion [GO:0007160];
cytokine-mediated signaling pathway [GO:0019221];
gene expression [GO:0010467];
hair follicle placode formation [GO:0060789];
immune response [GO:0006955];
odontogenesis of dentin-containing tooth [GO:0042475];
pigmentation [GO:0043473];
positive regulation of canonical Wnt signaling pathway [GO:0090263];
positive regulation of gene expression [GO:0010628];
positive regulation of NF-kappaB import into nucleus [GO:0042346];
positive regulation of NF-kappaB transcription factor activity [GO:0051092];
regulation of NIK/NF-kappaB signaling [GO:1901222];
salivary gland cavitation [GO:0060662];
trachea gland development [GO:0061153];
tumor necrosis factor-mediated signaling pathway [GO:0033209]
Gene Ontology
(Molecular Function)
Complete annatation
receptor binding [GO:0005102]
Gene Ontology
(Cellular Component)
Complete annatation
apical part of cell [GO:0045177];
collagen trimer [GO:0005581];
cytoskeleton [GO:0005856];
endoplasmic reticulum membrane [GO:0005789];
extracellular region [GO:0005576];
integral component of membrane [GO:0016021];
integral component of plasma membrane [GO:0005887];
intracellular membrane-bounded organelle [GO:0043231];
membrane [GO:0016020];
plasma membrane [GO:0005886]
Protein-protein interaction108224
Phylogenetic treeQ92838
HIV replication factor status Zhou et al., Cell. Host. Microbe., 2008
Brass et al., Science, 2008
Smith et al., J. Immunol, 2010
gene status
Lu et al., J. Virol., 2011
      Folds changes 8h: unknown; Folds changes 16h: unknown; Tested: unknown;
Schoggins JW and Rice CM, Curr. Opin. Virol., 2011
      Targeted viruses: unknown
      Viral life cycle: unknown
      Mechanism related to antiviral activity: unknown
Anti-viral restriction factor Liu et al., Retrovirology, 2011
      unknown (Triplicates)

Gene Expression Profile       top

            Up-regulated;            Down-regulated

For brief introduction to each study, please go to the help page.

Gene expression during HIV latency

(1). Mohammadi et al., PLoS Pathog., 2014

Differentially expressed transcripts (Pairwise) during latency and subsequent viral reactivation using several agents - Primary CD4+ T-cell based model

DMSO: Dimethyl suloxyde (negative control) - 0.0033% final
SAHA: Vorinostat (Histone deacetylase inhibitor) - 0.5 μM
CD3: TCR Stimulation by IL-2+ antiCD3/anti-CD28 antibodies
IL7: Interleukin-7 based stimulation
DISU: Disulfiram (alcohol dehydrogenase inhibitor) - 0.5 μM
AZA: 5-azacytidine (AZA; DNA methylation inhibitor) - 1 μM
Experimental Condition Log2 Fold Change P value Adjusted P value
AZA vs. CD3-1.668167808317784.38239475272217e-050.00023282147942555
AZA vs. DISU-0.310109360274740.4409152607437820.91814655876178
AZA vs. IL70.4250839136831920.4233419483680310.999311006273513
AZA vs. SAHA0.698669098060040.0384594143553360.230879017121599
DISU vs. CD3unknownunknownunknown
DISU vs. IL70.7285497328653540.1733082350329780.538987378220335
DISU vs. SAHA1.009569682292960.003909563479115860.0542051804910351
DMSO vs. AZA0.07333651383328450.8824833783257051
DMSO vs. CD31.718319792737970.0007995354606733510.00281293828001962
DMSO vs. DISU0.3770715041764070.4524914127978420.889111219335407
DMSO vs. IL70.3604393497587110.5550573462490790.899579585049435
DMSO vs. SAHA0.6226040383473720.1657476741500470.492116469092859
HIV vs. Mock in Activationunknownunknownunknown
HIV vs. Mock in Latency-0.8959116597354720.001256441860897240.0769902626470121
IL7 vs. CD32.121163614619990.0001551601286154950.00085479847171833
SAHA vs. CD32.339798165835321.10551492404909e-081.45099453621422e-07
SAHA vs. IL70.2709226737222120.5799090606113460.784186624203762
(2). Iglesias-Ussel et al., J. Virol., 2013

Up and Downregulated transcripts during Latency (Latently infected CD4+ T cells vs Uninfected)- Primary CD4+Tcell based model
Log2 Fold Change P Value
unknown unknown

Gene expression during HIV infection and replication

(1). Imbeault et al., PloS Pathog., 2012

Transcriptomic profiling of HIV-1 infected CD4+ T cells - Primary CD4+ T cells
Experiment type Log2 Fold Change P Value Adjusted P Value
Infected vs. Mock unknown unknown unknown
Infected vs. Bystander unknown unknown unknown
(2). Lefebvre et al., J. Virol., 2011

Transcriptome analysis of T-cell line (Sup T1)
Log2 Fold Change unknown
(3). Li et al., J. Immunol., 2013

Lymphatic tissue
Acute Fold Change Acute P Value Asymt Fold Change Asypt P Value AIDS Fold Change AIDS P Value
unknown unknown unknown unknown unknown unknown
(4). Chang et al., MBio., 2011

Transcriptome analysis of T-cell line (Sup T1)

Derived from Sherrill-Mix et al., BMC Retrovirol., 2015 cross validation
Up-regulated (True) TRUE
(5). Sherrill-Mix et al., BMC Retrovirol., 2015

Deep RNA-seq analysis of primary human T cell infected with low passage HIV isolate HIV89.6 - Primary CD4+ T cell based
Test Status Log2 Fold Change P Value
OK -1.80639 0.000305467
(6). Rotger et al., PLoS Pathog., 2010

Genome-wide mRNA expression of CD4+ T cells from HIV-infected patient
(Genes differentially expressed (at adjusted p<0.01) according to the empirical Bayes approach)
Log2 Fold Change P Value
unknown unknown

Proteomic/Transcriptomics studies indicating differentially expressed genes mediated by HIV

(1). Greenwood et al., Elife, 2016

Activated (CD3/CD28) Primary human CD4+ T cells infected with pNL4-3-dE-EGFP. The table shows the complete (unfiltered) TMT (tandem mass tag)-based proteomic time course dataset
6 h 24 h 48 h 72 h RTi
unknown unknown unknown unknown unknown
(2). Navare et al., Virology, 2012

SUP-T1 cell line
FC-4hpi P-value FC-8hpi P-value FC-20hpi P-value Category
unknown unknown unknown unknown unknown unknown unknown
(3). Hyrcza et al., J. Virolo., 2007

Primary human CD4+ and CD8+ T Cells
Affymetrix Prob ID Fold Change In CD8? Category
unknown unknown unknown unknown

Protein Overview       top

Drug-protein Interaction       (annotations from DrugBank)      top

not found

Protein Secondary Structure       (annotations from PDB)      top

PDB Accession Method Resolution Chain Structure Preview
1RJ7 X-ray 2.3Å A/B/D/E/F/G/H/I/J/K/L/M=233-391.
1RJ8 X-ray 2.2Å A/B/D/E/F/G=230-389.

HIV-1 Interaction       (annotations from NCBI HIV-1 Interaction Database)      top

not found

Metabolic/Signalling Pathway       (annotations from KEGG database)      top

Pathway Accession Number Description
hsa04060 Cytokine-cytokine receptor interaction - Homo sapiens (human)