Detailed entry information

Protein Information (annotations from UniProt)

Database IDHIV0000882
UniProt IDQ92997
Primary gene name(s)DVL3
Synonym gene name(s)KIAA0208
Protein nameSegment polarity protein dishevelled homolog DVL-3
Protein functionMay play a role in the signal transduction pathway mediated by multiple Wnt genes.
Subcellular locationCytoplasm {ECO:0000250}.
ECO codeClick here for more information.
Amino acid sequence
FASTA format: Q92997
Gene Ontology
(Biological Process)
Complete annatation
beta-catenin destruction complex disassembly [GO:1904886];
canonical Wnt signaling pathway [GO:0060070];
cochlea morphogenesis [GO:0090103];
intracellular signal transduction [GO:0035556];
negative regulation of canonical Wnt signaling pathway [GO:0090090];
non-canonical Wnt signaling pathway [GO:0035567];
non-canonical Wnt signaling pathway via JNK cascade [GO:0038031];
outflow tract septum morphogenesis [GO:0003148];
planar cell polarity pathway involved in neural tube closure [GO:0090179];
positive regulation of GTPase activity [GO:0043547];
positive regulation of JUN kinase activity [GO:0043507];
positive regulation of protein phosphorylation [GO:0001934];
positive regulation of transcription, DNA-templated [GO:0045893];
protein stabilization [GO:0050821];
regulation of cellular protein localization [GO:1903827];
response to drug [GO:0042493];
Wnt signaling pathway [GO:0016055];
Wnt signaling pathway, planar cell polarity pathway [GO:0060071]
Gene Ontology
(Molecular Function)
Complete annatation
beta-catenin binding [GO:0008013];
frizzled binding [GO:0005109];
protease binding [GO:0002020];
protein heterodimerization activity [GO:0046982];
Rac GTPase binding [GO:0048365];
receptor binding [GO:0005102]
Gene Ontology
(Cellular Component)
Complete annatation
cytosol [GO:0005829];
nuclear chromatin [GO:0000790];
Wnt signalosome [GO:1990909]
Protein-protein interaction108190
Phylogenetic treeQ92997
HIV replication factor status Zhou et al., Cell. Host. Microbe., 2008
Brass et al., Science, 2008
Smith et al., J. Immunol, 2010
      Negatively associated
gene status
Lu et al., J. Virol., 2011
      Folds changes 8h: unknown; Folds changes 16h: unknown; Tested: unknown;
Schoggins JW and Rice CM, Curr. Opin. Virol., 2011
      Targeted viruses: unknown
      Viral life cycle: unknown
      Mechanism related to antiviral activity: unknown
Anti-viral restriction factor Liu et al., Retrovirology, 2011
      unknown (Triplicates)

Gene Expression Profile       top

            Up-regulated;            Down-regulated

For brief introduction to each study, please go to the help page.

Gene expression during HIV latency

(1). Mohammadi et al., PLoS Pathog., 2014

Differentially expressed transcripts (Pairwise) during latency and subsequent viral reactivation using several agents - Primary CD4+ T-cell based model

DMSO: Dimethyl suloxyde (negative control) - 0.0033% final
SAHA: Vorinostat (Histone deacetylase inhibitor) - 0.5 μM
CD3: TCR Stimulation by IL-2+ antiCD3/anti-CD28 antibodies
IL7: Interleukin-7 based stimulation
DISU: Disulfiram (alcohol dehydrogenase inhibitor) - 0.5 μM
AZA: 5-azacytidine (AZA; DNA methylation inhibitor) - 1 μM
Experimental Condition Log2 Fold Change P value Adjusted P value
AZA vs. CD30.5256363553516820.1100224595478630.190036501295598
AZA vs. DISU0.4016115855415910.1143147532945070.666349803233335
AZA vs. IL7-0.1640381673699010.3949637888009450.999311006273513
AZA vs. SAHA0.4275983277295880.08088440708797130.354009323573951
DISU vs. CD3-0.1371288751230520.7084786402591470.795797840779909
DISU vs. IL7-0.5748447753880030.02344834830107070.194435561407393
DISU vs. SAHA0.02842737219733410.9230789080457080.982517142063809
DMSO vs. AZA0.08344729713193110.6196007455370241
DMSO vs. CD3-0.4551494081977330.1560922077771560.244670597249283
DMSO vs. DISU-0.3204149444329620.1913187897229440.707336034821741
DMSO vs. IL7-0.239785610443380.1837591973655250.69619751200937
DMSO vs. SAHA0.3389215743434020.1518093049014930.469894851955309
HIV vs. Mock in Activation0.288225327799730.6432405333176330.999983755607037
HIV vs. Mock in Latency0.05386984980954650.744710868761280.999834320637052
IL7 vs. CD3-0.6838286216652540.03449909966643390.0814034015767312
SAHA vs. CD3-0.1217648020368250.7300922534166270.804746215549193
SAHA vs. IL70.5888188975653930.01625122090608080.0878661778831641
(2). Iglesias-Ussel et al., J. Virol., 2013

Up and Downregulated transcripts during Latency (Latently infected CD4+ T cells vs Uninfected)- Primary CD4+Tcell based model
Log2 Fold Change P Value
unknown unknown

Gene expression during HIV infection and replication

(1). Imbeault et al., PloS Pathog., 2012

Transcriptomic profiling of HIV-1 infected CD4+ T cells - Primary CD4+ T cells
Experiment type Log2 Fold Change P Value Adjusted P Value
Infected vs. Mock unknown unknown unknown
Infected vs. Bystander unknown unknown unknown
(2). Lefebvre et al., J. Virol., 2011

Transcriptome analysis of T-cell line (Sup T1)
Log2 Fold Change unknown
(3). Li et al., J. Immunol., 2013

Lymphatic tissue
Acute Fold Change Acute P Value Asymt Fold Change Asypt P Value AIDS Fold Change AIDS P Value
unknown unknown unknown unknown unknown unknown
(4). Chang et al., MBio., 2011

Transcriptome analysis of T-cell line (Sup T1)

Derived from Sherrill-Mix et al., BMC Retrovirol., 2015 cross validation
Up-regulated (True) TRUE
(5). Sherrill-Mix et al., BMC Retrovirol., 2015

Deep RNA-seq analysis of primary human T cell infected with low passage HIV isolate HIV89.6 - Primary CD4+ T cell based
Test Status Log2 Fold Change P Value
OK -0.0725755 0.681415
(6). Rotger et al., PLoS Pathog., 2010

Genome-wide mRNA expression of CD4+ T cells from HIV-infected patient
(Genes differentially expressed (at adjusted p<0.01) according to the empirical Bayes approach)
Log2 Fold Change P Value
unknown unknown

Proteomic/Transcriptomics studies indicating differentially expressed genes mediated by HIV

(1). Greenwood et al., Elife, 2016

Activated (CD3/CD28) Primary human CD4+ T cells infected with pNL4-3-dE-EGFP. The table shows the complete (unfiltered) TMT (tandem mass tag)-based proteomic time course dataset
6 h 24 h 48 h 72 h RTi
unknown unknown unknown unknown unknown
(2). Navare et al., Virology, 2012

SUP-T1 cell line
FC-4hpi P-value FC-8hpi P-value FC-20hpi P-value Category
unknown unknown unknown unknown unknown unknown unknown
(3). Hyrcza et al., J. Virolo., 2007

Primary human CD4+ and CD8+ T Cells
Affymetrix Prob ID Fold Change In CD8? Category
unknown unknown unknown unknown

Protein Overview       top

Drug-protein Interaction       (annotations from DrugBank)      top

not found

Protein Secondary Structure       (annotations from PDB)      top

not found

HIV-1 Interaction       (annotations from NCBI HIV-1 Interaction Database)      top

not found

Metabolic/Signalling Pathway       (annotations from KEGG database)      top

Pathway Accession Number Description
hsa04150 mTOR signaling pathway - Homo sapiens (human)
hsa04310 Wnt signaling pathway - Homo sapiens (human)
hsa04330 Notch signaling pathway - Homo sapiens (human)
hsa04390 Hippo signaling pathway - Homo sapiens (human)
hsa04550 Signaling pathways regulating pluripotency of stem cells - Homo sapiens (human)
hsa04916 Melanogenesis - Homo sapiens (human)
hsa05166 HTLV-I infection - Homo sapiens (human)
hsa05200 Pathways in cancer - Homo sapiens (human)
hsa05217 Basal cell carcinoma - Homo sapiens (human)
hsa05224 Breast cancer - Homo sapiens (human)