Detailed entry information

Protein Information (annotations from UniProt)

Database IDHIV0000847
UniProt IDQ05193
Primary gene name(s)DNM1
Synonym gene name(s)DNM
Protein nameDynamin-1
Protein functionMicrotubule-associated force-producing protein involved in producing microtubule bundles and able to bind and hydrolyze GTP. Most probably involved in vesicular trafficking processes. Involved in receptor-mediated endocytosis.
Subcellular locationCytoplasm {ECO:0000269|PubMed:15703209}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:15703209}. Note=Microtubule-associated.
ECO codeClick here for more information.
Amino acid sequence
FASTA format: Q05193
Gene Ontology
(Biological Process)
Complete annatation
adult locomotory behavior [GO:0008344];
clathrin-dependent endocytosis [GO:0072583];
dynamin family protein polymerization involved in mitochondrial fission [GO:0003374];
endocytosis [GO:0006897];
endosome organization [GO:0007032];
ephrin receptor signaling pathway [GO:0048013];
G-protein coupled receptor internalization [GO:0002031];
membrane fusion [GO:0061025];
mitochondrial fission [GO:0000266];
positive regulation of synaptic vesicle recycling [GO:1903423];
protein tetramerization [GO:0051262];
receptor internalization [GO:0031623];
receptor-mediated endocytosis [GO:0006898];
sensory perception of sound [GO:0007605];
synaptic transmission, GABAergic [GO:0051932];
toxin transport [GO:1901998]
Gene Ontology
(Molecular Function)
Complete annatation
GTPase activity [GO:0003924];
GTP binding [GO:0005525];
identical protein binding [GO:0042802];
poly(A RNA binding [GO:0044822];
protein kinase binding [GO:0019901]
Gene Ontology
(Cellular Component)
Complete annatation
extracellular exosome [GO:0070062];
Golgi apparatus [GO:0005794];
membrane coat [GO:0030117];
microtubule [GO:0005874];
myelin sheath [GO:0043209];
photoreceptor inner segment [GO:0001917];
plasma membrane [GO:0005886];
synaptic vesicle [GO:0008021];
varicosity [GO:0043196]
Protein-protein interaction108099
Phylogenetic treeQ05193
HIV replication factor status Zhou et al., Cell. Host. Microbe., 2008
      unknown
Brass et al., Science, 2008
      unknown
Smith et al., J. Immunol, 2010
      unknown
Interferon-stimulated
gene status
Lu et al., J. Virol., 2011
      Folds changes 8h: unknown; Folds changes 16h: unknown; Tested: unknown;
Schoggins JW and Rice CM, Curr. Opin. Virol., 2011
      Targeted viruses: unknown
      Viral life cycle: unknown
      Mechanism related to antiviral activity: unknown
Anti-viral restriction factor Liu et al., Retrovirology, 2011
      unknown (Triplicates)

Gene Expression Profile       top

            Up-regulated;            Down-regulated

For brief introduction to each study, please go to the help page.

Gene expression during HIV latency

(1). Mohammadi et al., PLoS Pathog., 2014

Differentially expressed transcripts (Pairwise) during latency and subsequent viral reactivation using several agents - Primary CD4+ T-cell based model


DMSO: Dimethyl suloxyde (negative control) - 0.0033% final
SAHA: Vorinostat (Histone deacetylase inhibitor) - 0.5 μM
CD3: TCR Stimulation by IL-2+ antiCD3/anti-CD28 antibodies
IL7: Interleukin-7 based stimulation
DISU: Disulfiram (alcohol dehydrogenase inhibitor) - 0.5 μM
AZA: 5-azacytidine (AZA; DNA methylation inhibitor) - 1 μM
Experimental Condition Log2 Fold Change P value Adjusted P value
AZA vs. CD3unknownunknownunknown
AZA vs. DISU0.3055437887989960.4520791299608190.920247052782372
AZA vs. IL7-0.2433856238169880.4576466724607750.999311006273513
AZA vs. SAHA3.250794050583661.21014309684142e-141.07304100245809e-11
DISU vs. CD31.940632847909835.77391816336537e-064.57362282682972e-05
DISU vs. IL7-0.5575359392917850.1363026137807770.482565031175483
DISU vs. SAHA2.950349156099494.69100314148818e-112.01994595272481e-08
DMSO vs. AZA0.1460517489349050.6141419881018461
DMSO vs. CD3unknownunknownunknown
DMSO vs. DISU-0.1590682167927110.6432506814948950.94726363169221
DMSO vs. IL7-0.3798792468975790.1263345808173720.622383596673819
DMSO vs. SAHA3.0949231191427400
HIV vs. Mock in Activationunknownunknownunknown
HIV vs. Mock in Latency-0.07426732862937830.7871239005039470.999834320637052
IL7 vs. CD3unknownunknownunknown
SAHA vs. CD34.8730379358688800
SAHA vs. IL73.4885318593823700
(2). Iglesias-Ussel et al., J. Virol., 2013

Up and Downregulated transcripts during Latency (Latently infected CD4+ T cells vs Uninfected)- Primary CD4+Tcell based model
Log2 Fold Change P Value
unknown unknown

Gene expression during HIV infection and replication

(1). Imbeault et al., PloS Pathog., 2012

Transcriptomic profiling of HIV-1 infected CD4+ T cells - Primary CD4+ T cells
Experiment type Log2 Fold Change P Value Adjusted P Value
Infected vs. Mock unknown unknown unknown
Infected vs. Bystander unknown unknown unknown
(2). Lefebvre et al., J. Virol., 2011

Transcriptome analysis of T-cell line (Sup T1)
Log2 Fold Change unknown
(3). Li et al., J. Immunol., 2013

Lymphatic tissue
Acute Fold Change Acute P Value Asymt Fold Change Asypt P Value AIDS Fold Change AIDS P Value
unknown unknown unknown unknown unknown unknown
(4). Chang et al., MBio., 2011

Transcriptome analysis of T-cell line (Sup T1)

Derived from Sherrill-Mix et al., BMC Retrovirol., 2015 cross validation
Up-regulated (True) TRUE
(5). Sherrill-Mix et al., BMC Retrovirol., 2015

Deep RNA-seq analysis of primary human T cell infected with low passage HIV isolate HIV89.6 - Primary CD4+ T cell based
Test Status Log2 Fold Change P Value
OK -0.801651 0.00132191
(6). Rotger et al., PLoS Pathog., 2010

Genome-wide mRNA expression of CD4+ T cells from HIV-infected patient
(Genes differentially expressed (at adjusted p<0.01) according to the empirical Bayes approach)
Log2 Fold Change P Value
unknown unknown

Proteomic/Transcriptomics studies indicating differentially expressed genes mediated by HIV

(1). Greenwood et al., Elife, 2016

Activated (CD3/CD28) Primary human CD4+ T cells infected with pNL4-3-dE-EGFP. The table shows the complete (unfiltered) TMT (tandem mass tag)-based proteomic time course dataset
6 h 24 h 48 h 72 h RTi
unknown unknown unknown unknown unknown
(2). Navare et al., Virology, 2012

SUP-T1 cell line
FC-4hpi P-value FC-8hpi P-value FC-20hpi P-value Category
unknown unknown unknown unknown unknown unknown unknown
(3). Hyrcza et al., J. Virolo., 2007

Primary human CD4+ and CD8+ T Cells
Affymetrix Prob ID Fold Change In CD8? Category
unknown unknown unknown unknown

Protein Overview       top

Drug-protein Interaction       (annotations from DrugBank)      top

not found

Protein Secondary Structure       (annotations from PDB)      top

PDB Accession Method Resolution Chain Structure Preview
1DYN X-ray 2.2Å A/B=510-633.
2DYN X-ray 2.3Å A/B=509-630.
2X2E X-ray 2.0Å A/D=6-320# A/D=726-750.
2X2F X-ray 2.0Å A/D=6-320# A/D=726-750.
3SNH X-ray 3.7Å A=6-746.
3ZYC X-ray 2.2Å A/D=6-320# A/D=726-750.
3ZYS EM 12.2Å A/D=6-320# A/D=726-750# C/F=518-630.
4UUD EM 12.5Å A/B/C/D/E/F/G/H/I/J/K/L=1-864.
4UUK EM 12.5Å A/B/C/D/E/F/G/H/I/J/K/L=1-864.
5D3Q X-ray 1.7Å A/B=5-320# A/B=726-746.

HIV-1 Interaction       (annotations from NCBI HIV-1 Interaction Database)      top

HIV Partner Interaction Type PubMed
Pr55(Gag) co-localizes with 18602423
22846998
Pr55(Gag) regulated by 23170932

Metabolic/Signalling Pathway       (annotations from KEGG database)      top

Pathway Accession Number Description
hsa04072 Phospholipase D signaling pathway - Homo sapiens (human)
hsa04144 Endocytosis - Homo sapiens (human)
hsa04721 Synaptic vesicle cycle - Homo sapiens (human)
hsa04961 Endocrine and other factor-regulated calcium reabsorption - Homo sapiens (human)
hsa05100 Bacterial invasion of epithelial cells - Homo sapiens (human)
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