Detailed entry information

Protein Information (annotations from UniProt)

Database IDHIV0000790
UniProt IDQ9NUI1
Primary gene name(s)DECR2
Synonym gene name(s)PDCR, SDR17C1
Protein namePeroxisomal 2,4-dienoyl-CoA reductase
Protein functionAuxiliary enzyme of beta-oxidation. Participates in the degradation of unsaturated fatty enoyl-CoA esters having double bonds in both even- and odd-numbered positions in peroxisome. Catalyzes the NADP-dependent reduction of 2,4-dienoyl-CoA to yield trans-3-enoyl-CoA. Has activity towards short and medium chain 2,4-dienoyl-CoAs, but also towards 2,4,7,10,13,16,19-docosaheptaenoyl-CoA, suggesting that it does not constitute a rate limiting step in the peroxisomal degradation of docosahexaenoic acid.
Subcellular locationPeroxisome {ECO:0000250}.
ECO codeClick here for more information.
Amino acid sequence
FASTA format: Q9NUI1
Gene Ontology
(Biological Process)
Complete annatation
cellular lipid metabolic process [GO:0044255];
unsaturated fatty acid biosynthetic process [GO:0006636]
Gene Ontology
(Molecular Function)
Complete annatation
2,4-dienoyl-CoA reductase, NADPH activity [GO:0008670];
receptor binding [GO:0005102];
trans-2-enoyl-CoA reductase, NADPH activity [GO:0019166]
Gene Ontology
(Cellular Component)
Complete annatation
peroxisomal membrane [GO:0005778]
Protein-protein interaction117525
Phylogenetic treeQ9NUI1
HIV replication factor status Zhou et al., Cell. Host. Microbe., 2008
Brass et al., Science, 2008
Smith et al., J. Immunol, 2010
gene status
Lu et al., J. Virol., 2011
      Folds changes 8h: unknown; Folds changes 16h: unknown; Tested: unknown;
Schoggins JW and Rice CM, Curr. Opin. Virol., 2011
      Targeted viruses: unknown
      Viral life cycle: unknown
      Mechanism related to antiviral activity: unknown
Anti-viral restriction factor Liu et al., Retrovirology, 2011
      unknown (Triplicates)

Gene Expression Profile       top

            Up-regulated;            Down-regulated

For brief introduction to each study, please go to the help page.

Gene expression during HIV latency

(1). Mohammadi et al., PLoS Pathog., 2014

Differentially expressed transcripts (Pairwise) during latency and subsequent viral reactivation using several agents - Primary CD4+ T-cell based model

DMSO: Dimethyl suloxyde (negative control) - 0.0033% final
SAHA: Vorinostat (Histone deacetylase inhibitor) - 0.5 μM
CD3: TCR Stimulation by IL-2+ antiCD3/anti-CD28 antibodies
IL7: Interleukin-7 based stimulation
DISU: Disulfiram (alcohol dehydrogenase inhibitor) - 0.5 μM
AZA: 5-azacytidine (AZA; DNA methylation inhibitor) - 1 μM
Experimental Condition Log2 Fold Change P value Adjusted P value
AZA vs. CD30.8724500684343620.009553854613957970.0250688887084914
AZA vs. DISU-0.3620080201703740.4446621093458410.91814655876178
AZA vs. IL70.3035683110713850.1438804643780550.908692496481083
AZA vs. SAHA-0.688138569734680.01989617477162090.153802532567904
DISU vs. CD3-1.246981405304750.007838092093665930.0236728912482309
DISU vs. IL70.652819446527710.1604226320802630.518964484696561
DISU vs. SAHA-0.3264621876606430.5399672790744410.846033067371238
DMSO vs. AZA0.0649672070537080.7432846374288681
DMSO vs. CD3-0.8234373438465910.01211304254812240.029347537148193
DMSO vs. DISU0.4232467847992090.3542139875023310.845295578681978
DMSO vs. IL70.2464077043973010.2048756586144780.715439610328775
DMSO vs. SAHA-0.7554765128519190.005077310461169880.0559766978495181
HIV vs. Mock in Activation0.1259372539765440.8416787797354960.999983755607037
HIV vs. Mock in Latency-0.3674141345362660.1076512221917030.999834320637052
IL7 vs. CD3-0.5650805173463820.08464364068549290.166340755678284
SAHA vs. CD3-1.586801313185461.91580027555371e-050.000111385455835627
SAHA vs. IL7-0.9941251964889360.0002599264544559390.00412434881523034
(2). Iglesias-Ussel et al., J. Virol., 2013

Up and Downregulated transcripts during Latency (Latently infected CD4+ T cells vs Uninfected)- Primary CD4+Tcell based model
Log2 Fold Change P Value
0.2788 0.0497

Gene expression during HIV infection and replication

(1). Imbeault et al., PloS Pathog., 2012

Transcriptomic profiling of HIV-1 infected CD4+ T cells - Primary CD4+ T cells
Experiment type Log2 Fold Change P Value Adjusted P Value
Infected vs. Mock unknown unknown unknown
Infected vs. Bystander unknown unknown unknown
(2). Lefebvre et al., J. Virol., 2011

Transcriptome analysis of T-cell line (Sup T1)
Log2 Fold Change unknown
(3). Li et al., J. Immunol., 2013

Lymphatic tissue
Acute Fold Change Acute P Value Asymt Fold Change Asypt P Value AIDS Fold Change AIDS P Value
unknown unknown unknown unknown unknown unknown
(4). Chang et al., MBio., 2011

Transcriptome analysis of T-cell line (Sup T1)

Derived from Sherrill-Mix et al., BMC Retrovirol., 2015 cross validation
Up-regulated (True) TRUE
(5). Sherrill-Mix et al., BMC Retrovirol., 2015

Deep RNA-seq analysis of primary human T cell infected with low passage HIV isolate HIV89.6 - Primary CD4+ T cell based
Test Status Log2 Fold Change P Value
OK 0.171443 0.486014
(6). Rotger et al., PLoS Pathog., 2010

Genome-wide mRNA expression of CD4+ T cells from HIV-infected patient
(Genes differentially expressed (at adjusted p<0.01) according to the empirical Bayes approach)
Log2 Fold Change P Value
unknown unknown

Proteomic/Transcriptomics studies indicating differentially expressed genes mediated by HIV

(1). Greenwood et al., Elife, 2016

Activated (CD3/CD28) Primary human CD4+ T cells infected with pNL4-3-dE-EGFP. The table shows the complete (unfiltered) TMT (tandem mass tag)-based proteomic time course dataset
6 h 24 h 48 h 72 h RTi
1.013 0.983 1.05 1.307 1.361
(2). Navare et al., Virology, 2012

SUP-T1 cell line
FC-4hpi P-value FC-8hpi P-value FC-20hpi P-value Category
unknown unknown unknown unknown unknown unknown unknown
(3). Hyrcza et al., J. Virolo., 2007

Primary human CD4+ and CD8+ T Cells
Affymetrix Prob ID Fold Change In CD8? Category
unknown unknown unknown unknown

Protein Overview       top

Drug-protein Interaction       (annotations from DrugBank)      top

not found

Protein Secondary Structure       (annotations from PDB)      top

PDB Accession Method Resolution Chain Structure Preview
4FC6 X-ray 2.1Å A/B/C/D=2-278.
4FC7 X-ray 1.8Å A/B/C/D=2-278.

HIV-1 Interaction       (annotations from NCBI HIV-1 Interaction Database)      top

not found

Metabolic/Signalling Pathway       (annotations from KEGG database)      top

Pathway Accession Number Description
hsa04146 Peroxisome - Homo sapiens (human)