Detailed entry information

Protein Information (annotations from UniProt)

Database IDHIV0000735
UniProt IDQ7L576
Primary gene name(s)CYFIP1
Synonym gene name(s)KIAA0068
Protein nameCytoplasmic FMR1-interacting protein 1
Protein functionComponent of the CYFIP1-EIF4E-FMR1 complex which binds to the mRNA cap and mediates translational repression. In the CYFIP1-EIF4E-FMR1 complex this subunit is an adapter between EIF4E and FMR1. Promotes the translation repression activity of FMR1 in brain probably by mediating its association with EIF4E and mRNA, By similarity. Regulates formation of membrane ruffles and lamellipodia. Plays a role in axon outgrowth. Binds to F-actin but not to RNA. Part of the WAVE complex that regulates actin filament reorganization via its interaction with the Arp2/3 complex. Actin remodeling activity is regulated by RAC1. Regulator of epithelial morphogenesis. May act as an invasion suppressor in cancers. {ECO:0000250, ECO:0000269|PubMed:16260607, ECO:0000269|PubMed:19524508, ECO:0000269|PubMed:21107423, ECO:0000269|PubMed:9417078}.
Subcellular locationCytoplasm {ECO:0000250|UniProtKB:Q7TMB8}. Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:Q7TMB8}. Cell projection, lamellipodium {ECO:0000250|UniProtKB:Q7TMB8}. Cell projection, ruffle {ECO:0000250|UniProtKB:Q7TMB8}. Cell junction, synapse, synaptosome {ECO:0000250|UniProtKB:Q7TMB8}. Note=Highly expressed in the perinuclear region, By similarity. Enriched in synaptosomes, By similarity. Also enriched in membrane ruffles and at the tips of lamellipodia, By similarity. {ECO:0000250|UniProtKB:Q7TMB8}.
ECO codeClick here for more information.
Amino acid sequence
FASTA format: Q7L576
Gene Ontology
(Biological Process)
Complete annatation
axon extension [GO:0048675];
cognition [GO:0050890];
Fc-gamma receptor signaling pathway involved in phagocytosis [GO:0038096];
lamellipodium assembly [GO:0030032];
positive regulation of Arp2/3 complex-mediated actin nucleation [GO:2000601];
Rac protein signal transduction [GO:0016601];
regulation of cell shape [GO:0008360];
ruffle organization [GO:0031529];
vascular endothelial growth factor receptor signaling pathway [GO:0048010]
Gene Ontology
(Molecular Function)
Complete annatation
actin filament binding [GO:0051015];
protein complex binding [GO:0032403];
Rac GTPase binding [GO:0048365]
Gene Ontology
(Cellular Component)
Complete annatation
cytosol [GO:0005829];
extracellular exosome [GO:0070062];
focal adhesion [GO:0005925];
lamellipodium [GO:0030027];
mRNA cap binding complex [GO:0005845];
neuron projection [GO:0043005];
perinuclear region of cytoplasm [GO:0048471];
ruffle [GO:0001726];
SCAR complex [GO:0031209];
synapse [GO:0045202]
Protein-protein interaction116800
Phylogenetic treeQ7L576
HIV replication factor status Zhou et al., Cell. Host. Microbe., 2008
Brass et al., Science, 2008
Smith et al., J. Immunol, 2010
gene status
Lu et al., J. Virol., 2011
      Folds changes 8h: unknown; Folds changes 16h: unknown; Tested: unknown;
Schoggins JW and Rice CM, Curr. Opin. Virol., 2011
      Targeted viruses: unknown
      Viral life cycle: unknown
      Mechanism related to antiviral activity: unknown
Anti-viral restriction factor Liu et al., Retrovirology, 2011
      unknown (Triplicates)

Gene Expression Profile       top

            Up-regulated;            Down-regulated

For brief introduction to each study, please go to the help page.

Gene expression during HIV latency

(1). Mohammadi et al., PLoS Pathog., 2014

Differentially expressed transcripts (Pairwise) during latency and subsequent viral reactivation using several agents - Primary CD4+ T-cell based model

DMSO: Dimethyl suloxyde (negative control) - 0.0033% final
SAHA: Vorinostat (Histone deacetylase inhibitor) - 0.5 μM
CD3: TCR Stimulation by IL-2+ antiCD3/anti-CD28 antibodies
IL7: Interleukin-7 based stimulation
DISU: Disulfiram (alcohol dehydrogenase inhibitor) - 0.5 μM
AZA: 5-azacytidine (AZA; DNA methylation inhibitor) - 1 μM
Experimental Condition Log2 Fold Change P value Adjusted P value
AZA vs. CD30.7423096748033420.02666391241705260.0589976939534041
AZA vs. DISU-0.4191415237653260.1021762999485840.644788874295266
AZA vs. IL70.04469195762852660.8180779529293010.999311006273513
AZA vs. SAHA0.2441439859919060.32038730055190.691397250642243
DISU vs. CD3-1.174145962823870.001433129059093430.00562284941092513
DISU vs. IL70.4548132696602370.07387640408170230.361704057009309
DISU vs. SAHA0.6653632496188270.02526852511431980.18649458471984
DMSO vs. AZA-0.006236505907629570.9707280816428591
DMSO vs. CD3-0.7605741614975210.01965809490845970.0441684116026764
DMSO vs. DISU0.4109016026465070.09604360924805890.561569786929451
DMSO vs. IL70.05835653954584290.7480794638632480.950566607561045
DMSO vs. SAHA0.2446934618783470.3031713147143140.655769489080648
HIV vs. Mock in Activation0.02791941955900380.9692144391272290.999983755607037
HIV vs. Mock in Latency-0.04855271841657580.7713681396805340.999834320637052
IL7 vs. CD3-0.6905611554021590.03421581983025250.0809171940154551
SAHA vs. CD3-0.5222068644263760.1515345343156010.242879883133018
SAHA vs. IL70.1966806191370310.4235769389223540.665788755746975
(2). Iglesias-Ussel et al., J. Virol., 2013

Up and Downregulated transcripts during Latency (Latently infected CD4+ T cells vs Uninfected)- Primary CD4+Tcell based model
Log2 Fold Change P Value
unknown unknown

Gene expression during HIV infection and replication

(1). Imbeault et al., PloS Pathog., 2012

Transcriptomic profiling of HIV-1 infected CD4+ T cells - Primary CD4+ T cells
Experiment type Log2 Fold Change P Value Adjusted P Value
Infected vs. Mock unknown unknown unknown
Infected vs. Bystander unknown unknown unknown
(2). Lefebvre et al., J. Virol., 2011

Transcriptome analysis of T-cell line (Sup T1)
Log2 Fold Change -1.290454746
(3). Li et al., J. Immunol., 2013

Lymphatic tissue
Acute Fold Change Acute P Value Asymt Fold Change Asypt P Value AIDS Fold Change AIDS P Value
unknown unknown unknown unknown unknown unknown
(4). Chang et al., MBio., 2011

Transcriptome analysis of T-cell line (Sup T1)

Derived from Sherrill-Mix et al., BMC Retrovirol., 2015 cross validation
Up-regulated (True) FALSE
(5). Sherrill-Mix et al., BMC Retrovirol., 2015

Deep RNA-seq analysis of primary human T cell infected with low passage HIV isolate HIV89.6 - Primary CD4+ T cell based
Test Status Log2 Fold Change P Value
OK -0.08268 0.672305
(6). Rotger et al., PLoS Pathog., 2010

Genome-wide mRNA expression of CD4+ T cells from HIV-infected patient
(Genes differentially expressed (at adjusted p<0.01) according to the empirical Bayes approach)
Log2 Fold Change P Value
unknown unknown

Proteomic/Transcriptomics studies indicating differentially expressed genes mediated by HIV

(1). Greenwood et al., Elife, 2016

Activated (CD3/CD28) Primary human CD4+ T cells infected with pNL4-3-dE-EGFP. The table shows the complete (unfiltered) TMT (tandem mass tag)-based proteomic time course dataset
6 h 24 h 48 h 72 h RTi
unknown unknown unknown unknown unknown
(2). Navare et al., Virology, 2012

SUP-T1 cell line
FC-4hpi P-value FC-8hpi P-value FC-20hpi P-value Category
unknown unknown unknown unknown unknown unknown unknown
(3). Hyrcza et al., J. Virolo., 2007

Primary human CD4+ and CD8+ T Cells
Affymetrix Prob ID Fold Change In CD8? Category
212133_at 1.53 No upregulated in CD8+ cells

Protein Overview       top

Drug-protein Interaction       (annotations from DrugBank)      top

not found

Protein Secondary Structure       (annotations from PDB)      top

PDB Accession Method Resolution Chain Structure Preview
3P8C X-ray 2.2Å A=1-1253.
4N78 X-ray 2.4Å A=1-1253.

HIV-1 Interaction       (annotations from NCBI HIV-1 Interaction Database)      top

not found

Metabolic/Signalling Pathway       (annotations from KEGG database)      top

Pathway Accession Number Description
hsa03013 RNA transport - Homo sapiens (human)
hsa04810 Regulation of actin cytoskeleton - Homo sapiens (human)