Detailed entry information

Protein Information (annotations from UniProt)

Database IDHIV0000701
UniProt IDP55060
Primary gene name(s)CSE1L
Synonym gene name(s)CAS, XPO2
Protein nameExportin-2
Protein functionExport receptor for importin-alpha. Mediates importin-alpha re-export from the nucleus to the cytoplasm after import substrates, cargos have been released into the nucleoplasm. In the nucleus binds cooperatively to importin-alpha and to the GTPase Ran in its active GTP-bound form. Docking of this trimeric complex to the nuclear pore complex, NPC is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP, induced by RANBP1 and RANGAP1, respectively cause release of the importin-alpha from the export receptor. CSE1L/XPO2 then return to the nuclear compartment and mediate another round of transport. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. {ECO:0000269|PubMed:9323134}.
Subcellular locationCytoplasm. Nucleus. Note=Shuttles between the nucleus and the cytoplasm.
ECO codeClick here for more information.
Amino acid sequence
FASTA format: P55060
Gene Ontology
(Biological Process)
Complete annatation
apoptotic process [GO:0006915];
cell proliferation [GO:0008283];
protein import into nucleus [GO:0006606]
Gene Ontology
(Molecular Function)
Complete annatation
nuclear export signal receptor activity [GO:0005049]
Gene Ontology
(Cellular Component)
Complete annatation
cytoplasm [GO:0005737];
cytosol [GO:0005829];
extracellular exosome [GO:0070062];
membrane [GO:0016020];
nuclear envelope [GO:0005635];
nucleoplasm [GO:0005654];
nucleus [GO:0005634]
Protein-protein interaction107821
Phylogenetic treeP55060
HIV replication factor status Zhou et al., Cell. Host. Microbe., 2008
Brass et al., Science, 2008
Smith et al., J. Immunol, 2010
gene status
Lu et al., J. Virol., 2011
      Folds changes 8h: unknown; Folds changes 16h: unknown; Tested: unknown;
Schoggins JW and Rice CM, Curr. Opin. Virol., 2011
      Targeted viruses: unknown
      Viral life cycle: unknown
      Mechanism related to antiviral activity: unknown
Anti-viral restriction factor Liu et al., Retrovirology, 2011
      unknown (Triplicates)

Gene Expression Profile       top

            Up-regulated;            Down-regulated

For brief introduction to each study, please go to the help page.

Gene expression during HIV latency

(1). Mohammadi et al., PLoS Pathog., 2014

Differentially expressed transcripts (Pairwise) during latency and subsequent viral reactivation using several agents - Primary CD4+ T-cell based model

DMSO: Dimethyl suloxyde (negative control) - 0.0033% final
SAHA: Vorinostat (Histone deacetylase inhibitor) - 0.5 μM
CD3: TCR Stimulation by IL-2+ antiCD3/anti-CD28 antibodies
IL7: Interleukin-7 based stimulation
DISU: Disulfiram (alcohol dehydrogenase inhibitor) - 0.5 μM
AZA: 5-azacytidine (AZA; DNA methylation inhibitor) - 1 μM
Experimental Condition Log2 Fold Change P value Adjusted P value
AZA vs. CD31.751808044725062.23373861074627e-071.99212475391526e-06
AZA vs. DISU0.2387628034787840.3454658716718020.884134558502673
AZA vs. IL70.3912854497631780.04196370764880910.621677698380482
AZA vs. SAHA-0.2008432551285740.4102781459418760.765886411384252
DISU vs. CD3-1.52583415181363.83303981350558e-050.000244309691961028
DISU vs. IL70.143959303097740.5673997221765390.860729340936148
DISU vs. SAHA-0.4393840813258950.1322853396296030.467994232385558
DMSO vs. AZA-0.09467603918369120.5720712669643561
DMSO vs. CD3-1.859502321320732.13273612104103e-082.12638449129604e-07
DMSO vs. DISU-0.3358019112846460.1696181124597730.68075602221674
DMSO vs. IL70.4934582404983120.006168677282073490.161726626134361
DMSO vs. SAHA-0.1133846107975350.6304749134011360.879472942055701
HIV vs. Mock in Activation-0.1906773563886910.759296323358740.999983755607037
HIV vs. Mock in Latency-0.1063006370846890.5200452272767370.999834320637052
IL7 vs. CD3-1.351115317782513.71974888471183e-050.000244898780568767
SAHA vs. CD3-1.978681625784877.34705130067681e-088.04067270161217e-07
SAHA vs. IL7-0.5964741407060790.01457396127665180.0813630344308256
(2). Iglesias-Ussel et al., J. Virol., 2013

Up and Downregulated transcripts during Latency (Latently infected CD4+ T cells vs Uninfected)- Primary CD4+Tcell based model
Log2 Fold Change P Value
unknown unknown

Gene expression during HIV infection and replication

(1). Imbeault et al., PloS Pathog., 2012

Transcriptomic profiling of HIV-1 infected CD4+ T cells - Primary CD4+ T cells
Experiment type Log2 Fold Change P Value Adjusted P Value
Infected vs. Mock unknown unknown unknown
Infected vs. Bystander unknown unknown unknown
(2). Lefebvre et al., J. Virol., 2011

Transcriptome analysis of T-cell line (Sup T1)
Log2 Fold Change unknown
(3). Li et al., J. Immunol., 2013

Lymphatic tissue
Acute Fold Change Acute P Value Asymt Fold Change Asypt P Value AIDS Fold Change AIDS P Value
unknown unknown unknown unknown unknown unknown
(4). Chang et al., MBio., 2011

Transcriptome analysis of T-cell line (Sup T1)

Derived from Sherrill-Mix et al., BMC Retrovirol., 2015 cross validation
Up-regulated (True) FALSE
(5). Sherrill-Mix et al., BMC Retrovirol., 2015

Deep RNA-seq analysis of primary human T cell infected with low passage HIV isolate HIV89.6 - Primary CD4+ T cell based
Test Status Log2 Fold Change P Value
OK 0.441921 0.000580925
(6). Rotger et al., PLoS Pathog., 2010

Genome-wide mRNA expression of CD4+ T cells from HIV-infected patient
(Genes differentially expressed (at adjusted p<0.01) according to the empirical Bayes approach)
Log2 Fold Change P Value
unknown unknown

Proteomic/Transcriptomics studies indicating differentially expressed genes mediated by HIV

(1). Greenwood et al., Elife, 2016

Activated (CD3/CD28) Primary human CD4+ T cells infected with pNL4-3-dE-EGFP. The table shows the complete (unfiltered) TMT (tandem mass tag)-based proteomic time course dataset
6 h 24 h 48 h 72 h RTi
1.013 0.96 0.981 0.991 1.015
(2). Navare et al., Virology, 2012

SUP-T1 cell line
FC-4hpi P-value FC-8hpi P-value FC-20hpi P-value Category
unknown unknown unknown unknown unknown unknown unknown
(3). Hyrcza et al., J. Virolo., 2007

Primary human CD4+ and CD8+ T Cells
Affymetrix Prob ID Fold Change In CD8? Category
unknown unknown unknown unknown

Protein Overview       top

Drug-protein Interaction       (annotations from DrugBank)      top

not found

Protein Secondary Structure       (annotations from PDB)      top

not found

HIV-1 Interaction       (annotations from NCBI HIV-1 Interaction Database)      top

HIV Partner Interaction Type PubMed
integrase binds 20016921
Tat upregulates 18051367

Metabolic/Signalling Pathway       (annotations from KEGG database)      top

Pathway Accession Number Description
not found