Detailed entry information

Protein Information (annotations from UniProt)

Database IDHIV0000694
UniProt IDQ6UUV7
Primary gene name(s)CRTC3
Synonym gene name(s)TORC3
Protein nameCREB-regulated transcription coactivator 3
Protein functionTranscriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element, CRE sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates the expression of specific CREB-activated genes such as the steroidogenic gene, StAR. Potent coactivator of PPARGC1A and inducer of mitochondrial biogenesis in muscle cells. Also coactivator for TAX activation of the human T-cell leukemia virus type 1, HTLV-1 long terminal repeats, LTR. {ECO:0000269|PubMed:14506290, ECO:0000269|PubMed:15454081, ECO:0000269|PubMed:15466468, ECO:0000269|PubMed:16817901, ECO:0000269|PubMed:16980408, ECO:0000269|PubMed:17210223, ECO:0000269|PubMed:17644518}.
Subcellular locationNucleus {ECO:0000269|PubMed:15454081, ECO:0000269|PubMed:15589160, ECO:0000269|PubMed:16817901}. Cytoplasm {ECO:0000269|PubMed:15589160, ECO:0000269|PubMed:16817901}. Note=Appears to be mainly nuclear. {ECO:0000269|PubMed:15454081}.
ECO codeClick here for more information.
Amino acid sequence
FASTA format: Q6UUV7
Gene Ontology
(Biological Process)
Complete annatation
energy homeostasis [GO:0097009];
macrophage activation [GO:0042116];
negative regulation of cAMP-mediated signaling [GO:0043951];
negative regulation of lipid catabolic process [GO:0050995];
positive regulation of CREB transcription factor activity [GO:0032793];
positive regulation of transcription from RNA polymerase II promoter [GO:0045944];
protein homotetramerization [GO:0051289];
transcription, DNA-templated [GO:0006351];
viral process [GO:0016032]
Gene Ontology
(Molecular Function)
Complete annatation
cAMP response element binding protein binding [GO:0008140]
Gene Ontology
(Cellular Component)
Complete annatation
cytoplasm [GO:0005737];
nucleoplasm [GO:0005654];
nucleus [GO:0005634]
Protein-protein interaction122294
Phylogenetic treeQ6UUV7
HIV replication factor status Zhou et al., Cell. Host. Microbe., 2008
      unknown
Brass et al., Science, 2008
      Yes
Smith et al., J. Immunol, 2010
      unknown
Interferon-stimulated
gene status
Lu et al., J. Virol., 2011
      Folds changes 8h: unknown; Folds changes 16h: unknown; Tested: unknown;
Schoggins JW and Rice CM, Curr. Opin. Virol., 2011
      Targeted viruses: unknown
      Viral life cycle: unknown
      Mechanism related to antiviral activity: unknown
Anti-viral restriction factor Liu et al., Retrovirology, 2011
      unknown (Triplicates)

Gene Expression Profile       top

            Up-regulated;            Down-regulated

For brief introduction to each study, please go to the help page.

Gene expression during HIV latency

(1). Mohammadi et al., PLoS Pathog., 2014

Differentially expressed transcripts (Pairwise) during latency and subsequent viral reactivation using several agents - Primary CD4+ T-cell based model


DMSO: Dimethyl suloxyde (negative control) - 0.0033% final
SAHA: Vorinostat (Histone deacetylase inhibitor) - 0.5 μM
CD3: TCR Stimulation by IL-2+ antiCD3/anti-CD28 antibodies
IL7: Interleukin-7 based stimulation
DISU: Disulfiram (alcohol dehydrogenase inhibitor) - 0.5 μM
AZA: 5-azacytidine (AZA; DNA methylation inhibitor) - 1 μM
Experimental Condition Log2 Fold Change P value Adjusted P value
AZA vs. CD3-0.9256036016809240.005131630590551660.0148225251553842
AZA vs. DISU0.01937773389527080.9389702595514310.995996743310228
AZA vs. IL70.09594174358502510.6175543870641660.999311006273513
AZA vs. SAHA-0.2788379780731940.2530523619734970.623693803856849
DISU vs. CD30.9328103955367430.01130687153206770.0321402567366374
DISU vs. IL70.06738673066812330.7889320300245490.951924941439804
DISU vs. SAHA-0.2963790806445370.3094767251201810.69324948199978
DMSO vs. AZA0.03034035206847110.8562062122574241
DMSO vs. CD30.9434537223182220.003564273898517880.010316193329716
DMSO vs. DISU0.008922583738887710.9708097507422560.995077522347534
DMSO vs. IL70.07301836704407260.6843645430535170.936221809419134
DMSO vs. SAHA-0.3149222162071490.1816828104532890.514591549772886
HIV vs. Mock in Activation0.2624923799552650.6734947174634750.999983755607037
HIV vs. Mock in Latency-0.05891472528120460.7211051366637240.999834320637052
IL7 vs. CD31.028228554801160.001606292605332740.00637316357993692
SAHA vs. CD30.6224004842163810.08003302305356090.145593609646902
SAHA vs. IL7-0.3778301166453980.1210015042558330.322200437228834
(2). Iglesias-Ussel et al., J. Virol., 2013

Up and Downregulated transcripts during Latency (Latently infected CD4+ T cells vs Uninfected)- Primary CD4+Tcell based model
Log2 Fold Change P Value
unknown unknown

Gene expression during HIV infection and replication

(1). Imbeault et al., PloS Pathog., 2012

Transcriptomic profiling of HIV-1 infected CD4+ T cells - Primary CD4+ T cells
Experiment type Log2 Fold Change P Value Adjusted P Value
Infected vs. Mock unknown unknown unknown
Infected vs. Bystander unknown unknown unknown
(2). Lefebvre et al., J. Virol., 2011

Transcriptome analysis of T-cell line (Sup T1)
Log2 Fold Change unknown
(3). Li et al., J. Immunol., 2013

Lymphatic tissue
Acute Fold Change Acute P Value Asymt Fold Change Asypt P Value AIDS Fold Change AIDS P Value
unknown unknown unknown unknown unknown unknown
(4). Chang et al., MBio., 2011

Transcriptome analysis of T-cell line (Sup T1)

Derived from Sherrill-Mix et al., BMC Retrovirol., 2015 cross validation
Up-regulated (True) TRUE
(5). Sherrill-Mix et al., BMC Retrovirol., 2015

Deep RNA-seq analysis of primary human T cell infected with low passage HIV isolate HIV89.6 - Primary CD4+ T cell based
Test Status Log2 Fold Change P Value
OK -0.403185 0.00108419
(6). Rotger et al., PLoS Pathog., 2010

Genome-wide mRNA expression of CD4+ T cells from HIV-infected patient
(Genes differentially expressed (at adjusted p<0.01) according to the empirical Bayes approach)
Log2 Fold Change P Value
unknown unknown

Proteomic/Transcriptomics studies indicating differentially expressed genes mediated by HIV

(1). Greenwood et al., Elife, 2016

Activated (CD3/CD28) Primary human CD4+ T cells infected with pNL4-3-dE-EGFP. The table shows the complete (unfiltered) TMT (tandem mass tag)-based proteomic time course dataset
6 h 24 h 48 h 72 h RTi
0.978 1.099 0.972 1.023 0.937
(2). Navare et al., Virology, 2012

SUP-T1 cell line
FC-4hpi P-value FC-8hpi P-value FC-20hpi P-value Category
unknown unknown unknown unknown unknown unknown unknown
(3). Hyrcza et al., J. Virolo., 2007

Primary human CD4+ and CD8+ T Cells
Affymetrix Prob ID Fold Change In CD8? Category
unknown unknown unknown unknown

Protein Overview       top

Drug-protein Interaction       (annotations from DrugBank)      top

not found

Protein Secondary Structure       (annotations from PDB)      top

not found

HIV-1 Interaction       (annotations from NCBI HIV-1 Interaction Database)      top

HIV Partner Interaction Type PubMed
HIV-1 virus replication enhanced by expression of human gene 18187620

Metabolic/Signalling Pathway       (annotations from KEGG database)      top

Pathway Accession Number Description
hsa05166 HTLV-I infection - Homo sapiens (human)
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