Detailed entry information

Protein Information (annotations from UniProt)

Database IDHIV0000677
UniProt IDQ17RY0
Primary gene name(s)CPEB4
Synonym gene name(s)KIAA1673
Protein nameCytoplasmic polyadenylation element-binding protein 4
Protein functionRNA-binding protein which, in contrast to CPEB1, does not bind to the cytoplasmic polyadenylation element, CPE, a uridine-rich sequence element within the mRNA 3'-UTR. {ECO:0000250|UniProtKB:Q7TN98}.
Subcellular locationCell projection, dendrite {ECO:0000250|UniProtKB:Q7TN98}. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density {ECO:0000250|UniProtKB:Q7TN98}.
ECO codeClick here for more information.
Amino acid sequence
FASTA format: Q17RY0
Gene Ontology
(Biological Process)
Complete annatation
cellular response to amino acid stimulus [GO:0071230];
cellular response to decreased oxygen levels [GO:0036294];
cellular response to glucose starvation [GO:0042149];
ionotropic glutamate receptor signaling pathway [GO:0035235];
negative regulation of cytoplasmic translation [GO:2000766];
negative regulation of neuron apoptotic process [GO:0043524];
response to ischemia [GO:0002931]
Gene Ontology
(Molecular Function)
Complete annatation
mRNA 3'-UTR binding [GO:0003730];
nucleotide binding [GO:0000166];
poly(A RNA binding [GO:0044822];
ribosome binding [GO:0043022];
translation factor activity, RNA binding [GO:0008135];
translation repressor activity, nucleic acid binding [GO:0000900]
Gene Ontology
(Cellular Component)
Complete annatation
cytoplasm [GO:0005737];
dendrite [GO:0030425];
endoplasmic reticulum [GO:0005783];
messenger ribonucleoprotein complex [GO:1990124];
neuron projection [GO:0043005];
nucleus [GO:0005634];
postsynaptic density [GO:0014069];
synapse [GO:0045202]
Protein-protein interaction123228
Phylogenetic treeQ17RY0
HIV replication factor status Zhou et al., Cell. Host. Microbe., 2008
Brass et al., Science, 2008
Smith et al., J. Immunol, 2010
gene status
Lu et al., J. Virol., 2011
      Folds changes 8h: unknown; Folds changes 16h: unknown; Tested: unknown;
Schoggins JW and Rice CM, Curr. Opin. Virol., 2011
      Targeted viruses: unknown
      Viral life cycle: unknown
      Mechanism related to antiviral activity: unknown
Anti-viral restriction factor Liu et al., Retrovirology, 2011
      unknown (Triplicates)

Gene Expression Profile       top

            Up-regulated;            Down-regulated

For brief introduction to each study, please go to the help page.

Gene expression during HIV latency

(1). Mohammadi et al., PLoS Pathog., 2014

Differentially expressed transcripts (Pairwise) during latency and subsequent viral reactivation using several agents - Primary CD4+ T-cell based model

DMSO: Dimethyl suloxyde (negative control) - 0.0033% final
SAHA: Vorinostat (Histone deacetylase inhibitor) - 0.5 μM
CD3: TCR Stimulation by IL-2+ antiCD3/anti-CD28 antibodies
IL7: Interleukin-7 based stimulation
DISU: Disulfiram (alcohol dehydrogenase inhibitor) - 0.5 μM
AZA: 5-azacytidine (AZA; DNA methylation inhibitor) - 1 μM
Experimental Condition Log2 Fold Change P value Adjusted P value
AZA vs. CD3-0.1886102886751450.6299715114044890.730042335836418
AZA vs. DISU0.5153578233741150.04297688452284290.471468939475816
AZA vs. IL70.205545328325190.2899541621597650.999311006273513
AZA vs. SAHA0.2226262509050320.3672340275759960.734273210197715
DISU vs. CD30.6898486272465360.09009488223365090.171866648290313
DISU vs. IL7-0.3186381099038470.2081436008803650.58729666698644
DISU vs. SAHA-0.2910126943094830.3210122319185840.703603162775593
DMSO vs. AZA0.006480629802866190.9695952658725241
DMSO vs. CD30.185191787316480.6412977438051430.731849898524694
DMSO vs. DISU-0.5102920053579170.03767520616953160.391603965036916
DMSO vs. IL70.2059465073424440.2571374007605780.759019526361721
DMSO vs. SAHA0.2089231771795860.4040018690523610.746770759645673
HIV vs. Mock in Activation0.3085872519083190.7168919886341050.999983755607037
HIV vs. Mock in Latency0.09449332770576250.5708817384933610.999834320637052
IL7 vs. CD30.4022737642003230.3047836538816790.442526455690512
SAHA vs. CD30.3866118288743720.4154147740120010.530328268409489
SAHA vs. IL70.01349010084098010.9569268027595460.983615044309403
(2). Iglesias-Ussel et al., J. Virol., 2013

Up and Downregulated transcripts during Latency (Latently infected CD4+ T cells vs Uninfected)- Primary CD4+Tcell based model
Log2 Fold Change P Value
unknown unknown

Gene expression during HIV infection and replication

(1). Imbeault et al., PloS Pathog., 2012

Transcriptomic profiling of HIV-1 infected CD4+ T cells - Primary CD4+ T cells
Experiment type Log2 Fold Change P Value Adjusted P Value
Infected vs. Mock unknown unknown unknown
Infected vs. Bystander unknown unknown unknown
(2). Lefebvre et al., J. Virol., 2011

Transcriptome analysis of T-cell line (Sup T1)
Log2 Fold Change unknown
(3). Li et al., J. Immunol., 2013

Lymphatic tissue
Acute Fold Change Acute P Value Asymt Fold Change Asypt P Value AIDS Fold Change AIDS P Value
unknown unknown unknown unknown unknown unknown
(4). Chang et al., MBio., 2011

Transcriptome analysis of T-cell line (Sup T1)

Derived from Sherrill-Mix et al., BMC Retrovirol., 2015 cross validation
Up-regulated (True) TRUE
(5). Sherrill-Mix et al., BMC Retrovirol., 2015

Deep RNA-seq analysis of primary human T cell infected with low passage HIV isolate HIV89.6 - Primary CD4+ T cell based
Test Status Log2 Fold Change P Value
OK 0.624735 0.000305467
(6). Rotger et al., PLoS Pathog., 2010

Genome-wide mRNA expression of CD4+ T cells from HIV-infected patient
(Genes differentially expressed (at adjusted p<0.01) according to the empirical Bayes approach)
Log2 Fold Change P Value
unknown unknown

Proteomic/Transcriptomics studies indicating differentially expressed genes mediated by HIV

(1). Greenwood et al., Elife, 2016

Activated (CD3/CD28) Primary human CD4+ T cells infected with pNL4-3-dE-EGFP. The table shows the complete (unfiltered) TMT (tandem mass tag)-based proteomic time course dataset
6 h 24 h 48 h 72 h RTi
unknown unknown unknown unknown unknown
(2). Navare et al., Virology, 2012

SUP-T1 cell line
FC-4hpi P-value FC-8hpi P-value FC-20hpi P-value Category
unknown unknown unknown unknown unknown unknown unknown
(3). Hyrcza et al., J. Virolo., 2007

Primary human CD4+ and CD8+ T Cells
Affymetrix Prob ID Fold Change In CD8? Category
unknown unknown unknown unknown

Protein Overview       top

Drug-protein Interaction       (annotations from DrugBank)      top

not found

Protein Secondary Structure       (annotations from PDB)      top

PDB Accession Method Resolution Chain Structure Preview
2MKI NMR - A=460-662.
2MKJ NMR - A=460-662.
5DIF X-ray 2.0Å D=379-393.

HIV-1 Interaction       (annotations from NCBI HIV-1 Interaction Database)      top

not found

Metabolic/Signalling Pathway       (annotations from KEGG database)      top

Pathway Accession Number Description
hsa04114 Oocyte meiosis - Homo sapiens (human)
hsa04320 Dorso-ventral axis formation - Homo sapiens (human)
hsa04914 Progesterone-mediated oocyte maturation - Homo sapiens (human)