Detailed entry information

Protein Information (annotations from UniProt)

Database IDHIV0000670
UniProt IDP31146
Primary gene name(s)CORO1A
Synonym gene name(s)CORO1
Protein nameCoronin-1A
Protein functionMay be a crucial component of the cytoskeleton of highly motile cells, functioning both in the invagination of large pieces of plasma membrane, as well as in forming protrusions of the plasma membrane involved in cell locomotion. In mycobacteria-infected cells, its retention on the phagosomal membrane prevents fusion between phagosomes and lysosomes. {ECO:0000269|PubMed:10338208}.
Subcellular locationCytoplasm, cytoskeleton {ECO:0000250}. Cytoplasm, cell cortex {ECO:0000250}. Cytoplasmic vesicle, phagosome membrane {ECO:0000250}. Note=In non-infected macrophages, associated with the cortical microtubule network. In mycobacteria-infected macrophages, becomes progressively relocalized and retained around the mycobacterial phagosomes. Retention on the phagosomal membrane is strictly dependent on mycobacterial viability and not due to impaired acidification, By similarity. {ECO:0000250}.
ECO codeClick here for more information.
Amino acid sequence
FASTA format: P31146
Gene Ontology
(Biological Process)
Complete annatation
actin cytoskeleton organization [GO:0030036];
actin filament organization [GO:0007015];
calcium ion transport [GO:0006816];
cell-substrate adhesion [GO:0031589];
cellular response to interleukin-4 [GO:0071353];
early endosome to recycling endosome transport [GO:0061502];
homeostasis of number of cells within a tissue [GO:0048873];
innate immune response [GO:0045087];
leukocyte chemotaxis [GO:0030595];
movement of cell or subcellular component [GO:0006928];
natural killer cell degranulation [GO:0043320];
negative regulation of actin nucleation [GO:0051126];
negative regulation of neuron apoptotic process [GO:0043524];
negative regulation of vesicle fusion [GO:0031339];
nerve growth factor signaling pathway [GO:0038180];
phagocytosis [GO:0006909];
phagolysosome assembly [GO:0001845];
positive chemotaxis [GO:0050918];
positive regulation of cell migration [GO:0030335];
positive regulation of T cell proliferation [GO:0042102];
regulation of actin cytoskeleton organization [GO:0032956];
regulation of cell shape [GO:0008360];
regulation of release of sequestered calcium ion into cytosol [GO:0051279];
T cell homeostasis [GO:0043029];
uropod organization [GO:0032796]
Gene Ontology
(Molecular Function)
Complete annatation
actin binding [GO:0003779];
actin filament binding [GO:0051015];
actin monomer binding [GO:0003785];
cytoskeletal protein binding [GO:0008092];
myosin heavy chain binding [GO:0032036];
phosphatidylinositol 3-kinase binding [GO:0043548];
poly(A RNA binding [GO:0044822];
protein C-terminus binding [GO:0008022];
protein homodimerization activity [GO:0042803]
Gene Ontology
(Cellular Component)
Complete annatation
actin filament [GO:0005884];
axon [GO:0030424];
cell-cell junction [GO:0005911];
cortical actin cytoskeleton [GO:0030864];
cytoplasm [GO:0005737];
cytosol [GO:0005829];
early endosome [GO:0005769];
extracellular exosome [GO:0070062];
immunological synapse [GO:0001772];
lamellipodium [GO:0030027];
membrane [GO:0016020];
phagocytic cup [GO:0001891];
phagocytic vesicle [GO:0045335];
phagocytic vesicle membrane [GO:0030670];
plasma membrane [GO:0005886];
protein complex [GO:0043234]
Protein-protein interaction116322
Phylogenetic treeP31146
HIV replication factor status Zhou et al., Cell. Host. Microbe., 2008
      unknown
Brass et al., Science, 2008
      unknown
Smith et al., J. Immunol, 2010
      unknown
Interferon-stimulated
gene status
Lu et al., J. Virol., 2011
      Folds changes 8h: unknown; Folds changes 16h: unknown; Tested: unknown;
Schoggins JW and Rice CM, Curr. Opin. Virol., 2011
      Targeted viruses: unknown
      Viral life cycle: unknown
      Mechanism related to antiviral activity: unknown
Anti-viral restriction factor Liu et al., Retrovirology, 2011
      unknown (Triplicates)

Gene Expression Profile       top

            Up-regulated;            Down-regulated

For brief introduction to each study, please go to the help page.

Gene expression during HIV latency

(1). Mohammadi et al., PLoS Pathog., 2014

Differentially expressed transcripts (Pairwise) during latency and subsequent viral reactivation using several agents - Primary CD4+ T-cell based model


DMSO: Dimethyl suloxyde (negative control) - 0.0033% final
SAHA: Vorinostat (Histone deacetylase inhibitor) - 0.5 μM
CD3: TCR Stimulation by IL-2+ antiCD3/anti-CD28 antibodies
IL7: Interleukin-7 based stimulation
DISU: Disulfiram (alcohol dehydrogenase inhibitor) - 0.5 μM
AZA: 5-azacytidine (AZA; DNA methylation inhibitor) - 1 μM
Experimental Condition Log2 Fold Change P value Adjusted P value
AZA vs. CD3-2.178514518529710.0001137365534990.000541281128619174
AZA vs. DISU-0.4930883546720370.05249185010105630.509505568849531
AZA vs. IL70.1146767829617560.5491809733222840.999311006273513
AZA vs. SAHA-1.149076326594260.0001637974030047620.0053942208125098
DISU vs. CD31.673487582028010.005427849519302310.0173419677096149
DISU vs. IL70.5982040251858290.01828921404764110.168560821311828
DISU vs. SAHA-0.6530371015081320.06566946232168110.323750234429197
DMSO vs. AZA0.07935980985005360.6337727647300241
DMSO vs. CD32.246046884788844.57057410460093e-050.000223557463914977
DMSO vs. DISU0.5706685918909170.01994073935360330.288869453667608
DMSO vs. IL70.04271675696714350.8113443366972410.962475569829797
DMSO vs. SAHA-1.232927555901451.02992348883779e-050.000569123610399323
HIV vs. Mock in Activation0.157445437898250.8922622765310460.999983755607037
HIV vs. Mock in Latency0.03155944999148540.8478009504299030.999834320637052
IL7 vs. CD32.298530089818693.67578168444238e-050.000242579060112084
SAHA vs. CD31.007571673914820.08364038937298780.150881095026446
SAHA vs. IL7-1.265260458081881.75418328405286e-050.000482528445690014
(2). Iglesias-Ussel et al., J. Virol., 2013

Up and Downregulated transcripts during Latency (Latently infected CD4+ T cells vs Uninfected)- Primary CD4+Tcell based model
Log2 Fold Change P Value
unknown unknown

Gene expression during HIV infection and replication

(1). Imbeault et al., PloS Pathog., 2012

Transcriptomic profiling of HIV-1 infected CD4+ T cells - Primary CD4+ T cells
Experiment type Log2 Fold Change P Value Adjusted P Value
Infected vs. Mock unknown unknown unknown
Infected vs. Bystander unknown unknown unknown
(2). Lefebvre et al., J. Virol., 2011

Transcriptome analysis of T-cell line (Sup T1)
Log2 Fold Change unknown
(3). Li et al., J. Immunol., 2013

Lymphatic tissue
Acute Fold Change Acute P Value Asymt Fold Change Asypt P Value AIDS Fold Change AIDS P Value
unknown unknown unknown unknown unknown unknown
(4). Chang et al., MBio., 2011

Transcriptome analysis of T-cell line (Sup T1)

Derived from Sherrill-Mix et al., BMC Retrovirol., 2015 cross validation
Up-regulated (True) FALSE
(5). Sherrill-Mix et al., BMC Retrovirol., 2015

Deep RNA-seq analysis of primary human T cell infected with low passage HIV isolate HIV89.6 - Primary CD4+ T cell based
Test Status Log2 Fold Change P Value
OK -0.182319 0.593351
(6). Rotger et al., PLoS Pathog., 2010

Genome-wide mRNA expression of CD4+ T cells from HIV-infected patient
(Genes differentially expressed (at adjusted p<0.01) according to the empirical Bayes approach)
Log2 Fold Change P Value
unknown unknown

Proteomic/Transcriptomics studies indicating differentially expressed genes mediated by HIV

(1). Greenwood et al., Elife, 2016

Activated (CD3/CD28) Primary human CD4+ T cells infected with pNL4-3-dE-EGFP. The table shows the complete (unfiltered) TMT (tandem mass tag)-based proteomic time course dataset
6 h 24 h 48 h 72 h RTi
1.006 0.84 0.87 0.869 0.846
(2). Navare et al., Virology, 2012

SUP-T1 cell line
FC-4hpi P-value FC-8hpi P-value FC-20hpi P-value Category
unknown unknown unknown unknown unknown unknown unknown
(3). Hyrcza et al., J. Virolo., 2007

Primary human CD4+ and CD8+ T Cells
Affymetrix Prob ID Fold Change In CD8? Category
unknown unknown unknown unknown

Protein Overview       top

Drug-protein Interaction       (annotations from DrugBank)      top

not found

Protein Secondary Structure       (annotations from PDB)      top

not found

HIV-1 Interaction       (annotations from NCBI HIV-1 Interaction Database)      top

not found

Metabolic/Signalling Pathway       (annotations from KEGG database)      top

Pathway Accession Number Description
hsa04145 Phagosome - Homo sapiens (human)
hsa05152 Tuberculosis - Homo sapiens (human)
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