Detailed entry information

Protein Information (annotations from UniProt)

Database IDHIV0000664
UniProt IDP29400
Primary gene name(s)COL4A5
Synonym gene name(s)unknown
Protein nameCollagen alpha-5(IV chain
Protein functionType IV collagen is the major structural component of glomerular basement membranes, GBM, forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen.
Subcellular locationSecreted, extracellular space, extracellular matrix, basement membrane.
ECO codeClick here for more information.
Amino acid sequence
FASTA format: P29400
Gene Ontology
(Biological Process)
Complete annatation
collagen-activated tyrosine kinase receptor signaling pathway [GO:0038063];
collagen catabolic process [GO:0030574];
extracellular matrix organization [GO:0030198];
neuromuscular junction development [GO:0007528]
Gene Ontology
(Molecular Function)
Complete annatation
extracellular matrix structural constituent [GO:0005201]
Gene Ontology
(Cellular Component)
Complete annatation
basal lamina [GO:0005605];
collagen type IV trimer [GO:0005587];
endoplasmic reticulum lumen [GO:0005788];
extracellular region [GO:0005576];
neuromuscular junction [GO:0031594]
Protein-protein interaction107684
Phylogenetic treeP29400
HIV replication factor status Zhou et al., Cell. Host. Microbe., 2008
Brass et al., Science, 2008
Smith et al., J. Immunol, 2010
gene status
Lu et al., J. Virol., 2011
      Folds changes 8h: unknown; Folds changes 16h: unknown; Tested: unknown;
Schoggins JW and Rice CM, Curr. Opin. Virol., 2011
      Targeted viruses: unknown
      Viral life cycle: unknown
      Mechanism related to antiviral activity: unknown
Anti-viral restriction factor Liu et al., Retrovirology, 2011
      unknown (Triplicates)

Gene Expression Profile       top

            Up-regulated;            Down-regulated

For brief introduction to each study, please go to the help page.

Gene expression during HIV latency

(1). Mohammadi et al., PLoS Pathog., 2014

Differentially expressed transcripts (Pairwise) during latency and subsequent viral reactivation using several agents - Primary CD4+ T-cell based model

DMSO: Dimethyl suloxyde (negative control) - 0.0033% final
SAHA: Vorinostat (Histone deacetylase inhibitor) - 0.5 μM
CD3: TCR Stimulation by IL-2+ antiCD3/anti-CD28 antibodies
IL7: Interleukin-7 based stimulation
DISU: Disulfiram (alcohol dehydrogenase inhibitor) - 0.5 μM
AZA: 5-azacytidine (AZA; DNA methylation inhibitor) - 1 μM
Experimental Condition Log2 Fold Change P value Adjusted P value
AZA vs. CD3-0.9237787335548490.1753390903615940.275540691265765
AZA vs. DISU-0.2494233188296740.6976549886595860.969258184244663
AZA vs. IL7-0.6655717413250240.258500458806520.999311006273513
AZA vs. SAHA0.2095633837149180.7053047150977770.91681931791089
DISU vs. CD30.6589935617261510.3530281639320290.48680091567444
DISU vs. IL7-0.4238683853263860.4862255628899150.818278057719398
DISU vs. SAHA0.459052441009920.428486620478220.7772895832002
DMSO vs. AZA0.03251950415414680.9545780730861661
DMSO vs. CD30.9333834569722370.1195820701151710.19736019788399
DMSO vs. DISU0.2778873816434090.6373793741412820.946229564999022
DMSO vs. IL7-0.6896110637305710.1921993559706940.701710769886993
DMSO vs. SAHA0.1707267116390870.7244441521109330.919186547942741
HIV vs. Mock in Activationunknownunknownunknown
HIV vs. Mock in Latency-0.2609915890517770.5594839895862990.999834320637052
IL7 vs. CD3unknownunknownunknown
SAHA vs. CD31.104102988180880.05829346248201550.112395404248205
SAHA vs. IL70.8683490742384190.09083116730423850.271494884868088
(2). Iglesias-Ussel et al., J. Virol., 2013

Up and Downregulated transcripts during Latency (Latently infected CD4+ T cells vs Uninfected)- Primary CD4+Tcell based model
Log2 Fold Change P Value
unknown unknown

Gene expression during HIV infection and replication

(1). Imbeault et al., PloS Pathog., 2012

Transcriptomic profiling of HIV-1 infected CD4+ T cells - Primary CD4+ T cells
Experiment type Log2 Fold Change P Value Adjusted P Value
Infected vs. Mock unknown unknown unknown
Infected vs. Bystander unknown unknown unknown
(2). Lefebvre et al., J. Virol., 2011

Transcriptome analysis of T-cell line (Sup T1)
Log2 Fold Change unknown
(3). Li et al., J. Immunol., 2013

Lymphatic tissue
Acute Fold Change Acute P Value Asymt Fold Change Asypt P Value AIDS Fold Change AIDS P Value
unknown unknown unknown unknown unknown unknown
(4). Chang et al., MBio., 2011

Transcriptome analysis of T-cell line (Sup T1)

Derived from Sherrill-Mix et al., BMC Retrovirol., 2015 cross validation
Up-regulated (True) TRUE
(5). Sherrill-Mix et al., BMC Retrovirol., 2015

Deep RNA-seq analysis of primary human T cell infected with low passage HIV isolate HIV89.6 - Primary CD4+ T cell based
Test Status Log2 Fold Change P Value
(6). Rotger et al., PLoS Pathog., 2010

Genome-wide mRNA expression of CD4+ T cells from HIV-infected patient
(Genes differentially expressed (at adjusted p<0.01) according to the empirical Bayes approach)
Log2 Fold Change P Value
unknown unknown

Proteomic/Transcriptomics studies indicating differentially expressed genes mediated by HIV

(1). Greenwood et al., Elife, 2016

Activated (CD3/CD28) Primary human CD4+ T cells infected with pNL4-3-dE-EGFP. The table shows the complete (unfiltered) TMT (tandem mass tag)-based proteomic time course dataset
6 h 24 h 48 h 72 h RTi
unknown unknown unknown unknown unknown
(2). Navare et al., Virology, 2012

SUP-T1 cell line
FC-4hpi P-value FC-8hpi P-value FC-20hpi P-value Category
unknown unknown unknown unknown unknown unknown unknown
(3). Hyrcza et al., J. Virolo., 2007

Primary human CD4+ and CD8+ T Cells
Affymetrix Prob ID Fold Change In CD8? Category
unknown unknown unknown unknown

Protein Overview       top

Drug-protein Interaction       (annotations from DrugBank)      top

not found

Protein Secondary Structure       (annotations from PDB)      top

not found

HIV-1 Interaction       (annotations from NCBI HIV-1 Interaction Database)      top

HIV Partner Interaction Type PubMed
Tat enhances 24742657
Envelope surface glycoprotein gp160; precursor activates 7495302

Metabolic/Signalling Pathway       (annotations from KEGG database)      top

Pathway Accession Number Description
hsa04151 PI3K-Akt signaling pathway - Homo sapiens (human)
hsa04510 Focal adhesion - Homo sapiens (human)
hsa04512 ECM-receptor interaction - Homo sapiens (human)
hsa04933 AGE-RAGE signaling pathway in diabetic complications - Homo sapiens (human)
hsa04974 Protein digestion and absorption - Homo sapiens (human)
hsa05146 Amoebiasis - Homo sapiens (human)
hsa05200 Pathways in cancer - Homo sapiens (human)
hsa05222 Small cell lung cancer - Homo sapiens (human)