Detailed entry information

Protein Information (annotations from UniProt)

Database IDHIV0000659
UniProt IDQ9H9E3
Primary gene name(s)COG4
Synonym gene name(s)unknown
Protein nameConserved oligomeric Golgi complex subunit 4
Protein functionRequired for normal Golgi function. Plays a role in SNARE-pin assembly and Golgi-to-ER retrograde transport via its interaction with SCFD1. {ECO:0000269|PubMed:19536132}.
Subcellular locationGolgi apparatus membrane {ECO:0000305|PubMed:11703943};
Peripheral membrane protein {ECO:0000305|PubMed:11703943};
Cytoplasmic side {ECO:0000305|PubMed:11703943}.
ECO codeClick here for more information.
Amino acid sequence
FASTA format: Q9H9E3
Gene Ontology
(Biological Process)
Complete annatation
ER to Golgi vesicle-mediated transport [GO:0006888];
Golgi organization [GO:0007030];
Golgi vesicle prefusion complex stabilization [GO:0048213];
protein transport [GO:0015031];
retrograde transport, vesicle recycling within Golgi [GO:0000301];
retrograde vesicle-mediated transport, Golgi to ER [GO:0006890]
Gene Ontology
(Molecular Function)
Complete annatation
Gene Ontology
(Cellular Component)
Complete annatation
Golgi membrane [GO:0000139];
Golgi transport complex [GO:0017119];
trans-Golgi network membrane [GO:0032588]
Protein-protein interaction117365
Phylogenetic treeQ9H9E3
HIV replication factor status Zhou et al., Cell. Host. Microbe., 2008
Brass et al., Science, 2008
Smith et al., J. Immunol, 2010
gene status
Lu et al., J. Virol., 2011
      Folds changes 8h: unknown; Folds changes 16h: unknown; Tested: unknown;
Schoggins JW and Rice CM, Curr. Opin. Virol., 2011
      Targeted viruses: unknown
      Viral life cycle: unknown
      Mechanism related to antiviral activity: unknown
Anti-viral restriction factor Liu et al., Retrovirology, 2011
      unknown (Triplicates)

Gene Expression Profile       top

            Up-regulated;            Down-regulated

For brief introduction to each study, please go to the help page.

Gene expression during HIV latency

(1). Mohammadi et al., PLoS Pathog., 2014

Differentially expressed transcripts (Pairwise) during latency and subsequent viral reactivation using several agents - Primary CD4+ T-cell based model

DMSO: Dimethyl suloxyde (negative control) - 0.0033% final
SAHA: Vorinostat (Histone deacetylase inhibitor) - 0.5 μM
CD3: TCR Stimulation by IL-2+ antiCD3/anti-CD28 antibodies
IL7: Interleukin-7 based stimulation
DISU: Disulfiram (alcohol dehydrogenase inhibitor) - 0.5 μM
AZA: 5-azacytidine (AZA; DNA methylation inhibitor) - 1 μM
Experimental Condition Log2 Fold Change P value Adjusted P value
AZA vs. CD3-1.041991615966110.04823273306534960.0968626055221014
AZA vs. DISU-0.3358889761503110.1854673319917780.772196340408505
AZA vs. IL7-0.2049743454315260.2886795859697520.999311006273513
AZA vs. SAHA0.3014601450684250.2179456102572740.585967791750363
DISU vs. CD30.6937036656546030.1867436627630970.302490218406504
DISU vs. IL70.1212906294595350.6310903406004450.889794882580593
DISU vs. SAHA0.6394543424048180.02899826276550630.202799451572597
DMSO vs. AZA0.07289513025705130.664995091462561
DMSO vs. CD31.101935878866510.03652270408563860.0738245722595124
DMSO vs. DISU0.406541743606810.09671866834207240.562109653650224
DMSO vs. IL7-0.2705423990928130.1343972350494890.632122723648975
DMSO vs. SAHA0.223149582406510.345005798372230.69652811617788
HIV vs. Mock in Activation-0.08918256409743020.938035379937650.999983755607037
HIV vs. Mock in Latency0.06765535580360110.682510824806150.999834320637052
IL7 vs. CD30.8436210353624730.1090124819874010.202607292354635
SAHA vs. CD31.319492303669450.01536656482730110.0368396646432434
SAHA vs. IL70.5036213439704730.03994005816841230.157430869472588
(2). Iglesias-Ussel et al., J. Virol., 2013

Up and Downregulated transcripts during Latency (Latently infected CD4+ T cells vs Uninfected)- Primary CD4+Tcell based model
Log2 Fold Change P Value
unknown unknown

Gene expression during HIV infection and replication

(1). Imbeault et al., PloS Pathog., 2012

Transcriptomic profiling of HIV-1 infected CD4+ T cells - Primary CD4+ T cells
Experiment type Log2 Fold Change P Value Adjusted P Value
Infected vs. Mock unknown unknown unknown
Infected vs. Bystander unknown unknown unknown
(2). Lefebvre et al., J. Virol., 2011

Transcriptome analysis of T-cell line (Sup T1)
Log2 Fold Change unknown
(3). Li et al., J. Immunol., 2013

Lymphatic tissue
Acute Fold Change Acute P Value Asymt Fold Change Asypt P Value AIDS Fold Change AIDS P Value
unknown unknown unknown unknown unknown unknown
(4). Chang et al., MBio., 2011

Transcriptome analysis of T-cell line (Sup T1)

Derived from Sherrill-Mix et al., BMC Retrovirol., 2015 cross validation
Up-regulated (True) TRUE
(5). Sherrill-Mix et al., BMC Retrovirol., 2015

Deep RNA-seq analysis of primary human T cell infected with low passage HIV isolate HIV89.6 - Primary CD4+ T cell based
Test Status Log2 Fold Change P Value
OK -0.228622 0.117826
(6). Rotger et al., PLoS Pathog., 2010

Genome-wide mRNA expression of CD4+ T cells from HIV-infected patient
(Genes differentially expressed (at adjusted p<0.01) according to the empirical Bayes approach)
Log2 Fold Change P Value
unknown unknown

Proteomic/Transcriptomics studies indicating differentially expressed genes mediated by HIV

(1). Greenwood et al., Elife, 2016

Activated (CD3/CD28) Primary human CD4+ T cells infected with pNL4-3-dE-EGFP. The table shows the complete (unfiltered) TMT (tandem mass tag)-based proteomic time course dataset
6 h 24 h 48 h 72 h RTi
1.029 1.044 1.218 1.229 1.016
(2). Navare et al., Virology, 2012

SUP-T1 cell line
FC-4hpi P-value FC-8hpi P-value FC-20hpi P-value Category
unknown unknown unknown unknown unknown unknown unknown
(3). Hyrcza et al., J. Virolo., 2007

Primary human CD4+ and CD8+ T Cells
Affymetrix Prob ID Fold Change In CD8? Category
212189_s_at 1.38 No upregulated in CD8+ cells

Protein Overview       top

Drug-protein Interaction       (annotations from DrugBank)      top

not found

Protein Secondary Structure       (annotations from PDB)      top

PDB Accession Method Resolution Chain Structure Preview
3HR0 X-ray 1.9Å A/B=525-785.

HIV-1 Interaction       (annotations from NCBI HIV-1 Interaction Database)      top

HIV Partner Interaction Type PubMed
HIV-1 virus replication enhanced by expression of human gene 18187620

Metabolic/Signalling Pathway       (annotations from KEGG database)      top

Pathway Accession Number Description
not found