Detailed entry information

Protein Information (annotations from UniProt)

Database IDHIV0000657
UniProt IDP78357
Primary gene name(s)CNTNAP1
Synonym gene name(s)CASPR, NRXN4
Protein nameContactin-associated protein 1
Protein functionSeems to play a role in the formation of functional distinct domains critical for saltatory conduction of nerve impulses in myelinated nerve fibers. Seems to demarcate the paranodal region of the axo-glial junction. In association with contactin may have a role in the signaling between axons and myelinating glial cells.
Subcellular locationMembrane {ECO:0000305};
Single-pass type I membrane protein {ECO:0000305}.
ECO codeClick here for more information.
Amino acid sequence
FASTA format: P78357
Gene Ontology
(Biological Process)
Complete annatation
cell adhesion [GO:0007155];
cytoskeleton organization [GO:0007010];
neuromuscular process controlling balance [GO:0050885];
neuromuscular process controlling posture [GO:0050884];
neuronal action potential propagation [GO:0019227];
neuron projection morphogenesis [GO:0048812];
paranodal junction assembly [GO:0030913];
protein localization to paranode region of axon [GO:0002175];
signal transduction [GO:0007165]
Gene Ontology
(Molecular Function)
Complete annatation
receptor activity [GO:0004872];
SH3/SH2 adaptor activity [GO:0005070];
SH3 domain binding [GO:0017124]
Gene Ontology
(Cellular Component)
Complete annatation
integral component of membrane [GO:0016021];
integral component of plasma membrane [GO:0005887];
myelin sheath [GO:0043209];
paranode region of axon [GO:0033270];
voltage-gated potassium channel complex [GO:0008076]
Protein-protein interaction114078
Phylogenetic treeP78357
HIV replication factor status Zhou et al., Cell. Host. Microbe., 2008
Brass et al., Science, 2008
Smith et al., J. Immunol, 2010
gene status
Lu et al., J. Virol., 2011
      Folds changes 8h: unknown; Folds changes 16h: unknown; Tested: unknown;
Schoggins JW and Rice CM, Curr. Opin. Virol., 2011
      Targeted viruses: unknown
      Viral life cycle: unknown
      Mechanism related to antiviral activity: unknown
Anti-viral restriction factor Liu et al., Retrovirology, 2011
      unknown (Triplicates)

Gene Expression Profile       top

            Up-regulated;            Down-regulated

For brief introduction to each study, please go to the help page.

Gene expression during HIV latency

(1). Mohammadi et al., PLoS Pathog., 2014

Differentially expressed transcripts (Pairwise) during latency and subsequent viral reactivation using several agents - Primary CD4+ T-cell based model

DMSO: Dimethyl suloxyde (negative control) - 0.0033% final
SAHA: Vorinostat (Histone deacetylase inhibitor) - 0.5 μM
CD3: TCR Stimulation by IL-2+ antiCD3/anti-CD28 antibodies
IL7: Interleukin-7 based stimulation
DISU: Disulfiram (alcohol dehydrogenase inhibitor) - 0.5 μM
AZA: 5-azacytidine (AZA; DNA methylation inhibitor) - 1 μM
Experimental Condition Log2 Fold Change P value Adjusted P value
AZA vs. CD3-1.203915403566310.0006685930587936320.00255306207816194
AZA vs. DISU-0.0954471267397640.7259827810249280.974429666417572
AZA vs. IL7-0.3351669143604880.1525965008321940.920569985494164
AZA vs. SAHA0.0676944264631710.7983876913387440.947033054708862
DISU vs. CD31.093401335912340.004561926501617570.0150079616074603
DISU vs. IL7-0.2507594471154380.3570779774527610.735677259819649
DISU vs. SAHA0.1653901515881530.5906830838424520.868889883278733
DMSO vs. AZA-0.01020409948955310.9588856633780741
DMSO vs. CD31.18041127109570.0006403244898129930.00231219761242396
DMSO vs. DISU0.08265264720880350.7529134482934170.969857060964769
DMSO vs. IL7-0.3145558307746710.13091963579920.628939932974168
DMSO vs. SAHA0.07235982974819920.7767704299565040.936876457335883
HIV vs. Mock in Activation0.5996507944568650.3683750059490460.999983755607037
HIV vs. Mock in Latency0.1803363546683960.3201816722963280.999834320637052
IL7 vs. CD30.8697463941612560.01205244681829320.0347022981646864
SAHA vs. CD31.24515981652960.001041923180346460.00370849842414293
SAHA vs. IL70.3991529001931280.1333524843086590.341456658479486
(2). Iglesias-Ussel et al., J. Virol., 2013

Up and Downregulated transcripts during Latency (Latently infected CD4+ T cells vs Uninfected)- Primary CD4+Tcell based model
Log2 Fold Change P Value
unknown unknown

Gene expression during HIV infection and replication

(1). Imbeault et al., PloS Pathog., 2012

Transcriptomic profiling of HIV-1 infected CD4+ T cells - Primary CD4+ T cells
Experiment type Log2 Fold Change P Value Adjusted P Value
Infected vs. Mock unknown unknown unknown
Infected vs. Bystander unknown unknown unknown
(2). Lefebvre et al., J. Virol., 2011

Transcriptome analysis of T-cell line (Sup T1)
Log2 Fold Change unknown
(3). Li et al., J. Immunol., 2013

Lymphatic tissue
Acute Fold Change Acute P Value Asymt Fold Change Asypt P Value AIDS Fold Change AIDS P Value
unknown unknown unknown unknown unknown unknown
(4). Chang et al., MBio., 2011

Transcriptome analysis of T-cell line (Sup T1)

Derived from Sherrill-Mix et al., BMC Retrovirol., 2015 cross validation
Up-regulated (True) TRUE
(5). Sherrill-Mix et al., BMC Retrovirol., 2015

Deep RNA-seq analysis of primary human T cell infected with low passage HIV isolate HIV89.6 - Primary CD4+ T cell based
Test Status Log2 Fold Change P Value
NOTEST -0.694603 1
(6). Rotger et al., PLoS Pathog., 2010

Genome-wide mRNA expression of CD4+ T cells from HIV-infected patient
(Genes differentially expressed (at adjusted p<0.01) according to the empirical Bayes approach)
Log2 Fold Change P Value
unknown unknown

Proteomic/Transcriptomics studies indicating differentially expressed genes mediated by HIV

(1). Greenwood et al., Elife, 2016

Activated (CD3/CD28) Primary human CD4+ T cells infected with pNL4-3-dE-EGFP. The table shows the complete (unfiltered) TMT (tandem mass tag)-based proteomic time course dataset
6 h 24 h 48 h 72 h RTi
unknown unknown unknown unknown unknown
(2). Navare et al., Virology, 2012

SUP-T1 cell line
FC-4hpi P-value FC-8hpi P-value FC-20hpi P-value Category
unknown unknown unknown unknown unknown unknown unknown
(3). Hyrcza et al., J. Virolo., 2007

Primary human CD4+ and CD8+ T Cells
Affymetrix Prob ID Fold Change In CD8? Category
unknown unknown unknown unknown

Protein Overview       top

Drug-protein Interaction       (annotations from DrugBank)      top

not found

Protein Secondary Structure       (annotations from PDB)      top

not found

HIV-1 Interaction       (annotations from NCBI HIV-1 Interaction Database)      top

HIV Partner Interaction Type PubMed
Vpu interacts with 22190034

Metabolic/Signalling Pathway       (annotations from KEGG database)      top

Pathway Accession Number Description
hsa04514 Cell adhesion molecules (CAMs) - Homo sapiens (human)