Detailed entry information

Protein Information (annotations from UniProt)

Database IDHIV0000651
UniProt IDQ6P4Q7
Primary gene name(s)CNNM4
Synonym gene name(s)ACDP4, KIAA1592
Protein nameMetal transporter CNNM4
Protein functionProbable metal transporter. The interaction with the metal ion chaperone COX11 suggests that it may play a role in sensory neuron functions, By similarity. May play a role in biomineralization and retinal function. {ECO:0000250, ECO:0000269|PubMed:19200525, ECO:0000269|PubMed:19200527}.
Subcellular locationCell membrane {ECO:0000269|PubMed:22399287};
Multi-pass membrane protein {ECO:0000269|PubMed:22399287}.
ECO codeClick here for more information.
Amino acid sequence
FASTA format: Q6P4Q7
Gene Ontology
(Biological Process)
Complete annatation
enamel mineralization [GO:0070166];
magnesium ion homeostasis [GO:0010960];
magnesium ion transport [GO:0015693];
response to stimulus [GO:0050896];
visual perception [GO:0007601]
Gene Ontology
(Molecular Function)
Complete annatation
magnesium ion transmembrane transporter activity [GO:0015095];
sodium ion transmembrane transporter activity [GO:0015081]
Gene Ontology
(Cellular Component)
Complete annatation
basolateral plasma membrane [GO:0016323];
integral component of membrane [GO:0016021]
Protein-protein interaction117711
Phylogenetic treeQ6P4Q7
HIV replication factor status Zhou et al., Cell. Host. Microbe., 2008
Brass et al., Science, 2008
Smith et al., J. Immunol, 2010
gene status
Lu et al., J. Virol., 2011
      Folds changes 8h: unknown; Folds changes 16h: unknown; Tested: unknown;
Schoggins JW and Rice CM, Curr. Opin. Virol., 2011
      Targeted viruses: unknown
      Viral life cycle: unknown
      Mechanism related to antiviral activity: unknown
Anti-viral restriction factor Liu et al., Retrovirology, 2011
      unknown (Triplicates)

Gene Expression Profile       top

            Up-regulated;            Down-regulated

For brief introduction to each study, please go to the help page.

Gene expression during HIV latency

(1). Mohammadi et al., PLoS Pathog., 2014

Differentially expressed transcripts (Pairwise) during latency and subsequent viral reactivation using several agents - Primary CD4+ T-cell based model

DMSO: Dimethyl suloxyde (negative control) - 0.0033% final
SAHA: Vorinostat (Histone deacetylase inhibitor) - 0.5 μM
CD3: TCR Stimulation by IL-2+ antiCD3/anti-CD28 antibodies
IL7: Interleukin-7 based stimulation
DISU: Disulfiram (alcohol dehydrogenase inhibitor) - 0.5 μM
AZA: 5-azacytidine (AZA; DNA methylation inhibitor) - 1 μM
Experimental Condition Log2 Fold Change P value Adjusted P value
AZA vs. CD3-0.04834783528989750.8836313605601570.923905089584647
AZA vs. DISU0.08970980409556010.7264506607044540.974429666417572
AZA vs. IL7-0.02653001756285540.8930997103107580.999311006273513
AZA vs. SAHA0.1061423403312580.6690177321559860.901662144245747
DISU vs. CD30.1259427414575450.7294879923925650.810160023379173
DISU vs. IL7-0.126228954460590.6205961617227960.885149429261168
DISU vs. SAHA0.01901489855091320.9486688021264770.988800185925101
DMSO vs. AZA-0.06135290676818720.723960951590341
DMSO vs. CD3-0.02407370321547150.9404436289788390.958383499328026
DMSO vs. DISU-0.1528052457758360.5366008012284010.92112338311561
DMSO vs. IL70.04229859995903180.819015520346980.962956477091318
DMSO vs. SAHA0.1625579549135690.4985348860693260.813373183349618
HIV vs. Mock in Activation0.3020282944760970.6293691026980290.999983755607037
HIV vs. Mock in Latency0.08982165279282320.5969955639655370.999834320637052
IL7 vs. CD30.02636115486571350.9350627560320960.959637837657233
SAHA vs. CD30.1304577802574910.7155329194225830.793281916846784
SAHA vs. IL70.1308265320944190.5983133173464350.795955780220648
(2). Iglesias-Ussel et al., J. Virol., 2013

Up and Downregulated transcripts during Latency (Latently infected CD4+ T cells vs Uninfected)- Primary CD4+Tcell based model
Log2 Fold Change P Value
unknown unknown

Gene expression during HIV infection and replication

(1). Imbeault et al., PloS Pathog., 2012

Transcriptomic profiling of HIV-1 infected CD4+ T cells - Primary CD4+ T cells
Experiment type Log2 Fold Change P Value Adjusted P Value
Infected vs. Mock unknown unknown unknown
Infected vs. Bystander unknown unknown unknown
(2). Lefebvre et al., J. Virol., 2011

Transcriptome analysis of T-cell line (Sup T1)
Log2 Fold Change unknown
(3). Li et al., J. Immunol., 2013

Lymphatic tissue
Acute Fold Change Acute P Value Asymt Fold Change Asypt P Value AIDS Fold Change AIDS P Value
unknown unknown unknown unknown unknown unknown
(4). Chang et al., MBio., 2011

Transcriptome analysis of T-cell line (Sup T1)

Derived from Sherrill-Mix et al., BMC Retrovirol., 2015 cross validation
Up-regulated (True) TRUE
(5). Sherrill-Mix et al., BMC Retrovirol., 2015

Deep RNA-seq analysis of primary human T cell infected with low passage HIV isolate HIV89.6 - Primary CD4+ T cell based
Test Status Log2 Fold Change P Value
OK -0.0901474 0.615102
(6). Rotger et al., PLoS Pathog., 2010

Genome-wide mRNA expression of CD4+ T cells from HIV-infected patient
(Genes differentially expressed (at adjusted p<0.01) according to the empirical Bayes approach)
Log2 Fold Change P Value
unknown unknown

Proteomic/Transcriptomics studies indicating differentially expressed genes mediated by HIV

(1). Greenwood et al., Elife, 2016

Activated (CD3/CD28) Primary human CD4+ T cells infected with pNL4-3-dE-EGFP. The table shows the complete (unfiltered) TMT (tandem mass tag)-based proteomic time course dataset
6 h 24 h 48 h 72 h RTi
1.046 0.856 0.999 1.094 1.021
(2). Navare et al., Virology, 2012

SUP-T1 cell line
FC-4hpi P-value FC-8hpi P-value FC-20hpi P-value Category
unknown unknown unknown unknown unknown unknown unknown
(3). Hyrcza et al., J. Virolo., 2007

Primary human CD4+ and CD8+ T Cells
Affymetrix Prob ID Fold Change In CD8? Category
unknown unknown unknown unknown

Protein Overview       top

Drug-protein Interaction       (annotations from DrugBank)      top

not found

Protein Secondary Structure       (annotations from PDB)      top

PDB Accession Method Resolution Chain Structure Preview
4IY3 X-ray 3.6Å A/B/C/D=359-511.

HIV-1 Interaction       (annotations from NCBI HIV-1 Interaction Database)      top

not found

Metabolic/Signalling Pathway       (annotations from KEGG database)      top

Pathway Accession Number Description
not found