Detailed entry information

Protein Information (annotations from UniProt)

Database IDHIV0000632
UniProt IDQ13286
Primary gene name(s)CLN3
Synonym gene name(s)BTS
Protein nameBattenin
Protein functionInvolved in microtubule-dependent, anterograde transport of late endosomes and lysosomes. {ECO:0000269|PubMed:22261744}.
Subcellular locationLysosome membrane {ECO:0000269|PubMed:17286803, ECO:0000269|PubMed:17897319};
Multi-pass membrane protein {ECO:0000269|PubMed:17286803, ECO:0000269|PubMed:17897319}. Late endosome {ECO:0000269|PubMed:17286803}. Lysosome {ECO:0000269|PubMed:19941651}.
ECO codeClick here for more information.
Amino acid sequence
FASTA format: Q13286
Gene Ontology
(Biological Process)
Complete annatation
action potential [GO:0001508];
amyloid precursor protein catabolic process [GO:0042987];
arginine transport [GO:0015809];
associative learning [GO:0008306];
autophagosome maturation [GO:0097352];
cellular amino acid metabolic process [GO:0006520];
ceramide metabolic process [GO:0006672];
galactosylceramide metabolic process [GO:0006681];
globoside metabolic process [GO:0001575];
glucosylceramide metabolic process [GO:0006678];
ionotropic glutamate receptor signaling pathway [GO:0035235];
lysosomal lumen acidification [GO:0007042];
lysosomal lumen pH elevation [GO:0035752];
lysosome organization [GO:0007040];
macroautophagy [GO:0016236];
membrane organization [GO:0061024];
negative regulation of apoptotic process [GO:0043066];
negative regulation of catalytic activity [GO:0043086];
negative regulation of macroautophagy [GO:0016242];
negative regulation of neuron apoptotic process [GO:0043524];
negative regulation of proteolysis [GO:0045861];
neuromuscular process controlling balance [GO:0050885];
neurotransmitter metabolic process [GO:0042133];
protein catabolic process [GO:0030163];
protein processing [GO:0016485];
receptor-mediated endocytosis [GO:0006898];
regulation of cytosolic calcium ion concentration [GO:0051480];
sphingomyelin metabolic process [GO:0006684];
vacuolar transport [GO:0007034];
vesicle transport along microtubule [GO:0047496]
Gene Ontology
(Molecular Function)
Complete annatation
unfolded protein binding [GO:0051082]
Gene Ontology
(Cellular Component)
Complete annatation
autophagosome [GO:0005776];
caveola [GO:0005901];
cytoplasm [GO:0005737];
early endosome [GO:0005769];
endoplasmic reticulum [GO:0005783];
Golgi apparatus [GO:0005794];
Golgi membrane [GO:0000139];
Golgi stack [GO:0005795];
integral component of endoplasmic reticulum membrane [GO:0030176];
integral component of membrane [GO:0016021];
late endosome [GO:0005770];
lysosomal membrane [GO:0005765];
lysosome [GO:0005764];
membrane raft [GO:0045121];
mitochondrion [GO:0005739];
neuron projection [GO:0043005];
nucleus [GO:0005634];
plasma membrane [GO:0005886];
synaptic vesicle [GO:0008021];
trans-Golgi network [GO:0005802]
Protein-protein interaction107612
Phylogenetic treeQ13286
HIV replication factor status Zhou et al., Cell. Host. Microbe., 2008
      unknown
Brass et al., Science, 2008
      unknown
Smith et al., J. Immunol, 2010
      unknown
Interferon-stimulated
gene status
Lu et al., J. Virol., 2011
      Folds changes 8h: unknown; Folds changes 16h: unknown; Tested: unknown;
Schoggins JW and Rice CM, Curr. Opin. Virol., 2011
      Targeted viruses: unknown
      Viral life cycle: unknown
      Mechanism related to antiviral activity: unknown
Anti-viral restriction factor Liu et al., Retrovirology, 2011
      unknown (Triplicates)

Gene Expression Profile       top

            Up-regulated;            Down-regulated

For brief introduction to each study, please go to the help page.

Gene expression during HIV latency

(1). Mohammadi et al., PLoS Pathog., 2014

Differentially expressed transcripts (Pairwise) during latency and subsequent viral reactivation using several agents - Primary CD4+ T-cell based model


DMSO: Dimethyl suloxyde (negative control) - 0.0033% final
SAHA: Vorinostat (Histone deacetylase inhibitor) - 0.5 μM
CD3: TCR Stimulation by IL-2+ antiCD3/anti-CD28 antibodies
IL7: Interleukin-7 based stimulation
DISU: Disulfiram (alcohol dehydrogenase inhibitor) - 0.5 μM
AZA: 5-azacytidine (AZA; DNA methylation inhibitor) - 1 μM
Experimental Condition Log2 Fold Change P value Adjusted P value
AZA vs. CD3-1.425644412996872.09756065934208e-050.000120115631677826
AZA vs. DISU0.2868347103649520.2583429936608630.839581352451412
AZA vs. IL7-0.1608901791606060.5160899947016070.999311006273513
AZA vs. SAHA-0.6134808986212950.03887915415914220.232472974928564
DISU vs. CD31.699946054297635.24424471692875e-064.19595248741953e-05
DISU vs. IL7-0.4577604948985740.07049562353288770.352946371557052
DISU vs. SAHA-0.8967949659685150.002475470055574250.0397314262061336
DMSO vs. AZA0.07782415148161770.7176216225161711
DMSO vs. CD31.494936112208475.04487029862055e-063.10715335440387e-05
DMSO vs. DISU-0.2098922096540230.3909238013531940.860985887595918
DMSO vs. IL7-0.2317327009429770.2720201148616880.769218388958909
DMSO vs. SAHA-0.6964862344349520.009084658625728270.0847245607353656
HIV vs. Mock in Activation0.1691871823666420.7871735538149770.999983755607037
HIV vs. Mock in Latency0.3259483136237140.05025992254604690.883004746455841
IL7 vs. CD31.268906770280.0001061969169940950.000613298221844262
SAHA vs. CD30.7900796444231680.02714223516535720.0595044346729608
SAHA vs. IL7-0.4540910656297480.1182335823039550.317748800080196
(2). Iglesias-Ussel et al., J. Virol., 2013

Up and Downregulated transcripts during Latency (Latently infected CD4+ T cells vs Uninfected)- Primary CD4+Tcell based model
Log2 Fold Change P Value
0.4475 0.02865

Gene expression during HIV infection and replication

(1). Imbeault et al., PloS Pathog., 2012

Transcriptomic profiling of HIV-1 infected CD4+ T cells - Primary CD4+ T cells
Experiment type Log2 Fold Change P Value Adjusted P Value
Infected vs. Mock unknown unknown unknown
Infected vs. Bystander unknown unknown unknown
(2). Lefebvre et al., J. Virol., 2011

Transcriptome analysis of T-cell line (Sup T1)
Log2 Fold Change unknown
(3). Li et al., J. Immunol., 2013

Lymphatic tissue
Acute Fold Change Acute P Value Asymt Fold Change Asypt P Value AIDS Fold Change AIDS P Value
unknown unknown unknown unknown unknown unknown
(4). Chang et al., MBio., 2011

Transcriptome analysis of T-cell line (Sup T1)

Derived from Sherrill-Mix et al., BMC Retrovirol., 2015 cross validation
Up-regulated (True) TRUE
(5). Sherrill-Mix et al., BMC Retrovirol., 2015

Deep RNA-seq analysis of primary human T cell infected with low passage HIV isolate HIV89.6 - Primary CD4+ T cell based
Test Status Log2 Fold Change P Value
OK 0.0405213 0.979227
(6). Rotger et al., PLoS Pathog., 2010

Genome-wide mRNA expression of CD4+ T cells from HIV-infected patient
(Genes differentially expressed (at adjusted p<0.01) according to the empirical Bayes approach)
Log2 Fold Change P Value
unknown unknown

Proteomic/Transcriptomics studies indicating differentially expressed genes mediated by HIV

(1). Greenwood et al., Elife, 2016

Activated (CD3/CD28) Primary human CD4+ T cells infected with pNL4-3-dE-EGFP. The table shows the complete (unfiltered) TMT (tandem mass tag)-based proteomic time course dataset
6 h 24 h 48 h 72 h RTi
unknown unknown unknown unknown unknown
(2). Navare et al., Virology, 2012

SUP-T1 cell line
FC-4hpi P-value FC-8hpi P-value FC-20hpi P-value Category
unknown unknown unknown unknown unknown unknown unknown
(3). Hyrcza et al., J. Virolo., 2007

Primary human CD4+ and CD8+ T Cells
Affymetrix Prob ID Fold Change In CD8? Category
unknown unknown unknown unknown

Protein Overview       top

Drug-protein Interaction       (annotations from DrugBank)      top

not found

Protein Secondary Structure       (annotations from PDB)      top

not found

HIV-1 Interaction       (annotations from NCBI HIV-1 Interaction Database)      top

HIV Partner Interaction Type PubMed
Nef requires 25496667
HIV-1 virus replication enhanced by expression of human gene 18187620

Metabolic/Signalling Pathway       (annotations from KEGG database)      top

Pathway Accession Number Description
hsa04142 Lysosome - Homo sapiens (human)
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