Detailed entry information

Protein Information (annotations from UniProt)

Database IDHIV0000623
UniProt IDP56746
Primary gene name(s)CLDN15
Synonym gene name(s)unknown
Protein nameClaudin-15
Protein functionClaudins function as major constituents of the tight junction complexes that regulate the permeability of epithelia. While some claudin family members function as impermeable barriers, others mediate the permeability to ions and small molecules. Often, several claudin family members are coexpressed and interact with each other, and this determines the overall permeability. CLDN15 forms tight junctions that mediate the paracellular transport of small monovalent cations along a concentration gradient, due to selective permeability for Na(+, Li(+ and K(+ ions, but selects against Cl(- ions. Plays an important role in paracellular Na(+ transport in the intestine and in Na(+ homeostasis. Required for normal Na(+-dependent intestinal nutrient uptake. {ECO:0000269|PubMed:12055082, ECO:0000269|PubMed:13129853}.
Subcellular locationCell junction, tight junction. Cell membrane;
Multi-pass membrane protein. Note=Tight junctions form continuous circumferential cell-cell contacts at the borders of apical and lateral cell membranes that seal the intercellular space and show up as strand-like structures in electron microscopy.
ECO codeClick here for more information.
Amino acid sequence
FASTA format: P56746
Gene Ontology
(Biological Process)
Complete annatation
calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules [GO:0016338];
ion transport [GO:0006811]
Gene Ontology
(Molecular Function)
Complete annatation
identical protein binding [GO:0042802];
structural molecule activity [GO:0005198]
Gene Ontology
(Cellular Component)
Complete annatation
bicellular tight junction [GO:0005923];
integral component of membrane [GO:0016021];
lateral plasma membrane [GO:0016328]
Protein-protein interaction117296
Phylogenetic treeP56746
HIV replication factor status Zhou et al., Cell. Host. Microbe., 2008
Brass et al., Science, 2008
Smith et al., J. Immunol, 2010
gene status
Lu et al., J. Virol., 2011
      Folds changes 8h: unknown; Folds changes 16h: unknown; Tested: unknown;
Schoggins JW and Rice CM, Curr. Opin. Virol., 2011
      Targeted viruses: unknown
      Viral life cycle: unknown
      Mechanism related to antiviral activity: unknown
Anti-viral restriction factor Liu et al., Retrovirology, 2011
      unknown (Triplicates)

Gene Expression Profile       top

            Up-regulated;            Down-regulated

For brief introduction to each study, please go to the help page.

Gene expression during HIV latency

(1). Mohammadi et al., PLoS Pathog., 2014

Differentially expressed transcripts (Pairwise) during latency and subsequent viral reactivation using several agents - Primary CD4+ T-cell based model

DMSO: Dimethyl suloxyde (negative control) - 0.0033% final
SAHA: Vorinostat (Histone deacetylase inhibitor) - 0.5 μM
CD3: TCR Stimulation by IL-2+ antiCD3/anti-CD28 antibodies
IL7: Interleukin-7 based stimulation
DISU: Disulfiram (alcohol dehydrogenase inhibitor) - 0.5 μM
AZA: 5-azacytidine (AZA; DNA methylation inhibitor) - 1 μM
Experimental Condition Log2 Fold Change P value Adjusted P value
AZA vs. CD3-0.236470277363340.4788747052704660.597582344579935
AZA vs. DISU0.6512752766478140.03942052345028510.458329945605953
AZA vs. IL7-0.2125480852274480.2794660624254860.999311006273513
AZA vs. SAHA0.1420412212919210.5649146566736840.853857769447419
DISU vs. CD30.8735361736457510.03388425574506530.0790667602323706
DISU vs. IL7-0.8734446192930630.007247599729546030.0948269357945178
DISU vs. SAHA-0.5059924822907720.1267341210433640.457882929808574
DMSO vs. AZA0.07985960822717370.6423388411764991
DMSO vs. CD30.3035516257463670.3515203752400010.465920680361659
DMSO vs. DISU-0.5735668802763910.05445555218079910.455660839180812
DMSO vs. IL7-0.2846011844197340.1216024495676830.613377094567886
DMSO vs. SAHA0.05775248638910620.8084415746341520.946766717920598
HIV vs. Mock in Activation0.2618075689712210.6757029570045510.999983755607037
HIV vs. Mock in Latency0.1073610451762130.5243513434489150.999834320637052
IL7 vs. CD30.02796178293815570.9317404311104260.957923983229483
SAHA vs. CD30.3562064238614430.3226695045730.437641025462615
SAHA vs. IL70.3528164199522320.1525944580026310.370165571279636
(2). Iglesias-Ussel et al., J. Virol., 2013

Up and Downregulated transcripts during Latency (Latently infected CD4+ T cells vs Uninfected)- Primary CD4+Tcell based model
Log2 Fold Change P Value
unknown unknown

Gene expression during HIV infection and replication

(1). Imbeault et al., PloS Pathog., 2012

Transcriptomic profiling of HIV-1 infected CD4+ T cells - Primary CD4+ T cells
Experiment type Log2 Fold Change P Value Adjusted P Value
Infected vs. Mock unknown unknown unknown
Infected vs. Bystander unknown unknown unknown
(2). Lefebvre et al., J. Virol., 2011

Transcriptome analysis of T-cell line (Sup T1)
Log2 Fold Change unknown
(3). Li et al., J. Immunol., 2013

Lymphatic tissue
Acute Fold Change Acute P Value Asymt Fold Change Asypt P Value AIDS Fold Change AIDS P Value
unknown unknown unknown unknown unknown unknown
(4). Chang et al., MBio., 2011

Transcriptome analysis of T-cell line (Sup T1)

Derived from Sherrill-Mix et al., BMC Retrovirol., 2015 cross validation
Up-regulated (True) TRUE
(5). Sherrill-Mix et al., BMC Retrovirol., 2015

Deep RNA-seq analysis of primary human T cell infected with low passage HIV isolate HIV89.6 - Primary CD4+ T cell based
Test Status Log2 Fold Change P Value
OK -0.0751561 0.73538
(6). Rotger et al., PLoS Pathog., 2010

Genome-wide mRNA expression of CD4+ T cells from HIV-infected patient
(Genes differentially expressed (at adjusted p<0.01) according to the empirical Bayes approach)
Log2 Fold Change P Value
unknown unknown

Proteomic/Transcriptomics studies indicating differentially expressed genes mediated by HIV

(1). Greenwood et al., Elife, 2016

Activated (CD3/CD28) Primary human CD4+ T cells infected with pNL4-3-dE-EGFP. The table shows the complete (unfiltered) TMT (tandem mass tag)-based proteomic time course dataset
6 h 24 h 48 h 72 h RTi
unknown unknown unknown unknown unknown
(2). Navare et al., Virology, 2012

SUP-T1 cell line
FC-4hpi P-value FC-8hpi P-value FC-20hpi P-value Category
unknown unknown unknown unknown unknown unknown unknown
(3). Hyrcza et al., J. Virolo., 2007

Primary human CD4+ and CD8+ T Cells
Affymetrix Prob ID Fold Change In CD8? Category
unknown unknown unknown unknown

Protein Overview       top

Drug-protein Interaction       (annotations from DrugBank)      top

not found

Protein Secondary Structure       (annotations from PDB)      top

not found

HIV-1 Interaction       (annotations from NCBI HIV-1 Interaction Database)      top

not found

Metabolic/Signalling Pathway       (annotations from KEGG database)      top

Pathway Accession Number Description
hsa04514 Cell adhesion molecules (CAMs) - Homo sapiens (human)
hsa04530 Tight junction - Homo sapiens (human)
hsa04670 Leukocyte transendothelial migration - Homo sapiens (human)
hsa05160 Hepatitis C - Homo sapiens (human)