Detailed entry information

Protein Information (annotations from UniProt)

Database IDHIV0000616
UniProt IDP33552
Primary gene name(s)CKS2
Synonym gene name(s)unknown
Protein nameCyclin-dependent kinases regulatory subunit 2
Protein functionBinds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function.
Subcellular locationunknown
ECO codeClick here for more information.
Amino acid sequence
FASTA format: P33552
Gene Ontology
(Biological Process)
Complete annatation
cell division [GO:0051301];
cell proliferation [GO:0008283];
meiosis I [GO:0007127];
mitotic cell cycle phase transition [GO:0044772];
positive regulation of cyclin-dependent protein serine/threonine kinase activity [GO:0045737];
positive regulation of transcription, DNA-templated [GO:0045893];
regulation of mitotic cell cycle [GO:0007346];
regulation of transcription from RNA polymerase II promoter [GO:0006357]
Gene Ontology
(Molecular Function)
Complete annatation
cyclin-dependent protein serine/threonine kinase regulator activity [GO:0016538]
Gene Ontology
(Cellular Component)
Complete annatation
Protein-protein interaction107583
Phylogenetic treeP33552
HIV replication factor status Zhou et al., Cell. Host. Microbe., 2008
Brass et al., Science, 2008
Smith et al., J. Immunol, 2010
gene status
Lu et al., J. Virol., 2011
      Folds changes 8h: unknown; Folds changes 16h: unknown; Tested: unknown;
Schoggins JW and Rice CM, Curr. Opin. Virol., 2011
      Targeted viruses: unknown
      Viral life cycle: unknown
      Mechanism related to antiviral activity: unknown
Anti-viral restriction factor Liu et al., Retrovirology, 2011
      unknown (Triplicates)

Gene Expression Profile       top

            Up-regulated;            Down-regulated

For brief introduction to each study, please go to the help page.

Gene expression during HIV latency

(1). Mohammadi et al., PLoS Pathog., 2014

Differentially expressed transcripts (Pairwise) during latency and subsequent viral reactivation using several agents - Primary CD4+ T-cell based model

DMSO: Dimethyl suloxyde (negative control) - 0.0033% final
SAHA: Vorinostat (Histone deacetylase inhibitor) - 0.5 μM
CD3: TCR Stimulation by IL-2+ antiCD3/anti-CD28 antibodies
IL7: Interleukin-7 based stimulation
DISU: Disulfiram (alcohol dehydrogenase inhibitor) - 0.5 μM
AZA: 5-azacytidine (AZA; DNA methylation inhibitor) - 1 μM
Experimental Condition Log2 Fold Change P value Adjusted P value
AZA vs. CD31.920963956202431.50323169467725e-081.70953760083169e-07
AZA vs. DISU0.5292364551108860.04341834749666710.473515720621742
AZA vs. IL70.2631515618067710.2720990212279260.999311006273513
AZA vs. SAHA-0.1433970783654990.6093709536531080.871897540037369
DISU vs. CD3-1.403100795461440.0001494558142571820.00080546905402673
DISU vs. IL7-0.2746814120072140.2816314413343110.669187713984712
DISU vs. SAHA-0.6722987507907670.02545412661866260.187497136984294
DMSO vs. AZA-0.2240932214927990.3006953256104431
DMSO vs. CD3-2.157059782570221.08524300657109e-101.6907120883137e-09
DMSO vs. DISU-0.7557452892366740.002382996371383840.104116824504567
DMSO vs. IL70.494108942068490.007372202071093130.177817513954766
DMSO vs. SAHA0.07268166804227140.7630430838306730.931825079317738
HIV vs. Mock in Activation-0.264112795002810.6714782788126830.999983755607037
HIV vs. Mock in Latency-0.02236453706405270.9313128621626320.999834320637052
IL7 vs. CD3-1.647901234427915.95211911424975e-076.10730370381801e-06
SAHA vs. CD3-2.09006683240441.83241518625366e-082.30312734419037e-07
SAHA vs. IL7-0.409702288388390.1056865190553470.297010692323056
(2). Iglesias-Ussel et al., J. Virol., 2013

Up and Downregulated transcripts during Latency (Latently infected CD4+ T cells vs Uninfected)- Primary CD4+Tcell based model
Log2 Fold Change P Value
unknown unknown

Gene expression during HIV infection and replication

(1). Imbeault et al., PloS Pathog., 2012

Transcriptomic profiling of HIV-1 infected CD4+ T cells - Primary CD4+ T cells
Experiment type Log2 Fold Change P Value Adjusted P Value
Infected vs. Mock unknown unknown unknown
Infected vs. Bystander unknown unknown unknown
(2). Lefebvre et al., J. Virol., 2011

Transcriptome analysis of T-cell line (Sup T1)
Log2 Fold Change unknown
(3). Li et al., J. Immunol., 2013

Lymphatic tissue
Acute Fold Change Acute P Value Asymt Fold Change Asypt P Value AIDS Fold Change AIDS P Value
2.9 0.000401561 1.9 0.011404648 2.1 0.068190178
(4). Chang et al., MBio., 2011

Transcriptome analysis of T-cell line (Sup T1)

Derived from Sherrill-Mix et al., BMC Retrovirol., 2015 cross validation
Up-regulated (True) FALSE
(5). Sherrill-Mix et al., BMC Retrovirol., 2015

Deep RNA-seq analysis of primary human T cell infected with low passage HIV isolate HIV89.6 - Primary CD4+ T cell based
Test Status Log2 Fold Change P Value
OK 0.552143 0.000305467
(6). Rotger et al., PLoS Pathog., 2010

Genome-wide mRNA expression of CD4+ T cells from HIV-infected patient
(Genes differentially expressed (at adjusted p<0.01) according to the empirical Bayes approach)
Log2 Fold Change P Value
unknown unknown

Proteomic/Transcriptomics studies indicating differentially expressed genes mediated by HIV

(1). Greenwood et al., Elife, 2016

Activated (CD3/CD28) Primary human CD4+ T cells infected with pNL4-3-dE-EGFP. The table shows the complete (unfiltered) TMT (tandem mass tag)-based proteomic time course dataset
6 h 24 h 48 h 72 h RTi
0.975 0.93 0.814 0.933 1.103
(2). Navare et al., Virology, 2012

SUP-T1 cell line
FC-4hpi P-value FC-8hpi P-value FC-20hpi P-value Category
unknown unknown unknown unknown unknown unknown unknown
(3). Hyrcza et al., J. Virolo., 2007

Primary human CD4+ and CD8+ T Cells
Affymetrix Prob ID Fold Change In CD8? Category
204170_s_at 1.61 No upregulated in CD8+ cells

Protein Overview       top

Drug-protein Interaction       (annotations from DrugBank)      top

not found

Protein Secondary Structure       (annotations from PDB)      top

PDB Accession Method Resolution Chain Structure Preview
1CKS X-ray 2.1Å A/B/C=1-79.
4Y72 X-ray 2.3Å C=1-79.
4YC3 X-ray 2.7Å C=1-79.
5HQ0 X-ray 2.3Å C=1-79.

HIV-1 Interaction       (annotations from NCBI HIV-1 Interaction Database)      top

not found

Metabolic/Signalling Pathway       (annotations from KEGG database)      top

Pathway Accession Number Description
hsa05200 Pathways in cancer - Homo sapiens (human)
hsa05222 Small cell lung cancer - Homo sapiens (human)