Detailed entry information

Protein Information (annotations from UniProt)

Database IDHIV0000609
UniProt IDQ6FI81
Primary gene name(s)CIAPIN1
Synonym gene name(s)unknown
Protein nameAnamorsin
Protein functionHas anti-apoptotic effects in the cell. Involved in negative control of cell death upon cytokine withdrawal. Promotes development of hematopoietic cells, By similarity. Component of the cytosolic iron-sulfur, Fe-S protein assembly, CIA machinery. Required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis. Electrons are transferred to the Fe-S cluster from NADPH via the FAD- and FMN-containing protein NDOR1. {ECO:0000250, ECO:0000269|PubMed:23596212}.
Subcellular locationCytoplasm. Nucleus. Mitochondrion. Mitochondrion intermembrane space {ECO:0000305}. Note=Imported into mitochondria, in vitro.
ECO codeClick here for more information.
Amino acid sequence
FASTA format: Q6FI81
Gene Ontology
(Biological Process)
Complete annatation
apoptotic process [GO:0006915];
hemopoiesis [GO:0030097];
iron-sulfur cluster assembly [GO:0016226];
negative regulation of apoptotic process [GO:0043066]
Gene Ontology
(Molecular Function)
Complete annatation
2 iron, 2 sulfur cluster binding [GO:0051537];
electron carrier activity [GO:0009055];
metal ion binding [GO:0046872];
methyltransferase activity [GO:0008168]
Gene Ontology
(Cellular Component)
Complete annatation
cytoplasm [GO:0005737];
mitochondrial intermembrane space [GO:0005758];
nucleolus [GO:0005730];
nucleoplasm [GO:0005654]
Protein-protein interaction121328
Phylogenetic treeQ6FI81
HIV replication factor status Zhou et al., Cell. Host. Microbe., 2008
Brass et al., Science, 2008
Smith et al., J. Immunol, 2010
gene status
Lu et al., J. Virol., 2011
      Folds changes 8h: unknown; Folds changes 16h: unknown; Tested: unknown;
Schoggins JW and Rice CM, Curr. Opin. Virol., 2011
      Targeted viruses: unknown
      Viral life cycle: unknown
      Mechanism related to antiviral activity: unknown
Anti-viral restriction factor Liu et al., Retrovirology, 2011
      unknown (Triplicates)

Gene Expression Profile       top

            Up-regulated;            Down-regulated

For brief introduction to each study, please go to the help page.

Gene expression during HIV latency

(1). Mohammadi et al., PLoS Pathog., 2014

Differentially expressed transcripts (Pairwise) during latency and subsequent viral reactivation using several agents - Primary CD4+ T-cell based model

DMSO: Dimethyl suloxyde (negative control) - 0.0033% final
SAHA: Vorinostat (Histone deacetylase inhibitor) - 0.5 μM
CD3: TCR Stimulation by IL-2+ antiCD3/anti-CD28 antibodies
IL7: Interleukin-7 based stimulation
DISU: Disulfiram (alcohol dehydrogenase inhibitor) - 0.5 μM
AZA: 5-azacytidine (AZA; DNA methylation inhibitor) - 1 μM
Experimental Condition Log2 Fold Change P value Adjusted P value
AZA vs. CD31.286699642302140.0001101441433901670.000526178297678796
AZA vs. DISU-0.1419388188847510.5761865084612710.954304256505839
AZA vs. IL70.1665759740185020.3896068014430570.999311006273513
AZA vs. SAHA-0.1411112372558040.5648624812173380.853857769447419
DISU vs. CD3-1.441169610851469.66096648861159e-050.000548923516205545
DISU vs. IL70.2992689715305980.2366346944448510.621476593207524
DISU vs. SAHA0.002673309118353880.9926983872731770.999572425883731
DMSO vs. AZA-0.01079998848020870.9491382902878161
DMSO vs. CD3-1.310832832883685.53446943049041e-050.000265954647433295
DMSO vs. DISU0.1287410608865010.5991142253716780.937521870059328
DMSO vs. IL70.1849392436431240.3072698419689370.788758330558622
DMSO vs. SAHA-0.1356869672887180.5667177250700290.847322855847746
HIV vs. Mock in Activation-0.0733909435977940.9060803170858850.999983755607037
HIV vs. Mock in Latency-0.1044675579860560.5320527531514590.999834320637052
IL7 vs. CD3-1.113106792519710.0006198681614060230.00282018496736281
SAHA vs. CD3-1.451828556929095.61522961183281e-050.000287632597723727
SAHA vs. IL7-0.3105946637220850.2043091996807430.437963150737702
(2). Iglesias-Ussel et al., J. Virol., 2013

Up and Downregulated transcripts during Latency (Latently infected CD4+ T cells vs Uninfected)- Primary CD4+Tcell based model
Log2 Fold Change P Value
unknown unknown

Gene expression during HIV infection and replication

(1). Imbeault et al., PloS Pathog., 2012

Transcriptomic profiling of HIV-1 infected CD4+ T cells - Primary CD4+ T cells
Experiment type Log2 Fold Change P Value Adjusted P Value
Infected vs. Mock unknown unknown unknown
Infected vs. Bystander unknown unknown unknown
(2). Lefebvre et al., J. Virol., 2011

Transcriptome analysis of T-cell line (Sup T1)
Log2 Fold Change unknown
(3). Li et al., J. Immunol., 2013

Lymphatic tissue
Acute Fold Change Acute P Value Asymt Fold Change Asypt P Value AIDS Fold Change AIDS P Value
unknown unknown unknown unknown unknown unknown
(4). Chang et al., MBio., 2011

Transcriptome analysis of T-cell line (Sup T1)

Derived from Sherrill-Mix et al., BMC Retrovirol., 2015 cross validation
Up-regulated (True) FALSE
(5). Sherrill-Mix et al., BMC Retrovirol., 2015

Deep RNA-seq analysis of primary human T cell infected with low passage HIV isolate HIV89.6 - Primary CD4+ T cell based
Test Status Log2 Fold Change P Value
OK -0.0778576 0.722912
(6). Rotger et al., PLoS Pathog., 2010

Genome-wide mRNA expression of CD4+ T cells from HIV-infected patient
(Genes differentially expressed (at adjusted p<0.01) according to the empirical Bayes approach)
Log2 Fold Change P Value
unknown unknown

Proteomic/Transcriptomics studies indicating differentially expressed genes mediated by HIV

(1). Greenwood et al., Elife, 2016

Activated (CD3/CD28) Primary human CD4+ T cells infected with pNL4-3-dE-EGFP. The table shows the complete (unfiltered) TMT (tandem mass tag)-based proteomic time course dataset
6 h 24 h 48 h 72 h RTi
0.982 1.046 0.991 0.983 1.133
(2). Navare et al., Virology, 2012

SUP-T1 cell line
FC-4hpi P-value FC-8hpi P-value FC-20hpi P-value Category
unknown unknown unknown unknown unknown unknown unknown
(3). Hyrcza et al., J. Virolo., 2007

Primary human CD4+ and CD8+ T Cells
Affymetrix Prob ID Fold Change In CD8? Category
unknown unknown unknown unknown

Protein Overview       top

Drug-protein Interaction       (annotations from DrugBank)      top

not found

Protein Secondary Structure       (annotations from PDB)      top

PDB Accession Method Resolution Chain Structure Preview
2LD4 NMR - A=1-172.
2YUI NMR - A=1-170.
4M7R X-ray 1.8Å A/B=1-172.

HIV-1 Interaction       (annotations from NCBI HIV-1 Interaction Database)      top

not found

Metabolic/Signalling Pathway       (annotations from KEGG database)      top

Pathway Accession Number Description
not found