Detailed entry information

Protein Information (annotations from UniProt)

Database IDHIV0000586
UniProt IDO94986
Primary gene name(s)CEP152
Synonym gene name(s)KIAA0912
Protein nameCentrosomal protein of 152 kDa
Protein functionNecessary for centrosome duplication; the function seems also to involve CEP63, CDK5RAP2 and WDR62 through a stepwise assembled complex at the centrosome that recruits CDK2 required for centriole duplication, PubMed:26297806. Acts as a molecular scaffold facilitating the interaction of PLK4 and CENPJ, 2 molecules involved in centriole formation, PubMed:21059844, PubMed:20852615. Proposed to snatch PLK4 away from PLK4:CEP92 complexes in early G1 daughter centriole and to reposition PLK4 at the outer boundary of a newly forming CEP152 ring structure, PubMed:24997597. Also plays a key role in deuterosome-mediated centriole amplification in multiciliated that can generate more than 100 centrioles, By similarity. Overexpression of CEP152 can drive amplification of centrioles, PubMed:20852615. {ECO:0000250|UniProtKB:A2AUM9, ECO:0000250|UniProtKB:Q498G2, ECO:0000269|PubMed:20852615, ECO:0000269|PubMed:21059844, ECO:0000269|PubMed:21131973}.
Subcellular locationCytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:20598275, ECO:0000269|PubMed:21059844, ECO:0000269|PubMed:21131973, ECO:0000269|PubMed:21983783, ECO:0000269|PubMed:26297806}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000269|PubMed:21983783, ECO:0000269|PubMed:22020124, ECO:0000269|PubMed:26297806, ECO:0000269|PubMed:26337392}. Note=Colocalizes with CDK5RAP2, WDR62 and CEP63 in a discrete ring around the proximal end of the parental centriole. At this site, a cohesive structure is predicted to engage parental centrioles and procentrioles, PubMed:21983783, PubMed:26297806. Localizes to the deuterosome, By similarity. Localizes to pericentriolar material, PCM, PubMed:26337392. {ECO:0000250|UniProtKB:Q498G2, ECO:0000269|PubMed:21983783, ECO:0000269|PubMed:26297806, ECO:0000269|PubMed:26337392}.
ECO codeClick here for more information.
Amino acid sequence
FASTA format: O94986
Gene Ontology
(Biological Process)
Complete annatation
cell projection organization [GO:0030030];
centriole replication [GO:0007099];
centrosome duplication [GO:0051298];
de novo centriole assembly involved in multi-ciliated epithelial cell differentiation [GO:0098535];
G2/M transition of mitotic cell cycle [GO:0000086]
Gene Ontology
(Molecular Function)
Complete annatation
protein kinase binding [GO:0019901]
Gene Ontology
(Cellular Component)
Complete annatation
centriole [GO:0005814];
centrosome [GO:0005813];
cytosol [GO:0005829];
deuterosome [GO:0098536];
nucleoplasm [GO:0005654];
pericentriolar material [GO:0000242]
Protein-protein interaction116642
Phylogenetic treeO94986
HIV replication factor status Zhou et al., Cell. Host. Microbe., 2008
Brass et al., Science, 2008
Smith et al., J. Immunol, 2010
gene status
Lu et al., J. Virol., 2011
      Folds changes 8h: unknown; Folds changes 16h: unknown; Tested: unknown;
Schoggins JW and Rice CM, Curr. Opin. Virol., 2011
      Targeted viruses: unknown
      Viral life cycle: unknown
      Mechanism related to antiviral activity: unknown
Anti-viral restriction factor Liu et al., Retrovirology, 2011
      unknown (Triplicates)

Gene Expression Profile       top

            Up-regulated;            Down-regulated

For brief introduction to each study, please go to the help page.

Gene expression during HIV latency

(1). Mohammadi et al., PLoS Pathog., 2014

Differentially expressed transcripts (Pairwise) during latency and subsequent viral reactivation using several agents - Primary CD4+ T-cell based model

DMSO: Dimethyl suloxyde (negative control) - 0.0033% final
SAHA: Vorinostat (Histone deacetylase inhibitor) - 0.5 μM
CD3: TCR Stimulation by IL-2+ antiCD3/anti-CD28 antibodies
IL7: Interleukin-7 based stimulation
DISU: Disulfiram (alcohol dehydrogenase inhibitor) - 0.5 μM
AZA: 5-azacytidine (AZA; DNA methylation inhibitor) - 1 μM
Experimental Condition Log2 Fold Change P value Adjusted P value
AZA vs. CD3-0.01000940675949690.9843984704802480.989453400938866
AZA vs. DISU0.5113288786925620.04687556960200180.490233421986087
AZA vs. IL70.08656949766717260.6578698071843920.999311006273513
AZA vs. SAHA-0.4352530846356660.0789779548761330.349329134918671
DISU vs. CD30.5087547954988150.3216135909239260.454656594728243
DISU vs. IL7-0.4336375748268060.08760279492931220.391369246225174
DISU vs. SAHA-0.9456755825879920.001375011452234510.0258067217890738
DMSO vs. AZA-0.03605841515204450.8327729569043321
DMSO vs. CD3-0.03490547700927650.9460488713616780.962526254438015
DMSO vs. DISU-0.5483640631561680.0271012364058910.335677697037315
DMSO vs. IL70.1292593451360350.4797819485008550.880686160922201
DMSO vs. SAHA-0.406601405307630.08922964052759120.34856918413461
HIV vs. Mock in Activation0.2258275735840140.8362696227792460.999983755607037
HIV vs. Mock in Latency0.3639544164829430.03018459969481690.662379195939374
IL7 vs. CD30.1045786161178520.836215981365660.894428291734644
SAHA vs. CD3-0.4495505133031210.3733060569164190.490002811404097
SAHA vs. IL7-0.5255211027861230.03291701805153270.138989277475919
(2). Iglesias-Ussel et al., J. Virol., 2013

Up and Downregulated transcripts during Latency (Latently infected CD4+ T cells vs Uninfected)- Primary CD4+Tcell based model
Log2 Fold Change P Value
unknown unknown

Gene expression during HIV infection and replication

(1). Imbeault et al., PloS Pathog., 2012

Transcriptomic profiling of HIV-1 infected CD4+ T cells - Primary CD4+ T cells
Experiment type Log2 Fold Change P Value Adjusted P Value
Infected vs. Mock unknown unknown unknown
Infected vs. Bystander unknown unknown unknown
(2). Lefebvre et al., J. Virol., 2011

Transcriptome analysis of T-cell line (Sup T1)
Log2 Fold Change unknown
(3). Li et al., J. Immunol., 2013

Lymphatic tissue
Acute Fold Change Acute P Value Asymt Fold Change Asypt P Value AIDS Fold Change AIDS P Value
unknown unknown unknown unknown unknown unknown
(4). Chang et al., MBio., 2011

Transcriptome analysis of T-cell line (Sup T1)

Derived from Sherrill-Mix et al., BMC Retrovirol., 2015 cross validation
Up-regulated (True) TRUE
(5). Sherrill-Mix et al., BMC Retrovirol., 2015

Deep RNA-seq analysis of primary human T cell infected with low passage HIV isolate HIV89.6 - Primary CD4+ T cell based
Test Status Log2 Fold Change P Value
OK 0.541852 0.000305467
(6). Rotger et al., PLoS Pathog., 2010

Genome-wide mRNA expression of CD4+ T cells from HIV-infected patient
(Genes differentially expressed (at adjusted p<0.01) according to the empirical Bayes approach)
Log2 Fold Change P Value
unknown unknown

Proteomic/Transcriptomics studies indicating differentially expressed genes mediated by HIV

(1). Greenwood et al., Elife, 2016

Activated (CD3/CD28) Primary human CD4+ T cells infected with pNL4-3-dE-EGFP. The table shows the complete (unfiltered) TMT (tandem mass tag)-based proteomic time course dataset
6 h 24 h 48 h 72 h RTi
unknown unknown unknown unknown unknown
(2). Navare et al., Virology, 2012

SUP-T1 cell line
FC-4hpi P-value FC-8hpi P-value FC-20hpi P-value Category
unknown unknown unknown unknown unknown unknown unknown
(3). Hyrcza et al., J. Virolo., 2007

Primary human CD4+ and CD8+ T Cells
Affymetrix Prob ID Fold Change In CD8? Category
unknown unknown unknown unknown

Protein Overview       top

Drug-protein Interaction       (annotations from DrugBank)      top

not found

Protein Secondary Structure       (annotations from PDB)      top

PDB Accession Method Resolution Chain Structure Preview
4N7V X-ray 2.7Å C=1-60.

HIV-1 Interaction       (annotations from NCBI HIV-1 Interaction Database)      top

not found

Metabolic/Signalling Pathway       (annotations from KEGG database)      top

Pathway Accession Number Description
not found