Detailed entry information

Protein Information (annotations from UniProt)

Database IDHIV0000558
UniProt IDQ96FF9
Primary gene name(s)CDCA5
Synonym gene name(s)unknown
Protein nameSororin
Protein functionRegulator of sister chromatid cohesion in mitosis stabilizing cohesin complex association with chromatin. May antagonize the action of WAPL which stimulates cohesin dissociation from chromatin. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair. Required for efficient DNA double-stranded break repair. {ECO:0000269|PubMed:15837422, ECO:0000269|PubMed:17349791, ECO:0000269|PubMed:21111234}.
Subcellular locationNucleus {ECO:0000269|PubMed:15837422}. Chromosome {ECO:0000269|PubMed:15837422}. Cytoplasm {ECO:0000269|PubMed:15837422}. Note=Associates with nuclear chromatin from S phase until metaphase and is released in the cytoplasm upon nuclear envelope breakdown.
ECO codeClick here for more information.
Amino acid sequence
FASTA format: Q96FF9
Gene Ontology
(Biological Process)
Complete annatation
cell division [GO:0051301];
double-strand break repair [GO:0006302];
G1/S transition of mitotic cell cycle [GO:0000082];
mitotic chromosome condensation [GO:0007076];
mitotic metaphase plate congression [GO:0007080];
mitotic nuclear division [GO:0007067];
mitotic sister chromatid cohesion [GO:0007064];
positive regulation of cell cycle phase transition [GO:1901989];
positive regulation of exit from mitosis [GO:0031536];
regulation of cohesin loading [GO:0071922];
sister chromatid cohesion [GO:0007062]
Gene Ontology
(Molecular Function)
Complete annatation
chromatin binding [GO:0003682]
Gene Ontology
(Cellular Component)
Complete annatation
chromosome [GO:0005694];
chromosome, centromeric region [GO:0000775];
cohesin complex [GO:0008278];
cytoplasm [GO:0005737];
cytosol [GO:0005829];
nuclear chromatin [GO:0000790];
nucleoplasm [GO:0005654];
nucleus [GO:0005634];
plasma membrane [GO:0005886]
Protein-protein interaction125225
Phylogenetic treeQ96FF9
HIV replication factor status Zhou et al., Cell. Host. Microbe., 2008
Brass et al., Science, 2008
Smith et al., J. Immunol, 2010
gene status
Lu et al., J. Virol., 2011
      Folds changes 8h: unknown; Folds changes 16h: unknown; Tested: unknown;
Schoggins JW and Rice CM, Curr. Opin. Virol., 2011
      Targeted viruses: unknown
      Viral life cycle: unknown
      Mechanism related to antiviral activity: unknown
Anti-viral restriction factor Liu et al., Retrovirology, 2011
      unknown (Triplicates)

Gene Expression Profile       top

            Up-regulated;            Down-regulated

For brief introduction to each study, please go to the help page.

Gene expression during HIV latency

(1). Mohammadi et al., PLoS Pathog., 2014

Differentially expressed transcripts (Pairwise) during latency and subsequent viral reactivation using several agents - Primary CD4+ T-cell based model

DMSO: Dimethyl suloxyde (negative control) - 0.0033% final
SAHA: Vorinostat (Histone deacetylase inhibitor) - 0.5 μM
CD3: TCR Stimulation by IL-2+ antiCD3/anti-CD28 antibodies
IL7: Interleukin-7 based stimulation
DISU: Disulfiram (alcohol dehydrogenase inhibitor) - 0.5 μM
AZA: 5-azacytidine (AZA; DNA methylation inhibitor) - 1 μM
Experimental Condition Log2 Fold Change P value Adjusted P value
AZA vs. CD31.488678391441620.3035311509009610.422031504278531
AZA vs. DISU0.1150741901746490.835407513927760.986167923867511
AZA vs. IL70.2237356658655720.6908257880238840.999311006273513
AZA vs. SAHA-0.6396916481405570.1692078764627210.524930959003716
DISU vs. CD3-1.384927277589450.3284249635064460.461402751099294
DISU vs. IL70.0992812739447260.8708362842916960.975375630725941
DISU vs. SAHA-0.7543121003123140.154873025787890.506446263321052
DMSO vs. AZA0.002326160046869360.9963381925308251
DMSO vs. CD3-1.504144360481290.3006920624105770.411362687996307
DMSO vs. DISU-0.1167983255748850.8348574490847120.981834779672158
DMSO vs. IL70.2297538660660790.6870547404455580.936808128060378
DMSO vs. SAHA-0.6476383662268630.1700699719991190.498485355689936
HIV vs. Mock in Activation-0.04708194144588730.984179165862690.999983755607037
HIV vs. Mock in Latency0.3300470167153490.4872986037807070.999834320637052
IL7 vs. CD3-1.257125489169010.3746342725064050.511815679279348
SAHA vs. CD3-2.154831315170770.1444393036293810.233802395885583
SAHA vs. IL7-0.8672779005185970.1093020270797780.303307056952113
(2). Iglesias-Ussel et al., J. Virol., 2013

Up and Downregulated transcripts during Latency (Latently infected CD4+ T cells vs Uninfected)- Primary CD4+Tcell based model
Log2 Fold Change P Value
unknown unknown

Gene expression during HIV infection and replication

(1). Imbeault et al., PloS Pathog., 2012

Transcriptomic profiling of HIV-1 infected CD4+ T cells - Primary CD4+ T cells
Experiment type Log2 Fold Change P Value Adjusted P Value
Infected vs. Mock unknown unknown unknown
Infected vs. Bystander unknown unknown unknown
(2). Lefebvre et al., J. Virol., 2011

Transcriptome analysis of T-cell line (Sup T1)
Log2 Fold Change unknown
(3). Li et al., J. Immunol., 2013

Lymphatic tissue
Acute Fold Change Acute P Value Asymt Fold Change Asypt P Value AIDS Fold Change AIDS P Value
unknown unknown unknown unknown unknown unknown
(4). Chang et al., MBio., 2011

Transcriptome analysis of T-cell line (Sup T1)

Derived from Sherrill-Mix et al., BMC Retrovirol., 2015 cross validation
Up-regulated (True) FALSE
(5). Sherrill-Mix et al., BMC Retrovirol., 2015

Deep RNA-seq analysis of primary human T cell infected with low passage HIV isolate HIV89.6 - Primary CD4+ T cell based
Test Status Log2 Fold Change P Value
OK 0.306473 0.0184378
(6). Rotger et al., PLoS Pathog., 2010

Genome-wide mRNA expression of CD4+ T cells from HIV-infected patient
(Genes differentially expressed (at adjusted p<0.01) according to the empirical Bayes approach)
Log2 Fold Change P Value
0.08 3.85E-05

Proteomic/Transcriptomics studies indicating differentially expressed genes mediated by HIV

(1). Greenwood et al., Elife, 2016

Activated (CD3/CD28) Primary human CD4+ T cells infected with pNL4-3-dE-EGFP. The table shows the complete (unfiltered) TMT (tandem mass tag)-based proteomic time course dataset
6 h 24 h 48 h 72 h RTi
0.753 0.483 0.564 0.563 0.638
(2). Navare et al., Virology, 2012

SUP-T1 cell line
FC-4hpi P-value FC-8hpi P-value FC-20hpi P-value Category
unknown unknown unknown unknown unknown unknown unknown
(3). Hyrcza et al., J. Virolo., 2007

Primary human CD4+ and CD8+ T Cells
Affymetrix Prob ID Fold Change In CD8? Category
unknown unknown unknown unknown

Protein Overview       top

Drug-protein Interaction       (annotations from DrugBank)      top

not found

Protein Secondary Structure       (annotations from PDB)      top

not found

HIV-1 Interaction       (annotations from NCBI HIV-1 Interaction Database)      top

not found

Metabolic/Signalling Pathway       (annotations from KEGG database)      top

Pathway Accession Number Description
hsa05206 MicroRNAs in cancer - Homo sapiens (human)