Detailed entry information

Protein Information (annotations from UniProt)

Database IDHIV0000550
UniProt IDP30304
Primary gene name(s)CDC25A
Synonym gene name(s)unknown
Protein nameM-phase inducer phosphatase 1
Protein functionTyrosine protein phosphatase which functions as a dosage-dependent inducer of mitotic progression. Directly dephosphorylates CDK1 and stimulates its kinase activity. Also dephosphorylates CDK2 in complex with cyclin E, in vitro.
Subcellular locationunknown
ECO codeClick here for more information.
Amino acid sequence
FASTA format: P30304
Gene Ontology
(Biological Process)
Complete annatation
cell division [GO:0051301];
cell proliferation [GO:0008283];
cellular response to UV [GO:0034644];
DNA replication [GO:0006260];
G1/S transition of mitotic cell cycle [GO:0000082];
G2/M transition of mitotic cell cycle [GO:0000086];
mitotic nuclear division [GO:0007067];
regulation of cell cycle [GO:0051726];
regulation of cyclin-dependent protein serine/threonine kinase activity [GO:0000079];
response to radiation [GO:0009314]
Gene Ontology
(Molecular Function)
Complete annatation
phosphoprotein phosphatase activity [GO:0004721];
protein kinase binding [GO:0019901];
protein tyrosine phosphatase activity [GO:0004725]
Gene Ontology
(Cellular Component)
Complete annatation
cytosol [GO:0005829];
nucleoplasm [GO:0005654]
Protein-protein interaction107428
Phylogenetic treeP30304
HIV replication factor status Zhou et al., Cell. Host. Microbe., 2008
      unknown
Brass et al., Science, 2008
      unknown
Smith et al., J. Immunol, 2010
      unknown
Interferon-stimulated
gene status
Lu et al., J. Virol., 2011
      Folds changes 8h: unknown; Folds changes 16h: unknown; Tested: unknown;
Schoggins JW and Rice CM, Curr. Opin. Virol., 2011
      Targeted viruses: unknown
      Viral life cycle: unknown
      Mechanism related to antiviral activity: unknown
Anti-viral restriction factor Liu et al., Retrovirology, 2011
      unknown (Triplicates)

Gene Expression Profile       top

            Up-regulated;            Down-regulated

For brief introduction to each study, please go to the help page.

Gene expression during HIV latency

(1). Mohammadi et al., PLoS Pathog., 2014

Differentially expressed transcripts (Pairwise) during latency and subsequent viral reactivation using several agents - Primary CD4+ T-cell based model


DMSO: Dimethyl suloxyde (negative control) - 0.0033% final
SAHA: Vorinostat (Histone deacetylase inhibitor) - 0.5 μM
CD3: TCR Stimulation by IL-2+ antiCD3/anti-CD28 antibodies
IL7: Interleukin-7 based stimulation
DISU: Disulfiram (alcohol dehydrogenase inhibitor) - 0.5 μM
AZA: 5-azacytidine (AZA; DNA methylation inhibitor) - 1 μM
Experimental Condition Log2 Fold Change P value Adjusted P value
AZA vs. CD33.203425964804390.008678924246076080.0231560889072152
AZA vs. DISU-0.03977974395277220.945053605446730.996198528027442
AZA vs. IL70.6399916917851360.2216614944846490.989265982093417
AZA vs. SAHA-0.2056571209823730.527717729772610.836955054166947
DISU vs. CD3-3.258577775640.008363550053580910.0249351569437656
DISU vs. IL70.6721246057695440.3124511709312950.695612452737592
DISU vs. SAHA-0.1623076727688710.7676366799050110.934212193012113
DMSO vs. AZA-0.02601913003205520.9461042671615091
DMSO vs. CD3-3.243103961960590.007743674264341420.0199894538711966
DMSO vs. DISU0.01142665078019640.9841748079810050.997435138456314
DMSO vs. IL70.6733978726932840.1983435772914820.708530702115225
DMSO vs. SAHA-0.1856956870453450.566809205824730.847374421286034
HIV vs. Mock in Activation0.06364886598023570.9758984493706940.999983755607037
HIV vs. Mock in Latency0.1755274375630970.5522850696217940.999834320637052
IL7 vs. CD3-2.555822885477520.03420926982062510.0809171940154551
SAHA vs. CD3-3.429742104627840.005679023872011020.0159016889169837
SAHA vs. IL7-0.8465807992862210.085944313632330.261933801798169
(2). Iglesias-Ussel et al., J. Virol., 2013

Up and Downregulated transcripts during Latency (Latently infected CD4+ T cells vs Uninfected)- Primary CD4+Tcell based model
Log2 Fold Change P Value
unknown unknown

Gene expression during HIV infection and replication

(1). Imbeault et al., PloS Pathog., 2012

Transcriptomic profiling of HIV-1 infected CD4+ T cells - Primary CD4+ T cells
Experiment type Log2 Fold Change P Value Adjusted P Value
Infected vs. Mock unknown unknown unknown
Infected vs. Bystander unknown unknown unknown
(2). Lefebvre et al., J. Virol., 2011

Transcriptome analysis of T-cell line (Sup T1)
Log2 Fold Change -0.960979422
(3). Li et al., J. Immunol., 2013

Lymphatic tissue
Acute Fold Change Acute P Value Asymt Fold Change Asypt P Value AIDS Fold Change AIDS P Value
unknown unknown unknown unknown unknown unknown
(4). Chang et al., MBio., 2011

Transcriptome analysis of T-cell line (Sup T1)

Derived from Sherrill-Mix et al., BMC Retrovirol., 2015 cross validation
Up-regulated (True) FALSE
(5). Sherrill-Mix et al., BMC Retrovirol., 2015

Deep RNA-seq analysis of primary human T cell infected with low passage HIV isolate HIV89.6 - Primary CD4+ T cell based
Test Status Log2 Fold Change P Value
OK 1.10045 0.000305467
(6). Rotger et al., PLoS Pathog., 2010

Genome-wide mRNA expression of CD4+ T cells from HIV-infected patient
(Genes differentially expressed (at adjusted p<0.01) according to the empirical Bayes approach)
Log2 Fold Change P Value
unknown unknown

Proteomic/Transcriptomics studies indicating differentially expressed genes mediated by HIV

(1). Greenwood et al., Elife, 2016

Activated (CD3/CD28) Primary human CD4+ T cells infected with pNL4-3-dE-EGFP. The table shows the complete (unfiltered) TMT (tandem mass tag)-based proteomic time course dataset
6 h 24 h 48 h 72 h RTi
unknown unknown unknown unknown unknown
(2). Navare et al., Virology, 2012

SUP-T1 cell line
FC-4hpi P-value FC-8hpi P-value FC-20hpi P-value Category
unknown unknown unknown unknown unknown unknown unknown
(3). Hyrcza et al., J. Virolo., 2007

Primary human CD4+ and CD8+ T Cells
Affymetrix Prob ID Fold Change In CD8? Category
unknown unknown unknown unknown

Protein Overview       top

Drug-protein Interaction       (annotations from DrugBank)      top

not found

Protein Secondary Structure       (annotations from PDB)      top

PDB Accession Method Resolution Chain Structure Preview
1C25 X-ray 2.3Å A=337-496.

HIV-1 Interaction       (annotations from NCBI HIV-1 Interaction Database)      top

HIV Partner Interaction Type PubMed
Vpu stabilizes 17676996
Vpr relocalizes 18160429
18160429

Metabolic/Signalling Pathway       (annotations from KEGG database)      top

Pathway Accession Number Description
hsa04110 Cell cycle - Homo sapiens (human)
hsa04914 Progesterone-mediated oocyte maturation - Homo sapiens (human)
hsa05206 MicroRNAs in cancer - Homo sapiens (human)
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