Detailed entry information

Protein Information (annotations from UniProt)

Database IDHIV0000547
UniProt IDQ9UNH5
Primary gene name(s)CDC14A
Synonym gene name(s)unknown
Protein nameDual specificity protein phosphatase CDC14A
Protein functionDual-specificity phosphatase. Required for centrosome separation and productive cytokinesis during cell division. Dephosphorylates SIRT2 around early anaphase. May dephosphorylate the APC subunit FZR1/CDH1, thereby promoting APC-FZR1 dependent degradation of mitotic cyclins and subsequent exit from mitosis. {ECO:0000269|PubMed:11901424, ECO:0000269|PubMed:12134069, ECO:0000269|PubMed:17488717, ECO:0000269|PubMed:9367992}.
Subcellular locationNucleus {ECO:0000269|PubMed:9367992}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:11901424, ECO:0000269|PubMed:12134069}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000269|PubMed:11901424, ECO:0000269|PubMed:15263015}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:15263015}. Cell projection, kinocilium {ECO:0000250|UniProtKB:Q6GQT0}. Note=Centrosomal during interphase, released into the cytoplasm at the onset of mitosis. Subsequently localizes to the mitotic spindle pole and at the central spindle, PubMed:12134069, PubMed:11901424, PubMed:15263015. Present along both the transient kinocilia of developing cochlear hair cells and the persistent kinocilia of vestibular hair cells, By similarity. {ECO:0000250|UniProtKB:Q6GQT0, ECO:0000269|PubMed:11901424, ECO:0000269|PubMed:12134069, ECO:0000269|PubMed:15263015}.
ECO codeClick here for more information.
Amino acid sequence
FASTA format: Q9UNH5
Gene Ontology
(Biological Process)
Complete annatation
cell division [GO:0051301];
cell proliferation [GO:0008283];
mitotic cell cycle arrest [GO:0071850];
mitotic spindle midzone assembly [GO:0051256];
regulation of exit from mitosis [GO:0007096]
Gene Ontology
(Molecular Function)
Complete annatation
phosphoprotein phosphatase activity [GO:0004721];
protein serine/threonine phosphatase activity [GO:0004722];
protein tyrosine/serine/threonine phosphatase activity [GO:0008138];
protein tyrosine phosphatase activity [GO:0004725]
Gene Ontology
(Cellular Component)
Complete annatation
centrosome [GO:0005813];
cytoplasm [GO:0005737];
mitotic spindle [GO:0072686];
nucleoplasm [GO:0005654];
nucleus [GO:0005634];
spindle pole [GO:0000922]
Protein-protein interaction114126
Phylogenetic treeQ9UNH5
HIV replication factor status Zhou et al., Cell. Host. Microbe., 2008
      unknown
Brass et al., Science, 2008
      unknown
Smith et al., J. Immunol, 2010
      unknown
Interferon-stimulated
gene status
Lu et al., J. Virol., 2011
      Folds changes 8h: unknown; Folds changes 16h: unknown; Tested: unknown;
Schoggins JW and Rice CM, Curr. Opin. Virol., 2011
      Targeted viruses: unknown
      Viral life cycle: unknown
      Mechanism related to antiviral activity: unknown
Anti-viral restriction factor Liu et al., Retrovirology, 2011
      unknown (Triplicates)

Gene Expression Profile       top

            Up-regulated;            Down-regulated

For brief introduction to each study, please go to the help page.

Gene expression during HIV latency

(1). Mohammadi et al., PLoS Pathog., 2014

Differentially expressed transcripts (Pairwise) during latency and subsequent viral reactivation using several agents - Primary CD4+ T-cell based model


DMSO: Dimethyl suloxyde (negative control) - 0.0033% final
SAHA: Vorinostat (Histone deacetylase inhibitor) - 0.5 μM
CD3: TCR Stimulation by IL-2+ antiCD3/anti-CD28 antibodies
IL7: Interleukin-7 based stimulation
DISU: Disulfiram (alcohol dehydrogenase inhibitor) - 0.5 μM
AZA: 5-azacytidine (AZA; DNA methylation inhibitor) - 1 μM
Experimental Condition Log2 Fold Change P value Adjusted P value
AZA vs. CD3-2.180681990618833.4281755212362e-105.4160861065065e-09
AZA vs. DISU-0.06891718247962160.7853680948328440.978802499202466
AZA vs. IL7-0.1443781259292840.4522401949456740.999311006273513
AZA vs. SAHA-0.1176066647476610.6294792864308920.882758467174553
DISU vs. CD32.098824106704336.06508436806763e-087.9224507594672e-07
DISU vs. IL7-0.08442763486248150.7378756501344990.935060140028377
DISU vs. SAHA-0.04770573602312480.8698458430172130.965633964357132
DMSO vs. AZA-0.05485300704419610.7429900835583421
DMSO vs. CD32.114369172623544.08020395248343e-105.70206609871641e-09
DMSO vs. DISU0.0122442296096210.9599997277373290.994105021699463
DMSO vs. IL7-0.08239254959169130.6464377421341880.92438865873712
DMSO vs. SAHA-0.06995922110754030.7664953888129470.933319268036819
HIV vs. Mock in Activation0.329588244012820.6442578972548430.999983755607037
HIV vs. Mock in Latency0.07795750763760820.6367983634548340.999834320637052
IL7 vs. CD32.044443184910741.51988999164132e-092.66387230744298e-08
SAHA vs. CD32.03793508359135.47846402687568e-086.15204566952433e-07
SAHA vs. IL70.0223935791287560.9267179238385840.973196537691968
(2). Iglesias-Ussel et al., J. Virol., 2013

Up and Downregulated transcripts during Latency (Latently infected CD4+ T cells vs Uninfected)- Primary CD4+Tcell based model
Log2 Fold Change P Value
unknown unknown

Gene expression during HIV infection and replication

(1). Imbeault et al., PloS Pathog., 2012

Transcriptomic profiling of HIV-1 infected CD4+ T cells - Primary CD4+ T cells
Experiment type Log2 Fold Change P Value Adjusted P Value
Infected vs. Mock unknown unknown unknown
Infected vs. Bystander unknown unknown unknown
(2). Lefebvre et al., J. Virol., 2011

Transcriptome analysis of T-cell line (Sup T1)
Log2 Fold Change unknown
(3). Li et al., J. Immunol., 2013

Lymphatic tissue
Acute Fold Change Acute P Value Asymt Fold Change Asypt P Value AIDS Fold Change AIDS P Value
unknown unknown unknown unknown unknown unknown
(4). Chang et al., MBio., 2011

Transcriptome analysis of T-cell line (Sup T1)

Derived from Sherrill-Mix et al., BMC Retrovirol., 2015 cross validation
Up-regulated (True) TRUE
(5). Sherrill-Mix et al., BMC Retrovirol., 2015

Deep RNA-seq analysis of primary human T cell infected with low passage HIV isolate HIV89.6 - Primary CD4+ T cell based
Test Status Log2 Fold Change P Value
OK -0.246005 0.0842464
(6). Rotger et al., PLoS Pathog., 2010

Genome-wide mRNA expression of CD4+ T cells from HIV-infected patient
(Genes differentially expressed (at adjusted p<0.01) according to the empirical Bayes approach)
Log2 Fold Change P Value
unknown unknown

Proteomic/Transcriptomics studies indicating differentially expressed genes mediated by HIV

(1). Greenwood et al., Elife, 2016

Activated (CD3/CD28) Primary human CD4+ T cells infected with pNL4-3-dE-EGFP. The table shows the complete (unfiltered) TMT (tandem mass tag)-based proteomic time course dataset
6 h 24 h 48 h 72 h RTi
unknown unknown unknown unknown unknown
(2). Navare et al., Virology, 2012

SUP-T1 cell line
FC-4hpi P-value FC-8hpi P-value FC-20hpi P-value Category
unknown unknown unknown unknown unknown unknown unknown
(3). Hyrcza et al., J. Virolo., 2007

Primary human CD4+ and CD8+ T Cells
Affymetrix Prob ID Fold Change In CD8? Category
unknown unknown unknown unknown

Protein Overview       top

Drug-protein Interaction       (annotations from DrugBank)      top

not found

Protein Secondary Structure       (annotations from PDB)      top

not found

HIV-1 Interaction       (annotations from NCBI HIV-1 Interaction Database)      top

not found

Metabolic/Signalling Pathway       (annotations from KEGG database)      top

Pathway Accession Number Description
hsa04110 Cell cycle - Homo sapiens (human)
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