Detailed entry information

Protein Information (annotations from UniProt)

Database IDHIV0000538
UniProt IDP08962
Primary gene name(s)CD63
Synonym gene name(s)MLA1, TSPAN30
Protein nameCD63 antigen
Protein functionFunctions as cell surface receptor for TIMP1 and plays a role in the activation of cellular signaling cascades. Plays a role in the activation of ITGB1 and integrin signaling, leading to the activation of AKT, FAK/PTK2 and MAP kinases. Promotes cell survival, reorganization of the actin cytoskeleton, cell adhesion, spreading and migration, via its role in the activation of AKT and FAK/PTK2. Plays a role in VEGFA signaling via its role in regulating the internalization of KDR/VEGFR2. Plays a role in intracellular vesicular transport processes, and is required for normal trafficking of the PMEL luminal domain that is essential for the development and maturation of melanocytes. Plays a role in the adhesion of leukocytes onto endothelial cells via its role in the regulation of SELP trafficking. May play a role in mast cell degranulation in response to Ms4a2/FceRI stimulation, but not in mast cell degranulation in response to other stimuli. {ECO:0000269|PubMed:16917503, ECO:0000269|PubMed:21803846, ECO:0000269|PubMed:21962903, ECO:0000269|PubMed:23632027, ECO:0000269|PubMed:24635319}.
Subcellular locationCell membrane {ECO:0000269|PubMed:15351990, ECO:0000269|PubMed:19640571, ECO:0000269|PubMed:23632027};
Multi-pass membrane protein {ECO:0000255}. Lysosome membrane {ECO:0000269|PubMed:17897319, ECO:0000269|PubMed:19640571, ECO:0000269|PubMed:1993697, ECO:0000269|PubMed:22431521, ECO:0000269|PubMed:23632027};
Multi-pass membrane protein {ECO:0000255}. Late endosome membrane {ECO:0000269|PubMed:10793155, ECO:0000269|PubMed:23632027};
Multi-pass membrane protein {ECO:0000255}. Endosome, multivesicular body {ECO:0000269|PubMed:21962903}. Melanosome {ECO:0000269|PubMed:21962903}. Secreted, exosome {ECO:0000269|PubMed:22660413}. Cell surface {ECO:0000269|PubMed:16917503, ECO:0000269|PubMed:23632027, ECO:0000269|PubMed:24635319}. Note=Also found in Weibel-Palade bodies of endothelial cells, PubMed:10793155. Located in platelet dense granules, PubMed:7682577. Detected in a subset of pre-melanosomes. Detected on intralumenal vesicles, ILVs within multivesicular bodies, PubMed:21962903. {ECO:0000269|PubMed:10793155, ECO:0000269|PubMed:21962903, ECO:0000269|PubMed:7682577}.
ECO codeClick here for more information.
Amino acid sequence
FASTA format: P08962
Gene Ontology
(Biological Process)
Complete annatation
cell-matrix adhesion [GO:0007160];
cell migration [GO:0016477];
cellular protein localization [GO:0034613];
endosome to melanosome transport [GO:0035646];
pigment granule maturation [GO:0048757];
platelet degranulation [GO:0002576];
positive regulation of integrin-mediated signaling pathway [GO:2001046];
positive regulation of receptor internalization [GO:0002092];
protein transport [GO:0015031];
regulation of rubidium ion transport [GO:2000680];
regulation of vascular endothelial growth factor signaling pathway [GO:1900746]
Gene Ontology
(Molecular Function)
Complete annatation
unknown
Gene Ontology
(Cellular Component)
Complete annatation
cell surface [GO:0009986];
endosome lumen [GO:0031904];
endosome membrane [GO:0010008];
extracellular exosome [GO:0070062];
extracellular space [GO:0005615];
integral component of plasma membrane [GO:0005887];
intrinsic component of plasma membrane [GO:0031226];
late endosome membrane [GO:0031902];
lysosomal membrane [GO:0005765];
melanosome [GO:0042470];
multivesicular body, internal vesicle [GO:0097487];
multivesicular body membrane [GO:0032585];
plasma membrane [GO:0005886];
platelet dense granule membrane [GO:0031088];
protein complex [GO:0043234]
Protein-protein interaction107405
Phylogenetic treeP08962
HIV replication factor status Zhou et al., Cell. Host. Microbe., 2008
      unknown
Brass et al., Science, 2008
      unknown
Smith et al., J. Immunol, 2010
      unknown
Interferon-stimulated
gene status
Lu et al., J. Virol., 2011
      Folds changes 8h: unknown; Folds changes 16h: unknown; Tested: unknown;
Schoggins JW and Rice CM, Curr. Opin. Virol., 2011
      Targeted viruses: unknown
      Viral life cycle: unknown
      Mechanism related to antiviral activity: unknown
Anti-viral restriction factor Liu et al., Retrovirology, 2011
      unknown (Triplicates)

Gene Expression Profile       top

            Up-regulated;            Down-regulated

For brief introduction to each study, please go to the help page.

Gene expression during HIV latency

(1). Mohammadi et al., PLoS Pathog., 2014

Differentially expressed transcripts (Pairwise) during latency and subsequent viral reactivation using several agents - Primary CD4+ T-cell based model


DMSO: Dimethyl suloxyde (negative control) - 0.0033% final
SAHA: Vorinostat (Histone deacetylase inhibitor) - 0.5 μM
CD3: TCR Stimulation by IL-2+ antiCD3/anti-CD28 antibodies
IL7: Interleukin-7 based stimulation
DISU: Disulfiram (alcohol dehydrogenase inhibitor) - 0.5 μM
AZA: 5-azacytidine (AZA; DNA methylation inhibitor) - 1 μM
Experimental Condition Log2 Fold Change P value Adjusted P value
AZA vs. CD3-0.2922439919750880.3722510196810810.494192492612812
AZA vs. DISU0.0873885955237460.7373302171403880.974591756386051
AZA vs. IL70.03113219737286060.8778161922195170.999311006273513
AZA vs. SAHA-0.09699233749870740.6908109433359750.911526974776478
DISU vs. CD30.3679033285887920.3110596007166470.443102666906326
DISU vs. IL7-0.06646554169552550.7917757558866780.952725938130142
DISU vs. SAHA-0.1811628963064550.5344603293603890.843284828472982
DMSO vs. AZA0.02800185000823180.9051547455578821
DMSO vs. CD30.3147616613971930.325077833910920.438433085753627
DMSO vs. DISU-0.05970750705424350.8308928515836520.98111438763097
DMSO vs. IL70.009662565562419210.9656467771217010.993414945980946
DMSO vs. SAHA-0.1315862210424980.5838881131550760.857201504507045
HIV vs. Mock in Activation0.04838772983456240.9381733991617640.999983755607037
HIV vs. Mock in Latency0.1266980584376230.5152736475629720.999834320637052
IL7 vs. CD30.3280576035952610.3073194326200280.445320689086876
SAHA vs. CD30.1728875605516830.6242839237851420.717890784543464
SAHA vs. IL7-0.1295757196616690.5944714237421470.79308236217382
(2). Iglesias-Ussel et al., J. Virol., 2013

Up and Downregulated transcripts during Latency (Latently infected CD4+ T cells vs Uninfected)- Primary CD4+Tcell based model
Log2 Fold Change P Value
unknown unknown

Gene expression during HIV infection and replication

(1). Imbeault et al., PloS Pathog., 2012

Transcriptomic profiling of HIV-1 infected CD4+ T cells - Primary CD4+ T cells
Experiment type Log2 Fold Change P Value Adjusted P Value
Infected vs. Mock unknown unknown unknown
Infected vs. Bystander unknown unknown unknown
(2). Lefebvre et al., J. Virol., 2011

Transcriptome analysis of T-cell line (Sup T1)
Log2 Fold Change unknown
(3). Li et al., J. Immunol., 2013

Lymphatic tissue
Acute Fold Change Acute P Value Asymt Fold Change Asypt P Value AIDS Fold Change AIDS P Value
unknown unknown unknown unknown unknown unknown
(4). Chang et al., MBio., 2011

Transcriptome analysis of T-cell line (Sup T1)

Derived from Sherrill-Mix et al., BMC Retrovirol., 2015 cross validation
Up-regulated (True) TRUE
(5). Sherrill-Mix et al., BMC Retrovirol., 2015

Deep RNA-seq analysis of primary human T cell infected with low passage HIV isolate HIV89.6 - Primary CD4+ T cell based
Test Status Log2 Fold Change P Value
OK 0.325332 0.0250861
(6). Rotger et al., PLoS Pathog., 2010

Genome-wide mRNA expression of CD4+ T cells from HIV-infected patient
(Genes differentially expressed (at adjusted p<0.01) according to the empirical Bayes approach)
Log2 Fold Change P Value
unknown unknown

Proteomic/Transcriptomics studies indicating differentially expressed genes mediated by HIV

(1). Greenwood et al., Elife, 2016

Activated (CD3/CD28) Primary human CD4+ T cells infected with pNL4-3-dE-EGFP. The table shows the complete (unfiltered) TMT (tandem mass tag)-based proteomic time course dataset
6 h 24 h 48 h 72 h RTi
unknown unknown unknown unknown unknown
(2). Navare et al., Virology, 2012

SUP-T1 cell line
FC-4hpi P-value FC-8hpi P-value FC-20hpi P-value Category
unknown unknown unknown unknown unknown unknown unknown
(3). Hyrcza et al., J. Virolo., 2007

Primary human CD4+ and CD8+ T Cells
Affymetrix Prob ID Fold Change In CD8? Category
unknown unknown unknown unknown

Protein Overview       top

Drug-protein Interaction       (annotations from DrugBank)      top

not found

Protein Secondary Structure       (annotations from PDB)      top

not found

HIV-1 Interaction       (annotations from NCBI HIV-1 Interaction Database)      top

HIV Partner Interaction Type PubMed
Envelope surface glycoprotein gp160; precursor inhibited by 19458002
Envelope surface glycoprotein gp160; precursor co-localizes with 18076669
18946087
21909273
25009540
Envelope transmembrane glycoprotein gp41 co-localizes with 25184547
Pr55(Gag) co-localizes with 12230470
18321974
18369466
19802344
20012524
22980332
25009540
2518454716533950
16683918
16940516
17522207
17550307
18006034
18305041
18369466
18500329
18977142
19284574
19369333
19458002
19474101
19802344
20727121
22875976
23072732
24872578
25009540
25056899
25870000
2594034716682056
16683918
16735575
16940516
18006034
18059278
18076669
18321974
18369466
19426143
19458002
19802344
20012524
20727121
22808325
22830021
2500954018946087
22980332
23072732
25760631
Tat upregulates 21315401
capsid affects 25973004
Envelope surface glycoprotein gp120 co-localizes with 23072732
Envelope transmembrane glycoprotein gp41 enhanced by 24507450
HIV-1 virus replication enhanced by expression of human gene 25973004
25973004
25973004
25973004
18682304
21315401
24507450
Envelope surface glycoprotein gp120 enhanced by 24507450
Pr55(Gag) interacts with 14722309
1514099919458002
21248205
Nef enhances release of 26109641
Envelope transmembrane glycoprotein gp41 inhibited by 17989173
1945800219458002
capsid upregulates 21315401
Nef co-localizes with 19403684
19912576
24489825
2511828019403684
2062201019912576
Envelope surface glycoprotein gp160; precursor incorporates 9685355
11584299
12885763
17381240
18076669
25009540
capsid co-localizes with 12230470
18714047
1897714223072732
25973004
matrix co-localizes with 18076669
18321974
18714047
1929749925973004
Envelope surface glycoprotein gp120 inhibited by 17989173
19458002
19602278
19894777
2460808519458002
Nef downregulates 25275127
Vpu downregulates 25275127

Metabolic/Signalling Pathway       (annotations from KEGG database)      top

Pathway Accession Number Description
hsa04142 Lysosome - Homo sapiens (human)
hsa05205 Proteoglycans in cancer - Homo sapiens (human)
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