Detailed entry information

Protein Information (annotations from UniProt)

Database IDHIV0000536
UniProt IDP19256
Primary gene name(s)CD58
Synonym gene name(s)LFA3
Protein nameLymphocyte function-associated antigen 3
Protein functionLigand of the T-lymphocyte CD2 glycoprotein. This interaction is important in mediating thymocyte interactions with thymic epithelial cells, antigen-independent and -dependent interactions of T-lymphocytes with target cells and antigen-presenting cells and the T-lymphocyte rosetting with erythrocytes. In addition, the LFA-3/CD2 interaction may prime response by both the CD2+ and LFA-3+ cells.
Subcellular locationIsoform 1: Cell membrane;
Single-pass type I membrane protein.;
SUBCELLULAR LOCATION: Isoform 2: Cell membrane;
Lipid-anchor, GPI-anchor.
ECO codeClick here for more information.
Amino acid sequence
FASTA format: P19256
Gene Ontology
(Biological Process)
Complete annatation
cell adhesion [GO:0007155];
cellular response to interferon-gamma [GO:0071346];
cellular response to tumor necrosis factor [GO:0071356];
heterotypic cell-cell adhesion [GO:0034113];
leukocyte migration [GO:0050900];
positive regulation of interleukin-8 secretion [GO:2000484];
single organismal cell-cell adhesion [GO:0016337]
Gene Ontology
(Molecular Function)
Complete annatation
receptor binding [GO:0005102]
Gene Ontology
(Cellular Component)
Complete annatation
anchored component of membrane [GO:0031225];
cell surface [GO:0009986];
extracellular exosome [GO:0070062];
integral component of plasma membrane [GO:0005887];
membrane [GO:0016020];
plasma membrane [GO:0005886]
Protein-protein interaction107403
Phylogenetic treeP19256
HIV replication factor status Zhou et al., Cell. Host. Microbe., 2008
      unknown
Brass et al., Science, 2008
      unknown
Smith et al., J. Immunol, 2010
      unknown
Interferon-stimulated
gene status
Lu et al., J. Virol., 2011
      Folds changes 8h: unknown; Folds changes 16h: unknown; Tested: unknown;
Schoggins JW and Rice CM, Curr. Opin. Virol., 2011
      Targeted viruses: unknown
      Viral life cycle: unknown
      Mechanism related to antiviral activity: unknown
Anti-viral restriction factor Liu et al., Retrovirology, 2011
      unknown (Triplicates)

Gene Expression Profile       top

            Up-regulated;            Down-regulated

For brief introduction to each study, please go to the help page.

Gene expression during HIV latency

(1). Mohammadi et al., PLoS Pathog., 2014

Differentially expressed transcripts (Pairwise) during latency and subsequent viral reactivation using several agents - Primary CD4+ T-cell based model


DMSO: Dimethyl suloxyde (negative control) - 0.0033% final
SAHA: Vorinostat (Histone deacetylase inhibitor) - 0.5 μM
CD3: TCR Stimulation by IL-2+ antiCD3/anti-CD28 antibodies
IL7: Interleukin-7 based stimulation
DISU: Disulfiram (alcohol dehydrogenase inhibitor) - 0.5 μM
AZA: 5-azacytidine (AZA; DNA methylation inhibitor) - 1 μM
Experimental Condition Log2 Fold Change P value Adjusted P value
AZA vs. CD30.8521452523140560.01003958390429490.0261567171314664
AZA vs. DISU0.2676474028083280.294474309852020.859189309662628
AZA vs. IL7-0.09491039355775610.628218906422520.999311006273513
AZA vs. SAHA-0.01610063625618090.9479779464971610.98946264821342
DISU vs. CD3-0.5980959144636120.1012384692516030.18815403969755
DISU vs. IL7-0.3710891478976620.1445168939412440.495359749014155
DISU vs. SAHA-0.2826932366639150.3352779951193150.714706458902858
DMSO vs. AZA-0.07332715842434610.6698019276673331
DMSO vs. CD3-0.9366719900904890.00379624590460270.0108567008280057
DMSO vs. DISU-0.3426344096184570.1643573288673250.673415720210493
DMSO vs. IL7-0.01440568650455230.9374451788767630.987881055156488
DMSO vs. SAHA0.04961735101367610.8351559140771040.955395312907465
HIV vs. Mock in Activation0.01304602972823850.9833002685792220.999983755607037
HIV vs. Mock in Latency0.03572867174295760.8319153050075110.999834320637052
IL7 vs. CD3-0.9380866223259020.003921390630456050.0136790374850414
SAHA vs. CD3-0.893382752849350.01234864150955470.030652944745345
SAHA vs. IL70.07422922774238410.7630634452941850.894503334191193
(2). Iglesias-Ussel et al., J. Virol., 2013

Up and Downregulated transcripts during Latency (Latently infected CD4+ T cells vs Uninfected)- Primary CD4+Tcell based model
Log2 Fold Change P Value
unknown unknown

Gene expression during HIV infection and replication

(1). Imbeault et al., PloS Pathog., 2012

Transcriptomic profiling of HIV-1 infected CD4+ T cells - Primary CD4+ T cells
Experiment type Log2 Fold Change P Value Adjusted P Value
Infected vs. Mock unknown unknown unknown
Infected vs. Bystander unknown unknown unknown
(2). Lefebvre et al., J. Virol., 2011

Transcriptome analysis of T-cell line (Sup T1)
Log2 Fold Change unknown
(3). Li et al., J. Immunol., 2013

Lymphatic tissue
Acute Fold Change Acute P Value Asymt Fold Change Asypt P Value AIDS Fold Change AIDS P Value
unknown unknown unknown unknown unknown unknown
(4). Chang et al., MBio., 2011

Transcriptome analysis of T-cell line (Sup T1)

Derived from Sherrill-Mix et al., BMC Retrovirol., 2015 cross validation
Up-regulated (True) TRUE
(5). Sherrill-Mix et al., BMC Retrovirol., 2015

Deep RNA-seq analysis of primary human T cell infected with low passage HIV isolate HIV89.6 - Primary CD4+ T cell based
Test Status Log2 Fold Change P Value
OK 0.494054 0.00493672
(6). Rotger et al., PLoS Pathog., 2010

Genome-wide mRNA expression of CD4+ T cells from HIV-infected patient
(Genes differentially expressed (at adjusted p<0.01) according to the empirical Bayes approach)
Log2 Fold Change P Value
unknown unknown

Proteomic/Transcriptomics studies indicating differentially expressed genes mediated by HIV

(1). Greenwood et al., Elife, 2016

Activated (CD3/CD28) Primary human CD4+ T cells infected with pNL4-3-dE-EGFP. The table shows the complete (unfiltered) TMT (tandem mass tag)-based proteomic time course dataset
6 h 24 h 48 h 72 h RTi
unknown unknown unknown unknown unknown
(2). Navare et al., Virology, 2012

SUP-T1 cell line
FC-4hpi P-value FC-8hpi P-value FC-20hpi P-value Category
unknown unknown unknown unknown unknown unknown unknown
(3). Hyrcza et al., J. Virolo., 2007

Primary human CD4+ and CD8+ T Cells
Affymetrix Prob ID Fold Change In CD8? Category
unknown unknown unknown unknown

Protein Overview       top

Drug-protein Interaction       (annotations from DrugBank)      top

not found

Protein Secondary Structure       (annotations from PDB)      top

PDB Accession Method Resolution Chain Structure Preview
1CCZ X-ray 1.8Å A=29-122.
1CI5 NMR - A=29-123.
1QA9 X-ray 3.2Å B/D=30-123.

HIV-1 Interaction       (annotations from NCBI HIV-1 Interaction Database)      top

HIV Partner Interaction Type PubMed
Envelope surface glycoprotein gp120 interacts with 1757107
Envelope surface glycoprotein gp120 inhibited by 7589092
Nef upregulates 12853962

Metabolic/Signalling Pathway       (annotations from KEGG database)      top

Pathway Accession Number Description
hsa04514 Cell adhesion molecules (CAMs) - Homo sapiens (human)
hsa05169 Epstein-Barr virus infection - Homo sapiens (human)
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