Detailed entry information

Protein Information (annotations from UniProt)

Database IDHIV0000533
UniProt IDP01730
Primary gene name(s)CD4
Synonym gene name(s)unknown
Protein nameT-cell surface glycoprotein CD4
Protein functionAccessory protein for MHC class-II antigen/T-cell receptor interaction. May regulate T-cell activation. Induces the aggregation of lipid rafts.; FUNCTION:, Microbial infection Acts as a receptor for human immunodeficiency virus-1, PubMed:2214026, PubMed:16331979, PubMed:9641677. Down-regulated by HIV-1 Vpu, PubMed:17346169. Acts as a receptor for Human Herpes virus 7/HHV-7, PubMed:7909607. {ECO:0000269|PubMed:16331979, ECO:0000269|PubMed:17346169, ECO:0000269|PubMed:2214026, ECO:0000269|PubMed:7909607, ECO:0000269|PubMed:9641677}.
Subcellular locationCell membrane {ECO:0000269|PubMed:12517957};
Single-pass type I membrane protein {ECO:0000269|PubMed:12517957}. Note=Localizes to lipid rafts. Removed from plasma membrane by HIV-1 Nef protein that increases clathrin-dependent endocytosis of this antigen to target it to lysosomal degradation. Cell surface expression is also down-modulated by HIV-1 Envelope polyprotein gp160 that interacts with, and sequesters CD4 in the endoplasmic reticulum.
ECO codeClick here for more information.
Amino acid sequence
FASTA format: P01730
Gene Ontology
(Biological Process)
Complete annatation
adaptive immune response [GO:0002250];
cell surface receptor signaling pathway [GO:0007166];
cytokine production [GO:0001816];
defense response to Gram-negative bacterium [GO:0050829];
entry into host cell [GO:0030260];
enzyme linked receptor protein signaling pathway [GO:0007167];
fusion of virus membrane with host plasma membrane [GO:0019064];
helper T cell enhancement of adaptive immune response [GO:0035397];
immune response [GO:0006955];
induction by virus of host cell-cell fusion [GO:0006948];
maintenance of protein location in cell [GO:0032507];
positive regulation of calcium ion transport into cytosol [GO:0010524];
positive regulation of calcium-mediated signaling [GO:0050850];
positive regulation of interleukin-2 biosynthetic process [GO:0045086];
positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731];
positive regulation of protein kinase activity [GO:0045860];
positive regulation of T cell proliferation [GO:0042102];
regulation of defense response to virus by virus [GO:0050690];
regulation of T cell activation [GO:0050863];
response to estradiol [GO:0032355];
response to vitamin D [GO:0033280];
signal transduction [GO:0007165];
T cell costimulation [GO:0031295];
T cell differentiation [GO:0030217];
T cell receptor signaling pathway [GO:0050852];
T cell selection [GO:0045058];
transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169]
Gene Ontology
(Molecular Function)
Complete annatation
coreceptor activity [GO:0015026];
enzyme binding [GO:0019899];
extracellular matrix structural constituent [GO:0005201];
glycoprotein binding [GO:0001948];
MHC class II protein binding [GO:0042289];
protein homodimerization activity [GO:0042803];
protein kinase binding [GO:0019901];
receptor activity [GO:0004872];
transmembrane signaling receptor activity [GO:0004888];
virus receptor activity [GO:0001618];
zinc ion binding [GO:0008270]
Gene Ontology
(Cellular Component)
Complete annatation
early endosome [GO:0005769];
endoplasmic reticulum lumen [GO:0005788];
endoplasmic reticulum membrane [GO:0005789];
external side of plasma membrane [GO:0009897];
integral component of membrane [GO:0016021];
membrane raft [GO:0045121];
plasma membrane [GO:0005886];
T cell receptor complex [GO:0042101]
Protein-protein interaction107358
Phylogenetic treeP01730
HIV replication factor status Zhou et al., Cell. Host. Microbe., 2008
      Yes - Two siRNA pools inhibit HIV replication and inhibition of Tat-mediated transactivation of the HIV LTR is not observed
Brass et al., Science, 2008
      unknown
Smith et al., J. Immunol, 2010
      unknown
Interferon-stimulated
gene status
Lu et al., J. Virol., 2011
      Folds changes 8h: unknown; Folds changes 16h: unknown; Tested: unknown;
Schoggins JW and Rice CM, Curr. Opin. Virol., 2011
      Targeted viruses: unknown
      Viral life cycle: unknown
      Mechanism related to antiviral activity: unknown
Anti-viral restriction factor Liu et al., Retrovirology, 2011
      unknown (Triplicates)

Gene Expression Profile       top

            Up-regulated;            Down-regulated

For brief introduction to each study, please go to the help page.

Gene expression during HIV latency

(1). Mohammadi et al., PLoS Pathog., 2014

Differentially expressed transcripts (Pairwise) during latency and subsequent viral reactivation using several agents - Primary CD4+ T-cell based model


DMSO: Dimethyl suloxyde (negative control) - 0.0033% final
SAHA: Vorinostat (Histone deacetylase inhibitor) - 0.5 μM
CD3: TCR Stimulation by IL-2+ antiCD3/anti-CD28 antibodies
IL7: Interleukin-7 based stimulation
DISU: Disulfiram (alcohol dehydrogenase inhibitor) - 0.5 μM
AZA: 5-azacytidine (AZA; DNA methylation inhibitor) - 1 μM
Experimental Condition Log2 Fold Change P value Adjusted P value
AZA vs. CD3-1.545926561399734.48144371556491e-063.00464055520438e-05
AZA vs. DISU-0.5249051178345770.03804771647627260.450959390481316
AZA vs. IL7-0.1539931667156320.421692618859110.999311006273513
AZA vs. SAHA-0.1603179499023010.5105145838458710.827500374877265
DISU vs. CD31.010251393026140.006266731042630870.0196147640649123
DISU vs. IL70.360900315845420.1519910672803310.506369715733974
DISU vs. SAHA0.3666763918789570.2091108705563560.583127815370239
DMSO vs. AZA-0.008131163709735920.9611067033022231
DMSO vs. CD31.527156992905633.31639883732748e-062.13055643856454e-05
DMSO vs. DISU0.5151341056219730.03486347267208470.377037042518233
DMSO vs. IL7-0.1387335814112830.4387395152220260.861871017979157
DMSO vs. SAHA-0.1577862797366880.5024942004561650.815912026254924
HIV vs. Mock in Activation0.1133182509398330.8555880757965890.999983755607037
HIV vs. Mock in Latency0.02400126392868260.8842899370233430.999834320637052
IL7 vs. CD31.397646364366192.05507218223877e-050.000145975980220947
SAHA vs. CD31.362457812122950.00015455227502470.000701959850699887
SAHA vs. IL7-0.008501975268758130.9720766535970850.990006315541008
(2). Iglesias-Ussel et al., J. Virol., 2013

Up and Downregulated transcripts during Latency (Latently infected CD4+ T cells vs Uninfected)- Primary CD4+Tcell based model
Log2 Fold Change P Value
0.4483 0.03059

Gene expression during HIV infection and replication

(1). Imbeault et al., PloS Pathog., 2012

Transcriptomic profiling of HIV-1 infected CD4+ T cells - Primary CD4+ T cells
Experiment type Log2 Fold Change P Value Adjusted P Value
Infected vs. Mock unknown unknown unknown
Infected vs. Bystander unknown unknown unknown
(2). Lefebvre et al., J. Virol., 2011

Transcriptome analysis of T-cell line (Sup T1)
Log2 Fold Change -1.033330216
(3). Li et al., J. Immunol., 2013

Lymphatic tissue
Acute Fold Change Acute P Value Asymt Fold Change Asypt P Value AIDS Fold Change AIDS P Value
-1.2 0.087705998 -1.3 0.012816654 -1.7 0.000411536
(4). Chang et al., MBio., 2011

Transcriptome analysis of T-cell line (Sup T1)

Derived from Sherrill-Mix et al., BMC Retrovirol., 2015 cross validation
Up-regulated (True) FALSE
(5). Sherrill-Mix et al., BMC Retrovirol., 2015

Deep RNA-seq analysis of primary human T cell infected with low passage HIV isolate HIV89.6 - Primary CD4+ T cell based
Test Status Log2 Fold Change P Value
OK -1.22437 0.000305467
(6). Rotger et al., PLoS Pathog., 2010

Genome-wide mRNA expression of CD4+ T cells from HIV-infected patient
(Genes differentially expressed (at adjusted p<0.01) according to the empirical Bayes approach)
Log2 Fold Change P Value
unknown unknown

Proteomic/Transcriptomics studies indicating differentially expressed genes mediated by HIV

(1). Greenwood et al., Elife, 2016

Activated (CD3/CD28) Primary human CD4+ T cells infected with pNL4-3-dE-EGFP. The table shows the complete (unfiltered) TMT (tandem mass tag)-based proteomic time course dataset
6 h 24 h 48 h 72 h RTi
1.054 0.579 0.161 0.179 1.133
(2). Navare et al., Virology, 2012

SUP-T1 cell line
FC-4hpi P-value FC-8hpi P-value FC-20hpi P-value Category
unknown unknown unknown unknown unknown unknown unknown
(3). Hyrcza et al., J. Virolo., 2007

Primary human CD4+ and CD8+ T Cells
Affymetrix Prob ID Fold Change In CD8? Category
unknown unknown unknown unknown

Protein Overview       top

Drug-protein Interaction       (annotations from DrugBank)      top

Drugbank ID Drug Name Drug Status Pharmacological Action Drug Action
DB00098 Anti-thymocyte Globulin (Rabbit) approved yes unknown

Protein Secondary Structure       (annotations from PDB)      top

PDB Accession Method Resolution Chain Structure Preview
1CDH X-ray 2.3Å A=26-203.
1CDI X-ray 2.9Å A=26-203.
1CDJ X-ray 2.5Å A=26-203.
1CDU X-ray 2.7Å A=26-203.
1CDY X-ray 2.0Å A=26-203.
1G9M X-ray 2.2Å C=26-208.
1G9N X-ray 2.9Å C=26-208.
1GC1 X-ray 2.5Å C=26-206.
1JL4 X-ray 4.3Å D=26-203.
1OPN Model - C=26-206.
1OPT Model - C=26-206.
1OPW Model - C=26-206.
1Q68 NMR - A=421-458.
1RZJ X-ray 2.2Å C=26-208.
1RZK X-ray 2.9Å C=26-208.
1WBR NMR - A=428-444.
1WIO X-ray 3.9Å A/B=26-388.
1WIP X-ray 4.0Å A/B=26-388.
1WIQ X-ray 5.0Å A/B=26-388.
2B4C X-ray 3.3Å C=26-206.
2JKR X-ray 2.9Å P/Q=431-441.
2JKT X-ray 3.4Å P/Q=435-441.
2KLU NMR - A=397-458.
2NXY X-ray 2.0Å B=26-208.
2NXZ X-ray 2.0Å B=26-208.
2NY0 X-ray 2.2Å B=26-208.
2NY1 X-ray 1.9Å B=26-208.
2NY2 X-ray 2.0Å B=26-208.
2NY3 X-ray 2.0Å B=26-208.
2NY4 X-ray 2.0Å B=26-208.
2NY5 X-ray 2.5Å C=26-208.
2NY6 X-ray 2.8Å B=26-208.
2QAD X-ray 3.3Å B/F=26-206.
3B71 X-ray 2.8Å D/E/F=428-450.
3CD4 X-ray 2.2Å A=26-207.
3J70 EM - C/O/T=26-208.
3JWD X-ray 2.6Å C/D=26-208.
3JWO X-ray 3.5Å C=26-208.
3LQA X-ray 3.4Å C=26-207.
3O2D X-ray 2.1Å A=26-207.
3S4S X-ray 2.4Å G/H=26-203.
3S5L X-ray 2.1Å G/H=26-203.
3T0E X-ray 4.0Å E=26-388.
4H8W X-ray 1.8Å C=26-208.
4JM2 X-ray 3.1Å F=26-208.
4P9H X-ray 3.0Å C=26-207.
4Q6I X-ray 3.6Å C/I/J/K=1-208.
4R2G X-ray 3.2Å B/F/H/L=26-208.
4R4H X-ray 4.2Å B=26-203.
4RQS X-ray 4.4Å B=26-208.
5A7X EM 17.0Å B/F/J=26-206.
5A8H EM 23.0Å B/H/N=26-208.
5CAY X-ray 3.0Å B=26-208.

HIV-1 Interaction       (annotations from NCBI HIV-1 Interaction Database)      top

HIV Partner Interaction Type PubMed
Vpu degrades 1433512
7778293
7853484
8091666
8091684
8230446
8289353
8350411
8510209
8551619
8709227
8806575
8887470
9049413
9151836
9622505
10375528
15929700
18541215
20012522
20201792
20638642
20858517
21176220
21601230
21607084
21674066
21922073
22171785
22751485
22863293
23831603
24035804
24158820
248220528139011
8659106
9185604
11024464
12954211
17586316
19149577
20012522
20078884
20201792
20858517
21176220
21607084
21674066
22751485
23047923
232847579499087
9660940
14561767
15099523
15279589
16354571
17121803
17586316
17937819
18541215
18672082
19149577
19944437
20012522
20201792
20442859
20880565
21176220
21994772
22171785
22222210
23201263
23308067
23831603
24035804
24158820
24257748
24574397
24822052
Envelope surface glycoprotein gp120 downregulated by 1374095
2190096
Envelope surface glycoprotein gp120 induces rearrangement of 23575248
Envelope surface glycoprotein gp120 stimulates 8464887
Envelope surface glycoprotein gp120 interacts with 11352665
12083833
12191776
1310988
1979339
2851650
8801439
224332501356673
1388715
2468713
7589092
7615007
7913036
8552983
8575195
8801439
9002959
9036944
9043947
9123823
9269777
9344703
9548463
9604776
9637477
10202115
10623764
168296071380260
159360901381203
15936090
1857960916507315
2455039516963439
17005819
17082567
18045872
1816217617151103
17151103
17158233
17728240
18632854
21284901
22908191
24005480
24029736
2415790719066282
1970444
1970444
20494390
21216423
21325401
2537849721444771
21465559
2308645921612582
21849975
2188615021851958
22854780
23028850
2408668323077246
23100517
23135713
24179159
2417916024352444
2449887824569807
24778234
24778234
25231990
25569556
25688986
25688986
7774645
7874384
8437234
107581708419649
8648738
9002959
9226175
9548463
10505674
157190269263011
9417096
95732339443108
9525894
9600078
9826718
10213312
10213313
10233996
10589997
11070895
11201791
172342329548463
9621091
9637477
9724097
Pr55(Gag) co-localizes with 22846998
Envelope surface glycoprotein gp120 co-localizes with 18078954
Envelope surface glycoprotein gp120 imported by 23729440
Envelope surface glycoprotein gp120 inhibits 1356673
1402655
2198840
2543930
2846691
7541827
7914230
8168144
8356059
8575195
8801439
9186786
16829607
16855325
17180012
Nef complexes with 19129443
Envelope surface glycoprotein gp160; precursor binds 1501294
1520872
1677023
1678778
1697332
1727486
1727497
1979339
1984054
1985202
2104682
2111957
2187500
2190605
2214026
2523711
2538547
2545918
2558687
7504739
7576930
7688827
7853478
7903106
8091666
8151300
8151301
8178478
8438588
8560759
8635586
8661396
8661397
8738430
8862276
8882662
8896248
9269777
9360974
9499113
10606089
10873786
11333908
11414813
14646564
15033690
15977243
17083721
17888880
18508887
18672260
18715908
18977142
19020832
21249232
21346189
21411542
21444771
21487012
21593147
21709254
21909273
22163292
22163344
22773820
23514633
23966389
24075869
24967714
25395053
25490553
259413671501294
81513001501294
8151300
17888880
23454641
24068931
25395053
25512514
25569572
2558963721444771
21444771
22773820
23267106
23426631
23757493
24067980
2406893122163292
22687513
25490553
9269777
93447039443108
Envelope surface glycoprotein gp160; precursor interacts with 1535787
1548763
998960224075869
25320323
7917519
170837218661396
21444771
Nef binds 11922627
8599229
216254968599760
11264384
21738584
Envelope surface glycoprotein gp120 binds 10581250
2431209510593874
10779509
11453640
1503356711602639
1571902611804554
2128490112145207
1571902612218051
12218052
14592831
2455039512707350
1458521912787886
1279195
1280382
1281202
1348943
1352879
1354681
1356673
1370558
1373203
1373549
1374095
1376134
1376135
1378510
1381203
1381399
1382339
1388715
1402655
1438278
1457207
1465431
1472279
1493050
1500858
1501286
1503822
1512692
1543562
1546447
1548744
1548769
1549584
1563094
1567578
1569213
1588493
1599754
1602552
1614536
1627247
1636088
1685857
1690236
1691226
1691563
1693676
1696539
1698804
1698964
1701782
1702163
1702842
1703212
1706342
1709701
1710248
1711033
1713252
1717587
1717717
1720590
1720631
1721822
1722676
1727475
1727487
1730924
1732513
1736938
1738091
1742075
1810199
1832782
1845049
1870202
1870209
1871120
1889086
1899141
1910691
1931229
1959561
1967269
1967280
1970124
1971526
1977427
1978941
1979910
1983967
1985197
1991970
1995942
2006155
2018763
2040664
2045792
2059359
2068099
2076345
2078013
2078408
2078409
2082620
2103853
2107024
2111957
2115689
2125484
2136376
2171457
2182910
2187500
2190096
2190605
2198840
2212945
2243375
2251501
2261984
2324685
2325207
2335819
2341717
2363051
2364018
2374593
2402498
2441877
2453925
2458487
2465401
2475780
2479005
2482055
2523711
2536098
2537355
2541915
2542563
2543930
2550679
2555855
2558687
2559777
2561054
2574581
2649653
2783333
2824064
2842778
2843775
2846691
2851650
2884513
3029227
3031162
3037522
3037551
3259291
3260352
3261864
3264307
3500514
3682024
7506556
7515973
7521897
7522245
7529290
7537501
7539755
7541827
7543271
7543586
7544051
7545243
7545244
7546903
7576913
7589091
7589092
7592573
7616571
7618285
7678271
7684821
7685405
7686944
7687306
7689324
7690724
7692037
7692087
7693970
7707502
7734186
7754236
7769687
7774645
7821926
7831801
7832633
7867080
7874384
7897355
7897356
7902128
7903106
7904348
7904351
7904656
7906657
7913036
7914230
7935503
8043225
8075984
8086417
8122371
8129620
8139010
8139032
8160267
8178478
8196669
8212576
8218172
8280475
8331723
8341695
8361381
8363802
8369162
8406619
8416385
8417177
8419169
8419649
8421893
8437224
8437234
8438588
8455141
8460995
8466484
8474162
8497074
8497077
8503188
8524869
8537092
8547064
8551601
8560767
8575195
8599832
8605026
8615032
8621941
8623537
8627018
8627160
8627264
8627711
8629022
8648738
8649438
8663408
8671590
8674119
8707350
8726523
8738430
8743291
8760413
8790377
8794361
8794362
8798971
8798972
8798974
8801439
8805353
8806567
8810998
8811050
8811198
8814265
8827216
8827217
8849450
8862276
8875644
8878430
8882662
8883579
8887682
8891109
8892864
8898753
8906795
8906796
8906988
8948487
8973529
8976200
8977179
8985413
8986758
8989204
8995603
8995609
9000083
9002959
9013955
9020356
9036944
9037057
9043947
9123823
9128743
9184207
9186786
9188565
9235945
9261346
9264287
9269777
9274854
9334377
9344703
9349472
9377118
9417096
9426451
9443108
9451022
9525894
9548463
9573233
9600078
9604776
9621091
9637477
9641677
9658072
9658081
9669555
9724097
9739096
9759876
9826718
9862697
9918507
10202115
10213312
10233996
10235509
10356363
10358157
10364484
10393974
10422873
10430052
10446313
10505674
10512629
10557278
10558884
10559349
10581250
10582593
10589997
10590121
10593874
10600606
10623731
10623764
10738970
10774549
10779509
10799864
10816381
10843204
10888615
10922058
10941932
11024154
11069996
11075952
11086073
11118070
11201791
11238869
11264367
11265761
11287575
11311058
11312658
11327825
11333905
11350667
11352665
11356961
11356967
11397808
11413305
11413337
11453640
11462056
11485409
11504923
11517385
11533181
11602639
11704677
11734627
11799176
11804554
11827520
11855981
11878912
11888657
11906183
11967288
12008044
12033289
12033937
12072528
12083833
12120995
12134256
12163558
12191776
12208966
12218051
12218052
12239168
12406507
12438611
12477840
12477867
12487827
12502809
12502824
12505925
12531788
12584309
12597360
12608057
12646791
12646921
12689412
12707350
12714584
12719560
12719580
12768015
12769725
12787886
12829845
12857973
12864967
12871111
12873764
12873765
12885233
12887918
12930892
12943795
12960231
12963807
12970437
14557624
14570906
14576059
14585209
14585219
14592761
14592765
14592831
14659896
14739941
14965316
14967033
15016894
15033567
15051887
15090827
15103622
15109676
15113900
15113923
15131118
15168796
15180540
15180541
15183057
15194768
15215692
15258189
15279586
15308718
15481145
15489307
15572157
15577644
15585836
15613479
15644496
15650196
15665647
15719026
15729327
15729334
15767435
15784911
15795268
15797855
15836438
15857992
15857997
15890935
15893666
15946678
15956589
15990565
15996703
16002156
16014956
16046522
16047221
16051303
16103167
16106369
16148047
16160142
16174727
16182193
16185162
16266123
16282475
16284180
16284274
16300985
16306611
16331979
16437164
16569857
16571818
16611055
16611061
16702010
16725045
16728975
16778874
16817962
16827663
16829607
16844755
16855325
16886061
16912071
16956948
17005819
17006538
17014923
17015697
17030448
17034868
17035237
17050608
17083721
17084877
17118792
17121788
17131136
17132727
17144914
17157668
17158233
17187670
17227719
17239419
17251303
17260969
17263629
17269928
17301785
17320923
17334223
17344303
17346946
17360741
17436226
17485285
17599917
17628860
17728240
17803292
17825297
17901336
17954689
17959679
17980997
18032634
18045112
18045872
18097956
18162176
18187620
18205925
18237398
18242797
18296630
18310503
18322210
18339756
18377648
18378683
18390744
18468560
18480458
18524826
18539308
18566427
18579609
18590744
18594881
18619974
18624812
18632854
18638381
18668044
18672260
18691022
18704932
18715908
18768967
18833294
18952441
18976462
18976975
18977142
18991615
19000821
19004960
19018669
19019953
19020832
19066282
19170639
19180463
19187599
19193785
19208751
19349871
19457995
19478876
19535453
19556424
19567243
19620004
19632839
19661992
19671162
19734912
19763181
19783140
19813706
19837465
19839582
19851458
19926478
19965434
20007245
20016882
20041213
20080564
20088758
20147388
20164234
20166763
20186035
20195464
20227370
20229778
20304457
20357769
20369301
20369886
20420669
20463957
20494390
20501362
20507591
20538591
20558728
20570309
20610714
20624966
20657663
20660185
20681584
20698725
20718047
20730055
20825246
20890395
20943653
20953943
20956336
20969902
20974843
20980513
21041720
21068257
21152581
21159865
21169023
21216423
21249232
21284899
21310296
21325401
21351734
21382342
21411542
21440555
21444771
21465559
21474836
21487012
21488663
21543479
21612582
21613393
21635737
21660189
21697467
21715496
21760891
21763489
21793507
21849975
21851958
21875413
21886150
21931551
21937655
21957314
21962990
21994452
21994458
21994672
22006924
22014753
22031937
22069466
22079291
22083481
22090143
22117536
22124968
22163344
22167180
22178016
22192629
22237899
22266649
22284192
22286875
22291694
22291921
22297516
22312332
22332354
22345481
22414543
22419808
22421880
22422068
22433250
22451932
22470838
22474613
22479399
22497421
22524483
22551420
22553332
22583677
22606344
22624045
22650962
22674993
22687513
22693444
22696649
22745174
22807678
22908191
22947176
22957718
22959895
23011758
23043103
23043104
23055568
23066870
23077246
23086459
23087226
23135713
23135721
23143844
23202514
23211775
23217618
23219376
23255784
23267106
23297802
23300605
23304142
23330719
23375046
23389465
23454641
23468626
23514633
23535561
23616655
23658524
23665667
23692808
23707685
23710622
23711095
23742646
23747109
23757493
23762317
23776539
23777826
23804632
23825637
23840566
23862963
23878231
23884127
23884589
23908485
23989454
23991039
24005480
24029736
24074567
24074590
24075869
24109227
24131720
24145278
24146829
24156625
24157907
24158961
24179159
24179160
24237700
24277152
24284318
24304511
24307580
24312168
24338530
24352234
24352444
24352455
24382025
24390336
24416431
24418543
24441862
24454812
24492798
24498878
24516533
24550395
24558379
24583235
24656066
24661998
24729094
24741097
24778234
24788065
24801282
24804757
24819826
24884783
24920800
24920809
24931470
24965454
24965460
25008916
25031337
25105502
25166308
25174000
25193376
25203778
25231990
25245278
25296251
25296255
25298114
25313689
25339767
25350851
25355891
25378497
25453804
25461534
25462344
25472996
25522787
25555152
25569556
25589785
25631091
25646817
25691567
25704889
25712564
25723173
25762739
25803681
25807494
25880110
259725341279195
1280382
1370558
1374095
1376134
1376135
1380099
1382339
1543562
1548744
1588493
1690236
1702163
1703212
1710248
1717717
1720590
1722676
1724568
1888898
2068099
2136376
2324685
2431105
2431482
2432599
2436231
2437327
2438696
2441727
2446880
2462895
2482055
2821115
2833917
2986290
2986291
2990682
3006256
3018753
3023102
3027168
3038935
3304356
3466790
3484980
3495568
3497054
3652531
7529290
7529735
7533854
7543586
7544051
7545244
7546903
7562439
7592573
7594524
7615007
7685405
7686944
7687306
7689324
7690418
7690724
7692037
7769687
7935503
8139010
8212576
8331723
8363802
8417177
8455141
8460995
8497077
8551569
8568275
8575195
8615015
8627160
8627264
8627711
8663408
8760413
8827217
8892926
8973529
8995609
9000083
9037057
9264287
9641677
9658072
9739096
9862697
10558884
11413335
11413337
11533181
11734627
12072528
12134256
12208966
12477867
12487827
12502824
12584309
12597360
12646791
12646921
12719580
12768015
14505925
14557624
14585209
14659896
15016849
15090827
15168796
15183057
15279588
15308718
15321703
15572157
15650196
15893666
16035946
16051303
16106369
16160142
16284180
16551265
16616288
16702010
16731948
16817962
16827663
16956933
17006538
17034868
17079307
17090209
17118792
17121806
17239419
17251298
17251303
17263629
17267498
17301785
17360739
17409160
17409164
17413690
17721546
18322210
18377648
18524826
18619974
18638381
18691028
18768967
19965434
20357769
20369886
20463957
20558728
20616231
20616233
20702629
20705840
21037278
21152581
21193846
21226626
21248038
21325401
21357743
21440555
21660189
21760891
21849977
21931551
21938063
21994452
22033520
22113616
22167180
22170674
22284192
22291921
22345481
22419808
22553332
22573869
22623764
22745174
22798606
22807678
22826297
22846998
23023102
23055568
23087226
23115339
23152508
23152926
23237851
23267106
23300605
23539181
23616655
23658524
23692808
23707685
23747109
23757493
23776539
23843638
23878231
23991039
24030996
24172894
24172896
24172905
24179160
24189188
24204277
24243013
24251545
24352234
24409525
24478429
24550318
24554654
24589930
24590074
24767986
24802758
24982157
24990883
25215485
25253346
25339767
25341782
25504701
25504724
25691567
25751231
25803681
258105371280382
1281202
1348943
1373203
1563094
1567578
1599754
1605591
1627247
1639820
1674549
1687500
1690832
1693676
1713252
1727475
1727487
1870209
1871120
1977427
2007979
2015114
2078408
2190604
2190605
2341717
2538505
2549987
2550671
2829022
2829023
7592573
7618285
7687306
7690418
7693970
7734186
7904348
7904656
8139010
8363802
8419649
8464887
8510207
8663408
8827217
8906988
9658072
11533181
11827520
12943795
16702010
17413690
17526486
17959679
18045872
18524826
20197275
20494390
21957314
21994452
22117536
22284360
23616655
24131720
24145278
24198429
24284318
24965454
258493671352879
1354681
1354808
1376134
1382339
1489581
1551875
1592430
1711118
1717587
1931230
2062847
3682024
7494500
7616571
7692087
7737288
7831801
8102473
8356059
8419649
8460995
8615021
8649438
8811198
8827218
8977179
10557278
11311058
11413337
15665647
16611063
16736946
17320923
19553524
20186035
21152581
22083481
22524483
22551420
22559037
23176398
23209523
23300605
23692808
23931277
24304511
24390333
24502450
256396211370558
1493050
1549584
1698804
2076345
2111957
2136376
2536098
8122371
8160267
8416385
8627264
15183057
230872261373203
1378510
1381201
1381399
1438278
1503822
1614536
1690236
1691226
1698911
1701782
1702842
1706342
1757107
1888898
1977427
1983967
2040664
2078408
2198840
2461565
2482055
2537355
2555159
2571187
3029227
3260352
7506554
7544051
7592573
7685405
7686944
7690724
7769687
7904351
8196669
8363802
8464887
8497074
8615032
8827217
9739096
12477840
12943795
14505925
14592765
15168796
15321703
15650196
15893666
16106369
16426633
16616288
16702010
17158233
17239419
17721546
18205925
18237398
18296630
18377648
18668044
18704932
19478876
19965434
20357769
20463063
20463957
20507591
20558728
20610714
20860805
21110955
21152581
21289125
21351734
21357743
21382342
21487012
21593147
21660189
21760891
21957314
21994452
22329717
22551420
22553332
23300605
23616655
23692808
23776539
23924998
24758333
24846288
24884925
25058619
25215485
25298114
25341782
25522326
25803681
258105371373549
12885233
226966491402655
7589091
7754236
7913036
8547064
8801439
9344703
9604776
168296071457205
1465431
1713692
1888898
1889086
1967269
1978941
1203393714739941
157190261537337
1551875
1931230
197152615572157
156134791567578
2243375
2249742115778371
2188074916148047
1691226
1701782
1730924
1732513
2018763
2078013
2103853
2198840
2402498
2453925
2461565
2479005
2482055
2541915
2559777
3260352
3261864
8411350
8986758
10779509
12033937
16331979
17251298
21827143
232095231691563
7521897
7537501
7576913
8043225
8102473
9451022
9918507
1579785517030448
1711033
1889086
2549633
2555159
8075984
1153581117132727
17157668
191032081721822
1910691
1977427
21875001721822
1910691
2339113
18590744
21465559
226966491732513
2249742117344303
17360741
19813706
24489681
258493671738091
1757107
1763044
17653867
1810199
18480458
18566427
18590744
18668044
2580724818837996
1896455
1995942
2006155
2251501
7515973
7678271
7693970
7904348
7904656
8437224
8627160
8906988
12719560
21715496
23152926
23237851
23267106
23658524
23757493
2414682919018669
19066282
19366992
19478876
19535453
19734912
19851458
20080564
2015114
20227370
20420669
2045792
247578020730055
20980513
21041720
2107024
2115689
21613393
21697467
2182910
21931551
22006924
22606344
22624045
23840566
24134524
2531368922674993
22687513
22959895
23255784
2335819
2538547
7832633
8129620
8160267
8419650
8438588
1243861123742646
2402498
232095232441877
2482055
2550679
2558637
2559777
12477867
1631504024489681
24550395
24778234
24931470
2500722225298114
2550679
25915507
25972534
2842778
7506554
7774645
7914230
8125527
9043947
93447037522245
9036944
9123823
224332507541827
7589091
7589092
7897355
7897356
7906657
8105835
8738430
8806567
8891109
113978087821926
78670807903479
8331723
8497077
18837996
208740888411350
8599832
8887682
9377118
Tat downregulates 18432409
20139419
24717285
Envelope surface glycoprotein gp120 enhances 24778234
Vpu interacts with 20179761
2425774820442859
21176220
23831603
2482205222090097
23863698
24036078
24352444
Envelope transmembrane glycoprotein gp41 complexes with 8882662
10776787
12525600
14505910
14624372
14640682
15161081
15258189
15308751
15542675
17010381
17599917
17728240
18187620
18205925
18242797
18353949
18468560
18672260
18715908
18977142
18991615
19019953
19180463
19671162
19851458
20007245
20088758
20195464
20501362
20570309
20961591
21041720
21660189
21760891
21875413
22006924
22069466
22479399
23043103
23468626
24352444
25193376
25231990
25296251
25296255
25569556
25807248
Envelope surface glycoprotein gp120 cooperates with 20835359
Vpu binds 22863293
23514615
Vpu regulates 1727486
7961587
18672082
24400003
Vif interacts with 8924209
22017399
Vpu induces accumulation of 22090097
Envelope surface glycoprotein gp120 enhanced by 20458450
2094365320943653
20974843
Envelope surface glycoprotein gp120 induces phosphorylation of 3259291
Envelope surface glycoprotein gp160; precursor downregulates 22171785
8178478
8661397
16873261
18390744
221717858661397
Envelope surface glycoprotein gp120 mutation confers independence from 26246571
Vpr downregulates 11024150
16354571
17652391
1927558617652391
18987145
Nef enhances 18715908
Vpu inhibited by 10559275
24574397
Envelope surface glycoprotein gp120 stabilized by 25762739
Tat upregulates 2845147
16354571
17001685
Envelope transmembrane glycoprotein gp41 enhanced by 20974843
Pr55(Gag) interacts with 21060818
24307588
25320323
Envelope transmembrane glycoprotein gp41 binds 19851458
21041720
23217195
24931470
2500722225972534
Nef modulates 11396948
14557639
Envelope surface glycoprotein gp120 relocalizes 11799176
Nef downregulates 10375525
1037552810451539
11581379
11932428
12816953
12842621
17083721
23170180
23202450
2321576610684310
1252564711438519
11602785
13679604
14670336
15166428
15166429
15194762
15202998
1872593815494497
1565858
2014052
3118220
7902127
7903128
8437228
15638726
16454711
17329339
17586321
17632197
17632570
17652391
17824250
17904606
17947540
18438604
18473783
18541215
18725938
18808677
19129443
19146681
19149577
19324886
19327048
19403684
19439470
19449444
19643141
19770068
19895210
19917496
20012528
20380698
20463068
20465832
20594957
20638642
20826747
20881088
21068258
21165790
21482738
21543478
21845735
21861776
21917951
22013062
22103831
22103832
22103833
22103834
22103838
22171785
22175768
22291690
22301137
22301152
22345473
22479639
22640559
22808111
22844345
22980333
23151229
23170180
23202450
23215766
23289738
23490051
23847689
23853598
23986795
24023945
24041011
24058696
24172637
24187576
24352444
24465014
24473078
24489825
24495362
24620746
24705461
24706755
24748005
24789790
24904546
24965469
25062432
25118280
25193656
25275127
25423108
25496667
25505066
25525794
25807049
25827531
25972534
26423947
2643986315722538
16116206
1726750016365153
16439540
21165790
23170180
23202450
2321576616979207
2116579017652391
17947540
18523251
2148273818987145
19146681
19439470
19781555
19781555
2014052
20465832
2280811120739067
21543478
21917951
23151229
23151229
2447307823289738
24041011
24473078
24620746
24965469
25972534
26215564
7769669
158549037831289
7871751
8035515
8151774
10208934
16354571
16454711
194394707831289
8124721
8151774
11463741
15854903
18473783
18541215
216254967975260
7983750
8057354
115786958262036
16454711
221038368331733
8437228
8516299
21165790
240410118599214
8709227
8871625
216254969049297
9473011
12734410
12836198
14965316
15078178
16091223
16310238
16354571
16454711
16476977
16684552
16873261
17042973
17077296
17170457
17267500
17346169
17632570
18438604
18473783
18541215
18808677
20012528
219220739052838
9811606
9811611
17947540
20622010
231512299168885
9168885
197815559923610
Envelope surface glycoprotein gp160; precursor complexes with 1727486
2111957
2214026
8409933
86613971727486
7961587
8091666
Vpu relocalizes 24257748
Envelope surface glycoprotein gp120 downregulates 10941932
1491632
1535086
1622897
2040625
7545243
7774645
7821926
8862276
9473011
9621091
10941932
16873261
16886061
20380698
22291690
243524441970444
790631420739067
8707350
11290759
Nef interacts with 15956605
20179761
20659345
24352444
26423947
Envelope transmembrane glycoprotein gp41 interacts with 11861835
17653867
17728240
22553332
2321937621255440
21444771
22606344
22854780
24075869
2505861924766462
25231990
25569556
7688299
18242797
Nef degrades 19403684
25118280
7982906
10199403
11264386
18725938
Envelope surface glycoprotein gp120 cleavage induced by 8474162
HIV-1 virus replication enhanced by expression of human gene 18187620
22404213
2510071918976975
25973004
25973004
Envelope surface glycoprotein gp120 complexes with 10089882
11069996
11327825
17507486
20166763
21351734
21994672
23692808
2469647511711593
17269928
8605026
8948487
12769725
12930892
12970437
14967033
15016894
15051887
15109676
15113923
15180540
15180541
15194768
15258189
15321703
15577644
15729334
15778371
15807900
15857997
15956589
15996703
16002156
16103167
16185162
16309726
16515489
17251303
17328229
17676933
17825297
18624812
19000821
20162270
21152581
21193846
23153179
23278399
23308369
23541872
23692808
23862963
23931277
24039179
246143868629022
8805353
8849450
9499113
9499115
9600268
9601645
9614108
9632631
9653051
9658081
9696823
9721247
9770524
9780207
9826718
10074122
10329539
10358157
10364484
10371171
10393974
10430052
10446313
10482576
10559349
10582593
10590121
10600606
10738970
10816381
10875613
11024154
11069996
11086073
11201791
11264367
11265761
11287575
11333905
11356967
11397808
11413305
11489906
11504923
11602639
11752220
11799176
11861874
11876757
11877445
11878912
11884536
11931835
11967288
12120995
12163558
12368322
12402167
12429712
12429730
12502809
12614324
12634405
12713058
12832058
12845769
12857973
12864967
12871111
12873765
12953261
12960231
12963807
14576059
14592831
14990703
15014135
15018709
15113900
15113923
15215692
15258189
15585836
15737612
15748209
15784911
15890935
15990565
16046522
16047221
16103167
16174727
16188969
16227248
16886053
16886061
17121788
17144914
17187670
17251303
17292399
17346946
17507486
18032634
18197116
18310503
18500445
18624812
18691022
18833294
18976462
19493998
19692474
19926478
20041213
20051874
20697919
20967243
21152581
21284899
21284907
21310296
21474836
21760891
21994458
21994672
22157596
22163344
22178016
22226668
22237899
22297516
22422068
22470838
22583677
22732432
22783935
22908191
22947176
23043103
23043104
23143844
23211775
23304142
23692808
23804632
24039179
24145278
24312168
24441862
25193376
25231990
25463598
258801108674119
8805353
8898753
8906795
8906796
8976200
9420225
9445013
9525683
9576954
9632396
9653051
9870313
10393974
10446313
10590121
10623731
10644351
10738970
10774549
10816381
10888615
11024154
11069996
11118070
11201791
11238869
11264367
11265761
11312658
11356961
11356967
11397808
11413305
11489906
11504923
11861874
11876757
11877445
11878912
11884536
11906183
11967288
12120995
12163558
12368322
12392548
12429712
12429730
12441808
12610158
12634405
12692222
12845769
12857973
12871111
12873765
12887918
12960231
12963807
14512572
14517611
14592765
14967033
14990703
15018709
15113926
15194768
15215692
15258189
15321703
15767435
15767436
15784911
15807900
15857992
15890935
15956589
15964018
15983047
16002156
16103167
16282475
16300985
16702010
16753228
16775320
16817962
17030448
17035237
17121788
17239419
17328229
17485285
17507486
17628860
18197116
18310503
18480458
18500445
18590744
18619974
18624812
18672260
18691022
18786994
18833294
18976462
19144136
19170639
19553323
19692476
19692480
20041213
20051874
20229778
20377425
20494390
20657663
21152581
21284899
21284907
21310296
21325401
21647388
21760891
21763489
21793507
21994458
21994672
22157596
22163344
22178016
22297516
22421880
22422068
22470838
22547820
22583677
22693444
22732432
22733823
22783935
22818780
22908191
22947176
23011758
23043103
23043104
23143844
23211775
23217618
23269796
23304142
23616655
23692808
24145278
24307580
24312168
24441862
24454812
24788065
25174000
25193376
25231990
25463598
258801109261346
9334377
11333905
12887918
15857992
16702010
16777164
16796521
16817962
17053352
17239419
18833294
21325401
21351734
21760891
21994672
22291921
22547820
23692808
Tat inhibits 24717285
Nef downmodulates 26423947
Envelope surface glycoprotein gp120 inhibited by 11704677
120080441918997
8801439
96047768369162
Vpu downregulates 12746459
12842621
17121803
17346169
18579178
18672082
18789977
19917496
20201792
21176220
21310048
21922073
22291690
22301152
22357275
22980333
23218949
23831603
24352444
24551192
24822052
25275127
25827531
2587290815975620
2117622017121803
19149577
20201792
21176220
2131004817937819
20201792
21176220
2482205218579178
2020179219917496
20201792
21176220
23308067
2351461519944437
2117622020442859
2117622021607084
22090097
22171785
22222210
22357275
23047923
23201263
24465210
24465210
2457439726215564
26439863
Vpu depends on 26215564
Envelope surface glycoprotein gp120 requires 1281202
1348943
1370558
1370739
1376135
1380099
1457207
1501286
1527858
1546447
1548744
1548769
1602552
1622897
1627247
1636088
1706342
1709701
1720627
1721822
1742075
1845049
1870202
1899141
1910691
1985197
1995942
2109100
2374593
2830667
2995487
3001934
3016552
3095663
3257102
6096719
7592573
7618285
7688827
7707502
7737288
7754236
7897356
8129620
8160267
8280475
8331723
8361381
8437234
8510207
8551601
8560767
8726523
8806567
8891109
8892926
9349472
12406507
12885233
17084877
18837996
2458323517121788

Metabolic/Signalling Pathway       (annotations from KEGG database)      top

Pathway Accession Number Description
hsa04514 Cell adhesion molecules (CAMs) - Homo sapiens (human)
hsa04612 Antigen processing and presentation - Homo sapiens (human)
hsa04640 Hematopoietic cell lineage - Homo sapiens (human)
hsa04658 Th1 and Th2 cell differentiation - Homo sapiens (human)
hsa04659 Th17 cell differentiation - Homo sapiens (human)
hsa04660 T cell receptor signaling pathway - Homo sapiens (human)
hsa05340 Primary immunodeficiency - Homo sapiens (human)
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