Detailed entry information

Protein Information (annotations from UniProt)

Database IDHIV0000527
UniProt IDP06729
Primary gene name(s)CD2
Synonym gene name(s)SRBC
Protein nameT-cell surface antigen CD2
Protein functionCD2 interacts with lymphocyte function-associated antigen, LFA-3 and CD48/BCM1 to mediate adhesion between T-cells and other cell types. CD2 is implicated in the triggering of T-cells, the cytoplasmic domain is implicated in the signaling function.
Subcellular locationMembrane;
Single-pass type I membrane protein.
ECO codeClick here for more information.
Amino acid sequence
FASTA format: P06729
Gene Ontology
(Biological Process)
Complete annatation
apoptotic process [GO:0006915];
cell surface receptor signaling pathway [GO:0007166];
heterotypic cell-cell adhesion [GO:0034113];
leukocyte migration [GO:0050900];
membrane raft polarization [GO:0001766];
natural killer cell activation [GO:0030101];
positive regulation of interferon-gamma secretion [GO:1902715];
positive regulation of interleukin-8 secretion [GO:2000484];
positive regulation of myeloid dendritic cell activation [GO:0030887];
positive regulation of tumor necrosis factor production [GO:0032760];
regulation of T cell differentiation [GO:0045580];
single organismal cell-cell adhesion [GO:0016337];
T cell activation [GO:0042110]
Gene Ontology
(Molecular Function)
Complete annatation
receptor activity [GO:0004872];
receptor binding [GO:0005102]
Gene Ontology
(Cellular Component)
Complete annatation
anchored component of plasma membrane [GO:0046658];
cell-cell junction [GO:0005911];
cell surface [GO:0009986];
cytoplasmic side of plasma membrane [GO:0009898];
external side of plasma membrane [GO:0009897];
extracellular region [GO:0005576];
integral component of plasma membrane [GO:0005887];
plasma membrane [GO:0005886]
Protein-protein interaction107352
Phylogenetic treeP06729
HIV replication factor status Zhou et al., Cell. Host. Microbe., 2008
Brass et al., Science, 2008
Smith et al., J. Immunol, 2010
gene status
Lu et al., J. Virol., 2011
      Folds changes 8h: unknown; Folds changes 16h: unknown; Tested: unknown;
Schoggins JW and Rice CM, Curr. Opin. Virol., 2011
      Targeted viruses: unknown
      Viral life cycle: unknown
      Mechanism related to antiviral activity: unknown
Anti-viral restriction factor Liu et al., Retrovirology, 2011
      unknown (Triplicates)

Gene Expression Profile       top

            Up-regulated;            Down-regulated

For brief introduction to each study, please go to the help page.

Gene expression during HIV latency

(1). Mohammadi et al., PLoS Pathog., 2014

Differentially expressed transcripts (Pairwise) during latency and subsequent viral reactivation using several agents - Primary CD4+ T-cell based model

DMSO: Dimethyl suloxyde (negative control) - 0.0033% final
SAHA: Vorinostat (Histone deacetylase inhibitor) - 0.5 μM
CD3: TCR Stimulation by IL-2+ antiCD3/anti-CD28 antibodies
IL7: Interleukin-7 based stimulation
DISU: Disulfiram (alcohol dehydrogenase inhibitor) - 0.5 μM
AZA: 5-azacytidine (AZA; DNA methylation inhibitor) - 1 μM
Experimental Condition Log2 Fold Change P value Adjusted P value
AZA vs. CD30.7769969430804720.01814151264023380.0429852033506687
AZA vs. DISU-0.2254239574758240.3720843173971190.897838802696361
AZA vs. IL7-0.2909405925063420.1292719675504060.897328354403451
AZA vs. SAHA-0.3294007828595460.1787835195685460.539860331325374
DISU vs. CD3-1.014023343861690.005509322648312940.0175650443317828
DISU vs. IL7-0.07548336570634450.7640781098318290.94460205885803
DISU vs. SAHA-0.1017166108713790.7289629535945660.920459248834197
DMSO vs. AZA-0.03877771413871210.8161769173875471
DMSO vs. CD3-0.8253375270291010.01022601753411020.0254006519623035
DMSO vs. DISU0.1853424820934610.4466528736565850.887076202001854
DMSO vs. IL7-0.2452661188336410.1713857575635230.681879201707603
DMSO vs. SAHA-0.2963341732918140.2107314603118410.552913272694943
HIV vs. Mock in Activation-0.4175103998240130.5022175582769660.999983755607037
HIV vs. Mock in Latency0.2716975957496170.09851859951971280.999834320637052
IL7 vs. CD3-1.061833052073710.001064449591392290.00447419093448299
SAHA vs. CD3-1.129216450722880.00172526013229690.00570418389506676
SAHA vs. IL7-0.04072193011099710.8674882207573380.945384526563016
(2). Iglesias-Ussel et al., J. Virol., 2013

Up and Downregulated transcripts during Latency (Latently infected CD4+ T cells vs Uninfected)- Primary CD4+Tcell based model
Log2 Fold Change P Value
0.4224 0.0297

Gene expression during HIV infection and replication

(1). Imbeault et al., PloS Pathog., 2012

Transcriptomic profiling of HIV-1 infected CD4+ T cells - Primary CD4+ T cells
Experiment type Log2 Fold Change P Value Adjusted P Value
Infected vs. Mock unknown unknown unknown
Infected vs. Bystander unknown unknown unknown
(2). Lefebvre et al., J. Virol., 2011

Transcriptome analysis of T-cell line (Sup T1)
Log2 Fold Change unknown
(3). Li et al., J. Immunol., 2013

Lymphatic tissue
Acute Fold Change Acute P Value Asymt Fold Change Asypt P Value AIDS Fold Change AIDS P Value
1 0.87796452 -1.4 0.00833792 -2 0.003307401
(4). Chang et al., MBio., 2011

Transcriptome analysis of T-cell line (Sup T1)

Derived from Sherrill-Mix et al., BMC Retrovirol., 2015 cross validation
Up-regulated (True) FALSE
(5). Sherrill-Mix et al., BMC Retrovirol., 2015

Deep RNA-seq analysis of primary human T cell infected with low passage HIV isolate HIV89.6 - Primary CD4+ T cell based
Test Status Log2 Fold Change P Value
OK 1.72147 0.000305467
(6). Rotger et al., PLoS Pathog., 2010

Genome-wide mRNA expression of CD4+ T cells from HIV-infected patient
(Genes differentially expressed (at adjusted p<0.01) according to the empirical Bayes approach)
Log2 Fold Change P Value
unknown unknown

Proteomic/Transcriptomics studies indicating differentially expressed genes mediated by HIV

(1). Greenwood et al., Elife, 2016

Activated (CD3/CD28) Primary human CD4+ T cells infected with pNL4-3-dE-EGFP. The table shows the complete (unfiltered) TMT (tandem mass tag)-based proteomic time course dataset
6 h 24 h 48 h 72 h RTi
unknown unknown unknown unknown unknown
(2). Navare et al., Virology, 2012

SUP-T1 cell line
FC-4hpi P-value FC-8hpi P-value FC-20hpi P-value Category
unknown unknown unknown unknown unknown unknown unknown
(3). Hyrcza et al., J. Virolo., 2007

Primary human CD4+ and CD8+ T Cells
Affymetrix Prob ID Fold Change In CD8? Category
unknown unknown unknown unknown

Protein Overview       top

Drug-protein Interaction       (annotations from DrugBank)      top

Drugbank ID Drug Name Drug Status Pharmacological Action Drug Action
DB00092 Alefacept approved, withdrawn yes inhibitor

Protein Secondary Structure       (annotations from PDB)      top

PDB Accession Method Resolution Chain Structure Preview
1CDB NMR - A=25-129.
1GYA NMR - A=25-129.
1HNF X-ray 2.5Å A=25-206.
1L2Z NMR - B=294-304.
1QA9 X-ray 3.2Å A/C=28-129.
2J6O X-ray 2.2Å C=324-333.
2J7I X-ray 2.9Å C/D=324-333.

HIV-1 Interaction       (annotations from NCBI HIV-1 Interaction Database)      top

HIV Partner Interaction Type PubMed
nucleocapsid downregulates 18051367
Envelope surface glycoprotein gp120 interacts with 9475352
Envelope surface glycoprotein gp120 inhibited by 7589092
Envelope transmembrane glycoprotein gp41 inhibits 1832084
capsid interacts with 1385321

Metabolic/Signalling Pathway       (annotations from KEGG database)      top

Pathway Accession Number Description
hsa04514 Cell adhesion molecules (CAMs) - Homo sapiens (human)
hsa04640 Hematopoietic cell lineage - Homo sapiens (human)