Detailed entry information

Protein Information (annotations from UniProt)

Database IDHIV0000510
UniProt IDP78371
Primary gene name(s)CCT2
Synonym gene name(s)99D8.1, CCTB
Protein nameT-complex protein 1 subunit beta
Protein functionMolecular chaperone; assists the folding of proteins upon ATP hydrolysis. As part of the BBS/CCT complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. Known to play a role, in vitro, in the folding of actin and tubulin. {ECO:0000269|PubMed:20080638}.
Subcellular locationCytoplasm {ECO:0000269|PubMed:20080638}.
ECO codeClick here for more information.
Amino acid sequence
FASTA format: P78371
Gene Ontology
(Biological Process)
Complete annatation
binding of sperm to zona pellucida [GO:0007339];
chaperone-mediated protein complex assembly [GO:0051131];
chaperone mediated protein folding independent of cofactor [GO:0051086];
positive regulation of establishment of protein localization to telomere [GO:1904851];
positive regulation of protein localization to Cajal body [GO:1904871];
positive regulation of telomerase activity [GO:0051973];
positive regulation of telomerase RNA localization to Cajal body [GO:1904874];
positive regulation of telomere maintenance via telomerase [GO:0032212];
protein folding [GO:0006457];
protein stabilization [GO:0050821];
scaRNA localization to Cajal body [GO:0090666];
toxin transport [GO:1901998]
Gene Ontology
(Molecular Function)
Complete annatation
ATP binding [GO:0005524];
protein binding involved in protein folding [GO:0044183];
ubiquitin protein ligase binding [GO:0031625];
unfolded protein binding [GO:0051082]
Gene Ontology
(Cellular Component)
Complete annatation
cell body [GO:0044297];
chaperonin-containing T-complex [GO:0005832];
cytoplasm [GO:0005737];
cytosol [GO:0005829];
extracellular exosome [GO:0070062];
microtubule [GO:0005874];
myelin sheath [GO:0043209];
zona pellucida receptor complex [GO:0002199]
Protein-protein interaction115827
Phylogenetic treeP78371
HIV replication factor status Zhou et al., Cell. Host. Microbe., 2008
      Yes - Two siRNA pools inhibit HIV replication and inhibition of Tat-mediated transactivation of the HIV LTR is also observed
Brass et al., Science, 2008
      unknown
Smith et al., J. Immunol, 2010
      unknown
Interferon-stimulated
gene status
Lu et al., J. Virol., 2011
      Folds changes 8h: unknown; Folds changes 16h: unknown; Tested: unknown;
Schoggins JW and Rice CM, Curr. Opin. Virol., 2011
      Targeted viruses: unknown
      Viral life cycle: unknown
      Mechanism related to antiviral activity: unknown
Anti-viral restriction factor Liu et al., Retrovirology, 2011
      unknown (Triplicates)

Gene Expression Profile       top

            Up-regulated;            Down-regulated

For brief introduction to each study, please go to the help page.

Gene expression during HIV latency

(1). Mohammadi et al., PLoS Pathog., 2014

Differentially expressed transcripts (Pairwise) during latency and subsequent viral reactivation using several agents - Primary CD4+ T-cell based model


DMSO: Dimethyl suloxyde (negative control) - 0.0033% final
SAHA: Vorinostat (Histone deacetylase inhibitor) - 0.5 μM
CD3: TCR Stimulation by IL-2+ antiCD3/anti-CD28 antibodies
IL7: Interleukin-7 based stimulation
DISU: Disulfiram (alcohol dehydrogenase inhibitor) - 0.5 μM
AZA: 5-azacytidine (AZA; DNA methylation inhibitor) - 1 μM
Experimental Condition Log2 Fold Change P value Adjusted P value
AZA vs. CD32.26749103254583.45922179789682e-116.58300390630061e-10
AZA vs. DISU-0.1205006019204380.6333433730080150.960057478314726
AZA vs. IL70.5127435714103960.00768648607589550.275198110741028
AZA vs. SAHA-0.04593827014239310.8504112387554430.964571417122945
DISU vs. CD3-2.400491124542992.89398061070756e-106.57976828443525e-09
DISU vs. IL70.6244980749134550.01339045460413620.140571798856096
DISU vs. SAHA0.0751280795622490.7962658691238790.946472767948132
DMSO vs. AZA-0.079611022455430.6340633090782941
DMSO vs. CD3-2.359644479300671.98419058961008e-124.13441649135212e-11
DMSO vs. DISU0.03866926775330330.8739175075512150.987029666401619
DMSO vs. IL70.599846620266630.0008633960195126860.050842558570913
DMSO vs. SAHA0.02668091063204560.9097596810589980.978866863228397
HIV vs. Mock in Activation-0.1846878087144730.7662750273346280.999983755607037
HIV vs. Mock in Latency-0.1214863877658760.461364446063420.999834320637052
IL7 vs. CD3-1.745949920043371.20021280025639e-071.43577837605275e-06
SAHA vs. CD3-2.339029434564572.65804156462934e-105.08333583489393e-09
SAHA vs. IL7-0.5625377586583530.02105057542921860.104015314425225
(2). Iglesias-Ussel et al., J. Virol., 2013

Up and Downregulated transcripts during Latency (Latently infected CD4+ T cells vs Uninfected)- Primary CD4+Tcell based model
Log2 Fold Change P Value
-0.4006 0.03609

Gene expression during HIV infection and replication

(1). Imbeault et al., PloS Pathog., 2012

Transcriptomic profiling of HIV-1 infected CD4+ T cells - Primary CD4+ T cells
Experiment type Log2 Fold Change P Value Adjusted P Value
Infected vs. Mock unknown unknown unknown
Infected vs. Bystander unknown unknown unknown
(2). Lefebvre et al., J. Virol., 2011

Transcriptome analysis of T-cell line (Sup T1)
Log2 Fold Change -1.09021158
(3). Li et al., J. Immunol., 2013

Lymphatic tissue
Acute Fold Change Acute P Value Asymt Fold Change Asypt P Value AIDS Fold Change AIDS P Value
unknown unknown unknown unknown unknown unknown
(4). Chang et al., MBio., 2011

Transcriptome analysis of T-cell line (Sup T1)

Derived from Sherrill-Mix et al., BMC Retrovirol., 2015 cross validation
Up-regulated (True) FALSE
(5). Sherrill-Mix et al., BMC Retrovirol., 2015

Deep RNA-seq analysis of primary human T cell infected with low passage HIV isolate HIV89.6 - Primary CD4+ T cell based
Test Status Log2 Fold Change P Value
OK 0.360622 0.00605069
(6). Rotger et al., PLoS Pathog., 2010

Genome-wide mRNA expression of CD4+ T cells from HIV-infected patient
(Genes differentially expressed (at adjusted p<0.01) according to the empirical Bayes approach)
Log2 Fold Change P Value
unknown unknown

Proteomic/Transcriptomics studies indicating differentially expressed genes mediated by HIV

(1). Greenwood et al., Elife, 2016

Activated (CD3/CD28) Primary human CD4+ T cells infected with pNL4-3-dE-EGFP. The table shows the complete (unfiltered) TMT (tandem mass tag)-based proteomic time course dataset
6 h 24 h 48 h 72 h RTi
0.984 0.989 0.955 0.921 0.93
(2). Navare et al., Virology, 2012

SUP-T1 cell line
FC-4hpi P-value FC-8hpi P-value FC-20hpi P-value Category
unknown unknown unknown unknown unknown unknown unknown
(3). Hyrcza et al., J. Virolo., 2007

Primary human CD4+ and CD8+ T Cells
Affymetrix Prob ID Fold Change In CD8? Category
unknown unknown unknown unknown

Protein Overview       top

Drug-protein Interaction       (annotations from DrugBank)      top

not found

Protein Secondary Structure       (annotations from PDB)      top

not found

HIV-1 Interaction       (annotations from NCBI HIV-1 Interaction Database)      top

HIV Partner Interaction Type PubMed
Envelope surface glycoprotein gp120 complexes with 23125841
Gag-Pol complexes with 23125841
Pr55(Gag) complexes with 23125841
Tat upregulates 23166591
HIV-1 virus replication enhanced by expression of human gene 18976975
Nef complexes with 23125841

Metabolic/Signalling Pathway       (annotations from KEGG database)      top

Pathway Accession Number Description
not found
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