Detailed entry information

Protein Information (annotations from UniProt)

Database IDHIV0000506
UniProt IDQ9UK58
Primary gene name(s)CCNL1
Synonym gene name(s)unknown
Protein nameCyclin-L1
Protein functionInvolved in pre-mRNA splicing. Functions in association with cyclin-dependent kinases, CDKs, PubMed:18216018. Inhibited by the CDK-specific inhibitor CDKN1A/p21, PubMed:11980906. May play a role in the regulation of RNA polymerase II, pol II. May be a candidate proto-oncogene in head and neck squamous cell carcinomas, HNSCC, PubMed:12414649, PubMed:15700036. {ECO:0000269|PubMed:11980906, ECO:0000269|PubMed:12414649, ECO:0000269|PubMed:15700036, ECO:0000269|PubMed:18216018}.
Subcellular locationNucleus speckle {ECO:0000269|PubMed:18216018}. Nucleus, nucleoplasm {ECO:0000269|PubMed:18216018}. Note=Found in nuclear intrachromatin granules clusters, IGC, also called nuclear speckles, which are storage compartments for nuclear proteins involved in mRNA processing. {ECO:0000250}.
ECO codeClick here for more information.
Amino acid sequence
FASTA format: Q9UK58
Gene Ontology
(Biological Process)
Complete annatation
positive regulation of cyclin-dependent protein serine/threonine kinase activity [GO:0045737];
positive regulation of phosphorylation of RNA polymerase II C-terminal domain [GO:1901409];
positive regulation of transcription from RNA polymerase II promoter [GO:0045944];
RNA processing [GO:0006396];
transcription, DNA-templated [GO:0006351]
Gene Ontology
(Molecular Function)
Complete annatation
cyclin-dependent protein serine/threonine kinase regulator activity [GO:0016538]
Gene Ontology
(Cellular Component)
Complete annatation
cyclin-dependent protein kinase holoenzyme complex [GO:0000307];
nuclear speck [GO:0016607];
nucleus [GO:0005634]
Protein-protein interaction121327
Phylogenetic treeQ9UK58
HIV replication factor status Zhou et al., Cell. Host. Microbe., 2008
Brass et al., Science, 2008
Smith et al., J. Immunol, 2010
gene status
Lu et al., J. Virol., 2011
      Folds changes 8h: unknown; Folds changes 16h: unknown; Tested: unknown;
Schoggins JW and Rice CM, Curr. Opin. Virol., 2011
      Targeted viruses: unknown
      Viral life cycle: unknown
      Mechanism related to antiviral activity: unknown
Anti-viral restriction factor Liu et al., Retrovirology, 2011
      unknown (Triplicates)

Gene Expression Profile       top

            Up-regulated;            Down-regulated

For brief introduction to each study, please go to the help page.

Gene expression during HIV latency

(1). Mohammadi et al., PLoS Pathog., 2014

Differentially expressed transcripts (Pairwise) during latency and subsequent viral reactivation using several agents - Primary CD4+ T-cell based model

DMSO: Dimethyl suloxyde (negative control) - 0.0033% final
SAHA: Vorinostat (Histone deacetylase inhibitor) - 0.5 μM
CD3: TCR Stimulation by IL-2+ antiCD3/anti-CD28 antibodies
IL7: Interleukin-7 based stimulation
DISU: Disulfiram (alcohol dehydrogenase inhibitor) - 0.5 μM
AZA: 5-azacytidine (AZA; DNA methylation inhibitor) - 1 μM
Experimental Condition Log2 Fold Change P value Adjusted P value
AZA vs. CD3-0.2770260324014090.4002737013920180.521789070003503
AZA vs. DISU0.1074315325162580.6703530821840490.964024266441743
AZA vs. IL7-0.04317932564152640.8217707862416450.999311006273513
AZA vs. SAHA0.2134375506792430.3822759658140640.746235160409375
DISU vs. CD30.3704842655176170.3092783341604490.441437703595508
DISU vs. IL7-0.1590896674295120.5268261811957190.840724509849313
DISU vs. SAHA0.106992714578220.7136092346709850.915550590566598
DMSO vs. AZA0.05928455334017810.7224111269985971
DMSO vs. CD30.3237567848506610.313347974371480.425354769679793
DMSO vs. DISU-0.05011866489871680.8368637853625330.981844704166786
DMSO vs. IL7-0.09506088903458160.5958560346868960.911469276804156
DMSO vs. SAHA0.1473206409300710.5319717328700060.829574721334815
HIV vs. Mock in Activation-0.03600634396759990.9538000804511350.999983755607037
HIV vs. Mock in Latency-0.05050350846165270.7936884308833950.999834320637052
IL7 vs. CD30.242284608171980.4527157303744680.586638944629845
SAHA vs. CD30.4653527279225460.1880699641659930.28776671337004
SAHA vs. IL70.2521286727384790.3008409987322160.549548862686551
(2). Iglesias-Ussel et al., J. Virol., 2013

Up and Downregulated transcripts during Latency (Latently infected CD4+ T cells vs Uninfected)- Primary CD4+Tcell based model
Log2 Fold Change P Value
0.7571 0.01001

Gene expression during HIV infection and replication

(1). Imbeault et al., PloS Pathog., 2012

Transcriptomic profiling of HIV-1 infected CD4+ T cells - Primary CD4+ T cells
Experiment type Log2 Fold Change P Value Adjusted P Value
Infected vs. Mock unknown unknown unknown
Infected vs. Bystander unknown unknown unknown
(2). Lefebvre et al., J. Virol., 2011

Transcriptome analysis of T-cell line (Sup T1)
Log2 Fold Change unknown
(3). Li et al., J. Immunol., 2013

Lymphatic tissue
Acute Fold Change Acute P Value Asymt Fold Change Asypt P Value AIDS Fold Change AIDS P Value
unknown unknown unknown unknown unknown unknown
(4). Chang et al., MBio., 2011

Transcriptome analysis of T-cell line (Sup T1)

Derived from Sherrill-Mix et al., BMC Retrovirol., 2015 cross validation
Up-regulated (True) TRUE
(5). Sherrill-Mix et al., BMC Retrovirol., 2015

Deep RNA-seq analysis of primary human T cell infected with low passage HIV isolate HIV89.6 - Primary CD4+ T cell based
Test Status Log2 Fold Change P Value
OK 0.989048 0.000305467
(6). Rotger et al., PLoS Pathog., 2010

Genome-wide mRNA expression of CD4+ T cells from HIV-infected patient
(Genes differentially expressed (at adjusted p<0.01) according to the empirical Bayes approach)
Log2 Fold Change P Value
unknown unknown

Proteomic/Transcriptomics studies indicating differentially expressed genes mediated by HIV

(1). Greenwood et al., Elife, 2016

Activated (CD3/CD28) Primary human CD4+ T cells infected with pNL4-3-dE-EGFP. The table shows the complete (unfiltered) TMT (tandem mass tag)-based proteomic time course dataset
6 h 24 h 48 h 72 h RTi
1.018 0.923 0.823 0.732 0.768
(2). Navare et al., Virology, 2012

SUP-T1 cell line
FC-4hpi P-value FC-8hpi P-value FC-20hpi P-value Category
unknown unknown unknown unknown unknown unknown unknown
(3). Hyrcza et al., J. Virolo., 2007

Primary human CD4+ and CD8+ T Cells
Affymetrix Prob ID Fold Change In CD8? Category