Detailed entry information

Protein Information (annotations from UniProt)

Database IDHIV0000503
UniProt IDP41002
Primary gene name(s)CCNF
Synonym gene name(s)FBX1, FBXO1
Protein nameCyclin-F
Protein functionSubstrate recognition component of a SCF, SKP1-CUL1-F-box protein E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of CP110 during G2 phase, thereby acting as an inhibitor of centrosome reduplication. {ECO:0000269|PubMed:20596027}.
Subcellular locationNucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Note=Localization in the centrosome is rare in S phase cells and increases in G2 cells, Localizes on both the mother and daughter centrioles. Localization to centrosomes is not dependent on CP110. Also localizes to the nucleus.
ECO codeClick here for more information.
Amino acid sequence
FASTA format: P41002
Gene Ontology
(Biological Process)
Complete annatation
cell division [GO:0051301];
mitotic nuclear division [GO:0007067];
negative regulation of centrosome duplication [GO:0010826];
placenta development [GO:0001890];
protein ubiquitination [GO:0016567];
re-entry into mitotic cell cycle [GO:0000320];
SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031146]
Gene Ontology
(Molecular Function)
Complete annatation
Gene Ontology
(Cellular Component)
Complete annatation
centriole [GO:0005814];
nucleus [GO:0005634];
SCF ubiquitin ligase complex [GO:0019005]
Protein-protein interaction107339
Phylogenetic treeP41002
HIV replication factor status Zhou et al., Cell. Host. Microbe., 2008
Brass et al., Science, 2008
Smith et al., J. Immunol, 2010
gene status
Lu et al., J. Virol., 2011
      Folds changes 8h: unknown; Folds changes 16h: unknown; Tested: unknown;
Schoggins JW and Rice CM, Curr. Opin. Virol., 2011
      Targeted viruses: unknown
      Viral life cycle: unknown
      Mechanism related to antiviral activity: unknown
Anti-viral restriction factor Liu et al., Retrovirology, 2011
      unknown (Triplicates)

Gene Expression Profile       top

            Up-regulated;            Down-regulated

For brief introduction to each study, please go to the help page.

Gene expression during HIV latency

(1). Mohammadi et al., PLoS Pathog., 2014

Differentially expressed transcripts (Pairwise) during latency and subsequent viral reactivation using several agents - Primary CD4+ T-cell based model

DMSO: Dimethyl suloxyde (negative control) - 0.0033% final
SAHA: Vorinostat (Histone deacetylase inhibitor) - 0.5 μM
CD3: TCR Stimulation by IL-2+ antiCD3/anti-CD28 antibodies
IL7: Interleukin-7 based stimulation
DISU: Disulfiram (alcohol dehydrogenase inhibitor) - 0.5 μM
AZA: 5-azacytidine (AZA; DNA methylation inhibitor) - 1 μM
Experimental Condition Log2 Fold Change P value Adjusted P value
AZA vs. CD30.6308943721150440.05973398807615560.115542950241763
AZA vs. DISU0.07045677636215070.7847511339997080.978601802937756
AZA vs. IL70.04588714313521540.8183045024074830.999311006273513
AZA vs. SAHA0.340990145621210.2363570729192590.607591497803474
DISU vs. CD3-0.5725478472385260.1201650389297460.215459473870226
DISU vs. IL7-0.03348447732447960.8961529696203150.980682536591014
DISU vs. SAHA0.2720519672543440.3633418330438460.737124303158365
DMSO vs. AZA-0.02283444205340340.8970021529764721
DMSO vs. CD3-0.6688355295953150.04008813107549850.0798529280249087
DMSO vs. DISU-0.0970517797823680.6963878519791590.958803444206224
DMSO vs. IL70.0769896547012910.6803609861878210.934851394110377
DMSO vs. SAHA0.358092086338090.2286548416237040.575109665906348
HIV vs. Mock in Activation0.2050607789026010.7444645141742180.999983755607037
HIV vs. Mock in Latency-0.1590876744984490.3561256718908650.999834320637052
IL7 vs. CD3-0.5762983420838660.07713280329442280.154995699780941
SAHA vs. CD3-0.3158771193310050.4239169292174090.53842630622051
SAHA vs. IL70.2917019127684080.3392048568943010.588939646720191
(2). Iglesias-Ussel et al., J. Virol., 2013

Up and Downregulated transcripts during Latency (Latently infected CD4+ T cells vs Uninfected)- Primary CD4+Tcell based model
Log2 Fold Change P Value
unknown unknown

Gene expression during HIV infection and replication

(1). Imbeault et al., PloS Pathog., 2012

Transcriptomic profiling of HIV-1 infected CD4+ T cells - Primary CD4+ T cells
Experiment type Log2 Fold Change P Value Adjusted P Value
Infected vs. Mock unknown unknown unknown
Infected vs. Bystander unknown unknown unknown
(2). Lefebvre et al., J. Virol., 2011

Transcriptome analysis of T-cell line (Sup T1)
Log2 Fold Change unknown
(3). Li et al., J. Immunol., 2013

Lymphatic tissue
Acute Fold Change Acute P Value Asymt Fold Change Asypt P Value AIDS Fold Change AIDS P Value
unknown unknown unknown unknown unknown unknown
(4). Chang et al., MBio., 2011

Transcriptome analysis of T-cell line (Sup T1)

Derived from Sherrill-Mix et al., BMC Retrovirol., 2015 cross validation
Up-regulated (True) FALSE
(5). Sherrill-Mix et al., BMC Retrovirol., 2015

Deep RNA-seq analysis of primary human T cell infected with low passage HIV isolate HIV89.6 - Primary CD4+ T cell based
Test Status Log2 Fold Change P Value
OK 0.230612 0.0920975
(6). Rotger et al., PLoS Pathog., 2010

Genome-wide mRNA expression of CD4+ T cells from HIV-infected patient
(Genes differentially expressed (at adjusted p<0.01) according to the empirical Bayes approach)
Log2 Fold Change P Value
0.034 2.75E-04

Proteomic/Transcriptomics studies indicating differentially expressed genes mediated by HIV

(1). Greenwood et al., Elife, 2016

Activated (CD3/CD28) Primary human CD4+ T cells infected with pNL4-3-dE-EGFP. The table shows the complete (unfiltered) TMT (tandem mass tag)-based proteomic time course dataset
6 h 24 h 48 h 72 h RTi
unknown unknown unknown unknown unknown
(2). Navare et al., Virology, 2012

SUP-T1 cell line
FC-4hpi P-value FC-8hpi P-value FC-20hpi P-value Category
unknown unknown unknown unknown unknown unknown unknown
(3). Hyrcza et al., J. Virolo., 2007

Primary human CD4+ and CD8+ T Cells
Affymetrix Prob ID Fold Change In CD8? Category
204826_at 2.23 No upregulated in CD8+ cells

Protein Overview       top

Drug-protein Interaction       (annotations from DrugBank)      top

not found

Protein Secondary Structure       (annotations from PDB)      top

not found

HIV-1 Interaction       (annotations from NCBI HIV-1 Interaction Database)      top

not found

Metabolic/Signalling Pathway       (annotations from KEGG database)      top

Pathway Accession Number Description
not found