Detailed entry information

Protein Information (annotations from UniProt)

Database IDHIV0000501
UniProt IDO95067
Primary gene name(s)CCNB2
Synonym gene name(s)unknown
Protein nameG2/mitotic-specific cyclin-B2
Protein functionEssential for the control of the cell cycle at the G2/M, mitosis transition.
Subcellular locationunknown
ECO codeClick here for more information.
Amino acid sequence
FASTA format: O95067
Gene Ontology
(Biological Process)
Complete annatation
cell division [GO:0051301];
G2/M transition of mitotic cell cycle [GO:0000086];
growth [GO:0040007];
in utero embryonic development [GO:0001701];
mitotic nuclear division [GO:0007067];
mitotic nuclear envelope disassembly [GO:0007077];
regulation of cell cycle [GO:0051726];
T cell homeostasis [GO:0043029];
thymus development [GO:0048538]
Gene Ontology
(Molecular Function)
Complete annatation
cyclin-dependent protein serine/threonine kinase activity [GO:0004693]
Gene Ontology
(Cellular Component)
Complete annatation
centrosome [GO:0005813];
cytosol [GO:0005829];
membrane [GO:0016020];
microtubule cytoskeleton [GO:0015630];
nucleoplasm [GO:0005654]
Protein-protein interaction114581
Phylogenetic treeO95067
HIV replication factor status Zhou et al., Cell. Host. Microbe., 2008
Brass et al., Science, 2008
Smith et al., J. Immunol, 2010
gene status
Lu et al., J. Virol., 2011
      Folds changes 8h: unknown; Folds changes 16h: unknown; Tested: unknown;
Schoggins JW and Rice CM, Curr. Opin. Virol., 2011
      Targeted viruses: unknown
      Viral life cycle: unknown
      Mechanism related to antiviral activity: unknown
Anti-viral restriction factor Liu et al., Retrovirology, 2011
      unknown (Triplicates)

Gene Expression Profile       top

            Up-regulated;            Down-regulated

For brief introduction to each study, please go to the help page.

Gene expression during HIV latency

(1). Mohammadi et al., PLoS Pathog., 2014

Differentially expressed transcripts (Pairwise) during latency and subsequent viral reactivation using several agents - Primary CD4+ T-cell based model

DMSO: Dimethyl suloxyde (negative control) - 0.0033% final
SAHA: Vorinostat (Histone deacetylase inhibitor) - 0.5 μM
CD3: TCR Stimulation by IL-2+ antiCD3/anti-CD28 antibodies
IL7: Interleukin-7 based stimulation
DISU: Disulfiram (alcohol dehydrogenase inhibitor) - 0.5 μM
AZA: 5-azacytidine (AZA; DNA methylation inhibitor) - 1 μM
Experimental Condition Log2 Fold Change P value Adjusted P value
AZA vs. CD30.4208346436968660.6852676521086840.773659479594164
AZA vs. DISU-0.7540311633206620.1590061230377910.741012700423909
AZA vs. IL7-0.04433382472747320.9431722640895940.999311006273513
AZA vs. SAHA-0.6707329057761170.2336741245919490.605016103417904
DISU vs. CD3-1.18515127213390.2507417589466850.377552819334964
DISU vs. IL70.698655038527080.1807667277898020.550628090812541
DISU vs. SAHA0.08371565419959520.8466020565781720.959465754054541
DMSO vs. AZA-0.0794540642676650.8969318680013841
DMSO vs. CD3-0.5184259272613880.6159076306660220.709756632447305
DMSO vs. DISU0.6700778025025150.1846070204443440.700203440443708
DMSO vs. IL70.04317302054229130.9426627892259480.98911976609745
DMSO vs. SAHA-0.5959360222175030.2643140529021410.613238901698361
HIV vs. Mock in Activation0.4507866605883250.8192619659179410.999983755607037
HIV vs. Mock in Latency0.2732646232997470.628538171050510.999834320637052
IL7 vs. CD3-0.4570974371536270.6605783539449380.766454306753299
SAHA vs. CD3-1.117851190403720.2846359489283780.397835628858343
SAHA vs. IL7-0.6289756072965410.2526726877113480.496065133441112
(2). Iglesias-Ussel et al., J. Virol., 2013

Up and Downregulated transcripts during Latency (Latently infected CD4+ T cells vs Uninfected)- Primary CD4+Tcell based model
Log2 Fold Change P Value
unknown unknown

Gene expression during HIV infection and replication

(1). Imbeault et al., PloS Pathog., 2012

Transcriptomic profiling of HIV-1 infected CD4+ T cells - Primary CD4+ T cells
Experiment type Log2 Fold Change P Value Adjusted P Value
Infected vs. Mock unknown unknown unknown
Infected vs. Bystander unknown unknown unknown
(2). Lefebvre et al., J. Virol., 2011

Transcriptome analysis of T-cell line (Sup T1)
Log2 Fold Change unknown
(3). Li et al., J. Immunol., 2013

Lymphatic tissue
Acute Fold Change Acute P Value Asymt Fold Change Asypt P Value AIDS Fold Change AIDS P Value
3.4 0.000700294 1.9 0.025697711 2.2 0.117816525
(4). Chang et al., MBio., 2011

Transcriptome analysis of T-cell line (Sup T1)

Derived from Sherrill-Mix et al., BMC Retrovirol., 2015 cross validation
Up-regulated (True) FALSE
(5). Sherrill-Mix et al., BMC Retrovirol., 2015

Deep RNA-seq analysis of primary human T cell infected with low passage HIV isolate HIV89.6 - Primary CD4+ T cell based
Test Status Log2 Fold Change P Value
OK 0.302018 0.0267714
(6). Rotger et al., PLoS Pathog., 2010

Genome-wide mRNA expression of CD4+ T cells from HIV-infected patient
(Genes differentially expressed (at adjusted p<0.01) according to the empirical Bayes approach)
Log2 Fold Change P Value
0.072 2.98E-04

Proteomic/Transcriptomics studies indicating differentially expressed genes mediated by HIV

(1). Greenwood et al., Elife, 2016

Activated (CD3/CD28) Primary human CD4+ T cells infected with pNL4-3-dE-EGFP. The table shows the complete (unfiltered) TMT (tandem mass tag)-based proteomic time course dataset
6 h 24 h 48 h 72 h RTi
1.145 1.27 1.598 1.461 1.039
(2). Navare et al., Virology, 2012

SUP-T1 cell line
FC-4hpi P-value FC-8hpi P-value FC-20hpi P-value Category
unknown unknown unknown unknown unknown unknown unknown
(3). Hyrcza et al., J. Virolo., 2007

Primary human CD4+ and CD8+ T Cells
Affymetrix Prob ID Fold Change In CD8? Category
202705_at 5.42 No upregulated in CD8+ cells

Protein Overview       top

Drug-protein Interaction       (annotations from DrugBank)      top

not found

Protein Secondary Structure       (annotations from PDB)      top

not found

HIV-1 Interaction       (annotations from NCBI HIV-1 Interaction Database)      top

HIV Partner Interaction Type PubMed
Vpr inhibits 9560267
Vpr inactivates 11878934

Metabolic/Signalling Pathway       (annotations from KEGG database)      top

Pathway Accession Number Description
hsa04068 FoxO signaling pathway - Homo sapiens (human)
hsa04110 Cell cycle - Homo sapiens (human)
hsa04114 Oocyte meiosis - Homo sapiens (human)
hsa04115 p53 signaling pathway - Homo sapiens (human)
hsa04914 Progesterone-mediated oocyte maturation - Homo sapiens (human)
hsa05166 HTLV-I infection - Homo sapiens (human)