Detailed entry information

Protein Information (annotations from UniProt)

Database IDHIV0000500
UniProt IDP14635
Primary gene name(s)CCNB1
Synonym gene name(s)CCNB
Protein nameG2/mitotic-specific cyclin-B1
Protein functionEssential for the control of the cell cycle at the G2/M, mitosis transition. {ECO:0000269|PubMed:17495531, ECO:0000269|PubMed:17495533}.
Subcellular locationCytoplasm. Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.
ECO codeClick here for more information.
Amino acid sequence
FASTA format: P14635
Gene Ontology
(Biological Process)
Complete annatation
anaphase-promoting complex-dependent catabolic process [GO:0031145];
cell division [GO:0051301];
cellular response to fatty acid [GO:0071398];
cellular response to hypoxia [GO:0071456];
cellular response to iron(III ion [GO:0071283];
cellular response to organic cyclic compound [GO:0071407];
digestive tract development [GO:0048565];
DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest [GO:0006977];
G2/M transition of mitotic cell cycle [GO:0000086];
histone H3-S10 phosphorylation involved in chromosome condensation [GO:2000775];
in utero embryonic development [GO:0001701];
mitotic metaphase plate congression [GO:0007080];
mitotic nuclear envelope disassembly [GO:0007077];
mitotic spindle organization [GO:0007052];
negative regulation of gene expression [GO:0010629];
negative regulation of protein phosphorylation [GO:0001933];
negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle [GO:0051436];
oocyte maturation [GO:0001556];
positive regulation of attachment of spindle microtubules to kinetochore [GO:0051987];
positive regulation of cardiac muscle cell proliferation [GO:0060045];
positive regulation of fibroblast proliferation [GO:0048146];
positive regulation of histone phosphorylation [GO:0033129];
positive regulation of mitotic cell cycle [GO:0045931];
positive regulation of mRNA 3'-end processing [GO:0031442];
positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition [GO:0051437];
protein complex assembly [GO:0006461];
protein ubiquitination involved in ubiquitin-dependent protein catabolic process [GO:0042787];
regulation of cell cycle [GO:0051726];
regulation of chromosome condensation [GO:0060623];
regulation of mitotic cell cycle spindle assembly checkpoint [GO:0090266];
regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle [GO:0051439];
response to DDT [GO:0046680];
response to drug [GO:0042493];
response to mechanical stimulus [GO:0009612];
spermatogenesis [GO:0007283];
tissue regeneration [GO:0042246];
ventricular cardiac muscle cell development [GO:0055015]
Gene Ontology
(Molecular Function)
Complete annatation
cyclin-dependent protein serine/threonine kinase activity [GO:0004693];
histone kinase activity [GO:0035173];
patched binding [GO:0005113];
protein kinase binding [GO:0019901]
Gene Ontology
(Cellular Component)
Complete annatation
centrosome [GO:0005813];
condensed nuclear chromosome outer kinetochore [GO:0000942];
cytoplasm [GO:0005737];
cytosol [GO:0005829];
membrane [GO:0016020];
nucleoplasm [GO:0005654];
nucleus [GO:0005634];
spindle pole [GO:0000922]
Protein-protein interaction107332
Phylogenetic treeP14635
HIV replication factor status Zhou et al., Cell. Host. Microbe., 2008
Brass et al., Science, 2008
Smith et al., J. Immunol, 2010
gene status
Lu et al., J. Virol., 2011
      Folds changes 8h: unknown; Folds changes 16h: unknown; Tested: unknown;
Schoggins JW and Rice CM, Curr. Opin. Virol., 2011
      Targeted viruses: unknown
      Viral life cycle: unknown
      Mechanism related to antiviral activity: unknown
Anti-viral restriction factor Liu et al., Retrovirology, 2011
      unknown (Triplicates)

Gene Expression Profile       top

            Up-regulated;            Down-regulated

For brief introduction to each study, please go to the help page.

Gene expression during HIV latency

(1). Mohammadi et al., PLoS Pathog., 2014

Differentially expressed transcripts (Pairwise) during latency and subsequent viral reactivation using several agents - Primary CD4+ T-cell based model

DMSO: Dimethyl suloxyde (negative control) - 0.0033% final
SAHA: Vorinostat (Histone deacetylase inhibitor) - 0.5 μM
CD3: TCR Stimulation by IL-2+ antiCD3/anti-CD28 antibodies
IL7: Interleukin-7 based stimulation
DISU: Disulfiram (alcohol dehydrogenase inhibitor) - 0.5 μM
AZA: 5-azacytidine (AZA; DNA methylation inhibitor) - 1 μM
Experimental Condition Log2 Fold Change P value Adjusted P value
AZA vs. CD31.041317949468270.01186130266390510.0301778449949995
AZA vs. DISU0.03911453849001040.9381044479433050.995658835975946
AZA vs. IL7-0.07383288682630780.8795477509285580.999311006273513
AZA vs. SAHA-0.5676105132778830.1882773606527370.55388230571416
DISU vs. CD3-1.014515770758090.006854547674401970.0211819294063008
DISU vs. IL7-0.122857961652680.7716098453787070.946494508933597
DISU vs. SAHA-0.6061176738014040.08543729012560710.372792530249862
DMSO vs. AZA-0.04558649574731780.9320701299076571
DMSO vs. CD3-1.099477292633450.003290460769092670.00963100670028777
DMSO vs. DISU-0.08755408721479350.8539217338571160.983556672216537
DMSO vs. IL7-0.0205935540667410.9641324623035140.993369269778594
DMSO vs. SAHA-0.529487424733980.1796997095351210.512355391632483
HIV vs. Mock in Activation-0.1939462216364610.7569065485277430.999983755607037
HIV vs. Mock in Latency0.3055946288723230.4181466293898490.999834320637052
IL7 vs. CD3-1.108691537365030.0008524715287508980.00370232510049864
SAHA vs. CD3-1.635164780199777.8790917384941e-065.09386154007319e-05
SAHA vs. IL7-0.4962022164570590.1254660384128120.329031848127128
(2). Iglesias-Ussel et al., J. Virol., 2013

Up and Downregulated transcripts during Latency (Latently infected CD4+ T cells vs Uninfected)- Primary CD4+Tcell based model
Log2 Fold Change P Value
unknown unknown

Gene expression during HIV infection and replication

(1). Imbeault et al., PloS Pathog., 2012

Transcriptomic profiling of HIV-1 infected CD4+ T cells - Primary CD4+ T cells
Experiment type Log2 Fold Change P Value Adjusted P Value
Infected vs. Mock unknown unknown unknown
Infected vs. Bystander unknown unknown unknown
(2). Lefebvre et al., J. Virol., 2011

Transcriptome analysis of T-cell line (Sup T1)
Log2 Fold Change unknown
(3). Li et al., J. Immunol., 2013

Lymphatic tissue
Acute Fold Change Acute P Value Asymt Fold Change Asypt P Value AIDS Fold Change AIDS P Value
2.7 0.001284342 1.5 0.12909659 1.6 0.340803099
(4). Chang et al., MBio., 2011

Transcriptome analysis of T-cell line (Sup T1)

Derived from Sherrill-Mix et al., BMC Retrovirol., 2015 cross validation
Up-regulated (True) FALSE
(5). Sherrill-Mix et al., BMC Retrovirol., 2015

Deep RNA-seq analysis of primary human T cell infected with low passage HIV isolate HIV89.6 - Primary CD4+ T cell based
Test Status Log2 Fold Change P Value
OK -0.376439 0.00605069
(6). Rotger et al., PLoS Pathog., 2010

Genome-wide mRNA expression of CD4+ T cells from HIV-infected patient
(Genes differentially expressed (at adjusted p<0.01) according to the empirical Bayes approach)
Log2 Fold Change P Value
0.012 0.009

Proteomic/Transcriptomics studies indicating differentially expressed genes mediated by HIV

(1). Greenwood et al., Elife, 2016

Activated (CD3/CD28) Primary human CD4+ T cells infected with pNL4-3-dE-EGFP. The table shows the complete (unfiltered) TMT (tandem mass tag)-based proteomic time course dataset
6 h 24 h 48 h 72 h RTi
1.243 1.535 2.341 2.313 1.234
(2). Navare et al., Virology, 2012

SUP-T1 cell line
FC-4hpi P-value FC-8hpi P-value FC-20hpi P-value Category
unknown unknown unknown unknown unknown unknown unknown
(3). Hyrcza et al., J. Virolo., 2007

Primary human CD4+ and CD8+ T Cells
Affymetrix Prob ID Fold Change In CD8? Category
unknown unknown unknown unknown

Protein Overview       top

Drug-protein Interaction       (annotations from DrugBank)      top

not found

Protein Secondary Structure       (annotations from PDB)      top

PDB Accession Method Resolution Chain Structure Preview
2B9R X-ray 2.9Å A/B=165-433.
2JGZ X-ray 2.9Å B=167-426.
4Y72 X-ray 2.3Å B=165-433.
4YC3 X-ray 2.7Å B=165-433.
5HQ0 X-ray 2.3Å B=165-433.

HIV-1 Interaction       (annotations from NCBI HIV-1 Interaction Database)      top

HIV Partner Interaction Type PubMed
Vpr interacts with 18445273
Vif inhibits 21569376
Tat complexes with 22391203
Vpr induces accumulation of 22552851
Vpr inhibits 9560267
Vpr inactivates 11878934
Tat upregulates 16751065
Tat binds 19825974
Vpr induces release of 11691994
Envelope surface glycoprotein gp120 induces accumulation of 8524869

Metabolic/Signalling Pathway       (annotations from KEGG database)      top

Pathway Accession Number Description
hsa04068 FoxO signaling pathway - Homo sapiens (human)
hsa04110 Cell cycle - Homo sapiens (human)
hsa04114 Oocyte meiosis - Homo sapiens (human)
hsa04115 p53 signaling pathway - Homo sapiens (human)
hsa04914 Progesterone-mediated oocyte maturation - Homo sapiens (human)