Detailed entry information

Protein Information (annotations from UniProt)

Database IDHIV0000463
UniProt IDP42575
Primary gene name(s)CASP2
Synonym gene name(s)ICH1, NEDD2
Protein nameCaspase-2
Protein functionInvolved in the activation cascade of caspases responsible for apoptosis execution. Might function by either activating some proteins required for cell death or inactivating proteins necessary for cell survival.
Subcellular locationunknown
ECO codeClick here for more information.
Amino acid sequence
FASTA format: P42575
Gene Ontology
(Biological Process)
Complete annatation
activation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0006919];
aging [GO:0007568];
apoptotic process [GO:0006915];
apoptotic signaling pathway [GO:0097190];
brain development [GO:0007420];
cellular response to mechanical stimulus [GO:0071260];
DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest [GO:0006977];
ectopic germ cell programmed cell death [GO:0035234];
execution phase of apoptosis [GO:0097194];
extrinsic apoptotic signaling pathway in absence of ligand [GO:0097192];
intrinsic apoptotic signaling pathway in response to DNA damage [GO:0008630];
luteolysis [GO:0001554];
neural retina development [GO:0003407];
positive regulation of apoptotic process [GO:0043065];
positive regulation of apoptotic signaling pathway [GO:2001235];
positive regulation of neuron apoptotic process [GO:0043525];
protein processing [GO:0016485];
regulation of apoptotic process [GO:0042981]
Gene Ontology
(Molecular Function)
Complete annatation
cysteine-type endopeptidase activity [GO:0004197];
cysteine-type endopeptidase activity involved in apoptotic process [GO:0097153];
enzyme binding [GO:0019899];
protein domain specific binding [GO:0019904]
Gene Ontology
(Cellular Component)
Complete annatation
cytoplasm [GO:0005737];
cytosol [GO:0005829];
membrane [GO:0016020];
mitochondrion [GO:0005739];
nucleus [GO:0005634]
Protein-protein interaction107285
Phylogenetic treeP42575
HIV replication factor status Zhou et al., Cell. Host. Microbe., 2008
Brass et al., Science, 2008
Smith et al., J. Immunol, 2010
gene status
Lu et al., J. Virol., 2011
      Folds changes 8h: unknown; Folds changes 16h: unknown; Tested: unknown;
Schoggins JW and Rice CM, Curr. Opin. Virol., 2011
      Targeted viruses: unknown
      Viral life cycle: unknown
      Mechanism related to antiviral activity: unknown
Anti-viral restriction factor Liu et al., Retrovirology, 2011
      unknown (Triplicates)

Gene Expression Profile       top

            Up-regulated;            Down-regulated

For brief introduction to each study, please go to the help page.

Gene expression during HIV latency

(1). Mohammadi et al., PLoS Pathog., 2014

Differentially expressed transcripts (Pairwise) during latency and subsequent viral reactivation using several agents - Primary CD4+ T-cell based model

DMSO: Dimethyl suloxyde (negative control) - 0.0033% final
SAHA: Vorinostat (Histone deacetylase inhibitor) - 0.5 μM
CD3: TCR Stimulation by IL-2+ antiCD3/anti-CD28 antibodies
IL7: Interleukin-7 based stimulation
DISU: Disulfiram (alcohol dehydrogenase inhibitor) - 0.5 μM
AZA: 5-azacytidine (AZA; DNA methylation inhibitor) - 1 μM
Experimental Condition Log2 Fold Change P value Adjusted P value
AZA vs. CD3-0.7397699337643040.02726216784684850.0601163707077836
AZA vs. DISU0.1760708371990260.4868041121079340.931429104131977
AZA vs. IL70.08814735705225360.6467860246801350.999311006273513
AZA vs. SAHA0.4050939714130280.09770804742983350.395101742228949
DISU vs. CD30.9036729591334790.01414635273547150.0387924542722389
DISU vs. IL7-0.09708216491014720.699762249418370.922995529791052
DISU vs. SAHA0.2305826327048980.4315295040802140.779338664588724
DMSO vs. AZA0.07086266055641190.6724076534060781
DMSO vs. CD30.7987298891339930.01457716257858170.0342757849611882
DMSO vs. DISU-0.1070673999555630.6608941729322140.950993500250968
DMSO vs. IL70.02455491649263410.891393982798430.97624072378739
DMSO vs. SAHA0.3280145086257420.165192891698050.491667267304149
HIV vs. Mock in Activation0.3037237773030430.6269895741506710.999983755607037
HIV vs. Mock in Latency0.1188283009290490.4726514895773330.999834320637052
IL7 vs. CD30.8349369977757190.01065609500450030.031468039077321
SAHA vs. CD31.120821176152080.002353007198309890.00744172475939769
SAHA vs. IL70.3134879726783960.2002900790199060.432732213149787
(2). Iglesias-Ussel et al., J. Virol., 2013

Up and Downregulated transcripts during Latency (Latently infected CD4+ T cells vs Uninfected)- Primary CD4+Tcell based model
Log2 Fold Change P Value
unknown unknown

Gene expression during HIV infection and replication

(1). Imbeault et al., PloS Pathog., 2012

Transcriptomic profiling of HIV-1 infected CD4+ T cells - Primary CD4+ T cells
Experiment type Log2 Fold Change P Value Adjusted P Value
Infected vs. Mock unknown unknown unknown
Infected vs. Bystander unknown unknown unknown
(2). Lefebvre et al., J. Virol., 2011

Transcriptome analysis of T-cell line (Sup T1)
Log2 Fold Change unknown
(3). Li et al., J. Immunol., 2013

Lymphatic tissue
Acute Fold Change Acute P Value Asymt Fold Change Asypt P Value AIDS Fold Change AIDS P Value
unknown unknown unknown unknown unknown unknown
(4). Chang et al., MBio., 2011

Transcriptome analysis of T-cell line (Sup T1)

Derived from Sherrill-Mix et al., BMC Retrovirol., 2015 cross validation
Up-regulated (True) FALSE
(5). Sherrill-Mix et al., BMC Retrovirol., 2015

Deep RNA-seq analysis of primary human T cell infected with low passage HIV isolate HIV89.6 - Primary CD4+ T cell based
Test Status Log2 Fold Change P Value
OK 0.0516207 0.778801
(6). Rotger et al., PLoS Pathog., 2010

Genome-wide mRNA expression of CD4+ T cells from HIV-infected patient
(Genes differentially expressed (at adjusted p<0.01) according to the empirical Bayes approach)
Log2 Fold Change P Value
unknown unknown

Proteomic/Transcriptomics studies indicating differentially expressed genes mediated by HIV

(1). Greenwood et al., Elife, 2016

Activated (CD3/CD28) Primary human CD4+ T cells infected with pNL4-3-dE-EGFP. The table shows the complete (unfiltered) TMT (tandem mass tag)-based proteomic time course dataset
6 h 24 h 48 h 72 h RTi
0.905 0.869 0.684 0.68 1.008
(2). Navare et al., Virology, 2012

SUP-T1 cell line
FC-4hpi P-value FC-8hpi P-value FC-20hpi P-value Category
-0.1 0.8772 -0.2 0.1116 -0.83 0.0001 T-cell activation at 20 hpi
(3). Hyrcza et al., J. Virolo., 2007

Primary human CD4+ and CD8+ T Cells
Affymetrix Prob ID Fold Change In CD8? Category
unknown unknown unknown unknown

Protein Overview       top

Drug-protein Interaction       (annotations from DrugBank)      top

not found

Protein Secondary Structure       (annotations from PDB)      top

PDB Accession Method Resolution Chain Structure Preview
1PYO X-ray 1.6Å A/C=167-333# B/D=348-452.
2P2C X-ray 3.2Å A/C/E/G/I/K=167-333# B/D/F/H/J/L=348-452.
3R5J X-ray 1.7Å A/C=175-333# B/D=349-452.
3R6G X-ray 2.0Å A/C=175-333# B/D=349-452.
3R6L X-ray 1.9Å A/C=175-333# B/D=349-452.
3R7B X-ray 1.8Å A/C=175-333# B/D=349-452.
3R7N X-ray 2.3Å A/C=175-333# B/D=349-452.
3R7S X-ray 2.2Å A/C=175-333# B/D=349-452.
3RJM X-ray 2.5Å A/C=167-333# B/D=348-452.

HIV-1 Interaction       (annotations from NCBI HIV-1 Interaction Database)      top

not found

Metabolic/Signalling Pathway       (annotations from KEGG database)      top

Pathway Accession Number Description
hsa04210 Apoptosis - Homo sapiens (human)