Detailed entry information

Protein Information (annotations from UniProt)

Database IDHIV0000438
UniProt IDQ9P1Z2
Primary gene name(s)CALCOCO1
Synonym gene name(s)KIAA1536
Protein nameCalcium-binding and coiled-coil domain-containing protein 1
Protein functionFunctions as a coactivator for aryl hydrocarbon and nuclear receptors, NR. Recruited to promoters through its contact with the N-terminal basic helix-loop-helix-Per-Arnt-Sim, PAS domain of transcription factors or coactivators, such as NCOA2. During ER-activation acts synergistically in combination with other NCOA2-binding proteins, such as EP300, CREBBP and CARM1. Involved in the transcriptional activation of target genes in the Wnt/CTNNB1 pathway. Functions as a secondary coactivator in LEF1-mediated transcriptional activation via its interaction with CTNNB1. Coactivator function for nuclear receptors and LEF1/CTNNB1 involves differential utilization of two different activation regions, By similarity. In association with CCAR1 enhances GATA1- and MED1-mediated transcriptional activation from the gamma-globin promoter during erythroid differentiation of K562 erythroleukemia cells, PubMed:24245781. {ECO:0000250|UniProtKB:Q8CGU1, ECO:0000269|PubMed:24245781}.; FUNCTION: Seems to enhance inorganic pyrphosphatase thus activating phosphogluomutase, PMG. Probably functions as component of the calphoglin complex, which is involved in linking cellular metabolism, phosphate and glucose metabolism with other core functions including protein synthesis and degradation, calcium signaling and cell growth. {ECO:0000269|Ref.1}.
Subcellular locationCytoplasm. Nucleus. Note=Shuttles between nucleus and cytoplasm. {ECO:0000250}.
ECO codeClick here for more information.
Amino acid sequence
FASTA format: Q9P1Z2
Gene Ontology
(Biological Process)
Complete annatation
intracellular steroid hormone receptor signaling pathway [GO:0030518];
positive regulation of gene expression [GO:0010628];
positive regulation of transcription, DNA-templated [GO:0045893];
positive regulation of transcription from RNA polymerase II promoter [GO:0045944];
signal transduction [GO:0007165];
transcription, DNA-templated [GO:0006351];
Wnt signaling pathway [GO:0016055]
Gene Ontology
(Molecular Function)
Complete annatation
armadillo repeat domain binding [GO:0070016];
beta-catenin binding [GO:0008013];
chromatin binding [GO:0003682];
core promoter binding [GO:0001047];
ligand-dependent nuclear receptor transcription coactivator activity [GO:0030374];
protein C-terminus binding [GO:0008022];
sequence-specific DNA binding [GO:0043565];
transcription coactivator activity [GO:0003713];
transcription cofactor activity [GO:0003712];
transcription regulatory region DNA binding [GO:0044212]
Gene Ontology
(Cellular Component)
Complete annatation
cytoplasm [GO:0005737];
intracellular membrane-bounded organelle [GO:0043231];
nuclear chromatin [GO:0000790];
nucleus [GO:0005634]
Protein-protein interaction121692
Phylogenetic treeQ9P1Z2
HIV replication factor status Zhou et al., Cell. Host. Microbe., 2008
Brass et al., Science, 2008
Smith et al., J. Immunol, 2010
gene status
Lu et al., J. Virol., 2011
      Folds changes 8h: unknown; Folds changes 16h: unknown; Tested: unknown;
Schoggins JW and Rice CM, Curr. Opin. Virol., 2011
      Targeted viruses: unknown
      Viral life cycle: unknown
      Mechanism related to antiviral activity: unknown
Anti-viral restriction factor Liu et al., Retrovirology, 2011
      unknown (Triplicates)

Gene Expression Profile       top

            Up-regulated;            Down-regulated

For brief introduction to each study, please go to the help page.

Gene expression during HIV latency

(1). Mohammadi et al., PLoS Pathog., 2014

Differentially expressed transcripts (Pairwise) during latency and subsequent viral reactivation using several agents - Primary CD4+ T-cell based model

DMSO: Dimethyl suloxyde (negative control) - 0.0033% final
SAHA: Vorinostat (Histone deacetylase inhibitor) - 0.5 μM
CD3: TCR Stimulation by IL-2+ antiCD3/anti-CD28 antibodies
IL7: Interleukin-7 based stimulation
DISU: Disulfiram (alcohol dehydrogenase inhibitor) - 0.5 μM
AZA: 5-azacytidine (AZA; DNA methylation inhibitor) - 1 μM
Experimental Condition Log2 Fold Change P value Adjusted P value
AZA vs. CD3-2.30774513623031.9154233754648e-113.77536470319486e-10
AZA vs. DISU0.2971296772807790.2399205754655880.825134098692282
AZA vs. IL7-0.6710425072426830.0005122489313018620.0479573176491488
AZA vs. SAHA0.8180933005475960.0009405912388256170.019841431235692
DISU vs. CD32.590528400568061.63231650418538e-114.76851530699427e-10
DISU vs. IL7-0.9776560088310070.0001190573201623750.00596275448985979
DISU vs. SAHA0.5236163016432490.07536295095221990.347869841899206
DMSO vs. AZA0.1130104273806950.4996123389270671
DMSO vs. CD32.406560956542918.98281449224214e-131.9612478308062e-11
DMSO vs. DISU-0.1866098262430830.4439480743743320.885194162585496
DMSO vs. IL7-0.7765697857858491.7583362969642e-050.00315558567580183
DMSO vs. SAHA0.6998808619696870.003299331140060310.0412527877526263
HIV vs. Mock in Activation0.4141957679868270.5073366824574020.999983755607037
HIV vs. Mock in Latency0.1595198405504460.3444720822165130.999834320637052
IL7 vs. CD31.642394825028466.48401597969084e-076.61255567401083e-06
SAHA vs. CD33.101839170616475.55111512312578e-162.92501066103166e-14
SAHA vs. IL71.485552323536612.89088397664727e-092.96443435809395e-07
(2). Iglesias-Ussel et al., J. Virol., 2013

Up and Downregulated transcripts during Latency (Latently infected CD4+ T cells vs Uninfected)- Primary CD4+Tcell based model
Log2 Fold Change P Value
unknown unknown

Gene expression during HIV infection and replication

(1). Imbeault et al., PloS Pathog., 2012

Transcriptomic profiling of HIV-1 infected CD4+ T cells - Primary CD4+ T cells
Experiment type Log2 Fold Change P Value Adjusted P Value
Infected vs. Mock unknown unknown unknown
Infected vs. Bystander unknown unknown unknown
(2). Lefebvre et al., J. Virol., 2011

Transcriptome analysis of T-cell line (Sup T1)
Log2 Fold Change unknown
(3). Li et al., J. Immunol., 2013

Lymphatic tissue
Acute Fold Change Acute P Value Asymt Fold Change Asypt P Value AIDS Fold Change AIDS P Value
unknown unknown unknown unknown unknown unknown
(4). Chang et al., MBio., 2011

Transcriptome analysis of T-cell line (Sup T1)

Derived from Sherrill-Mix et al., BMC Retrovirol., 2015 cross validation
Up-regulated (True) TRUE
(5). Sherrill-Mix et al., BMC Retrovirol., 2015

Deep RNA-seq analysis of primary human T cell infected with low passage HIV isolate HIV89.6 - Primary CD4+ T cell based
Test Status Log2 Fold Change P Value
OK -0.718532 0.000305467
(6). Rotger et al., PLoS Pathog., 2010

Genome-wide mRNA expression of CD4+ T cells from HIV-infected patient
(Genes differentially expressed (at adjusted p<0.01) according to the empirical Bayes approach)
Log2 Fold Change P Value
unknown unknown

Proteomic/Transcriptomics studies indicating differentially expressed genes mediated by HIV

(1). Greenwood et al., Elife, 2016

Activated (CD3/CD28) Primary human CD4+ T cells infected with pNL4-3-dE-EGFP. The table shows the complete (unfiltered) TMT (tandem mass tag)-based proteomic time course dataset
6 h 24 h 48 h 72 h RTi
0.753 1.301 1.562 1.197 1.172
(2). Navare et al., Virology, 2012

SUP-T1 cell line
FC-4hpi P-value FC-8hpi P-value FC-20hpi P-value Category
unknown unknown unknown unknown unknown unknown unknown
(3). Hyrcza et al., J. Virolo., 2007

Primary human CD4+ and CD8+ T Cells
Affymetrix Prob ID Fold Change In CD8? Category
unknown unknown unknown unknown

Protein Overview       top

Drug-protein Interaction       (annotations from DrugBank)      top

not found

Protein Secondary Structure       (annotations from PDB)      top

not found

HIV-1 Interaction       (annotations from NCBI HIV-1 Interaction Database)      top

HIV Partner Interaction Type PubMed
HIV-1 virus replication enhanced by expression of human gene 18854154

Metabolic/Signalling Pathway       (annotations from KEGG database)      top

Pathway Accession Number Description
not found