Detailed entry information

Protein Information (annotations from UniProt)

Database IDHIV0000434
UniProt IDP54284
Primary gene name(s)CACNB3
Synonym gene name(s)CACNLB3
Protein nameVoltage-dependent L-type calcium channel subunit beta-3
Protein functionThe beta subunit of voltage-dependent calcium channels contributes to the function of the calcium channel by increasing peak calcium current, shifting the voltage dependencies of activation and inactivation, modulating G protein inhibition and controlling the alpha-1 subunit membrane targeting. {ECO:0000250|UniProtKB:P54287}.
Subcellular locationunknown
ECO codeClick here for more information.
Amino acid sequence
FASTA format: P54284
Gene Ontology
(Biological Process)
Complete annatation
calcium ion transmembrane transport via high voltage-gated calcium channel [GO:0061577];
calcium ion transport [GO:0006816];
calcium ion transport into cytosol [GO:0060402];
cardiac conduction [GO:0061337];
chemical synaptic transmission [GO:0007268];
membrane depolarization [GO:0051899];
neuromuscular junction development [GO:0007528];
protein localization to plasma membrane [GO:0072659];
regulation of membrane repolarization during action potential [GO:0098903];
regulation of voltage-gated calcium channel activity [GO:1901385];
T cell receptor signaling pathway [GO:0050852];
transport [GO:0006810]
Gene Ontology
(Molecular Function)
Complete annatation
calcium channel activity [GO:0005262];
high voltage-gated calcium channel activity [GO:0008331];
voltage-gated calcium channel activity [GO:0005245]
Gene Ontology
(Cellular Component)
Complete annatation
apical plasma membrane [GO:0016324];
cytosol [GO:0005829];
L-type voltage-gated calcium channel complex [GO:1990454];
membrane [GO:0016020];
plasma membrane [GO:0005886];
voltage-gated calcium channel complex [GO:0005891]
Protein-protein interaction107238
Phylogenetic treeP54284
HIV replication factor status Zhou et al., Cell. Host. Microbe., 2008
Brass et al., Science, 2008
Smith et al., J. Immunol, 2010
gene status
Lu et al., J. Virol., 2011
      Folds changes 8h: unknown; Folds changes 16h: unknown; Tested: unknown;
Schoggins JW and Rice CM, Curr. Opin. Virol., 2011
      Targeted viruses: unknown
      Viral life cycle: unknown
      Mechanism related to antiviral activity: unknown
Anti-viral restriction factor Liu et al., Retrovirology, 2011
      unknown (Triplicates)

Gene Expression Profile       top

            Up-regulated;            Down-regulated

For brief introduction to each study, please go to the help page.

Gene expression during HIV latency

(1). Mohammadi et al., PLoS Pathog., 2014

Differentially expressed transcripts (Pairwise) during latency and subsequent viral reactivation using several agents - Primary CD4+ T-cell based model

DMSO: Dimethyl suloxyde (negative control) - 0.0033% final
SAHA: Vorinostat (Histone deacetylase inhibitor) - 0.5 μM
CD3: TCR Stimulation by IL-2+ antiCD3/anti-CD28 antibodies
IL7: Interleukin-7 based stimulation
DISU: Disulfiram (alcohol dehydrogenase inhibitor) - 0.5 μM
AZA: 5-azacytidine (AZA; DNA methylation inhibitor) - 1 μM
Experimental Condition Log2 Fold Change P value Adjusted P value
AZA vs. CD3-0.3995270427832980.2349404505363880.345465606876531
AZA vs. DISU0.1766562497466240.4932256898347350.933092877581426
AZA vs. IL7-0.08161053065719110.6826795755285420.999311006273513
AZA vs. SAHA1.616635265863221.60801372217634e-105.15727635065662e-08
DISU vs. CD30.5634584375436120.131951307475730.231741117195521
DISU vs. IL7-0.2683453520656140.2953739581694770.679811056397689
DISU vs. SAHA1.442594210179551.43607398794821e-060.000133947368873034
DMSO vs. AZA0.01915411442924480.9133127118413811
DMSO vs. CD30.407649259336390.2138106412755080.315387967376435
DMSO vs. DISU-0.1589664854077340.5225230475217850.915204826377651
DMSO vs. IL7-0.0935460873289110.6167506965808010.916192033007053
DMSO vs. SAHA1.591855875118926.70601352226186e-111.98169274105899e-08
HIV vs. Mock in Activation0.146913034917450.8316509367753310.999983755607037
HIV vs. Mock in Latency-0.2560326323637090.1816048333053130.999834320637052
IL7 vs. CD30.3214536423047460.3378638408695090.475853289113478
SAHA vs. CD31.991879195464027.92851810871298e-088.55893752853185e-07
SAHA vs. IL71.696163587787582.00165439778743e-114.13327923181476e-09
(2). Iglesias-Ussel et al., J. Virol., 2013

Up and Downregulated transcripts during Latency (Latently infected CD4+ T cells vs Uninfected)- Primary CD4+Tcell based model
Log2 Fold Change P Value
0.3675 0.04674

Gene expression during HIV infection and replication

(1). Imbeault et al., PloS Pathog., 2012

Transcriptomic profiling of HIV-1 infected CD4+ T cells - Primary CD4+ T cells
Experiment type Log2 Fold Change P Value Adjusted P Value
Infected vs. Mock unknown unknown unknown
Infected vs. Bystander unknown unknown unknown
(2). Lefebvre et al., J. Virol., 2011

Transcriptome analysis of T-cell line (Sup T1)
Log2 Fold Change unknown
(3). Li et al., J. Immunol., 2013

Lymphatic tissue
Acute Fold Change Acute P Value Asymt Fold Change Asypt P Value AIDS Fold Change AIDS P Value
unknown unknown unknown unknown unknown unknown
(4). Chang et al., MBio., 2011

Transcriptome analysis of T-cell line (Sup T1)

Derived from Sherrill-Mix et al., BMC Retrovirol., 2015 cross validation
Up-regulated (True) TRUE
(5). Sherrill-Mix et al., BMC Retrovirol., 2015

Deep RNA-seq analysis of primary human T cell infected with low passage HIV isolate HIV89.6 - Primary CD4+ T cell based
Test Status Log2 Fold Change P Value
OK -0.322216 0.111064
(6). Rotger et al., PLoS Pathog., 2010

Genome-wide mRNA expression of CD4+ T cells from HIV-infected patient
(Genes differentially expressed (at adjusted p<0.01) according to the empirical Bayes approach)
Log2 Fold Change P Value
unknown unknown

Proteomic/Transcriptomics studies indicating differentially expressed genes mediated by HIV

(1). Greenwood et al., Elife, 2016

Activated (CD3/CD28) Primary human CD4+ T cells infected with pNL4-3-dE-EGFP. The table shows the complete (unfiltered) TMT (tandem mass tag)-based proteomic time course dataset
6 h 24 h 48 h 72 h RTi
unknown unknown unknown unknown unknown
(2). Navare et al., Virology, 2012

SUP-T1 cell line
FC-4hpi P-value FC-8hpi P-value FC-20hpi P-value Category
unknown unknown unknown unknown unknown unknown unknown
(3). Hyrcza et al., J. Virolo., 2007

Primary human CD4+ and CD8+ T Cells
Affymetrix Prob ID Fold Change In CD8? Category
unknown unknown unknown unknown

Protein Overview       top

Drug-protein Interaction       (annotations from DrugBank)      top

Drugbank ID Drug Name Drug Status Pharmacological Action Drug Action
DB00661 Verapamil approved yes inhibitor
DB04855 Dronedarone approved unknown unknown
DB00393 Nimodipine approved yes inhibitor
DB01388 Mibefradil withdrawn yes inhibitor
DB00421 Spironolactone approved unknown unknown

Protein Secondary Structure       (annotations from PDB)      top

not found

HIV-1 Interaction       (annotations from NCBI HIV-1 Interaction Database)      top

not found

Metabolic/Signalling Pathway       (annotations from KEGG database)      top

Pathway Accession Number Description
hsa04010 MAPK signaling pathway - Homo sapiens (human)
hsa04260 Cardiac muscle contraction - Homo sapiens (human)
hsa04261 Adrenergic signaling in cardiomyocytes - Homo sapiens (human)
hsa04921 Oxytocin signaling pathway - Homo sapiens (human)
hsa05410 Hypertrophic cardiomyopathy (HCM) - Homo sapiens (human)
hsa05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC) - Homo sapiens (human)
hsa05414 Dilated cardiomyopathy - Homo sapiens (human)