Detailed entry information

Protein Information (annotations from UniProt)

Database IDHIV0000395
UniProt IDQ8IUR6
Primary gene name(s)CREBRF
Synonym gene name(s)C5orf41
Protein nameCREB3 regulatory factor
Protein functionActs as a negative regulator of the endoplasmic reticulum stress response or unfolded protein response, UPR. Represses the transcriptional activity of CREB3 during the UPR. Recruits CREB3 into nuclear foci. {ECO:0000269|PubMed:18391022}.
Subcellular locationNucleus {ECO:0000269|PubMed:18391022}. Note=Colocalizes with CREB3 in nuclear foci.
ECO codeClick here for more information.
Amino acid sequence
FASTA format: Q8IUR6
Gene Ontology
(Biological Process)
Complete annatation
maternal behavior [GO:0042711];
negative regulation of endoplasmic reticulum unfolded protein response [GO:1900102];
negative regulation of glucocorticoid mediated signaling pathway [GO:1900170];
negative regulation of transcription from RNA polymerase II promoter [GO:0000122];
positive regulation of intracellular transport [GO:0032388];
positive regulation of prolactin signaling pathway [GO:1902213];
positive regulation of protein catabolic process [GO:0045732];
positive regulation of protein transport [GO:0051222];
response to endoplasmic reticulum stress [GO:0034976];
response to unfolded protein [GO:0006986];
transcription, DNA-templated [GO:0006351];
transport [GO:0006810]
Gene Ontology
(Molecular Function)
Complete annatation
sequence-specific DNA binding [GO:0043565];
transcription factor activity, sequence-specific DNA binding [GO:0003700]
Gene Ontology
(Cellular Component)
Complete annatation
cytoplasm [GO:0005737];
nuclear body [GO:0016604];
nucleoplasm [GO:0005654]
Protein-protein interaction127485
Phylogenetic treeQ8IUR6
HIV replication factor status Zhou et al., Cell. Host. Microbe., 2008
Brass et al., Science, 2008
Smith et al., J. Immunol, 2010
gene status
Lu et al., J. Virol., 2011
      Folds changes 8h: unknown; Folds changes 16h: unknown; Tested: unknown;
Schoggins JW and Rice CM, Curr. Opin. Virol., 2011
      Targeted viruses: unknown
      Viral life cycle: unknown
      Mechanism related to antiviral activity: unknown
Anti-viral restriction factor Liu et al., Retrovirology, 2011
      unknown (Triplicates)

Gene Expression Profile       top

            Up-regulated;            Down-regulated

For brief introduction to each study, please go to the help page.

Gene expression during HIV latency

(1). Mohammadi et al., PLoS Pathog., 2014

Differentially expressed transcripts (Pairwise) during latency and subsequent viral reactivation using several agents - Primary CD4+ T-cell based model

DMSO: Dimethyl suloxyde (negative control) - 0.0033% final
SAHA: Vorinostat (Histone deacetylase inhibitor) - 0.5 μM
CD3: TCR Stimulation by IL-2+ antiCD3/anti-CD28 antibodies
IL7: Interleukin-7 based stimulation
DISU: Disulfiram (alcohol dehydrogenase inhibitor) - 0.5 μM
AZA: 5-azacytidine (AZA; DNA methylation inhibitor) - 1 μM
Experimental Condition Log2 Fold Change P value Adjusted P value
AZA vs. CD3-1.688778017718745.39031418278491e-074.44922318526474e-06
AZA vs. DISU1.131071993766230.003043663710855960.143375583679509
AZA vs. IL7-0.5413652368992160.007316920189681660.273634381687483
AZA vs. SAHA0.02224080637680930.9274002827532240.983096474136575
DISU vs. CD32.806195736319912.23963070311584e-116.39397598840305e-10
DISU vs. IL7-1.680944716409756.23660268017634e-060.000606559905830054
DISU vs. SAHA-1.108732240095380.003187025426599540.0469217460957067
DMSO vs. AZA-0.08889046183796270.6474347599422131
DMSO vs. CD31.586912227505151.29690052430576e-069.0958130347608e-06
DMSO vs. DISU-1.222279478881810.0009902267636270330.0641903233706729
DMSO vs. IL7-0.4452981374033160.01381395080099690.247322218913335
DMSO vs. SAHA0.1033983998498790.6614129470882510.893619866777141
HIV vs. Mock in Activation-0.07826385225908780.9005720330765370.999983755607037
HIV vs. Mock in Latency0.1702570180353870.3481951097060980.999834320637052
IL7 vs. CD31.156619280222150.0004075136807227820.00196244527461166
SAHA vs. CD31.684354679153263.71526310827264e-062.61508711077387e-05
SAHA vs. IL70.5580925872028790.02242599195207660.108383905958834
(2). Iglesias-Ussel et al., J. Virol., 2013

Up and Downregulated transcripts during Latency (Latently infected CD4+ T cells vs Uninfected)- Primary CD4+Tcell based model
Log2 Fold Change P Value
unknown unknown

Gene expression during HIV infection and replication

(1). Imbeault et al., PloS Pathog., 2012

Transcriptomic profiling of HIV-1 infected CD4+ T cells - Primary CD4+ T cells
Experiment type Log2 Fold Change P Value Adjusted P Value
Infected vs. Mock unknown unknown unknown
Infected vs. Bystander -0.85 3.90E-06 5.25E-05
(2). Lefebvre et al., J. Virol., 2011

Transcriptome analysis of T-cell line (Sup T1)
Log2 Fold Change unknown
(3). Li et al., J. Immunol., 2013

Lymphatic tissue
Acute Fold Change Acute P Value Asymt Fold Change Asypt P Value AIDS Fold Change AIDS P Value
unknown unknown unknown unknown unknown unknown
(4). Chang et al., MBio., 2011

Transcriptome analysis of T-cell line (Sup T1)

Derived from Sherrill-Mix et al., BMC Retrovirol., 2015 cross validation
Up-regulated (True) TRUE
(5). Sherrill-Mix et al., BMC Retrovirol., 2015

Deep RNA-seq analysis of primary human T cell infected with low passage HIV isolate HIV89.6 - Primary CD4+ T cell based
Test Status Log2 Fold Change P Value
OK -0.418222 0.00457947
(6). Rotger et al., PLoS Pathog., 2010

Genome-wide mRNA expression of CD4+ T cells from HIV-infected patient
(Genes differentially expressed (at adjusted p<0.01) according to the empirical Bayes approach)
Log2 Fold Change P Value
unknown unknown

Proteomic/Transcriptomics studies indicating differentially expressed genes mediated by HIV

(1). Greenwood et al., Elife, 2016

Activated (CD3/CD28) Primary human CD4+ T cells infected with pNL4-3-dE-EGFP. The table shows the complete (unfiltered) TMT (tandem mass tag)-based proteomic time course dataset
6 h 24 h 48 h 72 h RTi
unknown unknown unknown unknown unknown
(2). Navare et al., Virology, 2012

SUP-T1 cell line
FC-4hpi P-value FC-8hpi P-value FC-20hpi P-value Category
unknown unknown unknown unknown unknown unknown unknown
(3). Hyrcza et al., J. Virolo., 2007

Primary human CD4+ and CD8+ T Cells
Affymetrix Prob ID Fold Change In CD8? Category
unknown unknown unknown unknown

Protein Overview       top

Drug-protein Interaction       (annotations from DrugBank)      top

not found

Protein Secondary Structure       (annotations from PDB)      top

not found

HIV-1 Interaction       (annotations from NCBI HIV-1 Interaction Database)      top

not found

Metabolic/Signalling Pathway       (annotations from KEGG database)      top

Pathway Accession Number Description
not found