Detailed entry information

Protein Information (annotations from UniProt)

Database IDHIV0000342
UniProt IDO94763
Primary gene name(s)URI1
Synonym gene name(s)C19orf2, NNX3, PPP1R19, RMP, URI
Protein nameUnconventional prefoldin RPB5 interactor 1
Protein functionInvolved in gene transcription regulation. Acts as a transcriptional repressor in concert with the corepressor UXT to regulate androgen receptor, AR transcription. May act as a tumor suppressor to repress AR-mediated gene transcription and to inhibit anchorage-independent growth in prostate cancer cells. Required for cell survival in ovarian cancer cells. Together with UXT, associates with chromatin to the NKX3-1 promoter region. Antagonizes transcriptional modulation via hepatitis B virus X protein.; FUNCTION: Plays a central role in maintaining S6K1 signaling and BAD phosphorylation under normal growth conditions thereby protecting cells from potential deleterious effects of sustained S6K1 signaling. The URI1-PPP1CC complex acts as a central component of a negative feedback mechanism that counteracts excessive S6K1 survival signaling to BAD in response to growth factors. Mediates inhibition of PPP1CC phosphatase activity in mitochondria. Coordinates the regulation of nutrient-sensitive gene expression availability in a mTOR-dependent manner. Seems to be a scaffolding protein able to assemble a prefoldin-like complex that contains PFDs and proteins with roles in transcription and ubiquitination.
Subcellular locationNucleus. Cytoplasm. Mitochondrion. Cell projection, dendrite {ECO:0000250}. Note=Colocalizes with PFDN2, PFDN4, PPP1CC, RPS6KB1 and STAP1 at mitochondrion.
ECO codeClick here for more information.
Amino acid sequence
FASTA format: O94763
Gene Ontology
(Biological Process)
Complete annatation
cellular response to growth factor stimulus [GO:0071363];
cellular response to steroid hormone stimulus [GO:0071383];
negative regulation of intrinsic apoptotic signaling pathway [GO:2001243];
negative regulation of phosphatase activity [GO:0010923];
negative regulation of transcription from RNA polymerase II promoter [GO:0000122];
regulation of cell growth [GO:0001558];
regulation of transcription from RNA polymerase II promoter [GO:0006357];
response to virus [GO:0009615];
transcription, DNA-templated [GO:0006351]
Gene Ontology
(Molecular Function)
Complete annatation
chromatin binding [GO:0003682];
phosphatase inhibitor activity [GO:0019212];
phosphoprotein binding [GO:0051219];
protein phosphatase inhibitor activity [GO:0004864];
RNA polymerase II transcription corepressor activity [GO:0001106]
Gene Ontology
(Cellular Component)
Complete annatation
cytoplasm [GO:0005737];
dendrite [GO:0030425];
DNA-directed RNA polymerase II, core complex [GO:0005665];
intracellular membrane-bounded organelle [GO:0043231];
mitochondrion [GO:0005739];
nucleus [GO:0005634]
Protein-protein interaction114264
Phylogenetic treeO94763
HIV replication factor status Zhou et al., Cell. Host. Microbe., 2008
Brass et al., Science, 2008
Smith et al., J. Immunol, 2010
gene status
Lu et al., J. Virol., 2011
      Folds changes 8h: unknown; Folds changes 16h: unknown; Tested: unknown;
Schoggins JW and Rice CM, Curr. Opin. Virol., 2011
      Targeted viruses: unknown
      Viral life cycle: unknown
      Mechanism related to antiviral activity: unknown
Anti-viral restriction factor Liu et al., Retrovirology, 2011
      unknown (Triplicates)

Gene Expression Profile       top

            Up-regulated;            Down-regulated

For brief introduction to each study, please go to the help page.

Gene expression during HIV latency

(1). Mohammadi et al., PLoS Pathog., 2014

Differentially expressed transcripts (Pairwise) during latency and subsequent viral reactivation using several agents - Primary CD4+ T-cell based model

DMSO: Dimethyl suloxyde (negative control) - 0.0033% final
SAHA: Vorinostat (Histone deacetylase inhibitor) - 0.5 μM
CD3: TCR Stimulation by IL-2+ antiCD3/anti-CD28 antibodies
IL7: Interleukin-7 based stimulation
DISU: Disulfiram (alcohol dehydrogenase inhibitor) - 0.5 μM
AZA: 5-azacytidine (AZA; DNA methylation inhibitor) - 1 μM
Experimental Condition Log2 Fold Change P value Adjusted P value
AZA vs. CD30.3590185546219490.2730292175395840.388214171519385
AZA vs. DISU-0.2580403483798250.3078656603000310.866242136589333
AZA vs. IL70.07815325894106380.6843976528819360.999311006273513
AZA vs. SAHA-0.4329622417911920.07766444760363590.346679962125166
DISU vs. CD3-0.6293200320912160.08330193890421680.16164951429482
DISU vs. IL70.3273228735537540.1941386189013140.568453962773618
DISU vs. SAHA-0.1742098980455580.5510698837492660.851725383856548
DMSO vs. AZA-0.02990601309543620.8584104556344011
DMSO vs. CD3-0.4007300893064420.2104624846350230.311455533499669
DMSO vs. DISU0.2261644690954890.3541315048217220.845295578681978
DMSO vs. IL70.1153468264195150.5212959460199120.890587176188056
DMSO vs. SAHA-0.4100729167180820.08385006692570450.337618584105206
HIV vs. Mock in Activation-0.2446776339605770.6940909577643940.999983755607037
HIV vs. Mock in Latency0.1024197456613220.5346936427738480.999834320637052
IL7 vs. CD3-0.2722200833421660.3966008942821160.533508726418057
SAHA vs. CD3-0.8171380174445670.02169084343186240.0493554296418794
SAHA vs. IL7-0.5149136923844190.0356322466136280.146036021058681
(2). Iglesias-Ussel et al., J. Virol., 2013

Up and Downregulated transcripts during Latency (Latently infected CD4+ T cells vs Uninfected)- Primary CD4+Tcell based model
Log2 Fold Change P Value
unknown unknown

Gene expression during HIV infection and replication

(1). Imbeault et al., PloS Pathog., 2012

Transcriptomic profiling of HIV-1 infected CD4+ T cells - Primary CD4+ T cells
Experiment type Log2 Fold Change P Value Adjusted P Value
Infected vs. Mock unknown unknown unknown
Infected vs. Bystander unknown unknown unknown
(2). Lefebvre et al., J. Virol., 2011

Transcriptome analysis of T-cell line (Sup T1)
Log2 Fold Change unknown
(3). Li et al., J. Immunol., 2013

Lymphatic tissue
Acute Fold Change Acute P Value Asymt Fold Change Asypt P Value AIDS Fold Change AIDS P Value
unknown unknown unknown unknown unknown unknown
(4). Chang et al., MBio., 2011

Transcriptome analysis of T-cell line (Sup T1)

Derived from Sherrill-Mix et al., BMC Retrovirol., 2015 cross validation
Up-regulated (True) FALSE
(5). Sherrill-Mix et al., BMC Retrovirol., 2015

Deep RNA-seq analysis of primary human T cell infected with low passage HIV isolate HIV89.6 - Primary CD4+ T cell based
Test Status Log2 Fold Change P Value
OK -0.304021 0.0221187
(6). Rotger et al., PLoS Pathog., 2010

Genome-wide mRNA expression of CD4+ T cells from HIV-infected patient
(Genes differentially expressed (at adjusted p<0.01) according to the empirical Bayes approach)
Log2 Fold Change P Value
unknown unknown

Proteomic/Transcriptomics studies indicating differentially expressed genes mediated by HIV

(1). Greenwood et al., Elife, 2016

Activated (CD3/CD28) Primary human CD4+ T cells infected with pNL4-3-dE-EGFP. The table shows the complete (unfiltered) TMT (tandem mass tag)-based proteomic time course dataset
6 h 24 h 48 h 72 h RTi
0.961 0.878 0.821 0.749 0.88
(2). Navare et al., Virology, 2012

SUP-T1 cell line
FC-4hpi P-value FC-8hpi P-value FC-20hpi P-value Category
unknown unknown unknown unknown unknown unknown unknown
(3). Hyrcza et al., J. Virolo., 2007

Primary human CD4+ and CD8+ T Cells
Affymetrix Prob ID Fold Change In CD8? Category