Detailed entry information

Protein Information (annotations from UniProt)

Database IDHIV0000269
UniProt IDP78543
Primary gene name(s)BTG2
Synonym gene name(s)PC3
Protein nameProtein BTG2
Protein functionAnti-proliferative protein; the function is mediated by association with deadenylase subunits of the CCR4-NOT complex. Activates mRNA deadenylation in a CNOT6 and CNOT7-dependent manner. In vitro can inhibit deadenylase activity of CNOT7 and CNOT8. Involved in cell cycle regulation. Could be involved in the growth arrest and differentiation of the neuronal precursors, By similarity. Modulates transcription regulation mediated by ESR1. Involved in mitochondrial depolarization and neurite outgrowth. {ECO:0000250, ECO:0000269|PubMed:12771185, ECO:0000269|PubMed:15788397, ECO:0000269|PubMed:18337750, ECO:0000269|PubMed:18773938, ECO:0000269|PubMed:23236473}.
Subcellular locationunknown
ECO codeClick here for more information.
Amino acid sequence
FASTA format: P78543
Gene Ontology
(Biological Process)
Complete annatation
anterior/posterior pattern specification [GO:0009952];
associative learning [GO:0008306];
cellular response to DNA damage stimulus [GO:0006974];
central nervous system neuron development [GO:0021954];
dentate gyrus development [GO:0021542];
DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest [GO:0006977];
DNA repair [GO:0006281];
negative regulation of cell proliferation [GO:0008285];
negative regulation of neural precursor cell proliferation [GO:2000178];
negative regulation of neuron apoptotic process [GO:0043524];
negative regulation of translation [GO:0017148];
neuron projection development [GO:0031175];
positive regulation of nuclear-transcribed mRNA poly(A tail shortening [GO:0060213];
protein methylation [GO:0006479];
response to electrical stimulus [GO:0051602];
response to mechanical stimulus [GO:0009612];
response to organic cyclic compound [GO:0014070];
response to peptide hormone [GO:0043434];
skeletal muscle cell differentiation [GO:0035914];
transcription, DNA-templated [GO:0006351]
Gene Ontology
(Molecular Function)
Complete annatation
transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding [GO:0001078]
Gene Ontology
(Cellular Component)
Complete annatation
cytosol [GO:0005829];
extracellular exosome [GO:0070062]
Protein-protein interaction113593
Phylogenetic treeP78543
HIV replication factor status Zhou et al., Cell. Host. Microbe., 2008
Brass et al., Science, 2008
Smith et al., J. Immunol, 2010
gene status
Lu et al., J. Virol., 2011
      Folds changes 8h: unknown; Folds changes 16h: unknown; Tested: unknown;
Schoggins JW and Rice CM, Curr. Opin. Virol., 2011
      Targeted viruses: unknown
      Viral life cycle: unknown
      Mechanism related to antiviral activity: unknown
Anti-viral restriction factor Liu et al., Retrovirology, 2011
      unknown (Triplicates)

Gene Expression Profile       top

            Up-regulated;            Down-regulated

For brief introduction to each study, please go to the help page.

Gene expression during HIV latency

(1). Mohammadi et al., PLoS Pathog., 2014

Differentially expressed transcripts (Pairwise) during latency and subsequent viral reactivation using several agents - Primary CD4+ T-cell based model

DMSO: Dimethyl suloxyde (negative control) - 0.0033% final
SAHA: Vorinostat (Histone deacetylase inhibitor) - 0.5 μM
CD3: TCR Stimulation by IL-2+ antiCD3/anti-CD28 antibodies
IL7: Interleukin-7 based stimulation
DISU: Disulfiram (alcohol dehydrogenase inhibitor) - 0.5 μM
AZA: 5-azacytidine (AZA; DNA methylation inhibitor) - 1 μM
Experimental Condition Log2 Fold Change P value Adjusted P value
AZA vs. CD30.348753310056730.2914208508715860.408851816469938
AZA vs. DISU-0.01077246607948080.9659887098577850.996872308646283
AZA vs. IL7-0.3754320283483030.05088574325104070.663193284328521
AZA vs. SAHA0.03283464104857890.8928982217934040.976874050805
DISU vs. CD3-0.3720012423306180.3078013891744550.439874681495614
DISU vs. IL7-0.3748994185602980.1370085258179610.484041135857925
DISU vs. SAHA0.04622512617970690.8737864406255270.966950993655183
DMSO vs. AZA-0.06465947716392620.6990031300215231
DMSO vs. CD3-0.4235976303171870.189238836513840.286089620881185
DMSO vs. DISU-0.05540768320718440.8201085890902680.980295078677667
DMSO vs. IL7-0.30382812349520.09104315987092860.558825584305476
DMSO vs. SAHA0.09192650902870150.6964145918497520.907814305100184
HIV vs. Mock in Activation-0.00513239840678850.9935860041288930.999983755607037
HIV vs. Mock in Latency-0.2704604692360830.1547088176059370.999834320637052
IL7 vs. CD3-0.7191081108470080.0275722083497540.0678856413681546
SAHA vs. CD3-0.3392784316126750.3385503868133610.454112534871148
SAHA vs. IL70.4062490325882740.09609371993512690.280557182704262
(2). Iglesias-Ussel et al., J. Virol., 2013

Up and Downregulated transcripts during Latency (Latently infected CD4+ T cells vs Uninfected)- Primary CD4+Tcell based model
Log2 Fold Change P Value
unknown unknown

Gene expression during HIV infection and replication

(1). Imbeault et al., PloS Pathog., 2012

Transcriptomic profiling of HIV-1 infected CD4+ T cells - Primary CD4+ T cells
Experiment type Log2 Fold Change P Value Adjusted P Value
Infected vs. Mock 0.795 6.03E-08 2.65E-06