Detailed entry information

Protein Information (annotations from UniProt)

Database IDHIV0000250
UniProt IDP12644
Primary gene name(s)BMP4
Synonym gene name(s)BMP2B, DVR4
Protein nameBone morphogenetic protein 4
Protein functionInduces cartilage and bone formation. Also act in mesoderm induction, tooth development, limb formation and fracture repair. Acts in concert with PTHLH/PTHRP to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair follicle induction, By similarity. {ECO:0000250}.
Subcellular locationSecreted, extracellular space, extracellular matrix.
ECO codeClick here for more information.
Amino acid sequence
FASTA format: P12644
Gene Ontology
(Biological Process)
Complete annatation
activation of MAPKK activity [GO:0000186];
anterior/posterior axis specification [GO:0009948];
aortic valve morphogenesis [GO:0003180];
blood vessel endothelial cell proliferation involved in sprouting angiogenesis [GO:0002043];
BMP signaling pathway [GO:0030509];
BMP signaling pathway involved in heart development [GO:0061312];
BMP signaling pathway involved in heart induction [GO:0003130];
BMP signaling pathway involved in nephric duct formation [GO:0071893];
BMP signaling pathway involved in renal system segmentation [GO:0061151];
BMP signaling pathway involved in ureter morphogenesis [GO:0061149];
branching involved in prostate gland morphogenesis [GO:0060442];
branching involved in ureteric bud morphogenesis [GO:0001658];
branching morphogenesis of an epithelial tube [GO:0048754];
bronchus development [GO:0060433];
bud dilation involved in lung branching [GO:0060503];
bud elongation involved in lung branching [GO:0060449];
cardiac muscle cell differentiation [GO:0055007];
cardiac septum development [GO:0003279];
cellular response to BMP stimulus [GO:0071773];
chondrocyte differentiation [GO:0002062];
cloacal septation [GO:0060197];
common-partner SMAD protein phosphorylation [GO:0007182];
coronary vasculature development [GO:0060976];
cranial suture morphogenesis [GO:0060363];
deltoid tuberosity development [GO:0035993];
dorsal/ventral neural tube patterning [GO:0021904];
embryonic cranial skeleton morphogenesis [GO:0048701];
embryonic digit morphogenesis [GO:0042733];
embryonic hindlimb morphogenesis [GO:0035116];
embryonic skeletal joint morphogenesis [GO:0060272];
endocardial cushion development [GO:0003197];
endochondral ossification [GO:0001958];
epithelial cell proliferation involved in lung morphogenesis [GO:0060502];
epithelial-mesenchymal cell signaling [GO:0060684];
epithelial tube branching involved in lung morphogenesis [GO:0060441];
erythrocyte differentiation [GO:0030218];
germ cell development [GO:0007281];
glomerular capillary formation [GO:0072104];
glomerular visceral epithelial cell development [GO:0072015];
hematopoietic progenitor cell differentiation [GO:0002244];
inner ear receptor cell differentiation [GO:0060113];
intermediate mesodermal cell differentiation [GO:0048392];
kidney development [GO:0001822];
lens induction in camera-type eye [GO:0060235];
lung alveolus development [GO:0048286];
lung morphogenesis [GO:0060425];
lymphoid progenitor cell differentiation [GO:0002320];
macrophage differentiation [GO:0030225];
mammary gland formation [GO:0060592];
membranous septum morphogenesis [GO:0003149];
mesenchymal cell differentiation involved in kidney development [GO:0072161];
mesenchymal cell proliferation involved in ureter development [GO:0072198];
mesenchymal cell proliferation involved in ureteric bud development [GO:0072138];
mesenchymal to epithelial transition involved in metanephros morphogenesis [GO:0003337];
mesodermal cell fate determination [GO:0007500];
mesonephros development [GO:0001823];
metanephric collecting duct development [GO:0072205];
monocyte differentiation [GO:0030224];
negative regulation of apoptotic process [GO:0043066];
negative regulation of branch elongation involved in ureteric bud branching by BMP signaling pathway [GO:0072097];
negative regulation of branching involved in ureteric bud morphogenesis [GO:0090191];
negative regulation of cell cycle [GO:0045786];
negative regulation of cell death [GO:0060548];
negative regulation of cell proliferation [GO:0008285];
negative regulation of cell proliferation involved in heart morphogenesis [GO:2000137];
negative regulation of chondrocyte differentiation [GO:0032331];
negative regulation of epithelial cell proliferation [GO:0050680];
negative regulation of extrinsic apoptotic signaling pathway [GO:2001237];
negative regulation of glomerular mesangial cell proliferation [GO:0072125];
negative regulation of glomerulus development [GO:0090194];
negative regulation of immature T cell proliferation in thymus [GO:0033088];
negative regulation of MAP kinase activity [GO:0043407];
negative regulation of mesenchymal cell proliferation involved in ureter development [GO:0072200];
negative regulation of metanephric comma-shaped body morphogenesis [GO:2000007];
negative regulation of metanephric S-shaped body morphogenesis [GO:2000005];
negative regulation of mitotic nuclear division [GO:0045839];
negative regulation of myoblast differentiation [GO:0045662];
negative regulation of phosphorylation [GO:0042326];
negative regulation of prostatic bud formation [GO:0060686];
negative regulation of striated muscle tissue development [GO:0045843];
negative regulation of T cell differentiation in thymus [GO:0033085];
negative regulation of thymocyte apoptotic process [GO:0070244];
negative regulation of transcription, DNA-templated [GO:0045892];
negative regulation of transcription from RNA polymerase II promoter [GO:0000122];
neural tube closure [GO:0001843];
neuron fate commitment [GO:0048663];
odontogenesis [GO:0042476];
odontogenesis of dentin-containing tooth [GO:0042475];
osteoblast differentiation [GO:0001649];
outflow tract septum morphogenesis [GO:0003148];
pharyngeal arch artery morphogenesis [GO:0061626];
pituitary gland development [GO:0021983];
positive regulation of apoptotic process [GO:0043065];
positive regulation of BMP signaling pathway [GO:0030513];
positive regulation of bone mineralization [GO:0030501];
positive regulation of branching involved in lung morphogenesis [GO:0061047];
positive regulation of cardiac muscle fiber development [GO:0055020];
positive regulation of cartilage development [GO:0061036];
positive regulation of cell death [GO:0010942];
positive regulation of cell proliferation involved in outflow tract morphogenesis [GO:1901964];
positive regulation of collagen biosynthetic process [GO:0032967];
positive regulation of DNA-dependent DNA replication [GO:2000105];
positive regulation of endothelial cell differentiation [GO:0045603];
positive regulation of endothelial cell migration [GO:0010595];
positive regulation of endothelial cell proliferation [GO:0001938];
positive regulation of epidermal cell differentiation [GO:0045606];
positive regulation of epithelial cell proliferation [GO:0050679];
positive regulation of ERK1 and ERK2 cascade [GO:0070374];
positive regulation of kidney development [GO:0090184];
positive regulation of neuron differentiation [GO:0045666];
positive regulation of ossification [GO:0045778];
positive regulation of osteoblast differentiation [GO:0045669];
positive regulation of pathway-restricted SMAD protein phosphorylation [GO:0010862];
positive regulation of pri-miRNA transcription from RNA polymerase II promoter [GO:1902895];
positive regulation of protein binding [GO:0032092];
positive regulation of protein phosphorylation [GO:0001934];
positive regulation of SMAD protein import into nucleus [GO:0060391];
positive regulation of smooth muscle cell proliferation [GO:0048661];
positive regulation of transcription, DNA-templated [GO:0045893];
positive regulation of transcription from RNA polymerase II promoter [GO:0045944];
post-embryonic development [GO:0009791];
protein localization to nucleus [GO:0034504];
pulmonary artery endothelial tube morphogenesis [GO:0061155];
pulmonary valve morphogenesis [GO:0003184];
regulation of branching involved in prostate gland morphogenesis [GO:0060687];
regulation of cell fate commitment [GO:0010453];
regulation of odontogenesis of dentin-containing tooth [GO:0042487];
regulation of pathway-restricted SMAD protein phosphorylation [GO:0060393];
regulation of protein import into nucleus [GO:0042306];
regulation of smooth muscle cell differentiation [GO:0051150];
renal system development [GO:0072001];
renal system process [GO:0003014];
secondary heart field specification [GO:0003139];
SMAD protein signal transduction [GO:0060395];
smoothened signaling pathway [GO:0007224];
smooth muscle tissue development [GO:0048745];
specification of animal organ position [GO:0010159];
specification of ureteric bud anterior/posterior symmetry by BMP signaling pathway [GO:0072101];
steroid hormone mediated signaling pathway [GO:0043401];
telencephalon development [GO:0021537];
telencephalon regionalization [GO:0021978];
tendon cell differentiation [GO:0035990];
trachea development [GO:0060438];
trachea formation [GO:0060440];
type B pancreatic cell development [GO:0003323];
ureter epithelial cell differentiation [GO:0072192];
ureteric bud development [GO:0001657];
ureter smooth muscle cell differentiation [GO:0072193]
Gene Ontology
(Molecular Function)
Complete annatation
BMP receptor binding [GO:0070700];
chemoattractant activity [GO:0042056];
co-receptor binding [GO:0039706];
cytokine activity [GO:0005125];
heparin binding [GO:0008201];
transforming growth factor beta receptor binding [GO:0005160]
Gene Ontology
(Cellular Component)
Complete annatation
cytoplasm [GO:0005737];
extracellular region [GO:0005576];
extracellular space [GO:0005615];
membrane-bounded vesicle [GO:0031988];
proteinaceous extracellular matrix [GO:0005578]
Protein-protein interaction107120
Phylogenetic treeP12644
HIV replication factor status Zhou et al., Cell. Host. Microbe., 2008
      unknown
Brass et al., Science, 2008
      unknown
Smith et al., J. Immunol, 2010
      unknown
Interferon-stimulated
gene status
Lu et al., J. Virol., 2011
      Folds changes 8h: unknown; Folds changes 16h: unknown; Tested: unknown;
Schoggins JW and Rice CM, Curr. Opin. Virol., 2011
      Targeted viruses: unknown
      Viral life cycle: unknown
      Mechanism related to antiviral activity: unknown
Anti-viral restriction factor Liu et al., Retrovirology, 2011
      unknown (Triplicates)

Gene Expression Profile       top

            Up-regulated;            Down-regulated

For brief introduction to each study, please go to the help page.

Gene expression during HIV latency

(1). Mohammadi et al., PLoS Pathog., 2014

Differentially expressed transcripts (Pairwise) during latency and subsequent viral reactivation using several agents - Primary CD4+ T-cell based model


DMSO: Dimethyl suloxyde (negative control) - 0.0033% final
SAHA: Vorinostat (Histone deacetylase inhibitor) - 0.5 μM
CD3: TCR Stimulation by IL-2+ antiCD3/anti-CD28 antibodies
IL7: Interleukin-7 based stimulation
DISU: Disulfiram (alcohol dehydrogenase inhibitor) - 0.5 μM
AZA: 5-azacytidine (AZA; DNA methylation inhibitor) - 1 μM
Experimental Condition Log2 Fold Change P value Adjusted P value
AZA vs. CD3-3.3046242947813500
AZA vs. DISU-0.8512573160581050.001734282181090510.107596817699906
AZA vs. IL70.2704300300021820.1917837158335790.954510558301023
AZA vs. SAHA-0.28468169264790.271579718579360.646081323625086
DISU vs. CD32.437515515704943.11961745325107e-095.53888262547781e-08
DISU vs. IL71.110417325890533.62302824116201e-050.00241337995883867
DISU vs. SAHA0.5694789322383450.06673240265817870.327064728605337
DMSO vs. AZA0.02463970399295070.8948841053810531
DMSO vs. CD33.3168041168282100
DMSO vs. DISU0.8721986999571230.0008881814629270180.0628398809685923
DMSO vs. IL70.2541478932728630.1903749624300450.701025358715273
DMSO vs. SAHA-0.3132661666191680.2092062596721810.550596516051036
HIV vs. Mock in Activationunknownunknownunknown
HIV vs. Mock in Latency-0.4181279492676180.09361574273981270.999834320637052
IL7 vs. CD33.5796566464817500
SAHA vs. CD32.996644507029791.47881706880071e-135.19481893399223e-12
SAHA vs. IL7-0.5564171624221260.03024334450242760.131455644472201
(2). Iglesias-Ussel et al., J. Virol., 2013

Up and Downregulated transcripts during Latency (Latently infected CD4+ T cells vs Uninfected)- Primary CD4+Tcell based model
Log2 Fold Change P Value
unknown unknown

Gene expression during HIV infection and replication

(1). Imbeault et al., PloS Pathog., 2012

Transcriptomic profiling of HIV-1 infected CD4+ T cells - Primary CD4+ T cells
Experiment type Log2 Fold Change P Value Adjusted P Value
Infected vs. Mock unknown unknown unknown
Infected vs. Bystander unknown unknown unknown
(2). Lefebvre et al., J. Virol., 2011

Transcriptome analysis of T-cell line (Sup T1)
Log2 Fold Change unknown
(3). Li et al., J. Immunol., 2013

Lymphatic tissue
Acute Fold Change Acute P Value Asymt Fold Change Asypt P Value AIDS Fold Change AIDS P Value
unknown unknown unknown unknown unknown unknown
(4). Chang et al., MBio., 2011

Transcriptome analysis of T-cell line (Sup T1)

Derived from Sherrill-Mix et al., BMC Retrovirol., 2015 cross validation
Up-regulated (True) FALSE
(5). Sherrill-Mix et al., BMC Retrovirol., 2015

Deep RNA-seq analysis of primary human T cell infected with low passage HIV isolate HIV89.6 - Primary CD4+ T cell based
Test Status Log2 Fold Change P Value
NOTEST 1.3979 1
(6). Rotger et al., PLoS Pathog., 2010

Genome-wide mRNA expression of CD4+ T cells from HIV-infected patient
(Genes differentially expressed (at adjusted p<0.01) according to the empirical Bayes approach)
Log2 Fold Change P Value
unknown unknown

Proteomic/Transcriptomics studies indicating differentially expressed genes mediated by HIV

(1). Greenwood et al., Elife, 2016

Activated (CD3/CD28) Primary human CD4+ T cells infected with pNL4-3-dE-EGFP. The table shows the complete (unfiltered) TMT (tandem mass tag)-based proteomic time course dataset
6 h 24 h 48 h 72 h RTi
unknown unknown unknown unknown unknown
(2). Navare et al., Virology, 2012

SUP-T1 cell line
FC-4hpi P-value FC-8hpi P-value FC-20hpi P-value Category
unknown unknown unknown unknown unknown unknown unknown
(3). Hyrcza et al., J. Virolo., 2007

Primary human CD4+ and CD8+ T Cells
Affymetrix Prob ID Fold Change In CD8? Category
unknown unknown unknown unknown

Protein Overview       top

Drug-protein Interaction       (annotations from DrugBank)      top

not found

Protein Secondary Structure       (annotations from PDB)      top

not found

HIV-1 Interaction       (annotations from NCBI HIV-1 Interaction Database)      top

not found

Metabolic/Signalling Pathway       (annotations from KEGG database)      top

Pathway Accession Number Description
hsa04350 TGF-beta signaling pathway - Homo sapiens (human)
hsa04390 Hippo signaling pathway - Homo sapiens (human)
hsa04550 Signaling pathways regulating pluripotency of stem cells - Homo sapiens (human)
hsa04919 Thyroid hormone signaling pathway - Homo sapiens (human)
hsa05200 Pathways in cancer - Homo sapiens (human)
hsa05217 Basal cell carcinoma - Homo sapiens (human)
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