Detailed entry information

Protein Information (annotations from UniProt)

Database IDHIV0000249
UniProt IDP13497
Primary gene name(s)BMP1
Synonym gene name(s)PCOLC
Protein nameBone morphogenetic protein 1
Protein functionCleaves the C-terminal propeptides of procollagen I, II and III. Induces cartilage and bone formation. May participate in dorsoventral patterning during early development by cleaving chordin, CHRD. Responsible for the proteolytic activation of lysyl oxidase LOX.
Subcellular locationGolgi apparatus, trans-Golgi network {ECO:0000269|PubMed:12637569}. Secreted, extracellular space, extracellular matrix {ECO:0000269|PubMed:12637569}. Note=Co-localizes with POSTN in the Golgi. {ECO:0000250}.
ECO codeClick here for more information.
Amino acid sequence
FASTA format: P13497
Gene Ontology
(Biological Process)
Complete annatation
BMP signaling pathway [GO:0030509];
cartilage condensation [GO:0001502];
cell development [GO:0048468];
extracellular matrix disassembly [GO:0022617];
lipoprotein metabolic process [GO:0042157];
multicellular organism development [GO:0007275];
ossification [GO:0001503];
positive regulation of cartilage development [GO:0061036];
positive regulation of pathway-restricted SMAD protein phosphorylation [GO:0010862];
proteolysis [GO:0006508];
regulation of apoptotic process [GO:0042981];
regulation of MAPK cascade [GO:0043408];
skeletal system development [GO:0001501];
SMAD protein signal transduction [GO:0060395]
Gene Ontology
(Molecular Function)
Complete annatation
calcium ion binding [GO:0005509];
cytokine activity [GO:0005125];
metalloendopeptidase activity [GO:0004222];
metallopeptidase activity [GO:0008237];
peptidase activity [GO:0008233];
serine-type endopeptidase activity [GO:0004252];
transforming growth factor beta receptor binding [GO:0005160];
zinc ion binding [GO:0008270]
Gene Ontology
(Cellular Component)
Complete annatation
extracellular region [GO:0005576];
extracellular space [GO:0005615];
Golgi apparatus [GO:0005794];
membrane-bounded vesicle [GO:0031988];
proteinaceous extracellular matrix [GO:0005578]
Protein-protein interaction107117
Phylogenetic treeP13497
HIV replication factor status Zhou et al., Cell. Host. Microbe., 2008
Brass et al., Science, 2008
Smith et al., J. Immunol, 2010
gene status
Lu et al., J. Virol., 2011
      Folds changes 8h: unknown; Folds changes 16h: unknown; Tested: unknown;
Schoggins JW and Rice CM, Curr. Opin. Virol., 2011
      Targeted viruses: unknown
      Viral life cycle: unknown
      Mechanism related to antiviral activity: unknown
Anti-viral restriction factor Liu et al., Retrovirology, 2011
      unknown (Triplicates)

Gene Expression Profile       top

            Up-regulated;            Down-regulated

For brief introduction to each study, please go to the help page.

Gene expression during HIV latency

(1). Mohammadi et al., PLoS Pathog., 2014

Differentially expressed transcripts (Pairwise) during latency and subsequent viral reactivation using several agents - Primary CD4+ T-cell based model

DMSO: Dimethyl suloxyde (negative control) - 0.0033% final
SAHA: Vorinostat (Histone deacetylase inhibitor) - 0.5 μM
CD3: TCR Stimulation by IL-2+ antiCD3/anti-CD28 antibodies
IL7: Interleukin-7 based stimulation
DISU: Disulfiram (alcohol dehydrogenase inhibitor) - 0.5 μM
AZA: 5-azacytidine (AZA; DNA methylation inhibitor) - 1 μM
Experimental Condition Log2 Fold Change P value Adjusted P value
AZA vs. CD30.684419608259490.08672461951860720.156709443158428
AZA vs. DISU0.009419830437407920.9706637400808890.997395038717064
AZA vs. IL7-0.03480392079760790.8747596620272920.999311006273513
AZA vs. SAHA-0.5339879399408520.2324643727420870.603542534397903
DISU vs. CD3-0.6886792065780590.1016060864729980.188668409398123
DISU vs. IL7-0.05373957240400670.832655204254260.964820397354322
DISU vs. SAHA-0.5396245362556780.2301343279230590.607949948488768
DMSO vs. AZA0.09396446204988460.5839818929387071
DMSO vs. CD3-0.6024461060485480.1108859211090480.185673178247846
DMSO vs. DISU0.08301291234798970.7371979654326510.967699562672189
DMSO vs. IL7-0.1212509078658570.5084010296042660.887680631570461
DMSO vs. SAHA-0.632119268034560.1415569717176680.451052023671383
HIV vs. Mock in Activation0.4183838468837250.5924235081639240.999983755607037
HIV vs. Mock in Latency0.2606248345496540.1212375050705160.999834320637052
IL7 vs. CD3-0.7154125913003990.0778375328587920.156203585778268
SAHA vs. CD3-1.240416344162060.03512364534214410.074133520350996
SAHA vs. IL7-0.500624196077290.2637917923679170.509506602293148
(2). Iglesias-Ussel et al., J. Virol., 2013

Up and Downregulated transcripts during Latency (Latently infected CD4+ T cells vs Uninfected)- Primary CD4+Tcell based model
Log2 Fold Change P Value
unknown unknown

Gene expression during HIV infection and replication

(1). Imbeault et al., PloS Pathog., 2012

Transcriptomic profiling of HIV-1 infected CD4+ T cells - Primary CD4+ T cells
Experiment type Log2 Fold Change P Value Adjusted P Value
Infected vs. Mock unknown unknown unknown
Infected vs. Bystander unknown unknown unknown
(2). Lefebvre et al., J. Virol., 2011

Transcriptome analysis of T-cell line (Sup T1)
Log2 Fold Change unknown
(3). Li et al., J. Immunol., 2013

Lymphatic tissue
Acute Fold Change Acute P Value Asymt Fold Change Asypt P Value AIDS Fold Change AIDS P Value
unknown unknown unknown unknown unknown unknown
(4). Chang et al., MBio., 2011

Transcriptome analysis of T-cell line (Sup T1)

Derived from Sherrill-Mix et al., BMC Retrovirol., 2015 cross validation
Up-regulated (True) TRUE
(5). Sherrill-Mix et al., BMC Retrovirol., 2015

Deep RNA-seq analysis of primary human T cell infected with low passage HIV isolate HIV89.6 - Primary CD4+ T cell based
Test Status Log2 Fold Change P Value
OK 0.269148 0.369295
(6). Rotger et al., PLoS Pathog., 2010

Genome-wide mRNA expression of CD4+ T cells from HIV-infected patient
(Genes differentially expressed (at adjusted p<0.01) according to the empirical Bayes approach)
Log2 Fold Change P Value
unknown unknown

Proteomic/Transcriptomics studies indicating differentially expressed genes mediated by HIV

(1). Greenwood et al., Elife, 2016

Activated (CD3/CD28) Primary human CD4+ T cells infected with pNL4-3-dE-EGFP. The table shows the complete (unfiltered) TMT (tandem mass tag)-based proteomic time course dataset
6 h 24 h 48 h 72 h RTi
unknown unknown unknown unknown unknown
(2). Navare et al., Virology, 2012

SUP-T1 cell line
FC-4hpi P-value FC-8hpi P-value FC-20hpi P-value Category
unknown unknown unknown unknown unknown unknown unknown
(3). Hyrcza et al., J. Virolo., 2007

Primary human CD4+ and CD8+ T Cells
Affymetrix Prob ID Fold Change In CD8? Category
unknown unknown unknown unknown

Protein Overview       top

Drug-protein Interaction       (annotations from DrugBank)      top

not found

Protein Secondary Structure       (annotations from PDB)      top

PDB Accession Method Resolution Chain Structure Preview
3EDG X-ray 1.2Å A=121-321.
3EDH X-ray 1.2Å A=121-321.

HIV-1 Interaction       (annotations from NCBI HIV-1 Interaction Database)      top

HIV Partner Interaction Type PubMed
Tat upregulates 15857508
HIV-1 virus replication enhanced by expression of human gene 18854154

Metabolic/Signalling Pathway       (annotations from KEGG database)      top

Pathway Accession Number Description
not found