Detailed entry information

Protein Information (annotations from UniProt)

Database IDHIV0000236
UniProt IDQ9C0K0
Primary gene name(s)BCL11B
Synonym gene name(s)CTIP2, RIT1
Protein nameB-cell lymphoma/leukemia 11B
Protein functionTumor-suppressor protein involved in T-cell lymphomas. May function on the P53-signaling pathway. May be a key regulator of both differentiation and survival during thymocyte development. Repress transcription through direct, TFCOUP2-independent binding to a GC-rich response element, By similarity. {ECO:0000250}.
Subcellular locationNucleus {ECO:0000305}.
ECO codeClick here for more information.
Amino acid sequence
FASTA format: Q9C0K0
Gene Ontology
(Biological Process)
Complete annatation
alpha-beta T cell differentiation [GO:0046632];
commitment of neuronal cell to specific neuron type in forebrain [GO:0021902];
epithelial cell morphogenesis [GO:0003382];
keratinocyte development [GO:0003334];
negative regulation of apoptotic process [GO:0043066];
negative regulation of cell proliferation [GO:0008285];
neurogenesis [GO:0022008];
odontogenesis of dentin-containing tooth [GO:0042475];
olfactory bulb axon guidance [GO:0071678];
positive regulation of transcription from RNA polymerase II promoter [GO:0045944];
positive T cell selection [GO:0043368];
post-embryonic camera-type eye development [GO:0031077];
regulation of keratinocyte proliferation [GO:0010837];
regulation of lipid metabolic process [GO:0019216];
regulation of neuron differentiation [GO:0045664];
signal transduction [GO:0007165];
striatal medium spiny neuron differentiation [GO:0021773];
T cell differentiation in thymus [GO:0033077];
T cell receptor V(DJ recombination [GO:0033153];
thymus development [GO:0048538]
Gene Ontology
(Molecular Function)
Complete annatation
metal ion binding [GO:0046872];
RNA polymerase II core promoter proximal region sequence-specific DNA binding [GO:0000978];
sequence-specific DNA binding [GO:0043565];
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding [GO:0001077];
transcription regulatory region DNA binding [GO:0044212]
Gene Ontology
(Cellular Component)
Complete annatation
neuron projection [GO:0043005];
nucleus [GO:0005634]
Protein-protein interaction122343
Phylogenetic treeQ9C0K0
HIV replication factor status Zhou et al., Cell. Host. Microbe., 2008
Brass et al., Science, 2008
Smith et al., J. Immunol, 2010
gene status
Lu et al., J. Virol., 2011
      Folds changes 8h: unknown; Folds changes 16h: unknown; Tested: unknown;
Schoggins JW and Rice CM, Curr. Opin. Virol., 2011
      Targeted viruses: unknown
      Viral life cycle: unknown
      Mechanism related to antiviral activity: unknown
Anti-viral restriction factor Liu et al., Retrovirology, 2011
      unknown (Triplicates)

Gene Expression Profile       top

            Up-regulated;            Down-regulated

For brief introduction to each study, please go to the help page.

Gene expression during HIV latency

(1). Mohammadi et al., PLoS Pathog., 2014

Differentially expressed transcripts (Pairwise) during latency and subsequent viral reactivation using several agents - Primary CD4+ T-cell based model

DMSO: Dimethyl suloxyde (negative control) - 0.0033% final
SAHA: Vorinostat (Histone deacetylase inhibitor) - 0.5 μM
CD3: TCR Stimulation by IL-2+ antiCD3/anti-CD28 antibodies
IL7: Interleukin-7 based stimulation
DISU: Disulfiram (alcohol dehydrogenase inhibitor) - 0.5 μM
AZA: 5-azacytidine (AZA; DNA methylation inhibitor) - 1 μM
Experimental Condition Log2 Fold Change P value Adjusted P value
AZA vs. CD3-2.370317590175995.66757751840896e-121.21165572138241e-10
AZA vs. DISU-0.2569458751210390.3097300279227940.866242136589333
AZA vs. IL7-0.2105436905014760.273307720761690.999311006273513
AZA vs. SAHA-0.05184275381282280.8315974373220070.959735633717235
DISU vs. CD32.100897785389642.57337960940518e-083.64921206323365e-07
DISU vs. IL70.03797108154002550.8800515686369810.977018349573079
DISU vs. SAHA0.2054595949639930.4803470501612440.811434633281613
DMSO vs. AZA-0.06544667649454230.6956298644284641
DMSO vs. CD32.292328641829387.88713538923957e-121.49458735394835e-10
DMSO vs. DISU0.1894585951824120.4372379656573380.882417684249389
DMSO vs. IL7-0.1377135683420740.4434364694047840.866468538726781
DMSO vs. SAHA0.006108053127872330.9793102924581180.995161917811945
HIV vs. Mock in Activation-0.1643353202285630.7921182211259070.999983755607037
HIV vs. Mock in Latency-0.1145481889153010.4872526920468050.999834320637052
IL7 vs. CD32.169015908947739.86710713135608e-112.10066251117133e-09
SAHA vs. CD32.292063393294986.02401351024184e-101.05071624536278e-08
SAHA vs. IL70.1533849965866680.5283643723162770.749535530613171
(2). Iglesias-Ussel et al., J. Virol., 2013

Up and Downregulated transcripts during Latency (Latently infected CD4+ T cells vs Uninfected)- Primary CD4+Tcell based model
Log2 Fold Change P Value
unknown unknown

Gene expression during HIV infection and replication

(1). Imbeault et al., PloS Pathog., 2012

Transcriptomic profiling of HIV-1 infected CD4+ T cells - Primary CD4+ T cells
Experiment type Log2 Fold Change P Value Adjusted P Value
Infected vs. Mock unknown unknown unknown
Infected vs. Bystander -0.778 2.36E-12 4.63E-10
(2). Lefebvre et al., J. Virol., 2011

Transcriptome analysis of T-cell line (Sup T1)
Log2 Fold Change unknown
(3). Li et al., J. Immunol., 2013

Lymphatic tissue
Acute Fold Change Acute P Value Asymt Fold Change Asypt P Value AIDS Fold Change AIDS P Value
1 0.810176245 -1.2 0.066119158 -1.8 0.042303977
(4). Chang et al., MBio., 2011

Transcriptome analysis of T-cell line (Sup T1)

Derived from Sherrill-Mix et al., BMC Retrovirol., 2015 cross validation
Up-regulated (True) FALSE
(5). Sherrill-Mix et al., BMC Retrovirol., 2015

Deep RNA-seq analysis of primary human T cell infected with low passage HIV isolate HIV89.6 - Primary CD4+ T cell based
Test Status Log2 Fold Change P Value
OK -0.468206 0.000305467
(6). Rotger et al., PLoS Pathog., 2010

Genome-wide mRNA expression of CD4+ T cells from HIV-infected patient
(Genes differentially expressed (at adjusted p<0.01) according to the empirical Bayes approach)
Log2 Fold Change P Value
unknown unknown

Proteomic/Transcriptomics studies indicating differentially expressed genes mediated by HIV

(1). Greenwood et al., Elife, 2016

Activated (CD3/CD28) Primary human CD4+ T cells infected with pNL4-3-dE-EGFP. The table shows the complete (unfiltered) TMT (tandem mass tag)-based proteomic time course dataset
6 h 24 h 48 h 72 h RTi
0.962 0.904 0.71 0.599 1.003
(2). Navare et al., Virology, 2012

SUP-T1 cell line
FC-4hpi P-value FC-8hpi P-value FC-20hpi P-value Category
unknown unknown unknown unknown unknown unknown unknown
(3). Hyrcza et al., J. Virolo., 2007

Primary human CD4+ and CD8+ T Cells
Affymetrix Prob ID Fold Change In CD8? Category