Detailed entry information

Protein Information (annotations from UniProt)

Database IDHIV0000223
UniProt IDQ9UIG0
Primary gene name(s)BAZ1B
Synonym gene name(s)WBSC10, WBSCR10, WBSCR9, WSTF
Protein nameTyrosine-protein kinase BAZ1B
Protein functionAtypical tyrosine-protein kinase that plays a central role in chromatin remodeling and acts as a transcription regulator. Involved in DNA damage response by phosphorylating 'Tyr-142' of histone H2AX, H2AXY142ph. H2AXY142ph plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress. Essential component of the WICH complex, a chromatin remodeling complex that mobilizes nucleosomes and reconfigures irregular chromatin to a regular nucleosomal array structure. The WICH complex regulates the transcription of various genes, has a role in RNA polymerase I and RNA polymerase III transcription, mediates the histone H2AX phosphorylation at 'Tyr-142', and is involved in the maintenance of chromatin structures during DNA replication processes. In the complex, it mediates the recruitment of the WICH complex to replication foci during DNA replication. {ECO:0000269|PubMed:11980720, ECO:0000269|PubMed:15543136, ECO:0000269|PubMed:16603771, ECO:0000269|PubMed:19092802, ECO:0000269|PubMed:19234442}.
Subcellular locationNucleus {ECO:0000255|PROSITE-ProRule:PRU00063, ECO:0000255|PROSITE-ProRule:PRU00475, ECO:0000269|PubMed:11980720, ECO:0000269|PubMed:15543136}. Note=Accumulates in pericentromeric heterochromatin during replication. Targeted to replication foci throughout S phase via its association with PCNA.
ECO codeClick here for more information.
Amino acid sequence
FASTA format: Q9UIG0
Gene Ontology
(Biological Process)
Complete annatation
cellular response to DNA damage stimulus [GO:0006974];
chromatin assembly or disassembly [GO:0006333];
chromatin-mediated maintenance of transcription [GO:0048096];
double-strand break repair [GO:0006302];
heart morphogenesis [GO:0003007];
histone phosphorylation [GO:0016572];
positive regulation of gene expression, epigenetic [GO:0045815];
regulation of transcription, DNA-templated [GO:0006355];
transcription, DNA-templated [GO:0006351]
Gene Ontology
(Molecular Function)
Complete annatation
ATP binding [GO:0005524];
chromatin binding [GO:0003682];
histone kinase activity [GO:0035173];
lysine-acetylated histone binding [GO:0070577];
non-membrane spanning protein tyrosine kinase activity [GO:0004715];
protein tyrosine kinase activity [GO:0004713];
vitamin D receptor activator activity [GO:0071884];
zinc ion binding [GO:0008270]
Gene Ontology
(Cellular Component)
Complete annatation
condensed chromosome [GO:0000793];
nucleoplasm [GO:0005654];
pericentric heterochromatin [GO:0005721]
Protein-protein interaction114497
Phylogenetic treeQ9UIG0
HIV replication factor status Zhou et al., Cell. Host. Microbe., 2008
Brass et al., Science, 2008
Smith et al., J. Immunol, 2010
gene status
Lu et al., J. Virol., 2011
      Folds changes 8h: unknown; Folds changes 16h: unknown; Tested: unknown;
Schoggins JW and Rice CM, Curr. Opin. Virol., 2011
      Targeted viruses: unknown
      Viral life cycle: unknown
      Mechanism related to antiviral activity: unknown
Anti-viral restriction factor Liu et al., Retrovirology, 2011
      unknown (Triplicates)

Gene Expression Profile       top

            Up-regulated;            Down-regulated

For brief introduction to each study, please go to the help page.

Gene expression during HIV latency

(1). Mohammadi et al., PLoS Pathog., 2014

Differentially expressed transcripts (Pairwise) during latency and subsequent viral reactivation using several agents - Primary CD4+ T-cell based model

DMSO: Dimethyl suloxyde (negative control) - 0.0033% final
SAHA: Vorinostat (Histone deacetylase inhibitor) - 0.5 μM
CD3: TCR Stimulation by IL-2+ antiCD3/anti-CD28 antibodies
IL7: Interleukin-7 based stimulation
DISU: Disulfiram (alcohol dehydrogenase inhibitor) - 0.5 μM
AZA: 5-azacytidine (AZA; DNA methylation inhibitor) - 1 μM
Experimental Condition Log2 Fold Change P value Adjusted P value
AZA vs. CD30.8025678517485290.01471125622656970.036165071578349
AZA vs. DISU0.144596866919860.5673932509075750.953890891072146
AZA vs. IL70.1477734268562360.4413594583807280.999311006273513
AZA vs. SAHA0.01352648953524670.9557793667765870.990779256780515
DISU vs. CD3-0.6700405804821250.06524601594084290.133630223409275
DISU vs. IL7-0.006090239015527720.9806815695387060.997754944136459
DISU vs. SAHA-0.1297388519949010.6574693834836670.894973041341809
DMSO vs. AZA-0.02297495885700820.890667237107611
DMSO vs. CD3-0.8355072843686040.009350430570039480.0235322814129042
DMSO vs. DISU-0.1690342953065010.4883456601477890.904230103543003
DMSO vs. IL70.1777438276421070.3221587942927430.799721223986312
DMSO vs. SAHA0.02940259240388940.9007315356555460.975996264087583
HIV vs. Mock in Activation0.2038189905439030.7436146844634040.999983755607037
HIV vs. Mock in Latency0.08586448388154950.6021546326867920.999834320637052
IL7 vs. CD3-0.647477326223830.04430515711771430.0991995890129691
SAHA vs. CD3-0.8136046282987130.02236020069487120.0505654598546983
SAHA vs. IL7-0.1375287431171090.5730498791900510.778843555938223
(2). Iglesias-Ussel et al., J. Virol., 2013

Up and Downregulated transcripts during Latency (Latently infected CD4+ T cells vs Uninfected)- Primary CD4+Tcell based model
Log2 Fold Change P Value
unknown unknown

Gene expression during HIV infection and replication

(1). Imbeault et al., PloS Pathog., 2012

Transcriptomic profiling of HIV-1 infected CD4+ T cells - Primary CD4+ T cells
Experiment type Log2 Fold Change P Value Adjusted P Value
Infected vs. Mock unknown unknown unknown
Infected vs. Bystander unknown unknown unknown
(2). Lefebvre et al., J. Virol., 2011

Transcriptome analysis of T-cell line (Sup T1)
Log2 Fold Change unknown
(3). Li et al., J. Immunol., 2013

Lymphatic tissue
Acute Fold Change Acute P Value Asymt Fold Change Asypt P Value AIDS Fold Change AIDS P Value
unknown unknown unknown unknown unknown unknown
(4). Chang et al., MBio., 2011

Transcriptome analysis of T-cell line (Sup T1)

Derived from Sherrill-Mix et al., BMC Retrovirol., 2015 cross validation
Up-regulated (True) FALSE
(5). Sherrill-Mix et al., BMC Retrovirol., 2015

Deep RNA-seq analysis of primary human T cell infected with low passage HIV isolate HIV89.6 - Primary CD4+ T cell based
Test Status Log2 Fold Change P Value
OK 0.115131 0.547327
(6). Rotger et al., PLoS Pathog., 2010

Genome-wide mRNA expression of CD4+ T cells from HIV-infected patient
(Genes differentially expressed (at adjusted p<0.01) according to the empirical Bayes approach)
Log2 Fold Change P Value
unknown unknown

Proteomic/Transcriptomics studies indicating differentially expressed genes mediated by HIV

(1). Greenwood et al., Elife, 2016

Activated (CD3/CD28) Primary human CD4+ T cells infected with pNL4-3-dE-EGFP. The table shows the complete (unfiltered) TMT (tandem mass tag)-based proteomic time course dataset
6 h 24 h 48 h 72 h RTi
0.907 0.843 0.755 0.661 0.982
(2). Navare et al., Virology, 2012

SUP-T1 cell line
FC-4hpi P-value FC-8hpi P-value FC-20hpi P-value Category
unknown unknown unknown unknown unknown unknown unknown
(3). Hyrcza et al., J. Virolo., 2007

Primary human CD4+ and CD8+ T Cells
Affymetrix Prob ID Fold Change In CD8? Category
208445_s_at 1.57 No upregulated in CD8+ cells

Protein Overview       top

Drug-protein Interaction       (annotations from DrugBank)      top

not found

Protein Secondary Structure       (annotations from PDB)      top

PDB Accession Method Resolution Chain Structure Preview
1F62 NMR - A=1185-1235.

HIV-1 Interaction       (annotations from NCBI HIV-1 Interaction Database)      top

HIV Partner Interaction Type PubMed
Tat interacts with 19454010

Metabolic/Signalling Pathway       (annotations from KEGG database)      top

Pathway Accession Number Description
not found