Detailed entry information

Protein Information (annotations from UniProt)

Database IDHIV0000215
UniProt IDQ9UL15
Primary gene name(s)BAG5
Synonym gene name(s)KIAA0873
Protein nameBAG family molecular chaperone regulator 5
Protein functionInhibits both auto-ubiquitination of PARK2 and ubiquitination of target proteins by PARK2, By similarity. May function as a nucleotide exchange factor for HSP/HSP70, promoting ADP release, and activating Hsp70-mediated refolding. {ECO:0000250, ECO:0000269|PubMed:20223214}.
Subcellular locationunknown
ECO codeClick here for more information.
Amino acid sequence
FASTA format: Q9UL15
Gene Ontology
(Biological Process)
Complete annatation
Golgi organization [GO:0007030];
negative regulation of neuron projection development [GO:0010977];
negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway [GO:1902176];
negative regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032435];
negative regulation of protein refolding [GO:0061084];
negative regulation of protein ubiquitination [GO:0031397];
negative regulation of ubiquitin-protein transferase activity [GO:0051444];
neuron death [GO:0070997];
protein folding [GO:0006457];
regulation of cellular response to heat [GO:1900034];
regulation of inclusion body assembly [GO:0090083];
regulation of ubiquitin-protein transferase activity [GO:0051438]
Gene Ontology
(Molecular Function)
Complete annatation
adenyl-nucleotide exchange factor activity [GO:0000774];
chaperone binding [GO:0051087];
protein kinase binding [GO:0019901];
ubiquitin protein ligase binding [GO:0031625]
Gene Ontology
(Cellular Component)
Complete annatation
cytosol [GO:0005829];
inclusion body [GO:0016234];
membrane [GO:0016020];
mitochondrion [GO:0005739];
nucleus [GO:0005634];
perinuclear region of cytoplasm [GO:0048471]
Protein-protein interaction114905
Phylogenetic treeQ9UL15
HIV replication factor status Zhou et al., Cell. Host. Microbe., 2008
Brass et al., Science, 2008
Smith et al., J. Immunol, 2010
gene status
Lu et al., J. Virol., 2011
      Folds changes 8h: unknown; Folds changes 16h: unknown; Tested: unknown;
Schoggins JW and Rice CM, Curr. Opin. Virol., 2011
      Targeted viruses: unknown
      Viral life cycle: unknown
      Mechanism related to antiviral activity: unknown
Anti-viral restriction factor Liu et al., Retrovirology, 2011
      unknown (Triplicates)

Gene Expression Profile       top

            Up-regulated;            Down-regulated

For brief introduction to each study, please go to the help page.

Gene expression during HIV latency

(1). Mohammadi et al., PLoS Pathog., 2014

Differentially expressed transcripts (Pairwise) during latency and subsequent viral reactivation using several agents - Primary CD4+ T-cell based model

DMSO: Dimethyl suloxyde (negative control) - 0.0033% final
SAHA: Vorinostat (Histone deacetylase inhibitor) - 0.5 μM
CD3: TCR Stimulation by IL-2+ antiCD3/anti-CD28 antibodies
IL7: Interleukin-7 based stimulation
DISU: Disulfiram (alcohol dehydrogenase inhibitor) - 0.5 μM
AZA: 5-azacytidine (AZA; DNA methylation inhibitor) - 1 μM
Experimental Condition Log2 Fold Change P value Adjusted P value
AZA vs. CD30.6155357381910960.06105305788924540.117522668274779
AZA vs. DISU0.1838953049135010.468204821709640.926047745875375
AZA vs. IL70.1335161312099540.4880998946149570.999311006273513
AZA vs. SAHA0.1112609895920580.6490194117892420.892475699079642
DISU vs. CD3-0.4445911122337510.2227077404817250.345949760925549
DISU vs. IL7-0.05937762766620410.8138766310103360.960029913941183
DISU vs. SAHA-0.07133353022076140.8077812617386540.950232067413365
DMSO vs. AZA-0.008410595318178850.9600688991841561
DMSO vs. CD3-0.6352164134215240.04783532236160530.0927463489546439
DMSO vs. DISU-0.1940678088507340.4273696401435190.881231908287284
DMSO vs. IL70.1491050000733880.4077880440514940.847494592253841
DMSO vs. SAHA0.1129654526837520.6325370197283950.880809219846706
HIV vs. Mock in Activation0.1125010001964560.8567671617160890.999983755607037
HIV vs. Mock in Latency0.05701129091578920.7301229043487830.999834320637052
IL7 vs. CD3-0.4744172946025650.1407559053019820.246727963788437
SAHA vs. CD3-0.5290930858126120.1348967868834450.221375866093163
SAHA vs. IL7-0.02564328862522450.9163399041701440.968167318220946
(2). Iglesias-Ussel et al., J. Virol., 2013

Up and Downregulated transcripts during Latency (Latently infected CD4+ T cells vs Uninfected)- Primary CD4+Tcell based model
Log2 Fold Change P Value
unknown unknown

Gene expression during HIV infection and replication

(1). Imbeault et al., PloS Pathog., 2012

Transcriptomic profiling of HIV-1 infected CD4+ T cells - Primary CD4+ T cells
Experiment type Log2 Fold Change P Value Adjusted P Value
Infected vs. Mock unknown unknown unknown
Infected vs. Bystander unknown unknown unknown
(2). Lefebvre et al., J. Virol., 2011

Transcriptome analysis of T-cell line (Sup T1)
Log2 Fold Change unknown
(3). Li et al., J. Immunol., 2013

Lymphatic tissue
Acute Fold Change Acute P Value Asymt Fold Change Asypt P Value AIDS Fold Change AIDS P Value
unknown unknown unknown unknown unknown unknown
(4). Chang et al., MBio., 2011

Transcriptome analysis of T-cell line (Sup T1)

Derived from Sherrill-Mix et al., BMC Retrovirol., 2015 cross validation
Up-regulated (True) FALSE
(5). Sherrill-Mix et al., BMC Retrovirol., 2015

Deep RNA-seq analysis of primary human T cell infected with low passage HIV isolate HIV89.6 - Primary CD4+ T cell based
Test Status Log2 Fold Change P Value
OK -0.371059 0.0040166
(6). Rotger et al., PLoS Pathog., 2010

Genome-wide mRNA expression of CD4+ T cells from HIV-infected patient
(Genes differentially expressed (at adjusted p<0.01) according to the empirical Bayes approach)
Log2 Fold Change P Value
unknown unknown

Proteomic/Transcriptomics studies indicating differentially expressed genes mediated by HIV

(1). Greenwood et al., Elife, 2016

Activated (CD3/CD28) Primary human CD4+ T cells infected with pNL4-3-dE-EGFP. The table shows the complete (unfiltered) TMT (tandem mass tag)-based proteomic time course dataset
6 h 24 h 48 h 72 h RTi
1.002 1.005 0.972 0.961 1.079
(2). Navare et al., Virology, 2012

SUP-T1 cell line
FC-4hpi P-value FC-8hpi P-value FC-20hpi P-value Category
unknown unknown unknown unknown unknown unknown unknown
(3). Hyrcza et al., J. Virolo., 2007

Primary human CD4+ and CD8+ T Cells
Affymetrix Prob ID Fold Change In CD8? Category
unknown unknown unknown unknown

Protein Overview       top

Drug-protein Interaction       (annotations from DrugBank)      top

not found

Protein Secondary Structure       (annotations from PDB)      top

PDB Accession Method Resolution Chain Structure Preview
2D9D NMR - A=275-350.
3A8Y X-ray 2.3Å C/D=341-447.

HIV-1 Interaction       (annotations from NCBI HIV-1 Interaction Database)      top

not found

Metabolic/Signalling Pathway       (annotations from KEGG database)      top

Pathway Accession Number Description
not found