Detailed entry information

Protein Information (annotations from UniProt)

Database IDHIV0000213
UniProt IDQ9BYV9
Primary gene name(s)BACH2
Synonym gene name(s)unknown
Protein nameTranscription regulator protein BACH2
Protein functionTranscriptional regulator that acts as repressor or activator, By similarity. Binds to Maf recognition elements, MARE, By similarity. Plays an important role in coordinating transcription activation and repression by MAFK, By similarity. Induces apoptosis in response to oxidative stress through repression of the antiapoptotic factor HMOX1, PubMed:17018862. Positively regulates the nuclear import of actin, By similarity. {ECO:0000250|UniProtKB:P97303, ECO:0000269|PubMed:17018862}.
Subcellular locationCytoplasm {ECO:0000269|PubMed:17018862}. Nucleus {ECO:0000255|PROSITE-ProRule:PRU00978, ECO:0000269|PubMed:17018862}. Note=Nucleocytoplasmic shuttling is controlled by phosphorylation. {ECO:0000269|PubMed:17018862}.
ECO codeClick here for more information.
Amino acid sequence
FASTA format: Q9BYV9
Gene Ontology
(Biological Process)
Complete annatation
protein ubiquitination [GO:0016567];
single-organism nuclear import [GO:1902593];
transcription from RNA polymerase II promoter [GO:0006366]
Gene Ontology
(Molecular Function)
Complete annatation
RNA polymerase II distal enhancer sequence-specific DNA binding [GO:0000980];
transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding [GO:0001206];
transcription factor activity, sequence-specific DNA binding [GO:0003700]
Gene Ontology
(Cellular Component)
Complete annatation
Cul3-RING ubiquitin ligase complex [GO:0031463];
cytoplasm [GO:0005737];
nucleus [GO:0005634]
Protein-protein interaction121913
Phylogenetic treeQ9BYV9
HIV replication factor status Zhou et al., Cell. Host. Microbe., 2008
Brass et al., Science, 2008
Smith et al., J. Immunol, 2010
gene status
Lu et al., J. Virol., 2011
      Folds changes 8h: unknown; Folds changes 16h: unknown; Tested: unknown;
Schoggins JW and Rice CM, Curr. Opin. Virol., 2011
      Targeted viruses: unknown
      Viral life cycle: unknown
      Mechanism related to antiviral activity: unknown
Anti-viral restriction factor Liu et al., Retrovirology, 2011
      unknown (Triplicates)

Gene Expression Profile       top

            Up-regulated;            Down-regulated

For brief introduction to each study, please go to the help page.

Gene expression during HIV latency

(1). Mohammadi et al., PLoS Pathog., 2014

Differentially expressed transcripts (Pairwise) during latency and subsequent viral reactivation using several agents - Primary CD4+ T-cell based model

DMSO: Dimethyl suloxyde (negative control) - 0.0033% final
SAHA: Vorinostat (Histone deacetylase inhibitor) - 0.5 μM
CD3: TCR Stimulation by IL-2+ antiCD3/anti-CD28 antibodies
IL7: Interleukin-7 based stimulation
DISU: Disulfiram (alcohol dehydrogenase inhibitor) - 0.5 μM
AZA: 5-azacytidine (AZA; DNA methylation inhibitor) - 1 μM
Experimental Condition Log2 Fold Change P value Adjusted P value
AZA vs. CD31.871329242213326.45193272252875e-075.23377448837209e-06
AZA vs. DISU0.2200067316559130.3845634283887340.900314181584008
AZA vs. IL70.3986364668316040.03854797591985560.601484100455469
AZA vs. SAHA-0.2430869132990680.3227734417737060.693392834564148
DISU vs. CD3-1.66407878699021.02834946174024e-057.6474295936223e-05
DISU vs. IL70.1692025731407840.5019470644145720.827186976914614
DISU vs. SAHA-0.4607263885484470.1176320020199890.440674099538467
DMSO vs. AZA0.01039759187227660.9506047844799821
DMSO vs. CD3-1.869928851641191.09135275261352e-067.78467292524746e-06
DMSO vs. DISU-0.2107498310549610.3879210156614140.86028854108019
DMSO vs. IL70.3951424639403560.02827447187230330.343066924812389
DMSO vs. SAHA-0.2598838126421040.2733397030548150.622469426524496
HIV vs. Mock in Activation0.1678529258956740.8387830117817550.999983755607037
HIV vs. Mock in Latency0.08841155642778190.729571253525460.999834320637052
IL7 vs. CD3-1.466543191648756.21631585139282e-050.00038479888635747
SAHA vs. CD3-2.137823297161064.55912497532296e-074.02495684698986e-06
SAHA vs. IL7-0.6443397091168220.008635342539870640.0565312589264904
(2). Iglesias-Ussel et al., J. Virol., 2013

Up and Downregulated transcripts during Latency (Latently infected CD4+ T cells vs Uninfected)- Primary CD4+Tcell based model
Log2 Fold Change P Value
unknown unknown

Gene expression during HIV infection and replication

(1). Imbeault et al., PloS Pathog., 2012

Transcriptomic profiling of HIV-1 infected CD4+ T cells - Primary CD4+ T cells
Experiment type Log2 Fold Change P Value Adjusted P Value
Infected vs. Mock unknown unknown unknown
Infected vs. Bystander unknown unknown unknown
(2). Lefebvre et al., J. Virol., 2011

Transcriptome analysis of T-cell line (Sup T1)
Log2 Fold Change unknown
(3). Li et al., J. Immunol., 2013

Lymphatic tissue
Acute Fold Change Acute P Value Asymt Fold Change Asypt P Value AIDS Fold Change AIDS P Value
unknown unknown unknown unknown unknown unknown
(4). Chang et al., MBio., 2011

Transcriptome analysis of T-cell line (Sup T1)

Derived from Sherrill-Mix et al., BMC Retrovirol., 2015 cross validation
Up-regulated (True) TRUE
(5). Sherrill-Mix et al., BMC Retrovirol., 2015

Deep RNA-seq analysis of primary human T cell infected with low passage HIV isolate HIV89.6 - Primary CD4+ T cell based
Test Status Log2 Fold Change P Value
OK -0.330644 0.0113224
(6). Rotger et al., PLoS Pathog., 2010

Genome-wide mRNA expression of CD4+ T cells from HIV-infected patient
(Genes differentially expressed (at adjusted p<0.01) according to the empirical Bayes approach)
Log2 Fold Change P Value
unknown unknown

Proteomic/Transcriptomics studies indicating differentially expressed genes mediated by HIV

(1). Greenwood et al., Elife, 2016

Activated (CD3/CD28) Primary human CD4+ T cells infected with pNL4-3-dE-EGFP. The table shows the complete (unfiltered) TMT (tandem mass tag)-based proteomic time course dataset
6 h 24 h 48 h 72 h RTi
unknown unknown unknown unknown unknown
(2). Navare et al., Virology, 2012

SUP-T1 cell line
FC-4hpi P-value FC-8hpi P-value FC-20hpi P-value Category
unknown unknown unknown unknown unknown unknown unknown
(3). Hyrcza et al., J. Virolo., 2007

Primary human CD4+ and CD8+ T Cells
Affymetrix Prob ID Fold Change In CD8? Category