Detailed entry information

Protein Information (annotations from UniProt)

Database IDHIV0000140
UniProt IDO15085
Primary gene name(s)ARHGEF11
Synonym gene name(s)KIAA0380
Protein nameRho guanine nucleotide exchange factor 11
Protein functionMay play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12, GNA12 and alpha-13, GNA13. Acts as guanine nucleotide exchange factor, GEF for RhoA GTPase and may act as GTPase-activating protein, GAP for GNA12 and GNA13. Involved in neurotrophin-induced neurite outgrowth. {ECO:0000269|PubMed:21670212}.
Subcellular locationCytoplasm {ECO:0000269|PubMed:10900204}. Membrane {ECO:0000269|PubMed:10900204}. Note=Translocated to the membrane upon stimulation.
ECO codeClick here for more information.
Amino acid sequence
FASTA format: O15085
Gene Ontology
(Biological Process)
Complete annatation
actin cytoskeleton organization [GO:0030036];
cytokinesis [GO:0000910];
establishment of cell polarity [GO:0030010];
G-protein coupled receptor signaling pathway [GO:0007186];
movement of cell or subcellular component [GO:0006928];
positive regulation of apoptotic process [GO:0043065];
positive regulation of transcription, DNA-templated [GO:0045893];
regulation of cell growth [GO:0001558];
regulation of Rho protein signal transduction [GO:0035023];
regulation of small GTPase mediated signal transduction [GO:0051056];
Rho protein signal transduction [GO:0007266];
striated muscle contraction [GO:0006941]
Gene Ontology
(Molecular Function)
Complete annatation
G-protein coupled receptor binding [GO:0001664];
GTPase activator activity [GO:0005096];
guanyl-nucleotide exchange factor activity [GO:0005085];
Rho guanyl-nucleotide exchange factor activity [GO:0005089]
Gene Ontology
(Cellular Component)
Complete annatation
cytoplasm [GO:0005737];
cytosol [GO:0005829];
intracellular [GO:0005622];
membrane [GO:0016020]
Protein-protein interaction115164
Phylogenetic treeO15085
HIV replication factor status Zhou et al., Cell. Host. Microbe., 2008
Brass et al., Science, 2008
Smith et al., J. Immunol, 2010
gene status
Lu et al., J. Virol., 2011
      Folds changes 8h: unknown; Folds changes 16h: unknown; Tested: unknown;
Schoggins JW and Rice CM, Curr. Opin. Virol., 2011
      Targeted viruses: unknown
      Viral life cycle: unknown
      Mechanism related to antiviral activity: unknown
Anti-viral restriction factor Liu et al., Retrovirology, 2011
      unknown (Triplicates)

Gene Expression Profile       top

            Up-regulated;            Down-regulated

For brief introduction to each study, please go to the help page.

Gene expression during HIV latency

(1). Mohammadi et al., PLoS Pathog., 2014

Differentially expressed transcripts (Pairwise) during latency and subsequent viral reactivation using several agents - Primary CD4+ T-cell based model

DMSO: Dimethyl suloxyde (negative control) - 0.0033% final
SAHA: Vorinostat (Histone deacetylase inhibitor) - 0.5 μM
CD3: TCR Stimulation by IL-2+ antiCD3/anti-CD28 antibodies
IL7: Interleukin-7 based stimulation
DISU: Disulfiram (alcohol dehydrogenase inhibitor) - 0.5 μM
AZA: 5-azacytidine (AZA; DNA methylation inhibitor) - 1 μM
Experimental Condition Log2 Fold Change P value Adjusted P value
AZA vs. CD3-3.008292844710031.3446711522036e-091.8870468906902e-08
AZA vs. DISU0.06516825493796150.8011606834532860.983438610789082
AZA vs. IL7-0.2157635494773540.4016269560232090.999311006273513
AZA vs. SAHA-0.7719268893253940.07649802255661120.343903544139222
DISU vs. CD33.05739705047734.53342574591176e-097.68693584857973e-08
DISU vs. IL7-0.2902864794216320.2980956559279050.682220327809483
DISU vs. SAHA-0.8362093859453030.07071186872312260.335653094023994
DMSO vs. AZA0.1460354120628890.5471067499228911
DMSO vs. CD33.135743834723771.03101494008939e-091.32981507469578e-08
DMSO vs. DISU0.07666851992801160.763612915403670.969857060964769
DMSO vs. IL7-0.3537218364427880.2227754227813050.730634444581427
DMSO vs. SAHA-0.9233177466504030.04214377995194070.228622320608691
HIV vs. Mock in Activation-0.2178234128479720.8300777600541560.999983755607037
HIV vs. Mock in Latency-0.3658604190269410.03052683907054980.662379195939374
IL7 vs. CD32.803578318542289.8114343538569e-081.19844205847395e-06
SAHA vs. CD32.214552008183160.0003168477263985060.0013175759483514
SAHA vs. IL7-0.5608009951937390.2219597585388010.461619950360636
(2). Iglesias-Ussel et al., J. Virol., 2013

Up and Downregulated transcripts during Latency (Latently infected CD4+ T cells vs Uninfected)- Primary CD4+Tcell based model
Log2 Fold Change P Value
unknown unknown

Gene expression during HIV infection and replication

(1). Imbeault et al., PloS Pathog., 2012

Transcriptomic profiling of HIV-1 infected CD4+ T cells - Primary CD4+ T cells
Experiment type Log2 Fold Change P Value Adjusted P Value
Infected vs. Mock unknown unknown unknown
Infected vs. Bystander unknown unknown unknown
(2). Lefebvre et al., J. Virol., 2011

Transcriptome analysis of T-cell line (Sup T1)
Log2 Fold Change unknown
(3). Li et al., J. Immunol., 2013

Lymphatic tissue
Acute Fold Change Acute P Value Asymt Fold Change Asypt P Value AIDS Fold Change AIDS P Value
unknown unknown unknown unknown unknown unknown
(4). Chang et al., MBio., 2011

Transcriptome analysis of T-cell line (Sup T1)

Derived from Sherrill-Mix et al., BMC Retrovirol., 2015 cross validation
Up-regulated (True) TRUE
(5). Sherrill-Mix et al., BMC Retrovirol., 2015

Deep RNA-seq analysis of primary human T cell infected with low passage HIV isolate HIV89.6 - Primary CD4+ T cell based
Test Status Log2 Fold Change P Value
OK -0.322745 0.12079
(6). Rotger et al., PLoS Pathog., 2010

Genome-wide mRNA expression of CD4+ T cells from HIV-infected patient
(Genes differentially expressed (at adjusted p<0.01) according to the empirical Bayes approach)
Log2 Fold Change P Value
unknown unknown

Proteomic/Transcriptomics studies indicating differentially expressed genes mediated by HIV

(1). Greenwood et al., Elife, 2016

Activated (CD3/CD28) Primary human CD4+ T cells infected with pNL4-3-dE-EGFP. The table shows the complete (unfiltered) TMT (tandem mass tag)-based proteomic time course dataset
6 h 24 h 48 h 72 h RTi
unknown unknown unknown unknown unknown
(2). Navare et al., Virology, 2012

SUP-T1 cell line
FC-4hpi P-value FC-8hpi P-value FC-20hpi P-value Category
unknown unknown unknown unknown unknown unknown unknown
(3). Hyrcza et al., J. Virolo., 2007

Primary human CD4+ and CD8+ T Cells
Affymetrix Prob ID Fold Change In CD8? Category
unknown unknown unknown unknown

Protein Overview       top

Drug-protein Interaction       (annotations from DrugBank)      top

not found

Protein Secondary Structure       (annotations from PDB)      top

PDB Accession Method Resolution Chain Structure Preview
1HTJ X-ray 2.2Å F=281-490.
1XCG X-ray 2.5Å A/E=714-1081.
2DLS NMR - A=44-123.
3KZ1 X-ray 2.7Å A/B=710-1085.
3T06 X-ray 2.8Å A/E=672-1081.
5E6P X-ray 3.2Å B=42-125.

HIV-1 Interaction       (annotations from NCBI HIV-1 Interaction Database)      top

not found

Metabolic/Signalling Pathway       (annotations from KEGG database)      top

Pathway Accession Number Description
hsa04270 Vascular smooth muscle contraction - Homo sapiens (human)
hsa05200 Pathways in cancer - Homo sapiens (human)