Detailed entry information

Protein Information (annotations from UniProt)

Database IDHIV0000126
UniProt IDQ92482
Primary gene name(s)AQP3
Synonym gene name(s)unknown
Protein nameAquaporin-3
Protein functionWater channel required to promote glycerol permeability and water transport across cell membranes. Acts as a glycerol transporter in skin and plays an important role in regulating SC, stratum corneum and epidermal glycerol content. Involved in skin hydration, wound healing, and tumorigenesis. Provides kidney medullary collecting duct with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient. Slightly permeable to urea and may function as a water and urea exit mechanism in antidiuresis in collecting duct cells. It may play an important role in gastrointestinal tract water transport and in glycerol metabolism, By similarity. {ECO:0000250}.
Subcellular locationBasolateral cell membrane;
Multi-pass membrane protein. Note=In collecting ducts of kidney.
ECO codeClick here for more information.
Amino acid sequence
FASTA format: Q92482
Gene Ontology
(Biological Process)
Complete annatation
cellular water homeostasis [GO:0009992];
excretion [GO:0007588];
ion transmembrane transport [GO:0034220];
odontogenesis [GO:0042476];
positive regulation of immune system process [GO:0002684];
regulation of keratinocyte differentiation [GO:0045616];
renal water absorption [GO:0070295];
renal water homeostasis [GO:0003091];
response to calcium ion [GO:0051592];
response to retinoic acid [GO:0032526];
response to vitamin D [GO:0033280];
transport [GO:0006810];
urea transmembrane transport [GO:0071918];
water transport [GO:0006833]
Gene Ontology
(Molecular Function)
Complete annatation
glycerol channel activity [GO:0015254];
transporter activity [GO:0005215];
urea transmembrane transporter activity [GO:0015204];
water channel activity [GO:0015250]
Gene Ontology
(Cellular Component)
Complete annatation
basolateral plasma membrane [GO:0016323];
cell-cell junction [GO:0005911];
cytoplasm [GO:0005737];
integral component of membrane [GO:0016021];
integral component of plasma membrane [GO:0005887];
nucleus [GO:0005634];
plasma membrane [GO:0005886]
Protein-protein interaction106856
Phylogenetic treeQ92482
HIV replication factor status Zhou et al., Cell. Host. Microbe., 2008
Brass et al., Science, 2008
Smith et al., J. Immunol, 2010
gene status
Lu et al., J. Virol., 2011
      Folds changes 8h: unknown; Folds changes 16h: unknown; Tested: unknown;
Schoggins JW and Rice CM, Curr. Opin. Virol., 2011
      Targeted viruses: unknown
      Viral life cycle: unknown
      Mechanism related to antiviral activity: unknown
Anti-viral restriction factor Liu et al., Retrovirology, 2011
      unknown (Triplicates)

Gene Expression Profile       top

            Up-regulated;            Down-regulated

For brief introduction to each study, please go to the help page.

Gene expression during HIV latency

(1). Mohammadi et al., PLoS Pathog., 2014

Differentially expressed transcripts (Pairwise) during latency and subsequent viral reactivation using several agents - Primary CD4+ T-cell based model

DMSO: Dimethyl suloxyde (negative control) - 0.0033% final
SAHA: Vorinostat (Histone deacetylase inhibitor) - 0.5 μM
CD3: TCR Stimulation by IL-2+ antiCD3/anti-CD28 antibodies
IL7: Interleukin-7 based stimulation
DISU: Disulfiram (alcohol dehydrogenase inhibitor) - 0.5 μM
AZA: 5-azacytidine (AZA; DNA methylation inhibitor) - 1 μM
Experimental Condition Log2 Fold Change P value Adjusted P value
AZA vs. CD3-3.833617146499343.33173840705303e-062.30348446197721e-05
AZA vs. DISU0.08596694079659570.7340626860607240.974560663114398
AZA vs. IL70.1595869370279960.4084281527136430.999311006273513
AZA vs. SAHA-0.8681579363878390.001184907060470810.0229284839917034
DISU vs. CD33.906298165761182.47703574651759e-062.15209434253637e-05
DISU vs. IL70.06440745904016780.798663204673650.955213923328671
DISU vs. SAHA-0.9530037219975620.001410488840860370.0262114393595643
DMSO vs. AZA0.02815903765224010.8669311826518881
DMSO vs. CD33.844305493834693.71055566528167e-062.35366404620919e-05
DMSO vs. DISU-0.06128535812545490.8017364022719130.977285200264502
DMSO vs. IL70.139444249040930.4395718919676840.862303452795029
DMSO vs. SAHA-0.9015130866337440.001513212548015290.0239554898226243
HIV vs. Mock in Activation0.625305051956460.6717323995299710.999983755607037
HIV vs. Mock in Latency-0.3480565295643980.03672321714011980.739073131068313
IL7 vs. CD33.999776871811032.25121018815333e-062.0246116447515e-05
SAHA vs. CD32.939626200085760.000927547152367980.00335690095729718
SAHA vs. IL7-1.032108994731990.0001574647621084280.00279908469813967
(2). Iglesias-Ussel et al., J. Virol., 2013

Up and Downregulated transcripts during Latency (Latently infected CD4+ T cells vs Uninfected)- Primary CD4+Tcell based model
Log2 Fold Change P Value
unknown unknown

Gene expression during HIV infection and replication

(1). Imbeault et al., PloS Pathog., 2012

Transcriptomic profiling of HIV-1 infected CD4+ T cells - Primary CD4+ T cells
Experiment type Log2 Fold Change P Value Adjusted P Value
Infected vs. Mock unknown unknown unknown
Infected vs. Bystander unknown unknown unknown
(2). Lefebvre et al., J. Virol., 2011

Transcriptome analysis of T-cell line (Sup T1)
Log2 Fold Change -0.977476096
(3). Li et al., J. Immunol., 2013

Lymphatic tissue
Acute Fold Change Acute P Value Asymt Fold Change Asypt P Value AIDS Fold Change AIDS P Value
1 0.704242309 -1.3 0.012168714 -1.7 0.007576683
(4). Chang et al., MBio., 2011

Transcriptome analysis of T-cell line (Sup T1)

Derived from Sherrill-Mix et al., BMC Retrovirol., 2015 cross validation
Up-regulated (True) FALSE
(5). Sherrill-Mix et al., BMC Retrovirol., 2015

Deep RNA-seq analysis of primary human T cell infected with low passage HIV isolate HIV89.6 - Primary CD4+ T cell based
Test Status Log2 Fold Change P Value
OK -0.934773 0.000305467
(6). Rotger et al., PLoS Pathog., 2010

Genome-wide mRNA expression of CD4+ T cells from HIV-infected patient
(Genes differentially expressed (at adjusted p<0.01) according to the empirical Bayes approach)
Log2 Fold Change P Value
unknown unknown

Proteomic/Transcriptomics studies indicating differentially expressed genes mediated by HIV

(1). Greenwood et al., Elife, 2016

Activated (CD3/CD28) Primary human CD4+ T cells infected with pNL4-3-dE-EGFP. The table shows the complete (unfiltered) TMT (tandem mass tag)-based proteomic time course dataset
6 h 24 h 48 h 72 h RTi
unknown unknown unknown unknown unknown
(2). Navare et al., Virology, 2012

SUP-T1 cell line
FC-4hpi P-value FC-8hpi P-value FC-20hpi P-value Category
unknown unknown unknown unknown unknown unknown unknown
(3). Hyrcza et al., J. Virolo., 2007

Primary human CD4+ and CD8+ T Cells
Affymetrix Prob ID Fold Change In CD8? Category
unknown unknown unknown unknown

Protein Overview       top

Drug-protein Interaction       (annotations from DrugBank)      top

not found

Protein Secondary Structure       (annotations from PDB)      top

not found

HIV-1 Interaction       (annotations from NCBI HIV-1 Interaction Database)      top

not found

Metabolic/Signalling Pathway       (annotations from KEGG database)      top

Pathway Accession Number Description
hsa04962 Vasopressin-regulated water reabsorption - Homo sapiens (human)