Detailed entry information

Protein Information (annotations from UniProt)

Database IDHIV0000115
UniProt IDQ02410
Primary gene name(s)APBA1
Synonym gene name(s)MINT1, X11
Protein nameAmyloid beta A4 precursor protein-binding family A member 1
Protein functionPutative function in synaptic vesicle exocytosis by binding to Munc18-1, an essential component of the synaptic vesicle exocytotic machinery. May modulate processing of the beta-amyloid precursor protein, APP and hence formation of beta-APP.
Subcellular locationCytoplasm {ECO:0000269|PubMed:20531236}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:20531236}. Nucleus {ECO:0000269|PubMed:20531236}. Note=Only about 5% of the protein is located in the nucleus.;
SUBCELLULAR LOCATION: Isoform 2: Golgi apparatus {ECO:0000269|PubMed:23737971}.
ECO codeClick here for more information.
Amino acid sequence
FASTA format: Q02410
Gene Ontology
(Biological Process)
Complete annatation
axo-dendritic transport [GO:0008088];
cell adhesion [GO:0007155];
chemical synaptic transmission [GO:0007268];
gamma-aminobutyric acid secretion [GO:0014051];
glutamate secretion [GO:0014047];
intracellular protein transport [GO:0006886];
in utero embryonic development [GO:0001701];
locomotory behavior [GO:0007626];
multicellular organism growth [GO:0035264];
nervous system development [GO:0007399];
neurotransmitter secretion [GO:0007269];
protein complex assembly [GO:0006461];
regulation of gene expression [GO:0010468]
Gene Ontology
(Molecular Function)
Complete annatation
beta-amyloid binding [GO:0001540];
phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]
Gene Ontology
(Cellular Component)
Complete annatation
cytosol [GO:0005829];
Golgi apparatus [GO:0005794];
neuron projection [GO:0043005];
nucleus [GO:0005634];
perinuclear region of cytoplasm [GO:0048471];
plasma membrane [GO:0005886];
protein complex [GO:0043234];
synaptic vesicle [GO:0008021]
Protein-protein interaction106817
Phylogenetic treeQ02410
HIV replication factor status Zhou et al., Cell. Host. Microbe., 2008
Brass et al., Science, 2008
Smith et al., J. Immunol, 2010
gene status
Lu et al., J. Virol., 2011
      Folds changes 8h: unknown; Folds changes 16h: unknown; Tested: unknown;
Schoggins JW and Rice CM, Curr. Opin. Virol., 2011
      Targeted viruses: unknown
      Viral life cycle: unknown
      Mechanism related to antiviral activity: unknown
Anti-viral restriction factor Liu et al., Retrovirology, 2011
      unknown (Triplicates)

Gene Expression Profile       top

            Up-regulated;            Down-regulated

For brief introduction to each study, please go to the help page.

Gene expression during HIV latency

(1). Mohammadi et al., PLoS Pathog., 2014

Differentially expressed transcripts (Pairwise) during latency and subsequent viral reactivation using several agents - Primary CD4+ T-cell based model

DMSO: Dimethyl suloxyde (negative control) - 0.0033% final
SAHA: Vorinostat (Histone deacetylase inhibitor) - 0.5 μM
CD3: TCR Stimulation by IL-2+ antiCD3/anti-CD28 antibodies
IL7: Interleukin-7 based stimulation
DISU: Disulfiram (alcohol dehydrogenase inhibitor) - 0.5 μM
AZA: 5-azacytidine (AZA; DNA methylation inhibitor) - 1 μM
Experimental Condition Log2 Fold Change P value Adjusted P value
AZA vs. CD3unknownunknownunknown
AZA vs. DISU-0.9195071620464640.06461252205758240.557950517715582
AZA vs. IL7-0.0621904475260090.8639524573236940.999311006273513
AZA vs. SAHA-0.3032397966252470.3173770057550910.688656081467151
DISU vs. CD3unknownunknownunknown
DISU vs. IL70.8424959260391590.1283433247102430.469244897684423
DISU vs. SAHAunknownunknownunknown
DMSO vs. AZA-0.07472308940395330.8077426368971431
DMSO vs. CD3unknownunknownunknown
DMSO vs. DISU0.8420565081100630.1046534569083950.577435017032927
DMSO vs. IL70.01929602715436550.960890898516670.993151606293804
DMSO vs. SAHA-0.2367356383549640.4230026773709710.761853855661689
HIV vs. Mock in Activationunknownunknownunknown
HIV vs. Mock in Latencyunknownunknownunknown
IL7 vs. CD3unknownunknownunknown
SAHA vs. CD3unknownunknownunknown
SAHA vs. IL7-0.2477824680620240.4757355300212910.708970576326341
(2). Iglesias-Ussel et al., J. Virol., 2013

Up and Downregulated transcripts during Latency (Latently infected CD4+ T cells vs Uninfected)- Primary CD4+Tcell based model
Log2 Fold Change P Value
unknown unknown

Gene expression during HIV infection and replication

(1). Imbeault et al., PloS Pathog., 2012

Transcriptomic profiling of HIV-1 infected CD4+ T cells - Primary CD4+ T cells
Experiment type Log2 Fold Change P Value Adjusted P Value
Infected vs. Mock unknown unknown unknown
Infected vs. Bystander unknown unknown unknown
(2). Lefebvre et al., J. Virol., 2011

Transcriptome analysis of T-cell line (Sup T1)
Log2 Fold Change unknown
(3). Li et al., J. Immunol., 2013

Lymphatic tissue
Acute Fold Change Acute P Value Asymt Fold Change Asypt P Value AIDS Fold Change AIDS P Value
unknown unknown unknown unknown unknown unknown
(4). Chang et al., MBio., 2011

Transcriptome analysis of T-cell line (Sup T1)

Derived from Sherrill-Mix et al., BMC Retrovirol., 2015 cross validation
Up-regulated (True) TRUE
(5). Sherrill-Mix et al., BMC Retrovirol., 2015

Deep RNA-seq analysis of primary human T cell infected with low passage HIV isolate HIV89.6 - Primary CD4+ T cell based
Test Status Log2 Fold Change P Value
OK 0.766646 0.000305467
(6). Rotger et al., PLoS Pathog., 2010

Genome-wide mRNA expression of CD4+ T cells from HIV-infected patient
(Genes differentially expressed (at adjusted p<0.01) according to the empirical Bayes approach)
Log2 Fold Change P Value
unknown unknown

Proteomic/Transcriptomics studies indicating differentially expressed genes mediated by HIV

(1). Greenwood et al., Elife, 2016

Activated (CD3/CD28) Primary human CD4+ T cells infected with pNL4-3-dE-EGFP. The table shows the complete (unfiltered) TMT (tandem mass tag)-based proteomic time course dataset
6 h 24 h 48 h 72 h RTi
unknown unknown unknown unknown unknown
(2). Navare et al., Virology, 2012

SUP-T1 cell line
FC-4hpi P-value FC-8hpi P-value FC-20hpi P-value Category
unknown unknown unknown unknown unknown unknown unknown
(3). Hyrcza et al., J. Virolo., 2007

Primary human CD4+ and CD8+ T Cells
Affymetrix Prob ID Fold Change In CD8? Category
unknown unknown unknown unknown

Protein Overview       top

Drug-protein Interaction       (annotations from DrugBank)      top

not found

Protein Secondary Structure       (annotations from PDB)      top

PDB Accession Method Resolution Chain Structure Preview
1AQC X-ray 2.3Å A/B=453-623.
1U37 NMR - A=655-741.
1U38 NMR - A=655-741.
1U39 NMR - A=743-822.
1U3B NMR - A=655-837.
1X11 X-ray 2.5Å A/B=453-623.
1X45 NMR - A=656-740.
1Y7N NMR - A=745-823.

HIV-1 Interaction       (annotations from NCBI HIV-1 Interaction Database)      top

not found

Metabolic/Signalling Pathway       (annotations from KEGG database)      top

Pathway Accession Number Description
not found