Detailed entry information

Protein Information (annotations from UniProt)

Database IDHIV0000112
UniProt IDQ16853
Primary gene name(s)AOC3
Synonym gene name(s)VAP1
Protein nameMembrane primary amine oxidase
Protein functionCell adhesion protein that participates in lymphocyte extravasation and recirculation by mediating the binding of lymphocytes to peripheral lymph node vascular endothelial cells in an L-selectin-independent fashion. Has semicarbazide-sensitive, SSAO monoamine oxidase activity. May play a role in adipogenesis. {ECO:0000269|PubMed:17400359, ECO:0000269|PubMed:19588076, ECO:0000269|PubMed:23349812, ECO:0000269|PubMed:9653080}.
Subcellular locationCell membrane {ECO:0000269|PubMed:9653080};
Single-pass type II membrane protein {ECO:0000269|PubMed:9653080}.
ECO codeClick here for more information.
Amino acid sequence
FASTA format: Q16853
Gene Ontology
(Biological Process)
Complete annatation
amine metabolic process [GO:0009308];
cell adhesion [GO:0007155];
inflammatory response [GO:0006954];
response to antibiotic [GO:0046677];
xenobiotic metabolic process [GO:0006805]
Gene Ontology
(Molecular Function)
Complete annatation
aliphatic-amine oxidase activity [GO:0052595];
aminoacetone:oxygen oxidoreductase(deaminating activity [GO:0052594];
calcium ion binding [GO:0005509];
copper ion binding [GO:0005507];
phenethylamine:oxygen oxidoreductase, deaminating activity [GO:0052596];
primary amine oxidase activity [GO:0008131];
protein heterodimerization activity [GO:0046982];
protein homodimerization activity [GO:0042803];
quinone binding [GO:0048038];
tryptamine:oxygen oxidoreductase, deaminating activity [GO:0052593]
Gene Ontology
(Cellular Component)
Complete annatation
cell surface [GO:0009986];
cytoplasm [GO:0005737];
early endosome [GO:0005769];
endoplasmic reticulum [GO:0005783];
Golgi apparatus [GO:0005794];
integral component of membrane [GO:0016021];
microvillus [GO:0005902];
plasma membrane [GO:0005886]
Protein-protein interaction114192
Phylogenetic treeQ16853
HIV replication factor status Zhou et al., Cell. Host. Microbe., 2008
Brass et al., Science, 2008
Smith et al., J. Immunol, 2010
gene status
Lu et al., J. Virol., 2011
      Folds changes 8h: unknown; Folds changes 16h: unknown; Tested: unknown;
Schoggins JW and Rice CM, Curr. Opin. Virol., 2011
      Targeted viruses: unknown
      Viral life cycle: unknown
      Mechanism related to antiviral activity: unknown
Anti-viral restriction factor Liu et al., Retrovirology, 2011
      unknown (Triplicates)

Gene Expression Profile       top

            Up-regulated;            Down-regulated

For brief introduction to each study, please go to the help page.

Gene expression during HIV latency

(1). Mohammadi et al., PLoS Pathog., 2014

Differentially expressed transcripts (Pairwise) during latency and subsequent viral reactivation using several agents - Primary CD4+ T-cell based model

DMSO: Dimethyl suloxyde (negative control) - 0.0033% final
SAHA: Vorinostat (Histone deacetylase inhibitor) - 0.5 μM
CD3: TCR Stimulation by IL-2+ antiCD3/anti-CD28 antibodies
IL7: Interleukin-7 based stimulation
DISU: Disulfiram (alcohol dehydrogenase inhibitor) - 0.5 μM
AZA: 5-azacytidine (AZA; DNA methylation inhibitor) - 1 μM
Experimental Condition Log2 Fold Change P value Adjusted P value
AZA vs. CD32.125679956730743.76291195980372e-083.94948531045694e-07
AZA vs. DISU1.785863465787040.009426432555364020.241656537992444
AZA vs. IL7unknownunknownunknown
AZA vs. SAHAunknownunknownunknown
DISU vs. CD3-0.3667317646378790.5896237648809980.702515901405569
DISU vs. IL7-1.73444810187710.01099150395800760.124479331695952
DISU vs. SAHA-0.9538547243605460.1722258792800970.53584150013013
DMSO vs. AZAunknownunknownunknown
DMSO vs. CD3-2.38563404015984.09456468730696e-105.71683197537343e-09
DMSO vs. DISU-2.04042865108360.00320054509692080.12186263762175
DMSO vs. IL7unknownunknownunknown
DMSO vs. SAHAunknownunknownunknown
HIV vs. Mock in Activation0.1358676607316440.8353561518290240.999983755607037
HIV vs. Mock in Latencyunknownunknownunknown
IL7 vs. CD3-2.083227603859543.09753384053479e-084.24446614348918e-07
SAHA vs. CD3-1.330653235870150.0006678015416110570.0025247790346409
SAHA vs. IL7unknownunknownunknown
(2). Iglesias-Ussel et al., J. Virol., 2013

Up and Downregulated transcripts during Latency (Latently infected CD4+ T cells vs Uninfected)- Primary CD4+Tcell based model
Log2 Fold Change P Value
unknown unknown

Gene expression during HIV infection and replication

(1). Imbeault et al., PloS Pathog., 2012

Transcriptomic profiling of HIV-1 infected CD4+ T cells - Primary CD4+ T cells
Experiment type Log2 Fold Change P Value Adjusted P Value
Infected vs. Mock unknown unknown unknown
Infected vs. Bystander unknown unknown unknown
(2). Lefebvre et al., J. Virol., 2011

Transcriptome analysis of T-cell line (Sup T1)
Log2 Fold Change unknown
(3). Li et al., J. Immunol., 2013

Lymphatic tissue
Acute Fold Change Acute P Value Asymt Fold Change Asypt P Value AIDS Fold Change AIDS P Value
-1.8 0.017961783 -1.3 0.11759469 -1.2 0.423484687
(4). Chang et al., MBio., 2011

Transcriptome analysis of T-cell line (Sup T1)

Derived from Sherrill-Mix et al., BMC Retrovirol., 2015 cross validation
Up-regulated (True) TRUE
(5). Sherrill-Mix et al., BMC Retrovirol., 2015

Deep RNA-seq analysis of primary human T cell infected with low passage HIV isolate HIV89.6 - Primary CD4+ T cell based
Test Status Log2 Fold Change P Value
OK 1.51109 0.00261319
(6). Rotger et al., PLoS Pathog., 2010

Genome-wide mRNA expression of CD4+ T cells from HIV-infected patient
(Genes differentially expressed (at adjusted p<0.01) according to the empirical Bayes approach)
Log2 Fold Change P Value
unknown unknown

Proteomic/Transcriptomics studies indicating differentially expressed genes mediated by HIV

(1). Greenwood et al., Elife, 2016

Activated (CD3/CD28) Primary human CD4+ T cells infected with pNL4-3-dE-EGFP. The table shows the complete (unfiltered) TMT (tandem mass tag)-based proteomic time course dataset
6 h 24 h 48 h 72 h RTi
unknown unknown unknown unknown unknown
(2). Navare et al., Virology, 2012

SUP-T1 cell line
FC-4hpi P-value FC-8hpi P-value FC-20hpi P-value Category
unknown unknown unknown unknown unknown unknown unknown
(3). Hyrcza et al., J. Virolo., 2007

Primary human CD4+ and CD8+ T Cells
Affymetrix Prob ID Fold Change In CD8? Category
unknown unknown unknown unknown

Protein Overview       top

Drug-protein Interaction       (annotations from DrugBank)      top

Drugbank ID Drug Name Drug Status Pharmacological Action Drug Action
DB00780 Phenelzine approved unknown inhibitor
DB01275 Hydralazine approved yes inhibitor
DB04334 6-hydroxydopa quinone experimental unknown unknown

Protein Secondary Structure       (annotations from PDB)      top

PDB Accession Method Resolution Chain Structure Preview
1PU4 X-ray 3.2Å A/B=1-763.
1US1 X-ray 2.9Å A/B=1-763.
2C10 X-ray 2.5Å A/B/C/D=29-763.
2C11 X-ray 2.9Å A/B/C/D=29-763.
2Y73 X-ray 2.6Å A/B=1-763.
2Y74 X-ray 2.9Å A/B=1-763.
3ALA X-ray 2.9Å A/B/C/D/E/F/G=33-763.
4BTW X-ray 2.8Å A/B=27-763.
4BTX X-ray 2.7Å A/B=27-763.
4BTY X-ray 3.1Å A/B=27-763.

HIV-1 Interaction       (annotations from NCBI HIV-1 Interaction Database)      top

not found

Metabolic/Signalling Pathway       (annotations from KEGG database)      top

Pathway Accession Number Description
hsa00260 Glycine# serine and threonine metabolism - Homo sapiens (human)
hsa00350 Tyrosine metabolism - Homo sapiens (human)
hsa00360 Phenylalanine metabolism - Homo sapiens (human)
hsa00410 beta-Alanine metabolism - Homo sapiens (human)
hsa01100 Metabolic pathways - Homo sapiens (human)